Uzawa Takanori 鵜澤尊規

… Alternative Names

鵜澤尊規ウザワタカノリ

UZAWA Takanori 鵜澤尊規

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Researcher Number	60554376
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 開拓研究所, 専任研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 専任研究員 2015 – 2017: 国立研究開発法人理化学研究所, 創発物性科学研究センター, 専任研究員 2014 – 2015: 国立研究開発法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 2014: 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 2011 – 2013: 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 研究員
Review Section/Research Field	Principal Investigator Bio-related chemistry / Biological Sciences / Chemistry related to living body Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Biofunction/Bioprocess / Biomedical engineering/Biological material science
Keywords	Principal Investigator 進化分子工学 / ルテニウム錯体 / 封入体 / 西洋わさびペルオキシターゼ / 西洋ワサビペルオキシターゼ / レアコドン / 金属錯体 / 蛍光性アミノ酸、 / アミノアシルtRNA合成酵素 / 非天然アミノ酸 … More / アジドローダミン / 電子移動 / エネルギー移動 / アプタマー / 発光寿命 / 両末端衝突速度 / ダイナミクス / 両末端の衝突速度 / 核酸 … More Except Principal Investigator 進化分子工学 / 癌治療 / 抗癌剤 / がん治療 / 高分子医薬 / 抗がん剤デリバリー / 免疫チェックポイント阻害剤 / ドラッグ・デリバリー / 免疫治療 / 超分子集合体形成 / 両親媒性ポリペプチド / ナノキャリア / 低分子医薬 / ペプチド医薬 / 非天然アミノ酸 / アルドール縮合 / ミスアシル化tRNA / ペプチド触媒 / mRNAディスプレイ / 分子進化工学 / 固定化 / 試験管内進化法 / バイオ直交化学 / 再生医療 / タンパク質工学 / バイオマテリアル / 融合タンパク質 / 結合性 / 成長因子 Less

Multimodal cancer therapy by combination of immune therapy and targeting nanostructured carrier containing anti-cancer drug
- Principal Investigator
  
  Ito Yoshihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Physical and Chemical Research
In-cell signal amplification system developed by evolutionally molecular engineering(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  UZAWA Takanori
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
ポリペプチド鎖合成におけるレアコドンによる正の折り畳み制御機構の検討Principal Investigator
- Principal Investigator
  
  鵜澤尊規
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
in cell Templated Reaction by employing in vitro selected RNA aptamersPrincipal Investigator
- Principal Investigator
  
  UZAWA Takanori
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Institute of Physical and Chemical Research
Screening of peptide catalyst by chemically extended molecular evlutionary engineering
- Principal Investigator
  
  ITO Yoshihiro
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  The Institute of Physical and Chemical Research
Investigation of intramolecular collision dynamics of RNAPrincipal Investigator
- Principal Investigator
  
  UZAWA Takanori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The Institute of Physical and Chemical Research
Creation of binding growth factors by molecular evolutionary engineering and their medical applications
- Principal Investigator
  
  ITO Yoshihiro
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The Institute of Physical and Chemical Research

All 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] “Creation of functional peptides by evolutionary engineering with bioorthogonal incorporation of artificial components”,　in "Green Polymer Chemistry III: Biobased Materials and Biocatalysis", ed. by H. N. Cheng, R. A. Gross, and P. B. Smith, ACS Symposium Series,2015
- Author(s)
  Seiichi Tada, Takanori Uzawa, and Yoshihiro Ito
- Publisher
  アメリカ化学会
- Data Source
  KAKENHI-PROJECT-22220009
[Book] 「進化分子工学のライブラリーの拡張―天然ソースから非天然ソースへ」、「進化分子工学の最前線」2013
- Author(s)
  鵜澤尊規、多田誠一、伊藤嘉浩
- Total Pages
  424
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-22220009
[Journal Article] In vitro selection of a peptide aptamer that changes fluorescence in response to verotoxin2015
- Author(s)
  Yasodha Manandhar, Tara Bahadur K.C., Wei Wang, Takanori Uzawa, Toshiro Aigaki, and Yoshihiro Ito
- Journal Title
  
  Biotechnol. Lett.
  
  Volume: 37 Issue: 3 Pages: 619-625
- DOI
  10.1007/s10529-014-1719-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22220009
[Journal Article] In vitro selection of a photoresponsive peptide aptamer to glutathione-immobilized microbeads2015
- Author(s)
  Seiichi Tada, Qingmin Zang, Wei Wang, Masuki Kawamoto, Mingzhe Liu, Michiru Iwashita, Takanori Uzawa, Daisuke Kiga, Masayuki Yamamura, and Yoshihiro Ito
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 119 Issue: 2 Pages: 137-139
- DOI
  10.1016/j.jbiosc.2014.06.018
- NAID
  110009922573
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22220009, KAKENHI-PROJECT-25871130, KAKENHI-PLANNED-23119008
[Journal Article] In vitro selection of a peptide aptamer that potentiates inhibition of cyclin-dependent kinase 2 by purvalanol2014
- Author(s)
  Wei Wang, Yoshinori Hirano, Takanori Uzawa, Mingzhe Liu, Makoto Taiji and Yoshihiro Ito
- Journal Title
  
  Med. Chem. Commun.
  
  Volume: 5 Issue: 9 Pages: 1400-1403
- DOI
  10.1039/c4md00142g
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22220009
[Journal Article] A fluorogenic peptide probe developed by in vitro selection using tRNA carrying a fluorogenic amino acid2014
- Author(s)
  Wei Wang, Takanori Uzawa, Naoya Tochio, Jumpei Hamatsu, Yoshinori Hirano, Seiichi Tada, Hisao Saneyoshi, Takanori Kigawa, Nobuhiro Hayashi, Yutaka Ito, Makoto Taiji, Toshiro Aigaki, and Yoshihiro Ito
- Journal Title
  
  Chem Commun.
  
  Volume: 50 Issue: 22 Pages: 2962-2964
- DOI
  10.1039/c3cc47624c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220009
[Journal Article] いよいよ化学の出番がきた進化分子工学―機能性を付与した分子認識を自由自在にデザイン2014
- Author(s)
  多田誠一、鵜澤尊規、伊藤嘉浩
- Journal Title
  
  化学
  
  Volume: 69 Pages: 70-71
- Data Source
  KAKENHI-PROJECT-22220009
[Journal Article] In vitro selection of peptide aptamers using a ribosome display for a conducting polymer2014
- Author(s)
  Zha Li, Takanori Uzawa, Haichao Zhao, Shyh-Chyang Luo, Hsiao-hua Yu, Eiry Kobatake, and Yoshihiro Ito
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 117 Issue: 4 Pages: 501-503
- DOI
  10.1016/j.jbiosc.2013.10.005
- NAID
  110009817067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220009, KAKENHI-PROJECT-23360364
[Journal Article] Sequence and temperature dependence of the end-to-end collision dynamics of single-stranded DNA2013
- Author(s)
  T. Uzawa
- Journal Title
  
  Biophysical journal
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750202
[Journal Article] Expansion of Aptamer Library from “Natural soup” to “Unnatural soup”2013
- Author(s)
  T. Uzawa
- Journal Title
  
  Chem. Commun.
  
  Volume: 49 Issue: 18 Pages: 1786-1795
- DOI
  10.1039/c2cc36348h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220009
[Journal Article] Electrostatic and Base Stacking Effects Define the End-to-end Collision Dynamics of Single-stranded DNA2013
- Author(s)
  Takanori Uzawa, Takashi Isoshima, Yoshihiro Ito, Koichiro Ishimori, Dmitrii E. Makarov, and Kevin W Plaxco
- Journal Title
  
  Biophys.J.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23750202
[Presentation] Selection of Ru(bpy)32+ motifs from a randomized peptide library2016
- Author(s)
  Karimi, Tada, Minagawa, Hirose, Ito, Uzawa
- Organizer
  54回生物物理学会年会
- Place of Presentation
  つくば国際会議場、茨木県つくば市
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PUBLICLY-15H01549
[Presentation] Improvement of a photosensitizer performance by employing an RNA aptamer2016
- Author(s)
  Uzawa
- Organizer
  CEMSupra
- Place of Presentation
  東京大学
- Year and Date
  2016-01-14
- Data Source
  KAKENHI-PROJECT-26708020
[Presentation] Incorporation of fluorescent amino acid for lifetime FRET2016
- Author(s)
  Uzawa
- Organizer
  生物物理学会年会
- Place of Presentation
  金沢大学（石川県、金沢市）
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PUBLICLY-15H01549
[Presentation] Selection of Ru(bpy)32+ motifs from a randomized peptide library2016
- Author(s)
  Karimi, Tada, Minagawa, Hirose, Ito, Uzawa
- Organizer
  Nascent chain biology meeting
- Place of Presentation
  Fuji Lake hotel、山梨県南都留郡
- Year and Date
  2016-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01549
[Presentation] Selection of Ru(bpy)32+ motifs from a randomized peptide library2016
- Author(s)
  2.Karimiavargani, Minagawa, Hirose, Ito, and Uzawa
- Organizer
  生物物理学会年会
- Place of Presentation
  金沢大学（石川県、金沢市）
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PUBLICLY-15H01549
[Presentation] Fabrication of photosensitizing and electron-storage RNA-modules2016
- Author(s)
  Thoa, Minagawa, Aigaki, Ito and Uzawa
- Organizer
  高分子学会埼玉地区懇話会
- Place of Presentation
  リンテック　さいたま市
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-26708020
[Presentation] Fabrication of photosensitizing and electron-storage RNA-modules2014
- Author(s)
  Tran, Minagawa, Ponnurengam, Aigaki, Ito and Uzawa
- Organizer
  生物物理学会年回
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26708020
[Presentation] Selection of RNA aptamers to develop a sensor using rhodamine as a fluorogenic probe2014
- Author(s)
  KC, Abe, Ito, Uzawa
- Organizer
  生物物理学会年回
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26708020
[Presentation] Selection of an RNA aptamer binding to a photosensitizer - Ru(bpy)32+2014
- Author(s)
  Tran, Aigaki, Ito, Uzawa
- Organizer
  Vietnamese – Japanese Student's Scientific Exchange Meeting
- Place of Presentation
  神戸大学
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26708020
[Presentation] ルテニウム錯体に結合するRNA アプタマーの選出2012
- Author(s)
  鵜澤尊規、Thoa TRAN、伊藤嘉浩
- Organizer
  光合成領域会議
- Place of Presentation
  東京工業大学
- Year and Date
  2012-12-17
- Data Source
  KAKENHI-PROJECT-23750202
[Presentation] ルテニウム錯体に結合するRNAアプタマーの選出2012
- Author(s)
  鵜澤尊規
- Organizer
  新学術領域第一回公開シンポジウム
- Place of Presentation
  大岡山, 日本
- Data Source
  KAKENHI-PROJECT-22220009
[Presentation] ルテニウム錯体に結合するRNAアプタマーの選出2012
- Author(s)
  鵜澤尊規
- Organizer
  新学術領域　人工光合成　第1回公開シンポジウム
- Place of Presentation
  東京工業大学大岡山キャンパス
- Data Source
  KAKENHI-PROJECT-23750202
[Presentation] A signaling peptide aptamers2012
- Author(s)
  W.Wang, T.Uzawa, T.Aigaki, Y.Ito
- Organizer
  Gordon Research Conferences "Peptides as signals, BioMaterials and Therapeutics
- Place of Presentation
  Ventura, CA., USA
- Data Source
  KAKENHI-PROJECT-22220009
[Presentation] A fluorescent sensor peptide aptamer by molecular evolutionary engineering2011
- Author(s)
  W.Wang, T.Uzawa, T.Aigaki, Y.Ito
- Organizer
  60th symposium on macromolecules
- Place of Presentation
  Okayama
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22220009
[Presentation] Peptide aptamer to carbon nanotubes by ribosome display2011
- Author(s)
  Z.Li, T.Uzawa, Y.Ito
- Organizer
  60th symposium on macromolecules
- Place of Presentation
  Okayama
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22220009

1. ITO Yoshihiro (40192497)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. TADA Seiichi (30598165)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. UEDA Motoki (10615040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MATSUKAWA Akihiro (90264283)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Yasuhiro (90281162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAKURAGI Makoto (10435828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KITAJIMA Takashi (40399556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. WANG Wei (30632955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ABE Hiroshi (80415067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 秋元淳 (80649682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Hollfelder Florian

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Uzawa Takanori 鵜澤 尊規

鵜澤 尊規 ウザワ タカノリ

UZAWA Takanori 鵜澤 尊規

Research Projects

Research Products

Co-Researchers

Multimodal cancer therapy by combination of immune therapy and targeting nanostructured carrier containing anti-cancer drug

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In-cell signal amplification system developed by evolutionally molecular engineering(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポリペプチド鎖合成におけるレアコドンによる正の折り畳み制御機構の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

in cell Templated Reaction by employing in vitro selected RNA aptamersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of peptide catalyst by chemically extended molecular evlutionary engineering

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of intramolecular collision dynamics of RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Creation of binding growth factors by molecular evolutionary engineering and their medical applications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] “Creation of functional peptides by evolutionary engineering with bioorthogonal incorporation of artificial components”, in "Green Polymer Chemistry III: Biobased Materials and Biocatalysis", ed. by H. N. Cheng, R. A. Gross, and P. B. Smith, ACS Symposium Series,2015

Author(s)

Publisher

Data Source

[Book] 「進化分子工学のライブラリーの拡張―天然ソースから非天然ソースへ」、「進化分子工学の最前線」2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] In vitro selection of a peptide aptamer that changes fluorescence in response to verotoxin2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro selection of a photoresponsive peptide aptamer to glutathione-immobilized microbeads2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] In vitro selection of a peptide aptamer that potentiates inhibition of cyclin-dependent kinase 2 by purvalanol2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A fluorogenic peptide probe developed by in vitro selection using tRNA carrying a fluorogenic amino acid2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] いよいよ化学の出番がきた進化分子工学―機能性を付与した分子認識を自由自在にデザイン2014

Author(s)

Uzawa Takanori 鵜澤尊規

鵜澤尊規ウザワタカノリ

UZAWA Takanori 鵜澤尊規

[Book] “Creation of functional peptides by evolutionary engineering with bioorthogonal incorporation of artificial components”,　in "Green Polymer Chemistry III: Biobased Materials and Biocatalysis", ed. by H. N. Cheng, R. A. Gross, and P. B. Smith, ACS Symposium Series,2015