Hara Akemi 原朱美

… Alternative Names

HARA Akemi 原朱美

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Researcher Number	60570009
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 研究員 2025: 埼玉医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2019 – 2021: 埼玉医科大学, 医学部, 非常勤講師 2016 – 2019: 順天堂大学, 医学部, その他 2016: 順天堂大学, 医学部, 研究員 2014 – 2015: 順天堂大学, 医学部, 博士研究員 2013: 順天堂大学, 医学部, その他、研究員
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Metabolomics
Keywords	Principal Investigator 糖尿病 / 分化転換 / β細胞 / PPY細胞 / PP細胞 / 膵ラ氏島 / 細胞系譜 / Pdx1 / Vβ細胞 / 電気穿孔法 … More / 膵島 / α細胞 / Virgin β細胞 / 細胞系譜の追跡 / 高血糖 … More Except Principal Investigator 膵β細胞 / 発生・分化 / 膵島 / 転写因子 / リプログラミング / 糖尿病 / β細胞 / PP細胞 Less

Elucidation of PPY cell lineage for development of new beta cell originPrincipal Investigator
- Principal Investigator
  
  Hara Akemi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Saitama Medical University
新規β細胞起源の探索に向けたPPY細胞の細胞系譜制御機構の解明Principal Investigator
- Principal Investigator
  
  原朱美
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Juntendo University
Lineage relationship between PP cells and beta cells
- Principal Investigator
  
  Fujitani Yoshio
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Gunma University
Elucidation of PPY cell lineage for development of new beta cell originPrincipal Investigator
- Principal Investigator
  
  Hara Akemi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Juntendo University
Elucidation of PPY cell lineage for development of new diabetes treatmentPrincipal Investigator
- Principal Investigator
  
  HARA Akemi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Juntendo University

All 2021 2019 2018 2017 2015 2014 2013

All Journal Article Presentation Book Patent

[Book] インフォームドコンセントのための図説シリーズ　改訂版2017
- Author(s)
  藤谷与士夫、荻原健ら
- Total Pages
  87
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-16K09765
[Journal Article] Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice2021
- Author(s)
  Fukaishi Takahiro、Nakagawa Yuko、Fukunaka Ayako、Sato Takashi、Hara Akemi、Nakao Keiko、Saito Michiko、Kohno Kenji、Miyatsuka Takeshi、Tamaki Motoyuki、Matsuhisa Munehide、Matsuoka Taka-aki、Yamada Tetsuya、Watada Hirotaka、Fujitani Yoshio
- Journal Title
  
  Diabetologia
  
  Volume: 64 Issue: 12 Pages: 2803-2816
- DOI
  10.1007/s00125-021-05560-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06435, KAKENHI-PROJECT-19K08971, KAKENHI-PROJECT-19K08984, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-20H03463
[Journal Article] Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide2019
- Author(s)
  Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 5 Pages: 459-468
- DOI
  10.1507/endocrj.EJ18-0441
- NAID
  130007655243
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-16K10429, KAKENHI-PROJECT-18K08462
[Journal Article] Normal pancreatic β-cell function in mice with <i>RIP-Cre</i>-mediated inactivation of p62/SQSTM12018
- Author(s)
  Honda A, Komiya K, Hara A, Fukunaka A, Suzuki L, Miyatsuka T, Ogihara T, Fujitani Y, Watada H.
- Journal Title
  
  Endocr J
  
  Volume: 65 Issue: 1 Pages: 83-89
- DOI
  10.1507/endocrj.EJ17-0333
- NAID
  130006321958
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09764, KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-17H04202
[Journal Article] Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.2018
- Author(s)
  Uesato T, Ogihara T, Hara A, Iida H, Miyatsuka T, Fujitani Y, Takeda S, Watada H.
- Journal Title
  
  J Endocr Soc.
  
  Volume: 2 Issue: 3 Pages: 207-219
- DOI
  10.1210/js.2017-00338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-17K09846
[Journal Article] Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.2017
- Author(s)
  Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: 13(8) Issue: 8 Pages: 1-23
- DOI
  10.1371/journal.pgen.1006950
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09764, KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-25291002, KAKENHI-PROJECT-17H03631, KAKENHI-PROJECT-17H04011
[Journal Article] Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy.2015
- Author(s)
  Iida H, Ogihara T, Min MK, Hara A, Kim YG, Fujimaki K, Tamaki M, Fujitani Y, Kim H, Watada H.
- Journal Title
  
  J Mol Endocrinol
  
  Volume: 55 (1) Issue: 1 Pages: 41-53
- DOI
  10.1530/jme-14-0299
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19526, KAKENHI-PROJECT-25461364
[Journal Article] Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.2014
- Author(s)
  Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
- Journal Title
  
  J Clin Invest.
  
  Volume: 124 Issue: 8 Pages: 3634-44
- DOI
  10.1172/jci69866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111002, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25461364, KAKENHI-PROJECT-25860757, KAKENHI-PUBLICLY-26111518, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-26251020, KAKENHI-PROJECT-26293220, KAKENHI-PROJECT-26860700
[Journal Article] Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure.2014
- Author(s)
  Yamamoto E, Uchida T, Abe H, Taka H, Fujimura T, Komiya K, Hara A, Ogihara T, Fujitani Y, Ueno T, Takeda S, Watada H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 453 Issue: 1 Pages: 19-24
- DOI
  10.1016/j.bbrc.2014.09.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430140, KAKENHI-PROJECT-25860757, KAKENHI-PROJECT-26430145
[Journal Article] Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice.2013
- Author(s)
  Ishibashi K, Hara A, Fujitani Y, Uchida T, Komiya K, Tamaki M, Abe H, Ogihara T, Kanazawa A, Kawamori R, Watada H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440 (4) Issue: 4 Pages: 570-575
- DOI
  10.1016/j.bbrc.2013.09.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860757
[Journal Article] The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance2013
- Author(s)
  Tamaki, M., Fujitani, Y, Uchida, T., Tamura, Y., Takeno, K., Kawaguchi, M., Watanabe, T., Hara, A., Ogihara, T., Shimizu, T., Mita, T., Hirose, T., Ohara-Imaizumi, M., Abe, T., Kiyonari, H., Hojyo, S., Fukada, T., Nagamatsu, S., Hirano, T., Kawamori, R., Watada, H.
- Journal Title
  
  J Clin Invest
  
  Volume: 123 Issue: 10 Pages: 4513-4524
- DOI
  10.1172/jci68807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590369, KAKENHI-PROJECT-23592239, KAKENHI-PROJECT-24790933, KAKENHI-PROJECT-24790936, KAKENHI-PROJECT-25461364, KAKENHI-PROJECT-25860371, KAKENHI-PROJECT-25860757
[Journal Article] Involvement of the parasympathetic nervous system in the initiation of regeneration of pancreatic β-cells.2013
- Author(s)
  Medina A1, Yamada S, Hara A, Hamamoto K, Kojima I.
- Journal Title
  
  Endocrine Journal
  
  Volume: 60 (5) Pages: 687-696
- NAID
  10031184537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860757
[Journal Article] Exendin-4 improves　β-cell function in autophagy-deficient β-cells.2013
- Author(s)
  Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku
- Journal Title
  
  Endocrinology
  
  Volume: 154 Issue: 12 Pages: 4512-24
- DOI
  10.1210/en.2013-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390244, KAKENHI-PROJECT-24659158, KAKENHI-PROJECT-25460276, KAKENHI-PROJECT-25860757
[Patent] 抗膵ポリペプチドモノクローナル抗体2015
- Inventor(s)
  藤谷与士夫、綿田裕孝、原朱美、中尾啓子
- Industrial Property Rights Holder
  藤谷与士夫、綿田裕孝、原朱美、中尾啓子
- Industrial Property Rights Type
  特許
- Filing Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-15K19526
[Presentation] 内分泌前駆細胞としての Ppy 発現細胞の解析2019
- Author(s)
  深石貴大, 佐藤隆史, 中川祐子, 福中彩子, 松岡孝昭, 原朱美, 宮塚健, 綿田裕孝, 藤谷与士夫
- Organizer
  第18回　生体機能研究会
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] 新規Ppyノックインレポーターマウスを用いた内分泌前駆細胞としてのPP細胞の解析2019
- Author(s)
  深石貴大、佐藤隆史、中川祐子、福中彩子、野口東美、原朱美、綿田裕孝、藤谷与士夫
- Organizer
  第33回日本糖尿病・肥満動物学会　年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] 新規Ppyノックインレポーターマウスを用いた、内分泌前駆細胞としてのPpy発現細胞の解析2019
- Author(s)
  深石貴大, 佐藤隆史, 中川祐子, 福中彩子, 野口東美, 原朱美, 松岡孝昭, 綿田裕孝, 藤谷与士夫
- Organizer
  第62回　日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] マウス遺伝学的手法による膵内分泌細胞の新規分化系譜の解析2019
- Author(s)
  佐藤隆史, 深石貴大, 中川祐子, 福中彩子, 松岡孝昭, 原朱美, 宮塚健, 綿田裕孝, 藤谷与士夫
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] 新規Ppyノックインレポーターマウスを用いた、内分泌前駆細胞としてのPpy発現細胞の解析2019
- Author(s)
  深石貴大, 佐藤隆史, 中川祐子, 福中彩子, 松岡孝昭, 原朱美, 宮塚健, 綿田裕孝, 藤谷与士夫
- Organizer
  第31回　分子糖尿病学会シンポジウム
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] 新規Ppyノックインレポーターマウスを用いた、内分泌前駆細胞としてのPP細胞の解析2019
- Author(s)
  深石貴大, 佐藤隆史, 中川祐子, 福中彩子, 松岡孝昭, 原朱美, 宮塚健, 綿田裕孝, 藤谷与士夫
- Organizer
  第69回　日本体質医学会総会
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] PP特異的抗PPモノクローナル抗体の作製2018
- Author(s)
  中川祐子、原朱美、中尾啓子、田蒔基行、松久宗英、水上浩哉、綿田裕孝、藤谷与士夫
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] PP cells as stage-specific precursors of endocrine pancreas development2018
- Author(s)
  Takahiro Fukaishi, Takashi Sato, Yuko Nakagawa, Ayako Fukunaka, Azumi Noguchi, Akemi Hara, Hirotaka Watada, Yoshio Fujitani
- Organizer
  4th IMCR Symposium on Endocrine and Metabolism
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09765
[Presentation] Human IAPP impairs the success of islet transplantation2015
- Author(s)
  A. Hara, Y. Fujitani, T. Ogihara, T. Miyatsuka, H. Watada
- Organizer
  51st EASD Annual Meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19526
[Presentation] ヒト型IAPPは膵島移植の成功率を低下させる2015
- Author(s)
  原　朱美、藤谷　与士夫、荻原　健、宮塚　健、綿田　裕孝
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K19526
[Presentation] 持続的高血糖は膵β細胞からPP細胞への分化転換を誘導する2014
- Author(s)
  原　朱美、藤谷　与士夫、田蒔　基行、宮塚　健、福中　彩子、小宮　幸次、金澤　昭雄、綿田　裕孝
- Organizer
  第28回日本糖尿病肥満・肥満動物学会
- Place of Presentation
  宮崎市民プラザ
- Data Source
  KAKENHI-PROJECT-25860757
[Presentation] ヒト型IAPPは膵島移植の成功率を低下させる2014
- Author(s)
  原　朱美、藤谷　与士夫、荻原　健、宮塚　健、綿田　裕孝
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル、ホテルNCB、堂島リバーフォーラム
- Data Source
  KAKENHI-PROJECT-25860757
[Presentation] 持続的高血糖は膵β細胞からPP 細胞への分化転換を誘導する2014
- Author(s)
  原朱美、藤谷与士夫、田蒔基行、荻原健、宮塚健、福中彩子、小宮幸次、荻原健、金澤昭雄、綿田裕孝
- Organizer
  第10 回Diabetes Research Forum in Tokyo
- Place of Presentation
  パレスホテル東京
- Year and Date
  2014-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-25860757

1. Fujitani Yoshio (30433783)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 中尾啓子 (70338185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FUKUNAKA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TAKA Hikari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. FUJIMURA Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 永松信哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 今泉美佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 吉森保

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 佐藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Akemi 原 朱美

HARA Akemi 原 朱美

Research Projects

Research Products

Co-Researchers

Elucidation of PPY cell lineage for development of new beta cell originPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規β細胞起源の探索に向けたPPY細胞の細胞系譜制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lineage relationship between PP cells and beta cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of PPY cell lineage for development of new beta cell originPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of PPY cell lineage for development of new diabetes treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] インフォームドコンセントのための図説シリーズ 改訂版2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Normal pancreatic β-cell function in mice with <i>RIP-Cre</i>-mediated inactivation of p62/SQSTM12018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.2014

Author(s)

Journal Title

DOI

Hara Akemi 原朱美

HARA Akemi 原朱美

[Book] インフォームドコンセントのための図説シリーズ　改訂版2017

[Journal Article] Exendin-4 improves　β-cell function in autophagy-deficient β-cells.2013