Zhang Kam ＺＨＡＮＧＫＡＭ

Researcher Number	60558906
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2017 – 2020: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー 2016: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー
Review Section/Research Field	Principal Investigator Biophysics / Chemical biology / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator Nanobodies / Unnatural amino acid / design / nanobody / Virtual screening / Drug design / Glutaminyl cyclase / Alzheimer's disease / EDA method / Protein Design … More / Fragment assembly / Repeat proteins / Protein folding / Evolutionary algorithm / Computation / Protein design / 計算タンパク質設計 Less

Development of Protein Design Methods and Their Experimental VerificationPrincipal Investigator
- Principal Investigator
  
  Zhang Kam
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Designing high affinity therapeutic nanobodies through the incorporation of unnatural a mino acidsPrincipal Investigator
- Principal Investigator
  
  ZHANG KAM
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Biophysics
- Research Institution
  Institute of Physical and Chemical Research
Discovery of human Glutaminyl Cyclase inhibitors for the treatment of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  ZHANG KAM
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Lean-Docking: Exploiting Ligands’ Predicted Docking Scores to Accelerate Molecular Docking2021
- Author(s)
  Berenger Francois、Kumar Ashutosh、Zhang Kam Y. J.、Yamanishi Yoshihiro
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 61 Issue: 5 Pages: 1-12
- DOI
  10.1021/acs.jcim.0c01452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02395, KAKENHI-PROJECT-18H03334
[Journal Article] A protein sequence fitness function for identifying natural and nonnatural proteins2020
- Author(s)
  Kaushik Rahul、Zhang Kam Y. J.
- Journal Title
  
  Proteins: Structure, Function, and Bioinformatics
  
  Volume: 88 Issue: 10 Pages: 1271-1284
- DOI
  10.1002/prot.25900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02395
[Journal Article] Computational design of symmetrical eight-bladed β-propeller proteins2019
- Author(s)
  Noguchi Hiroki、Addy Christine、Simoncini David、Wouters Staf、Mylemans Bram、Van Meervelt Luc、Schiex Thomas、Zhang Kam Y. J.、Tame Jeremy R. H.、Voet Arnout R. D.
- Journal Title
  
  IUCrJ
  
  Volume: 6 Issue: 1 Pages: 46-55
- DOI
  10.1107/s205225251801480x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04779, KAKENHI-PROJECT-18H02395
[Journal Article] A structural homology approach for computational protein design with flexible backbone2019
- Author(s)
  Simoncini David、Zhang Kam Y J、Schiex Thomas、Barbe Sophie
- Journal Title
  
  Bioinformatics
  
  Volume: 35 Issue: 14 Pages: 2418-2426
- DOI
  10.1093/bioinformatics/bty975
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02395
[Journal Article] Fragger: a protein fragment picker for structural queries2018
- Author(s)
  Berenger Francois、Simoncini David、Voet Arnout、Shrestha Rojan、Zhang Kam Y.J.
- Journal Title
  
  F1000Research
  
  Volume: 6 Pages: 1722-1722
- DOI
  10.12688/f1000research.12486.1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02395
[Presentation] Structure based design of peptide inhibitors against human glutaminyl cyclase2017
- Author(s)
  Dileep K. V. and Kam Y. J. Zhang
- Organizer
  The 7th Biennale RIKEN Joint Retreat
- Place of Presentation
  Hamamatsu, Shizuoka, Japan
- Year and Date
  2017-02-02
- Data Source
  KAKENHI-PROJECT-16F16385
[Presentation] Structure based design of peptide inhibitors against human glutaminyl cyclase2017
- Author(s)
  Dileep K. V. and Kam Y. J. Zhang
- Organizer
  Takeda Symposium on Bioscience. Chronic Inflammation - Initiation, Progression and Resolution
- Place of Presentation
  Osaka, Japan
- Year and Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-16F16385

1. VIJAYAN DILEEP

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. PADHI ADITYA

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAME J.R.H.

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zhang Kam ＺＨＡＮＧ ＫＡＭ

Research Projects

Research Products

Co-Researchers

Development of Protein Design Methods and Their Experimental VerificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Designing high affinity therapeutic nanobodies through the incorporation of unnatural a mino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of human Glutaminyl Cyclase inhibitors for the treatment of Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lean-Docking: Exploiting Ligands’ Predicted Docking Scores to Accelerate Molecular Docking2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A protein sequence fitness function for identifying natural and nonnatural proteins2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Computational design of symmetrical eight-bladed β-propeller proteins2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A structural homology approach for computational protein design with flexible backbone2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fragger: a protein fragment picker for structural queries2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Structure based design of peptide inhibitors against human glutaminyl cyclase2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Structure based design of peptide inhibitors against human glutaminyl cyclase2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Zhang Kam ＺＨＡＮＧＫＡＭ