FUKUI Ryutaro 福井竜太郎

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Fukui Ryutaro 福井竜太郎

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Researcher Number	60554508
Other IDs
Affiliation (Current)	2025: 千葉大学, 未来粘膜ワクチン研究開発シナジー拠点, 特任准教授
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医科学研究所, 特任准教授 2020: 東京大学, 医科学研究所, 特任准教授 2018 – 2019: 東京大学, 医科学研究所, 助教 2013 – 2015: 東京大学, 医科学研究所, 助教 2011: 東京大学, 医科学研究所, 特任助教 2010: 東京大学, 医科学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49030:Experimental pathology-related / Basic Section 49070:Immunology-related
Keywords	Principal Investigator 自己免疫疾患 / Toll-like receptor / 自然免疫 / TLR7 / 新規分子探索 / サイトカイン / 自然炎症 / Unc93 homolog B1 / 新規樹状細胞サブセット / B細胞 … More / 炎症誘導性単球 / 炎症 / 単球系細胞 / 表現型調節因子 / 核酸認識系TLR応答調節 / 遺伝子改変マウス / 新規分子 / 連鎖解析 / ゲノム編集 / sgRNAライブラリ / ファンクショナルクローニング / I型インターフェロン / 核酸認識 / 骨髄増殖性疾患 / 急性肝炎 / Th17 / 肝炎 / 内因性リガンド Less

核酸認識TLRによるANCA関連血管炎誘導メカニズムの解明Principal Investigator
- Principal Investigator
  
  福井竜太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Analysis of the mechanism that inflammation-inducible DC subset enhances the survival of B cellsPrincipal Investigator
- Principal Investigator
  
  Fukui Ryutaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Tokyo
Search for new molecules controlling the response of nucleic acid-sensing TLRsPrincipal Investigator
- Principal Investigator
  
  FUKUI Ryutaro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Analysis of the mechanism for controlling reciprocal balance in nucleic acid sensing-innate immune systemPrincipal Investigator
- Principal Investigator
  
  FUKUI Ryutaro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2016 2015 2014 2013 2011 2010

All Journal Article Presentation Book

[Book] 核酸認識Toll様受容体におけるDNAとRNAの相反的応答制御炎症と免疫 182010
- Author(s)
  福井竜太郎、三宅健介
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-22790454
[Book] Unc93B1によるTLR7とTLR9シグナルの相反的制御感染・炎症・免疫 402010
- Author(s)
  福井竜太郎
- Publisher
  医薬の門社
- Data Source
  KAKENHI-PROJECT-22790454
[Book] TLRの小胞からエンドリソソームへの転送とUnc93B1 臨床免疫・アレルギー科 532010
- Author(s)
  福井竜太郎、三宅健介
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22790454
[Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020
- Author(s)
  Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: 32 Issue: 12 Pages: 785-798
- DOI
  10.1093/intimm/dxaa055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-19K16685, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
[Journal Article] Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA2018
- Author(s)
  Fukui Ryutaro、Yamamoto Chikako、Matsumoto Fumi、Onji Masahiro、Shibata Takuma、Murakami Yusuke、Kanno Atsuo、Hayashi Takuto、Tanimura Natsuko、Yoshida Nobuaki、Miyake Kensuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1491-1491
- DOI
  10.3389/fimmu.2018.01491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells2016
- Author(s)
  Fukui R, Kanno A, Miyake K
- Journal Title
  
  J Immunol
  
  Volume: 196 Issue: 1 Pages: 416-427
- DOI
  10.4049/jimmunol.1500071
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-16H02629
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6119-6119
- DOI
  10.1038/ncomms7119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
[Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015
- Author(s)
  Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, *Miyake K
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 5853-5853
- DOI
  10.1038/ncomms6853
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-25291010
[Journal Article] Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Strand RNA Sensing2015
- Author(s)
  Murakami Y, Fukui R, Motoi Y, Kanno A, Shibata T, Tanimura N, Saitoh S, Miyake K
- Journal Title
  
  Journal of Immunology
  
  Volume: 193 Issue: 10 Pages: 5208-5217
- DOI
  10.4049/jimmunol.1400386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] Double-stranded RNA of small intestinal commensal but not pathogenic bacteria triggers TLR3-mediated IFN-β production by dendritic cells2013
- Author(s)
  T. Kawashima, A. Kosaka, H. Yan, G. Zijin, R. Uchiyama, R. Fukui, D. Kaneko; Y. Kumagai; D.-J. You, J. Carreras, S. Uematsu, M. H. Jang, O. Takeuchi, T. Kaisho, S. Akira, K. Miyake, H. Tsutsui, T. Saito, I. Nishimura, N. M. Tsuji
- Journal Title
  
  Immunity
  
  Volume: 38 Issue: 6 Pages: 1187-1197
- DOI
  10.1016/j.immuni.2013.02.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-24229004, KAKENHI-PROJECT-24590582, KAKENHI-PROJECT-25460585
[Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013
- Author(s)
  Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
- Journal Title
  
  Nat. Commun.
  
  Volume: 4 Issue: 1 Pages: 1949-1949
- DOI
  10.1038/ncomms2949
- NAID
  120005359107
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-25860353
[Journal Article] Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking.2011
- Author(s)
  Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, and Kensuke Miyake
- Journal Title
  
  Immunity 35
  
  Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790454
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking2011
- Author(s)
  Fukui R
- Journal Title
  
  Immunity
  
  Volume: 35 Issue: 1 Pages: 69-81
- DOI
  10.1016/j.immuni.2011.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059010, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-21390298, KAKENHI-PROJECT-22500286, KAKENHI-PROJECT-22659097, KAKENHI-PROJECT-22790454, KAKENHI-PUBLICLY-23118520
[Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.2010
- Author(s)
  Makiko Hirai, Norimitsu Kadowaki, Toshio Kitawaki, Haruyuki Fujita, Akifumi Takaori-Kondo, Ryutaro Fukui, Kensuke Miyake, Takahiro Maeda, Shimeru Kamihira, Yoshiki Miyachi, Takashi Uchiyama.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 500-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Toll-like receptor 7 is a factor of type 1 diabetes in NOD mice2019
- Author(s)
  FUKUI Ryutaro, KANNO Atsuo, MOTOI Yuji, MURAKAMI Yusuke, MIYAKE Kensuke
- Organizer
  第４８回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07169
[Presentation] マウスToll-like receptor 7阻害抗体は炎症性疾患モデルマウスの症状を緩和する2019
- Author(s)
  福井　竜太郎
- Organizer
  第４０回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07169
[Presentation] I型インターフェロンはB細胞と樹状細胞のTLR7発現を維持し、TLR7の過剰応答による致死的な炎症に関与する.2015
- Author(s)
  福井竜太郎, 菅野敦夫, 三宅健介.
- Organizer
  第80回日本インターフェロン・サイトカイン学会学術集会
- Place of Presentation
  東京工業大学蔵前会館
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-25460585
[Presentation] Expression patterns of TLR7 in DCs and B cells are controlled by Type-I IFN and influence TLR7 dependent inflammation2014
- Author(s)
  Ryutaro Fukui, Atsuo Kanno and Kensuke Miyake
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館, 京都府
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25460585
[Presentation] shRNAライブラリーを用いたファンクショナルクローニングによるTLR7応答の制御因子の探索2014
- Author(s)
  高橋紀子, 福井竜太郎, 三宅健介
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜, 神奈川県
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25460585
[Presentation] Search for regulatory molecules of nucleic acid sensing Toll-like receptors dependent systemic inflammation2013
- Author(s)
  Ryutaro Fukui and Kensuke Miyake
- Organizer
  第４３回　日本免疫学会
- Place of Presentation
  日本・幕張
- Data Source
  KAKENHI-PROJECT-25460585
[Presentation] Collapse of TLR7/TLR9 balance leads genetical background dependent phenotypes2013
- Author(s)
  Ryutaro Fukui and Kensuke Miyake
- Organizer
  第１５回　国際免疫学会
- Place of Presentation
  イタリア・ミラノ
- Data Source
  KAKENHI-PROJECT-25460585
[Presentation] Unc93 homolog B1restricts lethal homeostatic inflammation by regulating TLR7 and TLR9 reciprocally2011
- Author(s)
  Ryutaro Fukui, Shin-Ichiroh Saitoh, Atuso Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, and Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会ワークショップ
- Place of Presentation
  幕張メッセ,千葉県
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Unc93 homolog B1 restricts lethal homeostatic inflammation by controlling TLR7 and TLR9 response2011
- Author(s)
  Ryutaro Fukui, Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会シンポジウム
- Place of Presentation
  幕張メッセ・千葉(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response2011
- Author(s)
  Ryutaro Fukui
- Organizer
  Bio-Rheumatology International Congress (BRIC) Tokyo, The 8th GARN Meeting
- Place of Presentation
  ヒルトン東京ベイホテル・千葉
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Unc93 homolog B1 restricts systemic lethal inflammation by or chestrating TLR7 and TLR9 response2011
- Author(s)
  Ryutaro Fukui
- Organizer
  Bio-Rheumatology International Congress(BRIC) Tokyo, The 8th GARN Meeting
- Place of Presentation
  ヒルトン東京ベイホテル,千葉県
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response2011
- Author(s)
  Ryutaro Fukui, Shin-Ichiroh Saitoh, Atuso Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake
- Organizer
  TOLL2011
- Place of Presentation
  Riva del Garda, Italy
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Unc93 homolog B1 restricts lethal homeostatic inflammation by regulating TLR7 and TLR9 reciprocally2011
- Author(s)
  Ryutaro Fukui, Shin-Ichiroh Saitoh, Atuso Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会ワークショップ
- Place of Presentation
  幕張メツセ・千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response2011
- Author(s)
  Ryutaro Fukui, Shin-Ichiroh Saitoh, Atuso Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Shizuo Akira, Nobuaki Yoshida, and Kensuke Miyake
- Organizer
  TOLL2011
- Place of Presentation
  Rivadel Garda, Italy
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Roles for Unc93 homologB1-dependent TLR7/TLR9 balance invivo2010
- Author(s)
  Ryutaro Fukui, Shin-ichiroh Saitoh, Masahiro Onji, Takuma Shibata, Akihiko Ito, Keiko B. Kimura, Nobuaki Yoshida, Kensuke Miyake
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790454
[Presentation] Roles for Unc93 homolog B1-dependent TLR7/TLR9 balance in vivo2010
- Author(s)
  Ryutaro Fukui, Atsuo Kanno, Takurua Shibata, Masahiro Onji, Nobuaki Yoshida, Keiko B, Kimura, Akihiko Ito, Shin-ichiroh Saitoh, Kensuke Miyake
- Organizer
  第14回国際免疫学会
- Place of Presentation
  神戸ポートピアホテル神戸国際展示場
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790454

1. 斉藤伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 三宅健介

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 改正恒康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUKUI Ryutaro 福井 竜太郎

Fukui Ryutaro 福井 竜太郎

Research Projects

Research Products

Co-Researchers

核酸認識TLRによるANCA関連血管炎誘導メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism that inflammation-inducible DC subset enhances the survival of B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for new molecules controlling the response of nucleic acid-sensing TLRsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism for controlling reciprocal balance in nucleic acid sensing-innate immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 核酸認識Toll様受容体におけるDNAとRNAの相反的応答制御 炎症と免疫 182010

Author(s)

Publisher

Data Source

[Book] Unc93B1によるTLR7とTLR9シグナルの相反的制御 感染・炎症・免疫 402010

Author(s)

Publisher

Data Source

[Book] TLRの小胞からエンドリソソームへの転送とUnc93B1 臨床免疫・アレルギー科 532010

Author(s)

Publisher

Data Source

[Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Strand RNA Sensing2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Double-stranded RNA of small intestinal commensal but not pathogenic bacteria triggers TLR3-mediated IFN-β production by dendritic cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013

Author(s)

Journal Title

DOI

FUKUI Ryutaro 福井竜太郎

Fukui Ryutaro 福井竜太郎

[Book] 核酸認識Toll様受容体におけるDNAとRNAの相反的応答制御炎症と免疫 182010

[Book] Unc93B1によるTLR7とTLR9シグナルの相反的制御感染・炎症・免疫 402010