KAMIKUBO Yasuhiko 上久保靖彦

… Alternative Names

上久保靖彦カミクボヤスヒコ

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Researcher Number	60548527
Other IDs	https://orcid.org/0000-0003-2761-8508
Affiliation (Current)	2025: 千葉県がんセンター(研究所), 発がん研究グループ発がん制御研究部, 部長
Affiliation (based on the past Project Information) *help	2024: 千葉県がんセンター(研究所), 発がん研究グループ発がん制御研究部, 部長 2022: 千葉県がんセンター(研究所), 発がん研究グループ発がん制御研究部, 客員研究員 2018 – 2020: 京都大学, 医学研究科, 特定教授 2016 – 2017: 京都大学, 医学研究科, 准教授 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 … More 2013: 京都大学, 医学部, 准教授 2012: 大阪大学, 医学(系)研究科(研究院), 助教 2012: 大阪大学, 医学系研究科, 助教 2010 – 2011: 東京大学, 医学部附属病院, 助教 Less
Review Section/Research Field	Principal Investigator Hematology / Tumor therapeutics / Basic Section 50010:Tumor biology-related / Biological Sciences Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 55010:General surgery and pediatric surgery-related / Laboratory medicine / Surgery related to the biological and sensory functions and related fields / Hematology
Keywords	Principal Investigator 白血病 / シグナル伝達 / 癌 / RUNX / レセプターチロシンキナーゼ / 癌増殖機構 / 遺伝子発現制御 / 肺癌 / RUNX1 / ノックアウトマウス … More / AML1/RUNX1 / CBF白血病 / HAT / 発現制御 / 担癌マウスモデル / 抗腫瘍免疫 / 転移 / 核酸 / マイクロ・ナノデバイス / 人工知能 / スーパーエンハンサー / 前立腺癌 / 悪性グリオブラストーマ / 脳腫瘍 / 大腸癌 / 膵癌 / 難治性白血病 / RTK / Ras Gene Module / p300 / スパコンシミュレーション法 / 人工遺伝子スイッチ法 / Inv16白血病 / PML / NFκB / HIF2 / エピジェネティック制御 / DDSナノテクノロジー / シュミレーション創薬 / バーキットリンパ腫 / APL白血病 / BCR-ABL白血病 / MLL白血病 / 転写因子 / 胃癌 / 転写因子創薬 / 低分子化合物 / ASXL1 / 家族性血小板減少症 / 骨髄異形成症候群 / 造血幹細胞 / 骨髄ニッチ / ASXL1遺伝子 / 白血病マウス / RUNX1コンプレックス / 遺伝子 / 動物 / 薬理学 / 免疫学 / CROX / 遺伝子スイッチ … More Except Principal Investigator 転写ネットワーク / コンセンサス配列 / グリオーマ / トリプルネガティブ乳癌 / 腫瘍幹細胞 / 核酸類似化合物 / 転写活性制御 / SOX2 / マスター転写因子 / ステムネス / がん幹細胞 / 臨床病理学 / 遺伝子検査学 / 臨床血液学 / 腫瘍検査学 / ゲノム解析 / 予後因子 / 癌遺伝子 / レーザーマイクロダイセクション / フローサイトメトリー法 / ゲノム / 転座型腎細胞癌 / 創薬 / 抗がん剤 / TFE3 / 融合転写因子 / 転座腎細胞癌 / 転写スイッチ低分子化合物 / エピゲノム / RUNX１ / 低分子化合物 / 転写スイッチ / Mesenchymal型転換 / 悪性転化 / RUNX1 / iPS cells / 白血病幹細胞 / iPS細胞 Less

腫瘍集積性誘導体及びPI-Pを用いたトリプルネガティブ乳癌制御戦略の構築
- Principal Investigator
  
  中村力也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
CROX: Construction of tumor immunity / metastasis control strategy by suppressing RUNXPrincipal Investigator
- Principal Investigator
  
  上久保靖彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Study to develop nucleic acid analog to inhibit transcription network to maintain glioma stemness
- Principal Investigator
  
  Miyamoto Susumu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Developing novel therapeutics for Translocation Renal Cell Carcinoma by sequence specific DNA alkylation
- Principal Investigator
  
  Baba Masaya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kumamoto University
Establishment of novel anti-cancer concept overcoming drug resisitancies.Principal Investigator
- Principal Investigator
  
  Kamikubo Yasuhkiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University
Development of low molecular weight compounds switching transcription activity for abnormal epigenetic regulation in glioma
- Principal Investigator
  
  Miyamoto Susumu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Development of new diagnostic method for refractory maliganant diseases
- Principal Investigator
  
  Adachi Souichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyoto University
Development of cancer immunity through innovative immune switchPrincipal Investigator
- Principal Investigator
  
  Kamikubo Yasuhiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University
Elucidating common oncogenic pathway and generating anti-cancer agentsPrincipal Investigator
- Principal Investigator
  
  Kamikubo Yasuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
骨髄微小環境におけるＡＭＬ１／ＲＵＮＸ１及び癌抑制遺伝子ＷＴＸの役割の解明Principal Investigator
- Principal Investigator
  
  上久保靖彦
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  The University of Tokyo
The analysis of leukemia stem cell using iPS cell technology
- Principal Investigator
  
  KUMANO keiki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kansai Medical University
  The University of Tokyo
Studying the CBF leukemogenesis and developing anti-cancer agentsPrincipal Investigator
- Principal Investigator
  
  KAMIKUBO Yasuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
  The University of Tokyo

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All Journal Article Presentation Book Patent Other

[Book] 日本小児血液・がん学会雑誌2015
- Author(s)
  上久保靖彦
- Total Pages
  8
- Publisher
  中西印刷株式会社
- Data Source
  KAKENHI-PROJECT-25461420
[Book] 平成 23 年度造血器疾患治療マニュアル平成2011
- Author(s)
  上久保担当一般事項、付録、HLA 項目
- Publisher
  コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia2018
- Author(s)
  Matsuo Hidemasa、Itonaga Hidehiro、et al.
- Journal Title
  
  Blood Advances
  
  Volume: 2 Issue: 21 Pages: 2879-2889
- DOI
  10.1182/bloodadvances.2018019398
- NAID
  120006534600
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16189, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-17H03597, KAKENHI-PROJECT-17H04110, KAKENHI-PROJECT-17H04209, KAKENHI-PROJECT-16K10050, KAKENHI-PROJECT-16K19193, KAKENHI-PROJECT-16K20951
[Journal Article] Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification2018
- Author(s)
  Uni Masahiro、Masamoto Yosuke、Sato Tomohiko、Kamikubo Yasuhiko、Arai Shunya、Hara Eiji、Kurokawa Mineo
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 191-204
- DOI
  10.1038/s41375-018-0198-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-17H03597, KAKENHI-PROJECT-17H06632, KAKENHI-PROJECT-18K16110
[Journal Article] RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells.2018
- Author(s)
  Mitsuda Y, Morita K, Kashiwazaki G, Taniguchi J, Bando T, Obara M, Hirata M, Kataoka TR, Muto M, Kaneda Y, Nakahata T, Liu PP, Adachi S, Sugiyama H, Kamikubo Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 6423-6423
- DOI
  10.1038/s41598-018-24969-w
- NAID
  120006510275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0053, KAKENHI-PROJECT-18K07014, KAKENHI-PROJECT-16H04712, KAKENHI-PROJECT-17H03597, KAKENHI-PROJECT-17H04110, KAKENHI-PROJECT-16H06356
[Journal Article] PAS positivity of erythroid precursor cells is associated with a poor prognosis in newly diagnosed myelodysplastic syndrome patients2018
- Author(s)
  Masuda K, Shiga S, Kawabata H, Takaori-K A, Ichiyama S and Kamikubo Y
- Journal Title
  
  Int J Hematol.
  
  Volume: 108(1) Issue: 1 Pages: 30-38
- DOI
  10.1007/s12185-018-2443-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03597
[Journal Article] Genetic compensation of RUNX family transcription factors in leukemia.2018
- Author(s)
  Kamikubo Y
- Journal Title
  
  Cancer Science
  
  Volume: Jun 8. Issue: 8 Pages: 123-134
- DOI
  10.1111/cas.13664
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03597
[Journal Article] RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice.2018
- Author(s)
  Morita K, Tokushige C, Maeda S, Kiyose H, Noura M, Iwai A, Yamada M, Kashiwazaki G, Taniguchi J, Bando T, Hirata M, Kataoka TR, Nakahata T, Adachi S, Sugiyama H, Kamikubo Y.
- Journal Title
  
  Blood Adv
  
  Volume: 2 Issue: 5 Pages: 509-515
- DOI
  10.1182/bloodadvances.2017009324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08362, KAKENHI-PROJECT-17H04110
[Journal Article] Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells.2017
- Author(s)
  Morita K, Noura M, Tokushige C, Maeda S, Kiyose H, Kashiwazaki G, Taniguchi J, Bando T, Yoshida K, Ozaki T, Matsuo H, Ogawa S, Liu PP, Nakahata T, Sugiyama H, Adachi S, Kamikubo Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Issue: 1 Pages: 16604-16604
- DOI
  10.1038/s41598-017-16799-z
- NAID
  120006368172
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19193, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17H04110
[Journal Article] The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.2015
- Author(s)
  Matsuo H, Goyama S, Kamikubo Y, Adachi S
- Journal Title
  
  Haematologica
  
  Volume: 100(3) Issue: 3 Pages: 116-117
- DOI
  10.3324/haematol.2015.124396
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461420
[Journal Article] The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.2015
- Author(s)
  Matsuo H, Goyama S, Kamikubo Y, Adachi S
- Journal Title
  
  Haematologica.
  
  Volume: 100
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461420
[Journal Article] Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.2015
- Author(s)
  Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S
- Journal Title
  
  Leukemia
  
  Volume: 29 Issue: 12 Pages: 2438-2441
- DOI
  10.1038/leu.2015.121
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461599, KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-25461611, KAKENHI-PROJECT-25670482, KAKENHI-PROJECT-26670484
[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against　multi-drug-resistant bacteria as well as drug sensitive strains.2015
- Author(s)
  Itoh H, Matsuo H, Kitamura N, Yamamoto S, Higuchi T, Takematsu H, Kamikubo Y, Kondo T, Yamashita K, Sasada M, Takaori-Kondo A, Adachi S.
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 98 Issue: 1 Pages: 107-117
- DOI
  10.1189/jlb.4a0813-422rrr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09499, KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-26670484
[Journal Article] Intravenous immunoglobulin enhances the killing activity and autophagy of neutrophils isolated from immunocompromised patients against multidrug-resistant bacteria.2015
- Author(s)
  Matsuo H, Itoh H, Kitamura N, Kamikubo Y, Higuchi T, Shiga S, Ichiyama S, Kondo T, Takaori-Kondo A, Adachi S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 464 Issue: 1 Pages: 94-9
- DOI
  10.1016/j.bbrc.2015.06.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-26670484
[Journal Article] Adverse Prognostic Impact of KIT Mutations in Childhood CBF-AML: the Results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 Trial2015
- Author(s)
  Mayu Tokumasu, Chisato Kubota-Murata, Akira Shimada, Kentaro Ohki, Yasuhide Hayashi, Akiko Saito, Junichiro Fujimoto, Keizo Horibe, Miho Nagao, Hiroshi Itoh, Yasuhiko Kamikubo, Hideki Nakayama, Akitoshi Kinoshita, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Shiro Tanaka, Toshio Heike, and Souichi Adachi
- Journal Title
  
  Leukemia
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461420
[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against multi-drug-resistant bacteria as same as drug sensitive strains2015
- Author(s)
  Hiroshi Itoh, Hidemasa Matsuo, Naoko Kitamura, Sho Yamamoto, Takeshi Higuchi, Hiromu Takematsu, Yasuhiko Kamikubo, Tadakazu Kondo, Kouhei Yamashita, Masataka Sasada§, Akifumi Takaori-Kondo, Souichi Adachi
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461420
[Journal Article] Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples2014
- Author(s)
  Hosoi M, Kumano K, Taoka K, Arai S, Kataoka K, Ueda K, Kamikubo Y, Takayama N, Otsu M, Eto K, Nakauchi H, Kurokawa M
- Journal Title
  
  Exp Hematol
  
  Volume: (in press) Issue: 9 Pages: 816-25
- DOI
  10.1016/j.exphem.2014.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-26461170
[Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy2013
- Author(s)
  Sho Hangai
- Journal Title
  
  Annals of Hematology
  
  Volume: 92 Issue: 5 Pages: 707-709
- DOI
  10.1007/s00277-012-1603-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-24659457, KAKENHI-PROJECT-25461420, KAKENHI-PUBLICLY-23112504, KAKENHI-PUBLICLY-23130503
[Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D.2013
- Author(s)
  Kobayashi T, Ichikawa M, Kamikubo Y, Kurokawa M.
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 6 Pages: 110-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461420
[Journal Article] The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects andleukemogenesis.2013
- Author(s)
  Kamikubo Y, Hyde RK, Zhao L, Alemu L, Rivas C, Garrett LJ, Liu PP.
- Journal Title
  
  Blood 2013
  
  Volume: 24 Issue: 4 Pages: 638-42
- DOI
  10.1182/blood-2012-06-434688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-25461420, KAKENHI-PUBLICLY-23112504
[Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D.2013
- Author(s)
  Kobayashi T, Ichikawa M, Kamikubo Y, Kurokawa M.
- Journal Title
  
  Int J Clin Exp Pathol.
  
  Volume: 6 Pages: 110-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Catheter-related septic shock by Micrococcus in an autologous hematopoietic stem cell transplantation recipient2013
- Author(s)
  Kogure Y, Nakamura F, Nukina A, Kamikubo Y, Ichikawa M, Kurokawa M, Kamikubo Y, Kurokawa M
- Journal Title
  
  Am J Infect Control.
  
  Volume: 42 Issue: 1 Pages: 87-87
- DOI
  10.1016/j.ajic.2013.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-25670445
[Journal Article] HIV-associated Burkitt lymphoma in a Japanese patient with early submandibular swelling.2013
- Author(s)
  Komatsu N, Kawase-Koga Y, Mori Y, Kamikubo Y, Kurokawa M, Takato T.
- Journal Title
  
  BMC Res Notes
  
  Volume: 6 Issue: 1 Pages: 557-557
- DOI
  10.1186/1756-0500-6-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461420
[Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy.2012
- Author(s)
  Hangai S, Nakamura F, Kamikubo Y, Honda A, Arai S, Nakagawa M, Ichikawa M, Kurokawa M.
- Journal Title
  
  Ann Hematol.
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia2012
- Author(s)
  Keiki Kumano
- Journal Title
  
  BLOOD
  
  Volume: 119 Issue: 26 Pages: 6234-6242
- DOI
  10.1182/blood-2011-07-367441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23790775, KAKENHI-PROJECT-23791154, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249055, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-24659127, KAKENHI-PROJECT-24659457, KAKENHI-PROJECT-24659489, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23112504, KAKENHI-PUBLICLY-23130503
[Journal Article] Pituitary lymphoma developing within pituitary adenoma2012
- Author(s)
  Ken Morita, Fumihiko Nakamura, Yasuhiko Kamikubo, Naoaki Mizuno, Masashi Miyauchi, Yasuhito Nannya, Motoshi Ichikawa, Mineo Kurokawa
- Journal Title
  
  Int J Hematol
  
  Volume: 96 Pages: 721-4
- NAID
  10030793836
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation2012
- Author(s)
  Sho Hangai
- Journal Title
  
  Annals of Hematology
  
  Volume: December12 Issue: 7 Pages: 1654-1655
- DOI
  10.1007/s00277-012-1654-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026, KAKENHI-PROJECT-25461420, KAKENHI-PUBLICLY-23112504
[Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples2012
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka , Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi and Mineo Kurokawa
- Journal Title
  
  Blood.
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis in Mice.2012
- Author(s)
  Martha Kirby, Stacie Anderson, Shelly H Miller, Yasuhiko Kamikubo, Gary Gilliland, and Pu Paul Liu
- Journal Title
  
  Blood.
  
  Volume: 9 Pages: 1511-21
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation.2012
- Author(s)
  Hangai S, Nakamura F, Kamikubo Y, Ichikawa M, Suzuki H, Yoshida S, Yamada A, Takazawa Y,Fukayama M, Koike K, Kurokawa M
- Journal Title
  
  Ann Hematol
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through downregulation of p19ARF2011
- Author(s)
  黒川峰夫, 他
- Journal Title
  
  Blood
  
  Volume: 118 Issue: 9 Pages: 2541-2550
- DOI
  10.1182/blood-2010-10-315440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679004, KAKENHI-PROJECT-22790901, KAKENHI-PUBLICLY-23130503, KAKENHI-PROJECT-23591369, KAKENHI-PROJECT-23591409
[Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia throughdownregulation of p19AR2011
- Author(s)
  Nahoko Nishimoto, Shunya Arai, Motoshi Ichikawa, Masahiro Nakagawa, Susumu Goyama, Keiki Kumano,Tsuyoshi Takahashi, Yasuhiko Kamikubo, Yoichi Imai, and Mineo Kurokawa
- Journal Title
  
  Blood.
  
  Volume: 118 Pages: 2541-50
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Lymphoma with specific affinity to endocrine organs.2011
- Author(s)
  Morita K, Nakamura F, Nannya Y, Kamikubo Y, Ichikawa M, and Kurokawa M.
- Journal Title
  
  Ann Hematol
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma.2011
- Author(s)
  Sho Yamazaki, Yosei Fujioka, Fumihiko Nakamura, Satoshi Ota, Aya Shinozaki, Go Yamamoto, Yasuhiko Kamikubo, Yasuhito Nannya, Motoshi Ichikawa, Masashi Fukayama, Mineo Kurokawa
- Journal Title
  
  Pathol Int
  
  Volume: 61 Pages: 662-6
- NAID
  10031185137
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.2011
- Author(s)
  Sachiko Seo, Tetsuya Nakamoto, Masataka Takeshita, Jun Lu, Tomohiko Sato, Takahiro Suzuki, Yasuhiko Kamikubo, Motoshi Ichikawa, Masaki Noda, Seishi Ogawa, Hiroaki Honda, Hideaki Oda and Mineo Kurokawa
- Journal Title
  
  Cancer Science
- NAID
  10030245544
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity bindingwith RUNX12010
- Author(s)
  Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S,Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP
- Journal Title
  
  Cancer Cell
  
  Volume: 17 Pages: 455-68
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX12010
- Author(s)
  上久保靖彦
- Journal Title
  
  Cancer Cell
  
  Volume: 17(5) Pages: 455-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591026
[Journal Article] A Case of splenic abscess due to Propionibacterium acnes
- Author(s)
  Kiriya S, Sugimoto M, Kamikubo Y, Kurokawa M, Norihiro Kokudo
- Journal Title
  
  CLINCIAL GASTROENTEROLOGY AND HEPATOLOGY
- Data Source
  KAKENHI-PROJECT-22591026
[Patent] ＲＵＮＸ結合配列を標的とする医薬組成物およびＲＵＮＸ阻害剤2018
- Inventor(s)
  杉山弘・上久保靖彦
- Industrial Property Rights Holder
  杉山弘・上久保靖彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-101788
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Suppression of glioblastoma through novel drug based on “Gene Switch Technology”2020
- Author(s)
  Etsuko Yamamoto Hattori, Yoshiki Arakawa, Youhei Mineharu, Masamitsu Mikami, Yasuzumi Matsui, Hiroshi Sugiyama, Souichi Adachi,Yasuhiko Kamikubo
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22685
[Presentation] 遺伝子スイッチ法を用いた、glioblastoma に対する新規治療戦略の構築2020
- Author(s)
  山本悦子、荒川芳輝、峰晴陽平、三上真充、松井恭澄、杉山弘、足立壯一、上久保靖彦
- Organizer
  第38回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22685
[Presentation] Coexistence and prognostic significance of EVI1 expression and driver mutations in KMT2A-rearranged acute myeloid leukemia.2019
- Author(s)
  Matsuo H, Yoshida K, Nakatani K, Kamikubo Y, Tomizawa D, Taga T, Kiyokawa N, Ogawa S, Meggendorfer M, Haferlach C, Adachi S.
- Organizer
  61st Annual Meeting of the American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Combinatorial Histone Acetyltransferases(HATs) inhibition as a potential therapeutic approach for pancreatic cancer.2018
- Author(s)
  Shino Kobyaashi, Yuki Noguchi, Erika Okinak, Natsuki Wariishi, Shiina Iwai, Sae Shimada, Yuta Suzuki, Mai Oyama, Souichi Adachi, Yasuhiko Kamikubo
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Highly Efficient Elimination of p210-,p190-BCR=ABL Protein Through CROX Strategy.2018
- Author(s)
  Shimada S, Noguchi Y, Suzuki Y, Iwai S, Furuichi K, Sugiyama H, Kamikubo Y, Adachi S:
- Organizer
  第9回日本血液学会国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Genetic regulation of RUNX2-cancer stem cell marker X axis in CRPC-NE cells.2018
- Author(s)
  Yuki Noguchi, Natsuki Wariishi, Shiina Iwai, Sae Shimada, Yuta Suzuki, Mai Ohyama, Yasuzumi Matsui, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Inhibition of BCR-ABL expression through CROX(Cluster regulation of RUNX).2018
- Author(s)
  Sae Shimada, Yuki Noguchi, Shiina Iwai, Yuta Suzuki, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Suppression of malignant rhabdoid tumors through novel drug based on“Gene Switch Technology”2018
- Author(s)
  Mikami M, Daifu T, Kanatani T, Furuichi K, Takasaki S, Iwai A, Noguchi Y, Suzuki Y, Matsui Y, Hattori E, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Vascular Niche Regulation Through RUNX1 Attenuating E-Selectin.2018
- Author(s)
  Noguchi Y, Suzuki Y, Furuichi K, Iwai S, Shimada S, Sugiyama H, Adachi S, Kamikubo Y
- Organizer
  第9回日本血液学会国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Vital roke of RUNX1 both in the regulation of BCR-ABL expression and in the maintenanceof CML cells.2018
- Author(s)
  Shimada S, Maeda S, Noguch Y, Iwai S, Suzuki Y, Sugiyama H, Kamikubo Y, Adachi S
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Vascular niche regulation through RUNX1 attenuating E-selectin2018
- Author(s)
  Noguchi Y, Suzuki Y, Furuichi K, Iwai S, Shimada S, Sugiyama H, Adachi S and Kamikubo Y
- Organizer
  第9回JSH国際シンポジウム（京都）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] 神経芽細胞におけるRUNX1-TRIM24/BCL11A-p53 axisの重要性に関する検討2018
- Author(s)
  Yuki Noguchi, Akifumi Nakatani, Shiina Iwai, Yuta Suzuki, Sae Shimada, Masamitsu Mikami, Katsutsugu Umeda, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL-Rearranged Acute Myeloid Leukemia、2018
- Author(s)
  Matsuo H, Yoshida K, Kamikubo Y, Ogawa S, Adachi S et al.
- Organizer
  第60回アメリカ血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] CD146 is a potential therapeutic target in hepatoblastoma2018
- Author(s)
  Sonoda M, Umeda K, Nodomi S, Obu S, Saida S, Kato I, Hiramatsu H, Ogawa E, Okamoto S, Morita K, Kamikubo Y, Adachi S, Nakahata T, Okajima H, Umemoto S, Takita J, and Heike T.
- Organizer
  第60回日本小児血液がん学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] 去勢抵抗性前立腺癌（神経内分泌型）：CRPC-NEに対する新規細胞死誘導法2018
- Author(s)
  割石菜月＊、野口勇貴＊、杉山弘、上久保靖彦、足立壮一
- Organizer
  第27回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] The importance of novel “CROX: Cluster regulation of RUNX” approach for ErbB2/HER2 gastric cancer.2018
- Author(s)
  Obara M, Takasaki S, Noguchi Y, Suzuki Y, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Apoptosis induced by CROX (Cluster regulation of RUNX) in neuroblastoma cells.2018
- Author(s)
  Iwai S, Noguchi Y, Shimada S, Suzuki Y, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] 難治性白血病におけるRUNX1を介した不死化機構の解明2018
- Author(s)
  立田俊也＊、古市華菜＊、野口勇貴、高崎作歩、上久保靖彦、足立壮一
- Organizer
  第27回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Inhibition of neuroblastoma through targeting the RUNX1-TRIM24/BCL11A-p53 axis2018
- Author(s)
  Noguchi Y¶, Nakatani A¶, Iwai S, Suzuki Y, Shimada S, Mikami M, Umeda K, Sugiyama H, Adachi S and Kamikubo Y
- Organizer
  第60回日本小児血液がん学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] CROX (Cluster regulation of RUNX) induces apoptotic cell death through regulating Factor “X” in ATRA-resistance APL cells.2018
- Author(s)
  Furuichi K, Iwai A, Mikami M, Takasaki S, Obara M, Hattori E, Noguchi Y, SugiyamaH, Adachi S and Kamikubo Y
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Vital role of RUNX1 both in the regulation of BCR-ABL expression and in the maintenance of CML cells2018
- Author(s)
  Shimada S, Noguchi Y, Iwai S, Suzuki Y, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] 肝芽腫に対するCD146をターゲットとした新規治療の開発2018
- Author(s)
  Mari Sonoda, Katsutsugu Umeda, Seishiro Nodomi, Satoshi Obu, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Eri Ogawa, Shinya Okamoto, Ken MOrita, Yasuhiko Kamikubo, Souichi Adachi, Tatsutoshi Nakahata, Hideaki Okajima, Shinji Uemoto, Junko Takita,
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Histone acetyltransferases(HATs)コンビネーション制御による膵癌新規治療戦略の構築2018
- Author(s)
  小林紫乃、野口勇貴、沖中えり佳、佐々木亜沙美、武田瑞穂、割石菜月、大山舞、鈴木雄太、足立壮一、上久保靖彦
- Organizer
  第27回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Development of novel therapeutic strategy targeting Histone acetyltransferases for colorectal cancer2018
- Author(s)
  Okinaka E, Noguchi Y, Kobayashi S, Iwai S, Shimada S, Suzuki Y, Oyama M, Adachi S and Kamikubo Y
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Suppression of malignant rhabdoid tumors through novel drug based on “Gene Switch Technology”2018
- Author(s)
  Miami M, Daifu T, Kanatani T, Furuichi K, Takasaki S, Iwai A, Umeda K, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第60回日本小児血液がん学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Highly efficient elimination of p210-, p190-BCR-ABL protein through CROX strategy.2018
- Author(s)
  Shimada S, Noguchi Y, Suzuki Y, Iwai S, Furuichi K, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第9回JSH国際シンポジウム（京都）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Novel anti-leukemia therapeutic strategy through CROX (Cluster regulation of RUNX family).2018
- Author(s)
  Furuichi K, Noguchi Y, Suzuki Y, Iwai S, Shimada S, Iwai A, Sugiyama H, Adachi S and Kamikubo Y
- Organizer
  第9回JSH国際シンポジウム（京都）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] CROX（Cluster regulation of RUNX）strategy for hematological malignancies.2018
- Author(s)
  上久保靖彦
- Organizer
  日本血液学会　北陸地方会　金沢
- Invited
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] CROXによるMRT制御法2018
- Author(s)
  金谷卓弥＊、三上真充＊、大封智雄＊,　高崎作歩, 古市華菜, 野口勇貴, 杉山弘, 上久保靖彦, 足立壯一
- Organizer
  第27回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Paradoxical enhancement of AML through moderately attenuated RUNX1 expression.2018
- Author(s)
  Okinaka E*, Kobayashi S*, Noguchi Y, Furuichi K, Suzuki Y, Iwai S, Shimada S, Iwai A, Sugiyama H, Adachi S and Kamikubo Y
- Organizer
  第9回JSH国際シンポジウム（京都）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Inhibition of BCR-ABL expression through CROX (Cluster regulation of RUNX)2018
- Author(s)
  Shimada S, Maeda S, Noguchi Y, Iwai S, Suzuki Y, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Cluster regulation of RUNX induces apoptotic cell death through regulating gene X in acute promyelocytic leukemia (APL).2018
- Author(s)
  Kana Furuichi, Atsushi Iwai, Masamitsu Mikami, Saho Takasaki, Moeka Obara, Etsuko Hattori, Yuki Noguchi, Toshiya Tatsuta, Yuta Suzuki, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo:
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Regulation of HAT induces apoptotic cell death through regulating hypoxia mechanism in RCC and osteosarcoma cells.2018
- Author(s)
  Saho Takasaki, Masamitsu Mikami, Kana Furuichi, Atsushi Iwai, Moeka Obara, Yuki Noguchi, Takuya Kanatani, Yuta Suzuki, Yasuhiko Kamikubo, Souichi Adachi.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Analysis of the functional role of CBFB in leukemogenesis.2018
- Author(s)
  Noura M, Morita K, Matsuo H, Sugiyama H, Kamikubo Y and Adachi S
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Genetic regulation of RUNX2-cancer stem cell marker X axis in CRPC-NE cells2018
- Author(s)
  Noguchi Y, Wariishi N, Iwai S, Shimada S, Suzuki Y, Ohyama M, Matsui Y, SugiyamaH, Adachi S and Kamikubo Y
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Combinatorial Histone Acetyltransferases(HATs) inhibition as a potential therapeutic approach for pancreatic ductal adenocarcinoma2018
- Author(s)
  Kobayashi S, Noguchi Y, Okinaka E, Wariishi N, Iwai S, Shimada S, Suzuki Y, OyamaY, Adachi S and Kamikubo Y
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Identification of recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia.2018
- Author(s)
  Matsuo H, Yoshida K, Kamikubo Y, Ogawa S, Adachi S et al.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] 遺伝子スイッチ法を用いた、悪性ラブドイド腫瘍に対する新規治療戦略の構築2018
- Author(s)
  Masamitsu Mikami, Tomoo Daifu, Takuya Kanatani, Kana Furuichi, Saho Takasaki, Atsushi Iwai, Katsutsugu Umeda, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Novel Anti-Leukemia Therapeutic Strategy Through CROX(Cluster Regulation of RUNX Family)2018
- Author(s)
  Furuichi K, Noguchi Y, Suzuki Y, Iwai S, Shimada S, Iwai A, Sugiyama H, Adachi S, Kamikubo Y:
- Organizer
  第9回日本血液学会国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Genetic regulation of RUNX2 induce apoptotic cell death through regulating the expression of SOX2 in CRPC-NE cells2018
- Author(s)
  Yuki Noguchi, Natsuki Wariishi, Shiina Iwai, Gengo Kashiwazaki, Junichi Taniguchi, Toshikazu Bando, Masaya Baba, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19619
[Presentation] Genetic regulation of RUNX2 induce apoptotic cell death through regulating the expression of SOX2 in CRPC-NE cells.2018
- Author(s)
  Noguchi Y, Wariishi N, Iwai S, Kashiwazaki G, Taniguchi J, Bando T, Baba M, Adachi S, Sugiyama H and Kamikubo Y
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Regulation of HAT-X induces apoptotic cell death through regulating hypoxia mechanism in renal cell carcinoma and osteosarcoma cells.2018
- Author(s)
  Takasaki S, Mikami M, Furuichi K, Iwai A, Obara M, Noguchi Y, Kanatani T, Suzuki Y, Kamikubo Y and Adachi S
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Suppression of malignant rhabdoid tumors through novel drug based on Gene Switch Technology.2018
- Author(s)
  Masamitsu Mikami, Tomoo Daifu, Takuya Kanatani, Kana Furuichi, Saho Takasaki, Atsushi Iwai, Yuki Noguchi, Yuta Suzuki, Etsuko Httori, Yasuzumi Matsui, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] UNX1と血液悪性疾患2018
- Author(s)
  上久保靖彦
- Organizer
  JACLS総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] CROX(Cluster regulation of RUNX)induces apoptoic cell death through regulatin g Gene X in APL cells.2018
- Author(s)
  Furuichi K, Iwai A, Mikami M, Takasaki S, Obara M, Hattori E, Noguchi Y, Sugiyama H, Adachi S, Kamikubo Y:
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] Cluster regulation of RUNX induces apoptotic cell death through regulating gene X in acute promyelocytic leukemia(APL).2018
- Author(s)
  Furuichi K, Iwai A, Mikami M, Takasaki S, Obara M, Hattori E, Tatsuta T, Noguchi Y, Suzuki Y, Sugiyama H, Adachi S and Kamikubo Y
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03597
[Presentation] Cell-Autonoumous Feedback loop of RUNX-p53 CBFb in Acute Myelogous Leukemia Cells.2017
- Author(s)
  Noura M, Morita K, Tokushige C, Maeda S, Kiyose H, Bando T, Yoshida K, Matsuo H, Ogawa S, Liu P.P, Sugiyama H, Kamikubo Y, Adachi S
- Organizer
  American Society of Hematology 59th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] .RUNX1 enhances leukemia cell engraftment in the vascular niche through up-regulating E-selectin.2017
- Author(s)
  Tokushige C, Morita K, Maeda S, Kiyose H, Noura M, Bando T, Hirata M, Kataoka T, Sugiyama H, Kamikubo Y, Adachi S
- Organizer
  American Society of Hematology 59th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] RUNX1 controls EGFR signaling pathway in non-small cell lung cancers.2017
- Author(s)
  Matsuo A, Morita K, Maeda S, Suzuki K, Kashiwazaki G, Taniguchi J, Bando T, Sugiyama H, Adachi S, Kamikubo Y
- Organizer
  AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] .RUNX1 positively regulates Erb2/HER2 signaling pathway through modulating the expression of SOS1 in gastric cancer cells.2017
- Author(s)
  Mitsuda Y, Morita K, Maeda S, Suzuki K, Kashiwazaki G, Taniguchi J, Bando T, Sugiyama H, Adachi S, Kamikubo Y
- Organizer
  AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04110
[Presentation] スパコンシミュレーション創薬による革新的抗がん剤開発2016
- Author(s)
  上久保靖彦
- Organizer
  京都大学メディカルイノベーションセンターセミナー
- Place of Presentation
  京都
- Year and Date
  2016-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] 難治性白血病に対する新たな耐性克服戦略2016
- Author(s)
  上久保靖彦
- Organizer
  第105回近畿血液学地方会
- Place of Presentation
  兵庫県
- Year and Date
  2016-06-18
- Invited
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] エピジェネティック制御による遺伝子変異阻害メカニズムの解明と難治性急性骨髄性白血病個別化治療法の開発2015
- Author(s)
  野路　由依　矢野　礼佳　上久保　靖彦　足立　壮一
- Organizer
  第29回京都がん研究会
- Place of Presentation
  京都教育文化センター　２F　ホール　京都
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] Induction of cell cycle arrest and apoptosis in ph+ALL cells through inhibition of p3002015
- Author(s)
  Masumi Mori, Yasuhiko Kamikubo, Ayaka Ikeuchi, Yui Noji, Hiroshi Ito, Souichi Adachi
- Organizer
  第77回日本血液学会総会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] 小児がんへの挑戦：夢の創薬　日米～アジア小児がん学術ネットワークの創生2015
- Author(s)
  上久保靖彦
- Organizer
  第20回西日本小児がんセミナー
- Place of Presentation
  大阪リーガロイヤルホテル　大阪
- Year and Date
  2015-02-28
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] The mechanism and the effct of p300 inhibitor on MLL-rearranged ALL cells2015
- Author(s)
  Ayaka Ikeuchi, Yasuhiko Kamikubo, Masumi Mori, Yui Noji, Hiroshi Itoh, Souichi Adachi :
- Organizer
  第77回日本血液学会総会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] Prognostic significance of CXCR4 overexpressio in pediatric AML : the JPLSG AML-05 study2015
- Author(s)
  Hidemasa Matsuo, Naomi Nakamura, Daisuke Tomizawa, Tomoyuki Watanabe, Akiko Moriya Saito, Jun-Ichiro Fujimoto, Keizo Horibe, Yoko Nichinak, Mayu Tokumasu, Hiroshi Itoh, Yasuhiko Kamikubo, Hideki Nakayama, Akitoshi Kinoshita, Takashi Taga, Akio Tawa, Tomohiko Taki, ※Souichi Adachi
- Organizer
  第77回日本血液学会総会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] 腫瘍抑制因子の逆説的要求性：新規白血病診療・治療戦略2015
- Author(s)
  上久保靖彦
- Organizer
  第３３回京都大学小児血液腫瘍研究会
- Place of Presentation
  京都タワーホテル　京都
- Year and Date
  2015-02-21
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] エピジェネティック創薬による白血病克服戦略の構築2015
- Author(s)
  上久保靖彦
- Organizer
  京滋血液研究会
- Place of Presentation
  京都
- Year and Date
  2015-05-15
- Invited
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] がん・成人病への挑戦：各種癌共通増殖機構の解明及びそれをターゲットとした新規エピジェネティック創薬2015
- Author(s)
  上久保靖彦
- Organizer
  京滋血液研究会
- Place of Presentation
  公益財団法人HLA研究所　京都
- Year and Date
  2015-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] 白血病リンパ腫共通増殖機構解明の試み及び新規治療薬開発2013
- Author(s)
  上久保靖彦
- Organizer
  兵庫県白血病懇話会
- Place of Presentation
  兵庫県神戸市
- Invited
- Data Source
  KAKENHI-PROJECT-25461420
[Presentation] 遥かなるワシントンDC：私のNIH 研究留学活用法2012
- Author(s)
  上久保靖彦
- Organizer
  日米医学医療交流セミナー
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PUBLICLY-23112504
[Presentation] 米国におけるunmet population を対象とした開発治験の動向とわが国の取り組み2012
- Author(s)
  上久保靖彦
- Organizer
  第33回日本臨床薬理学会学術集会
- Place of Presentation
  沖縄
- Year and Date
  2012-11-29
- Invited
- Data Source
  KAKENHI-PUBLICLY-23112504
[Presentation] 遥かなるワシントンDC：私のNIH 研究留学活用法2012
- Author(s)
  上久保靖彦
- Organizer
  日米医学医療交流セミナー
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22591026
[Presentation] 新規白血病発症機構解明とNIH MLP/HTS による抗癌剤開発について2012
- Author(s)
  上久保靖彦
- Organizer
  独立行政法人医薬基盤研究所研究振興部セミナー
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22591026
[Presentation] 米国におけるunmet population を対象とした開発治験の動向とわが国の取り組み2012
- Author(s)
  上久保靖彦
- Organizer
  第33回日本臨床薬理学会学術集会
- Place of Presentation
  沖縄
- Invited
- Data Source
  KAKENHI-PROJECT-22591026
[Presentation] Generation of induced pluripotent stem cells from primary hematological malignancies2012
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Mineo Kurokawa
- Organizer
  International Society for Stem cell Research (ISSCR) annual meeting
- Place of Presentation
  Yokohama
- Year and Date
  2012-06-12
- Data Source
  KAKENHI-PROJECT-23591369
[Presentation] 「新規白血病発症機構解明とNIH MLP/HTS による抗癌剤開発について2012
- Author(s)
  上久保靖彦
- Organizer
  独立行政法人医薬基盤研究所研究振興部セミナー
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PUBLICLY-23112504
[Presentation] Generation of induced pluripotent stem cells from primary hematological malignancies.2012
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Mineo Kurokawa.
- Organizer
  International Society for Stem cell Research (ISSCR) annual meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23591369
[Presentation] Generation of induced pluripotent stem cells from primary hematological malignancies and search for the novel targeted therapy2011
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Mineo Kurokawa
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23591369
[Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis2011
- Author(s)
  上久保靖彦
- Organizer
  JACLS(小児白血病研究会)総会
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22591026
[Presentation] Generation of induced pluripotent stem cells from primary hematological malignancies and search for the novel targeted therapy2011
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Mineo Kurokawa
- Organizer
  The 9^<th> Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-23591369
[Presentation] Generation of induced pluripotent stem cells from primary hematological malignancies2011
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Mineo Kurokawa
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23591369
[Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis2011
- Author(s)
  上久保靖彦
- Organizer
  JACLS(小児白血病研究会)総会
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PUBLICLY-23112504
[Presentation] Generation of induced pluripotent stem cells from primary hematological malignancies and search for the novel targeted therapy.2011
- Author(s)
  Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, and Mineo Kurokawa.
- Organizer
  The 9th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23591369
[Presentation] CBF白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis2011
- Author(s)
  上久保靖彦
- Organizer
  Kyoto Hematology Forum
- Place of Presentation
  京都
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-22591026
[]

1. 杉山弘 (50183843)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. Adachi Souichi (10273450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Miyamoto Susumu (70239440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 荒川芳輝 (20378649)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. KUMANO keiki (90396721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. Baba Masaya (10347304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 水田秀一 (10367708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 正木康史 (40238895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中村力也 (50456026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 筆宝義隆 (30359632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Terada Yukinori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Matsui Yasuzumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Makino Yasuhide

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Hattori Etsuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OHKI Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. YAMASHITA Kouhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 足立壮一

# of Collaborated Projects: 0 results

# of Collaborated Products: 45 results
18. 糸永英弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 黒川峰夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 金田安史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 林泰秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 松尾英将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 片岡竜貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAMIKUBO Yasuhiko 上久保 靖彦

上久保 靖彦 カミクボ ヤスヒコ

Research Projects

Research Products

Co-Researchers

腫瘍集積性誘導体及びPI-Pを用いたトリプルネガティブ乳癌制御戦略の構築

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CROX: Construction of tumor immunity / metastasis control strategy by suppressing RUNXPrincipal Investigator

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Study to develop nucleic acid analog to inhibit transcription network to maintain glioma stemness

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Developing novel therapeutics for Translocation Renal Cell Carcinoma by sequence specific DNA alkylation

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Establishment of novel anti-cancer concept overcoming drug resisitancies.Principal Investigator

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Development of low molecular weight compounds switching transcription activity for abnormal epigenetic regulation in glioma

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Development of new diagnostic method for refractory maliganant diseases

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Development of cancer immunity through innovative immune switchPrincipal Investigator

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Elucidating common oncogenic pathway and generating anti-cancer agentsPrincipal Investigator

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骨髄微小環境におけるＡＭＬ１／ＲＵＮＸ１及び癌抑制遺伝子ＷＴＸの役割の解明Principal Investigator

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The analysis of leukemia stem cell using iPS cell technology

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Studying the CBF leukemogenesis and developing anti-cancer agentsPrincipal Investigator

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[Book] 日本小児血液・がん学会雑誌2015

Author(s)

Total Pages

KAMIKUBO Yasuhiko 上久保靖彦

上久保靖彦カミクボヤスヒコ

[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against　multi-drug-resistant bacteria as well as drug sensitive strains.2015