Akasaki Yukio 赤崎幸穂

Researcher Number	60568963
Affiliation (Current)	2025: 九州大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2025: 九州大学, 大学病院, 講師 2022 – 2023: 九州大学, 大学病院, 講師 2015 – 2021: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator 軟骨変性 / 変形性関節症 / 軟骨代謝 / 早期変形性関節症 / 滑膜炎 / Transthyretin / アミロイド / osteoarthritis / amyloid / transthyretin

IκBキナーゼε（IKKε）阻害による変形性関節症の疼痛制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  赤崎幸穂
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyushu University
実臨床に即した変形性関節症の病期特異的治療ターゲットの探索Principal Investigator
- Principal Investigator
  
  赤崎幸穂
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyushu University
Research on therapeutic targets for early-stage osteoarthritisPrincipal Investigator
- Principal Investigator
  
  Akasaki Yukio
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University
transthyretin deposition in the pathogenesis of osteoarthritisPrincipal Investigator
- Principal Investigator
  
  Akasaki Yukio
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2016

All Journal Article Presentation Patent

[Journal Article] Promotion of Knee Cartilage Degradation by <scp>IκB</scp> Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models2023
- Author(s)
  Uchida Taisuke、Akasaki Yukio、Sueishi Takuya、Kurakazu Ichiro、Toya Masakazu、Kuwahara Masanari、Hirose Ryota、Hyodo Yuki、Tsushima Hidetoshi、Lotz Martin K.、Nakashima Yasuharu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: Online ahead of print Issue: 6 Pages: 937-949
- DOI
  10.1002/art.42421
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16658, KAKENHI-PROJECT-22K09306
[Journal Article] C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis2022
- Author(s)
  Kuwahara Masanari、Akasaki Yukio、Kurakazu Ichiro、Sueishi Takuya、Toya Masakazu、Uchida Taisuke、Tsutsui Tomoaki、Hirose Ryota、Tsushima Hidetoshi、Teramura Takeshi、Nakashima Yasuharu
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 2 Pages: 22145-22161
- DOI
  10.1096/fj.202100896r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05097, KAKENHI-PROJECT-20H03810, KAKENHI-PROJECT-21K16658
[Journal Article] TGFβ1 signaling protects chondrocytes against oxidative stress via FOXO1?autophagy axis2021
- Author(s)
  Kurakazu I.、Akasaki Y.、Tsushima H.、Sueishi T.、Toya M.、Kuwahara M.、Uchida T.、Lotz M.K.、Nakashima Y.
- Journal Title
  
  Osteoarthritis and Cartilage
  
  Volume: 29 Issue: 11 Pages: 1600-1613
- DOI
  10.1016/j.joca.2021.07.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05097
[Journal Article] G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis2021
- Author(s)
  Toya Masakazu、Akasaki Yukio、Sueishi Takuya、Kurakazu Ichiro、Kuwahara Masanari、Uchida Taisuke、Tsutsui Tomoaki、Tsushima Hidetoshi、Yamada Hisakata、Lotz Martin K.、Nakashima Yasuharu
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-90020-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05097
[Journal Article] GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signalling.2020
- Author(s)
  Sueishi T, Akasaki Y, Goto N, Kurakazu I, Toya M, Kuwahara M, Uchida T, Hayashida M, Tsushima H, Bekki H, Lotz MK, Nakashima Y
- Journal Title
  
  Arthritis and Rheumatology
  
  Volume: 72 Issue: 4 Pages: 620-631
- DOI
  10.1002/art.41152
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05097, KAKENHI-PROJECT-19J12002
[Journal Article] The influence of post-operative knee coronal alignment parameters on long-term patient-reported outcomes after closed-wedge high tibial osteotomy.2020
- Author(s)
  Goto N, Akasaki Y, Okazaki K, Kuwashima U, Iwasaki K, Kawamura H, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Nakashima Y.
- Journal Title
  
  Journal of Orthopaedics
  
  Volume: 20 Pages: 177-180
- DOI
  10.1016/j.jor.2020.01.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05097
[Journal Article] FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.2019
- Author(s)
  Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y
- Journal Title
  
  Journal of Biological Chemistry.
  
  Volume: 294 Issue: 46 Pages: 17555-17569
- DOI
  10.1074/jbc.ra119.009409
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05097
[Patent] 変形性関節症の予防又は治療剤、及び医薬組成物2019
- Inventor(s)
  中島康晴、赤崎幸穂、居石卓也、遠矢正和、倉員市郎、桑原正成
- Industrial Property Rights Holder
  中島康晴、赤崎幸穂、居石卓也、遠矢正和、倉員市郎、桑原正成
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-015993
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] GRK5 阻害薬は、NF-κB経路を介して軟骨変性を抑制し、OA治療薬候補となる2021
- Author(s)
  赤崎幸穂, 居石卓也, 桑原正成, 内田泰輔, 筒井知明, 津嶋秀俊, Martin Lotz, 中島康晴
- Organizer
  第1回日本Knee Osteotomy and Joint Preservation研究会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] C10orf10/Decidual protein induced by progesterone (DEPP)はオートファジーフラックスを介して軟骨細胞の酸化ストレス抵抗性を維持する2021
- Author(s)
  桑原正成, 赤崎幸穂, 倉員市郎, 居石卓也, 遠矢政和, 内田泰輔, 筒井知明, 津嶋秀俊, 中島康晴
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] GRK5 (G protein-coupled receptor kinase 5)阻害は自然免疫細胞及び線維芽細胞様滑膜細胞を介して炎症性関節炎の発症・増悪を抑制する2021
- Author(s)
  遠矢政和, 赤崎幸穂, 津嶋秀俊, 居石卓也, 倉員市郎, 桑原正成, 内田泰輔, 筒井知明, 中島康晴
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] TGFβ-Alk5-Smad3 Signaling Promotes FOXO1 Expression And Protects Chondrocytes Against Oxidative Stress By Regulating Autophagy.2020
- Author(s)
  Kurakazu I, Akasaki Y, Tsushima H, Sueishi T, Toya M, Kuwahara M, Uchida T, Nakashima Y
- Organizer
  The 2020 Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] GRK5 Deletion Suppresses The Progression Of Inflammatory Arthritis In Mice.2020
- Author(s)
  Toya M, Akasaki Y, Tsushima H, Sueishi T, Kurakazu I, Kuwahara M, Uchida T, Nakashima Y
- Organizer
  The 2020 Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] FoxO1 transcription factor regulates chondrogenic differentiation via TGFβ1 signaling2019
- Author(s)
  Ichiro Kurakazu, Yukio Akasaki, Mitsumasa Hayashida, Norio Goto, Takuya Sueishi, Masakazu Toya, Masanari Kuwahara, Yasuharu Nakashima
- Organizer
  Orthopaedic Research Society 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] 外側楔状足底板を使用した全下肢立位XpによるHTO前後JLCA変化の術前予測2019
- Author(s)
  赤崎幸穂, 水内秀城, 濵井敏, 津嶋秀俊, 川原慎也, 中島康晴
- Organizer
  第47回日本関節病学会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] 炎症性関節炎の病態形成におけるGRK5(G protein-coupled receptor kinase 5)の機能解析2019
- Author(s)
  遠矢政和, 赤崎幸穂, 津嶋秀俊, 居石卓也, 倉員市郎, 桑原正成, 内田泰輔, 池村聡, 藤原稔史, 山田久方, 中島康晴
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] G protein-coupled receptor kinase (GRK)-5阻害は、NFκB経路の制御を介して変形性関節症における軟骨変性を抑制する2019
- Author(s)
  居石卓也, 赤崎幸穂, 津嶋秀俊, 倉員市郎, 遠矢政和, 桑原正成, 内田泰輔, 中島康晴
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] G protein-coupled receptor kinase (GRK)-5阻害は、NFκB経路の制御を介して変形性関節症における軟骨変性を抑制する2019
- Author(s)
  居石卓也, 赤崎幸穂, 池村聡, 藤原稔史, 津嶋秀俊, 倉員市郎, 遠矢政和, 桑原正成, 内田泰輔, 中島康晴
- Organizer
  第83回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] FoxO1転写因子はp21の発現および細胞周期抑制を促進し、TGFβシグナルによる軟骨分化を制御する2019
- Author(s)
  倉員市郎, 赤崎幸穂, 林田　光正, 後藤　徳雄, 居石卓也, 遠矢政和, 桑原正成, 中島康晴
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] FoxO1転写因子はTGFβ1シグナルによる軟骨分化を制御する2019
- Author(s)
  倉員市郎、赤崎幸穂、林田光正、後藤徳雄、居石卓也、遠矢政和、桑原正成、中島康晴
- Organizer
  第32回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] The regulation of cartilage degradation by GRK-5 during osteoarthritis development2019
- Author(s)
  Takuya Sueishi, Yukio Akasaki, Norio Goto, Ichiro Kurakazu, Masakazu Toya, Masanari Kuwahara, Yasuharu Nakashima
- Organizer
  Orthopaedic Research Society 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] Forkhead box O（FOXO）転写因子は、オートファジー関連蛋白を制御し、軟骨細胞の酸化ストレス抵抗を維持する2018
- Author(s)
  赤崎幸穂、林田光正、後藤徳雄、倉員市郎、居石卓也、遠矢政和、中島康晴
- Organizer
  第91回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] G protein-coupled receptor kinase (GRK)-5阻害は、NFκB経路を介した炎症反応を抑えることにより変形性関節症の軟骨変性を抑制する2018
- Author(s)
  居石卓也, 赤崎幸穂, 後藤徳雄, 倉員市郎, 遠矢政和, 林田光正, 中島康晴
- Organizer
  第31回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] G protein-coupled receptor kinase (GRK)-5阻害は, NFκB経路を介した炎症反応を抑えることにより変形性関節症の軟骨変性を抑制する2018
- Author(s)
  居石卓也, 赤崎幸穂, 福士純一, 池村聡, 後藤徳雄, 倉員市郎, 遠矢政和, 中島康晴
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] G protein-coupled receptor kinase (GRK)-5阻害は、NFκB経路の制御を介して変形性関節症における軟骨変性を抑制する2018
- Author(s)
  居石卓也, 赤崎幸穂, 後藤徳雄, 倉員市郎, 遠矢政和, 桑原正成, 中島康晴
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H05097
[Presentation] 変形性関節症におけるTransthyretin性アミロイド沈着の病態意義の検討2016
- Author(s)
  赤崎幸穂、Martin K. Lotz、岡崎賢、岩本幸英
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15H06483
[Presentation] 軟骨変性過程におけるTransthyretin性アミロイド沈着の病的意義の検討2016
- Author(s)
  赤崎幸穂、Lotz MK、岡崎賢、水内秀城、岩本幸英
- Organizer
  第8回JOSKAS
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15H06483
[Presentation] 変性軟骨過程におけるTransthyretin性アミロイド沈着の病態意義の検討2016
- Author(s)
  赤崎幸穂、岡崎賢、岩本幸英
- Organizer
  第60回日本リウマチ学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-15H06483
[Presentation] 変性軟骨におけるTransthyretin性アミロイド沈着2016
- Author(s)
  赤崎幸穂、Martin K. Lotz、岡崎賢、岩本幸英
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島大学
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-15H06483
[Presentation] 変形性関節症におけるtransthyretin性アミロイド沈着の病的意義2016
- Author(s)
  赤崎幸穂, Martin K. Lotz, 岡崎賢, 岩本幸英
- Organizer
  第31回日本整形外科学会基礎学集会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-15H06483

1. 居石卓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akasaki Yukio 赤崎 幸穂

Research Projects

Research Products

Co-Researchers

IκBキナーゼε（IKKε）阻害による変形性関節症の疼痛制御メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

実臨床に即した変形性関節症の病期特異的治療ターゲットの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on therapeutic targets for early-stage osteoarthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

transthyretin deposition in the pathogenesis of osteoarthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Promotion of Knee Cartilage Degradation by <scp>IκB</scp> Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TGFβ1 signaling protects chondrocytes against oxidative stress via FOXO1?autophagy axis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signalling.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The influence of post-operative knee coronal alignment parameters on long-term patient-reported outcomes after closed-wedge high tibial osteotomy.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.2019

Author(s)

Journal Title

DOI

Data Source

[Patent] 変形性関節症の予防又は治療剤、及び医薬組成物2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] GRK5 阻害薬は、NF-κB経路を介して軟骨変性を抑制し、OA治療薬候補となる2021

Author(s)

Organizer

Data Source

[Presentation] C10orf10/Decidual protein induced by progesterone (DEPP)はオートファジーフラックスを介して軟骨細胞の酸化ストレス抵抗性を維持する2021

Author(s)

Organizer

Data Source

[Presentation] GRK5 (G protein-coupled receptor kinase 5)阻害は自然免疫細胞及び線維芽細胞様滑膜細胞を介して炎症性関節炎の発症・増悪を抑制する2021

Author(s)

Akasaki Yukio 赤崎幸穂