KURASHIGE Tomomi 蔵重智美

Researcher Number	60568955
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 原爆後障害医療研究所, 客員研究員
Affiliation (based on the past Project Information) *help	2022: 長崎大学, 原爆後障害医療研究所, 客員研究員 2014 – 2021: 長崎大学, 原爆後障害医療研究所, 助教
Review Section/Research Field	Principal Investigator Risk sciences of radiation and chemicals / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 甲状腺 / 放射線 / オートファジー / DNA損傷 / 発癌 / 内部被ばく / DNA二重鎖切断 / 癌 / PKCシグナル伝達経路 / 細胞死 … More / PKCシグナル伝達回路 / 酸化ストレス / 甲状腺ホルモン / TSH / アポトーシス / ジスルフィド結合 / RET/PTC / UV / 活性酸素種 / 発がん / ROS / comet assay / 抗酸化剤 … More Except Principal Investigator キナーゼ阻害剤 / 逆作動薬 / 遺伝子改変 / マウスモデル / インバースアゴニスト / オートファジー / TSH受容体 / 甲状腺がん Less

Autophagy regulatory mechanisms in thyroid and significance for carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Kurashige Tomomi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Nagasaki University
Studies on thyorid cancer pathogenesis using mouse models
- Principal Investigator
  
  NAGAYAMA Yuji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Nagasaki University
Elucidation of pathogenic mechanism of internal radiation-induced thyroid cancerPrincipal Investigator
- Principal Investigator
  
  KURASHIGE Tomomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nagasaki University
The establishment of the model of radiation-induced thyroid cancer and analysis of the inhibitory effect of an antioxidant on DNA damage in thyroid.Principal Investigator
- Principal Investigator
  
  KURASHIGE Tomomi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nagasaki University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.2023
- Author(s)
  Kurashige T, Shimamura M, Hamada K, Matsuse M, Mitsutake N, Nagayama Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 149-160
- DOI
  10.1038/s41598-023-27461-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07668, KAKENHI-PROJECT-19K09028
[Journal Article] Re-evaluation of the role of autophagy in thyroid cancer treatment2022
- Author(s)
  Kazakova D, Shimamura M, Kurashige T, Hamada K, Nagayama Y.
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 7 Pages: 847-862
- DOI
  10.1507/endocrj.EJ22-0017
- NAID
  130008162464
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08888, KAKENHI-PROJECT-19K09028
[Journal Article] MIEAP and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer2022
- Author(s)
  Hamada Koichiro、Kurashige Tomomi、Shimamura Mika、Arakawa Hirofumi、Nakamura Yasuyuki、Nagayama Yuji
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 13 Pages: 932754-932754
- DOI
  10.3389/fendo.2022.932754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19412, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K08888, KAKENHI-PROJECT-23K24169, KAKENHI-PROJECT-19K07655
[Journal Article] Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid2021
- Author(s)
  Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 19096-19096
- DOI
  10.1038/s41598-021-98481-z
- NAID
  120007175565
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10027, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886, KAKENHI-PROJECT-21K10399, KAKENHI-PROJECT-19KK0266
[Journal Article] Acceleration of BRAFV600E-mediated thyroid carcinogenesis by TGFβ signal deficiency.2020
- Author(s)
  Shimamura M, Kurashige T, Kuatov R, Nagayama Y.
- Journal Title
  
  Endocrine
  
  Volume: in press Issue: 3 Pages: 571-577
- DOI
  10.1007/s12020-020-02298-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886
[Journal Article] 甲状腺特異的オートファジーノックアウトマウスでは、濾胞上皮細胞死が誘導される2020
- Author(s)
  永山雄二 , 蔵重智美 , 中島康代 , 嶋村美加 , 松山睦美 , 中島正洋 , 山田正信
- Journal Title
  
  日本内分泌学会雑誌
  
  Volume: 95 Pages: 1335-1335
- Data Source
  KAKENHI-PROJECT-20K08888
[Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.2020
- Author(s)
  Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 8 Pages: 2814-2823
- DOI
  10.1111/cas.14501
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886, KAKENHI-PROJECT-19KK0266
[Journal Article] Re-evaluation of the effect of iodine on thyroid cell survival and function with PCCL3 and Nthy-ori 3-1 cells.2020
- Author(s)
  Kurashige T, Shimamura M, Nagayama Y.
- Journal Title
  
  Journal of Endocrine Society
  
  Volume: 4 (11) Issue: 11
- DOI
  10.1210/jendso/bvaa146
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09028
[Journal Article] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019
- Author(s)
  Kurashige Tomomi、Nakajima Yasuyo、Shimamura Mika、Matsuyama Mutsumi、Yamada Masanobu、Nakashima Masahiro、Nagayama Yuji
- Journal Title
  
  Endocrinology
  
  Volume: 160 Issue: 9 Pages: 2085-2092
- DOI
  10.1210/en.2019-00312
- NAID
  120006988409
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-17K00554
[Journal Article] Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.2018
- Author(s)
  Shimamura M, Shibusawa N, Kurashige T, Mussazhanova Z, Matsuzaki H, Nakashima M, Yamada M, Nagayama Y
- Journal Title
  
  PloS one
  
  Volume: 13 Issue: 8 Pages: e0201365-e0201365
- DOI
  10.1371/journal.pone.0201365
- NAID
  120006987838
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-16K08702, KAKENHI-PROJECT-16K08714
[Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines2018
- Author(s)
  Shimamura Mika、Yamamoto Kazuo、Kurashige Tomomi、Nagayama Yuji
- Journal Title
  
  Experimental Cell Research
  
  Volume: 370 Issue: 2 Pages: 699-707
- DOI
  10.1016/j.yexcr.2018.07.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07235, KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-17K16167, KAKENHI-PROJECT-16H06276
[Journal Article] N-Acetyl-L-cysteine protects thyroid cells against DNA damage induced by external and internal irradiation.2017
- Author(s)
  Tomomi Kurashige, Mika Shimamura, Yuji Nagayama.
- Journal Title
  
  Radiation and Environmental Biophysics
  
  Volume: 56 Issue: 4 Pages: 405-412
- DOI
  10.1007/s00411-017-0711-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-15K09437
[Journal Article] Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.2016
- Author(s)
  Kurashige T, Shimamura M, Nagayama Y.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 印刷中 Issue: 3 Pages: 312-317
- DOI
  10.1093/jrr/rrw001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870440, KAKENHI-PROJECT-15K09437
[Presentation] MIEAP, ATG5は甲状腺がんの腫瘍抑制遺伝子である2022
- Author(s)
  濵田航一郎, 蔵重智美, 嶋村美加, 荒川博文, 中村康之, 永山雄二
- Organizer
  第65回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08888
[Presentation] MIEAP and ATG5 are tumor suppressors in a mouse model of thyroid cancer2022
- Author(s)
  濵田航一郎, 蔵重智美, 嶋村美加, 荒川博文, 中村康之, 永山雄二
- Organizer
  第6回放射線災害・医科学研究拠点国際シンポジウム
- Data Source
  KAKENHI-PROJECT-20K08888
[Presentation] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019
- Author(s)
  Yuji Nagayama, Tomomi Kurashige, Mika Shimamura, Mutsumi Matsuyama, Masahiro Nakashima.
- Organizer
  第3回放射線災害・医科学研究拠点国際シンポジウム
- Data Source
  KAKENHI-PROJECT-16K00548
[Presentation] マウス甲状腺におけるオートファジーの役割2018
- Author(s)
  蔵重智美、松山睦美、中島正洋、嶋村美加、永山雄二
- Organizer
  第3回放射線災害・医科学研究拠点カンファランス
- Data Source
  KAKENHI-PROJECT-16K00548
[Presentation] 甲状腺細胞における放射線外照射・内照射誘発DNA 二重鎖切断と抗酸化剤の効果の検討2016
- Author(s)
  蔵重智美・永山雄二
- Organizer
  第12回広島大学・長崎大学連携研究カンファレンス
- Place of Presentation
  長崎大学良順会館（長崎県長崎市）
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-26870440
[Presentation] 甲状腺細胞における放射線誘導性DNA二重鎖切断に対する抗酸化剤の効果2016
- Author(s)
  蔵重智美
- Organizer
  第 1 回放射線災害・医科学研究拠点カンファランス
- Place of Presentation
  長崎大学良順会館 (長崎県長崎市）
- Data Source
  KAKENHI-PROJECT-16K00548
[Presentation] 甲状腺細胞における放射線誘導性DNA損傷に対する抗酸化剤の抑制効果の検討2015
- Author(s)
  永山雄二・蔵重智美
- Organizer
  第11回広島大学・長崎大学連携研究カンファレンス
- Place of Presentation
  広島大学広仁会館（広島県広島市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26870440
[Presentation] 甲状腺細胞における放射線誘導性DNA損傷に対する抗酸化剤の抑制効果の検討2015
- Author(s)
  永山雄二、蔵重智美
- Organizer
  第11回広島大学・長崎大学連携研究事業カンファランス
- Place of Presentation
  広島大学広仁会館（広島県広島市）
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26870440
[Presentation] 甲状腺細胞における放射線誘導性発癌モデルの作製および抗酸化剤のDNA損傷抑制効果の検討2014
- Author(s)
  蔵重智美、永山雄二
- Organizer
  第10回広島大学・長崎大学連携研究事業カンファランス
- Place of Presentation
  長崎大学医学部良順会館（長崎県長崎市）
- Year and Date
  2014-06-02
- Data Source
  KAKENHI-PROJECT-26870440
[Presentation] 甲状腺細胞における放射線外照射・内照射誘発DNA 二重鎖切断と抗酸化剤の効果の検討
- Author(s)
  永山雄二、蔵重智美
- Organizer
  日本放射線影響学会　第57回大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-26870440

1. NAGAYAMA Yuji (30274632)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 嶋村美加 (90736406)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. MATSUSE Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 七條和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中島正洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 山本一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 荒川博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 伊東正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KURASHIGE Tomomi 蔵重 智美

Research Projects

Research Products

Co-Researchers

Autophagy regulatory mechanisms in thyroid and significance for carcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on thyorid cancer pathogenesis using mouse models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenic mechanism of internal radiation-induced thyroid cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The establishment of the model of radiation-induced thyroid cancer and analysis of the inhibitory effect of an antioxidant on DNA damage in thyroid.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Re-evaluation of the role of autophagy in thyroid cancer treatment2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] MIEAP and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Acceleration of BRAFV600E-mediated thyroid carcinogenesis by TGFβ signal deficiency.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 甲状腺特異的オートファジーノックアウトマウスでは、濾胞上皮細胞死が誘導される2020

Author(s)

Journal Title

Data Source

[Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Re-evaluation of the effect of iodine on thyroid cell survival and function with PCCL3 and Nthy-ori 3-1 cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.2018

Author(s)

Journal Title

KURASHIGE Tomomi 蔵重智美