SAKASAI AKIKO 坂井亜紀子

… Alternative Names

SAKASAI-SAKAI Akiko 逆井亜紀子

坂井亜紀子

Less

Researcher Number	60570059
Other IDs	https://orcid.org/0000-0002-1258-1725
Affiliation (Current)	2024: 金沢医科大学, 総合医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 金沢医科大学, 総合医学研究所, 准教授 2019 – 2021: 金沢医科大学, 総合医学研究所, 講師 2017 – 2018: 金沢医科大学, 総合医学研究所, 助教 2016: 金沢医科大学, 総合医学研究所, 特定助教 2015: 金沢医科大学, 総合医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Eating habits
Keywords	Principal Investigator 生活習慣病 / 非アルコール性脂肪肝炎 / TAGE / AGEs / 終末糖化産物 (AGEs） / NASH / 終末糖化産物 / 細胞老化 / プロテアソーム / オートファジー … More / 毒性終末糖化産物 / 毒性AGEs / 抗酸化タンパク質 / 酸化ストレス応答 / ミトコンドリア / 活性酸素種 / 酸化ストレス / 肝細胞 / toxic AGEs / Toxic-AGEs (TAGE) Less

AGEsがつなぐ「糖の代謝―細胞老化―生活習慣病」の解明Principal Investigator
- Principal Investigator
  
  坂井亜紀子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa Medical University
毎日の食生活により徐々に蓄積される毒性終末糖化産物に対する除去機構の解明Principal Investigator
- Principal Investigator
  
  坂井亜紀子 (逆井亜紀子 / 坂井亜紀子)
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa Medical University
Intracellular toxic advanced glycation end-products promote the production of reactive oxygen species in HepG2 cells.Principal Investigator
- Principal Investigator
  
  SAKASAI-SAKAI Akiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa Medical University
Identification of new advanced glycation end-products and food ingredients to diagnose and prevent lifestyle diseasesPrincipal Investigator
- Principal Investigator
  
  SAKASAI-SAKAI Akiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  Kanazawa Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Toxic advanced glycation end-products (TAGE) are major structures of cytotoxic AGEs derived from glyceraldehyde2024
- Author(s)
  Takeuchi Masayoshi、Suzuki Hirokazu、Takeda Kenji、Sakai-Sakasai Akiko
- Journal Title
  
  Medical Hypotheses
  
  Volume: 183 Pages: 111248-111248
- DOI
  10.1016/j.mehy.2023.111248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21H04865
[Journal Article] Structures of Toxic Advanced Glycation End-Products Derived from Glyceraldehyde, A Sugar Metabolite2024
- Author(s)
  Sakai-Sakasai Akiko、Takeda Kenji、Suzuki Hirokazu、Takeuchi Masayoshi
- Journal Title
  
  Biomolecules
  
  Volume: 14 Issue: 2 Pages: 202-202
- DOI
  10.3390/biom14020202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08410, KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21H04865
[Journal Article] A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model2023
- Author(s)
  Takeda Kenji、Sakai-Sakasai Akiko、Kajinami Kouji、Takeuchi Masayoshi
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 24 Pages: 2838-2838
- DOI
  10.3390/cells12242838
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08139, KAKENHI-PROJECT-20K08410, KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21H04865
[Journal Article] Involvement of Intracellular TAGE and the TAGE?RAGE?ROS Axis in the Onset and Progression of NAFLD/NASH2023
- Author(s)
  Sakasai-Sakai Akiko、Takeda Kenji、Takeuchi Masayoshi
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 3 Pages: 748-748
- DOI
  10.3390/antiox12030748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21H04865
[Journal Article] Toxic AGEs (TAGE)と健康:I. 細胞障害因子としてのTAGE2023
- Author(s)
  坂井(逆井)亜紀子、竹田健史、竹内正義
- Journal Title
  
  金沢医科大学雑誌
  
  Volume: 48 Pages: 1-11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11583
[Journal Article] Toxic AGEs (TAGE)と健康:II. 生活習慣病予測マーカーとしてのTAGE2023
- Author(s)
  竹内正義、竹田健史、坂井(逆井)亜紀子
- Journal Title
  
  金沢医科大学雑誌
  
  Volume: 48 Pages: 12-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11583
[Journal Article] Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts2022
- Author(s)
  Takata Takanobu、Sakasai-Sakai Akiko、Takeuchi Masayoshi
- Journal Title
  
  Metabolites
  
  Volume: 12 Issue: 7 Pages: 615-615
- DOI
  10.3390/metabo12070615
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21K11607, KAKENHI-PROJECT-21H04865
[Journal Article] Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Microtubule-Associated Protein 1 Light Chain 3 and p622022
- Author(s)
  Takata Takanobu、Sakasai-Sakai Akiko、Takeuchi Masayoshi
- Journal Title
  
  Nutrients
  
  Volume: 14 Issue: 2 Pages: 332-332
- DOI
  10.3390/nu14020332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21K11607
[Journal Article] Effects of Toxic AGEs (TAGE) on Human Health2022
- Author(s)
  Takeuchi Masayoshi、Sakasai-Sakai Akiko、Takata Takanobu、Takino Jun-ichi、Koriyama Yoshiki
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 14 Pages: 2178-2178
- DOI
  10.3390/cells11142178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21K11607, KAKENHI-PROJECT-22K09844, KAKENHI-PROJECT-21H04865
[Journal Article] Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells2021
- Author(s)
  Kikuchi Chigusa、Sakasai-Sakai Akiko、Okimura Risa、Tanaka Hinako、Takata Takanobu、Takeuchi Masayoshi、Matsunaga Tamihide
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 10 Pages: 1399-1402
- DOI
  10.1248/bpb.b21-00520
- NAID
  130008095843
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21K11583, KAKENHI-PROJECT-21K11607
[Journal Article] Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage.2021
- Author(s)
  Takeuchi M, Sakasai-Sakai A, Takata T, Takino JI, Koriyama Y, Kikuchi C, Furukawa A, Nagamine K, Hori T, Matsunaga T.
- Journal Title
  
  Biomolecules.
  
  Volume: 11 Issue: 3 Pages: 387-387
- DOI
  10.3390/biom11030387
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11781, KAKENHI-PROJECT-20K20320, KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-18K11139, KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21K11583
[Journal Article] Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products2021
- Author(s)
  Takino Jun-ichi、Sato Takuma、Nagamine Kentaro、Sakasai-Sakai Akiko、Takeuchi Masayoshi、Hori Takamitsu
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 1 Pages: 112-117
- DOI
  10.1248/bpb.b20-00708
- NAID
  130007965327
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-01-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-21K11583
[Journal Article] NAFLD/ALD と Toxic AGEs（TAGE）2021
- Author(s)
  逆井（坂井）亜紀子、竹内正義
- Journal Title
  
  糖尿病・内分泌代謝科
  
  Volume: 52 Pages: 50-57
- Data Source
  KAKENHI-PROJECT-21K11583
[Journal Article] Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis2021
- Author(s)
  Tanaka Kenji、Sakasai-Sakai Akiko、Motomiya Yasuki、Yoneda Tatsuo、Takeuchi Masayoshi
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 13 Issue: 1 Pages: 85-85
- DOI
  10.1186/s13098-021-00685-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21K11583
[Journal Article] Impact of intracellular toxic advanced glycation end-products (TAGE) on murine myoblast cell death2020
- Author(s)
  Takata Takanobu、Sakasai-Sakai Akiko、Takeuchi Masayoshi
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 12 Issue: 1 Pages: 54-54
- DOI
  10.1186/s13098-020-00561-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-18K11139
[Journal Article] Intracellular Toxic Advanced Glycation End-Products Promote the Production of Reactive Oxygen Species in HepG2 Cells2020
- Author(s)
  Sakasai-Sakai Akiko、Takata Takanobu、Takeuchi Masayoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 14 Pages: 4861-4861
- DOI
  10.3390/ijms21144861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-18K11139
[Journal Article] NAFLD/ALD と Toxic AGEs(TAGE)2020
- Author(s)
  逆井（坂井）亜紀子, 竹内正義
- Journal Title
  
  糖尿病・内分泌代謝科
  
  Volume: 52 Pages: 50-57
- Data Source
  KAKENHI-PROJECT-18K11003
[Journal Article] 第3のグリコーゲン代謝産物1,5-アンヒドロ-D-フルクトース(1,5-AF)の謎を探る2020
- Author(s)
  逆井(坂井)亜紀子、高田尊信、鈴木宏一、丸山征郎、田中賢治、本宮善恢、竹内正義
- Journal Title
  
  日本未病学会雑誌
  
  Volume: 26 Pages: 67-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11003
[Journal Article] Evidence for Toxic Advanced Glycation End-Products Generated in the Normal Rat Liver2019
- Author(s)
  Takata Takanobu、Sakasai-Sakai Akiko、Takino Jun-ichi、Takeuchi Masayoshi
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 7 Pages: 1612-1612
- DOI
  10.3390/nu11071612
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-16H01811
[Journal Article] Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease2019
- Author(s)
  Takata Takanobu、Sakasai-Sakai Akiko、Ueda Tadashi、Takeuchi Masayoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2121-2121
- DOI
  10.1038/s41598-019-39202-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-18K11139, KAKENHI-PROJECT-16H01811
[Journal Article] Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite2019
- Author(s)
  Sakasai-Sakai Akiko、Takata Takanobu、Suzuki Hirokazu、Maruyama Ikuro、Motomiya Yoshihiro、Takeuchi Masayoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10194-10194
- DOI
  10.1038/s41598-019-46333-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-18K11139, KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review2019
- Author(s)
  Sakasai-Sakai Akiko、Takata Takanobu、Takino Jun-ichi、Takeuchi Masayoshi
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 2 Pages: 462-462
- DOI
  10.3390/nu11020462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-16H01811
[Journal Article] NAFLDとALDの発症におけるToxic AGEs（TAGE）病因説2018
- Author(s)
  逆井（坂井）亜紀子、瀧野純一、福村敦、高田尊信、堤幹宏、竹内正義
- Journal Title
  
  日本未病システム学会雑誌
  
  Volume: 24 Pages: 19-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16239
[Journal Article] 生活習慣病の発症・進展における新規バイオマーカー Toxic AGEs （TAGE）2018
- Author(s)
  髙田尊信、逆井（坂井）亜紀子、竹内正義
- Journal Title
  
  日本未病システム学会雑誌
  
  Volume: 24(2) Pages: 27-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11003
[Journal Article] NAFLDとALDの発症・進展におけるToxic AGEs (TAGE)　病因説2018
- Author(s)
  逆井（坂井）亜紀子、瀧野純一、福村敦、高田尊信、堤幹宏、竹内正義
- Journal Title
  
  日本未病システム学会雑誌
  
  Volume: 24(1) Pages: 19-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11003
[Journal Article] Toxic AGE (TAGE) theory for the pathophysiology of the onset/progression of NAFLD and ALD.2017
- Author(s)
  Takeuchi M, Takino J, Sakasai-Sakai A, Takata T, and Tsutsumi M
- Journal Title
  
  Nutrients
  
  Volume: 9 Issue: 6 Pages: 634-634
- DOI
  10.3390/nu9060634
- NAID
  40021547961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-15K16239
[Journal Article] Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death.2017
- Author(s)
  Sakasai-Sakai A, Takata T, Takino J, and Takeuchi M
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 14282-14282
- DOI
  10.1038/s41598-017-14711-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-15K16239
[Journal Article] ERAP1 protein identified as a potential non-invasive biomarker for nonalcoholic steatohepatitis related to glycated heterogeneous nuclear ribonucleoprotein M. Hepatol. Res.2017
- Author(s)
  Jun-ichi Takino, Kentaro Nagamine, Shinya Nagai, Jun Yamane, Isamu Hiraishi, Akiko Sakasai-Sakai, Masayoshi Takeuchi, and Takamitsu Hori.
- Journal Title
  
  Hepatol. Res.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16239
[Journal Article] Gene expression changes associated with the loss of heterogeneous nuclear ribonucleoprotein M function2017
- Author(s)
  Jun-ichi Takino, Kentaro Nagamine, Mikoto Suzuki, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hori
- Journal Title
  
  American Journal of Molecular Biology
  
  Volume: 7 Issue: 02 Pages: 87-98
- DOI
  10.4236/ajmb.2017.72007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K00931, KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-15K16239
[Journal Article] Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion.2017
- Author(s)
  Takata T, Ueda T, Sakasai-Sakai A, and Takeuchi M
- Journal Title
  
  World J. Gastroenterol.
  
  Volume: 23 Issue: 27 Pages: 4910-4919
- DOI
  10.3748/wjg.v23.i27.4910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-15K16239
[Journal Article] Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD.2015
- Author(s)
  Takeuchi M, Sakasai-Sakai A, Takino J, Takata T, Ueda T, Tsutsumi M.
- Journal Title
  
  Int. J. Diabetes Clin. Res.
  
  Volume: 2: 4 Pages: 1-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K16239
[Journal Article] Contribution of toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma.2015
- Author(s)
  Takino J, Nagamine K, Hori T, Sakasai-Sakai A, Takeuchi M.
- Journal Title
  
  World J. Hepatol.
  
  Volume: ７ Issue: 23 Pages: 2459-2469
- DOI
  10.4254/wjh.v7.i23.2459
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25282029, KAKENHI-PROJECT-15K16239
[Journal Article] Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH.2015
- Author(s)
  Takeuchi M, Sakasai-Sakai A, Takata T, Ueda T, Takino J, Tsutsumi M, Hyogo H, Yamagishi S.
- Journal Title
  
  Med. Hypotheses
  
  Volume: ８４ Issue: 5 Pages: 490-493
- DOI
  10.1016/j.mehy.2015.02.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25282029, KAKENHI-PROJECT-15K16239
[Patent] カスパーゼ-3の異常高分子化を抑制または阻止する物質のスクリーニング法2015
- Inventor(s)
  逆井亜紀子、竹内正義
- Industrial Property Rights Holder
  学校法人金沢医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-189096
- Filing Date
  2015-09-28
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] TAGEと肝障害2024
- Author(s)
  坂井亜紀子、竹田健史、竹内正義
- Organizer
  日本薬学会第144年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] ヒトの健康に対するToxic AGEs (TAGE)の影響2023
- Author(s)
  竹内正義、逆井(坂井)亜紀子、高田尊信、郡山恵樹、古川絢子、瀧野純一、長嶺憲太郎、堀隆光、菊池千草、堀英生、岩尾岳洋、松永民秀
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] Novel approach: Elucidating the intracellular clearance mechanism of toxic AGEs (TAGE) utilizing the artificial CHK1 mutant d270KD as a substrate model2023
- Author(s)
  Takeda Kenji、Sakai-Sakasai Akiko、Kajinami Kouji、Takeuchi Masayoshi
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 糖代謝中間体グリセルアルデヒドが引き起こす骨芽細胞障害2023
- Author(s)
  坂井(逆井)亜紀子、竹田健史、竹内正義
- Organizer
  第23回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] Toxic AGEs (TAGE) と健康2023
- Author(s)
  坂井亜紀子、竹田健史、竹内正義
- Organizer
  第27回糖化ストレス研究会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 毒性終末糖化産物(TAGE)の生成・蓄積が引き起こす心筋細胞および心臓線維芽細胞障害2022
- Author(s)
  高田尊信、逆井(坂井)亜紀子、竹内正義
- Organizer
  第70回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 生活習慣病予防および健康寿命延伸における新規ターゲットToxic AGEs (TAGE)2022
- Author(s)
  竹内正義、高田尊信、逆井(坂井)亜紀子、瀧野純一、郡山恵樹、松永民秀
- Organizer
  第22回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 生活習慣病予防における新規ターゲットToxic AGEs (TAGE)2022
- Author(s)
  竹内正義、逆井(坂井)亜紀子、高田尊信
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] グリセルアルデヒド(GA)およびGA由来AGEs(TAGE)による骨芽細胞障害2022
- Author(s)
  逆井(坂井)亜紀子、高田尊信、竹内正義
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 生活習慣病における新たな概念Toxic AGEs (TAGE)2022
- Author(s)
  竹内正義、逆井(坂井)亜紀子、高田尊信、瀧野純一、郡山恵樹、古川絢子、那須隆斗、菊池千草、長嶺憲太郎、堀隆光、松永民秀
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 肝実質細胞内における毒性AGEs(TAGE)蓄積が酸化ストレスに及ぼす影響2021
- Author(s)
  逆井(坂井)亜紀子、高田尊信、瀧野純一、竹内正義
- Organizer
  第7回肝臓と糖尿病・代謝研究会学会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] Accumulation of toxic advanced glycation end-products induces cell death and inhibits osteoblastic differentiation in MC3T3- E1 cells2021
- Author(s)
  逆井(坂井)亜紀子、髙田尊信、竹内正義
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 生活習慣病の発症・進展予防における新規概念Toxic AGEs (TAGE)と食事療法2021
- Author(s)
  高田尊信、逆井(坂井)亜紀子、瀧野純一、竹内正義
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K11583
[Presentation] 心筋細胞内毒性終末糖化産物（Toxic AGEs, TAGAE）が心血管疾患を発症させる2020
- Author(s)
  高田尊信, 逆井(坂井)亜紀子, 竹内正義
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 血糖コントロールマーカー1,5-AG前駆体1,5-Anhydro-D-fructose (1,5-AF) 由来新規AGEsの生理作用2020
- Author(s)
  竹内正義, 逆井-坂井亜紀子, 高田尊信, 鈴木征郎, 田中賢治, 本宮善恢
- Organizer
  第74回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 食後高血糖マーカー1,5－AG前駆体1,5-Anhydro-D-fructose (1,5-AF)の謎を解明する2020
- Author(s)
  逆井(坂井) 亜紀子、竹内正義、高田尊信、鈴木宏一、丸山征郎、田中賢治、本宮善恢
- Organizer
  第23回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] グリコーゲン代謝中間体1,5-Anhydro-D-fructose (1,5-AF) の生理的意味合い2020
- Author(s)
  高田尊信, 逆井(逆井)亜紀子, 鈴木宏一, 丸山征郎, 田中賢治, 本宮善恢, 竹内正義
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 肝実質細胞内に蓄積したグリセルアルデヒド由来終末糖化産物が酸化ストレスに及ぼす影響2020
- Author(s)
  逆井(坂井) 亜紀子、高田尊信、竹内正義
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] グリコーゲン代謝産物1,5-アンヒドロ-D-フルクトース（1,5-AF）由来AGEsを捉える2020
- Author(s)
  逆井(坂井) 亜紀子、竹内正義、高田尊信、鈴木宏一、丸山征郎、田中賢治、本宮善恢
- Organizer
  第63回日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] Glycogen代謝中間体1,5-Anhydro-D-fructose由来新規AGEsの免疫学的証拠2020
- Author(s)
  竹内正義、高田尊信、逆井(逆井)亜紀子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 血中Toxic AGEs (TAGE) は生活習慣病予防/健康寿命延伸の新規バイオマーカー2019
- Author(s)
  高田尊信, 竹内正義, 逆井(坂井), 亜紀子, 兵庫秀幸, 神野正雄
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] Toxic AGEs (TAGE) 生成・蓄積が引き起こす心筋細胞障害2019
- Author(s)
  高田尊信, 逆井-坂井亜紀子, 竹内正義
- Organizer
  第34回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 第3のグリコーゲン代謝産物1,5-アンヒドロ-D-フルクトース（1,5-AF）の謎を探る2019
- Author(s)
  竹内正義、逆井(坂井) 亜紀子、高田尊信、鈴木宏一、丸山征郎、田中賢治、本宮善恢
- Organizer
  第26回日本未病システム学会学術総会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 非アルコール性脂肪肝炎 (NASH) の発症・進展における新規ターゲット毒性終末糖化産物 (toxic AGEs, TAGE)2019
- Author(s)
  逆井（坂井）亜紀子、竹内正義、高田尊信、瀧野純一
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 非アルコール性脂肪肝炎 (NASH) の発症・進展におけるToxic AGEs (TAGE) の関与2019
- Author(s)
  竹内正義, 瀧野純一, 逆井(坂井)亜紀子, 高田尊信
- Organizer
  第73回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 肝実質細胞死におけるグリセルアルデヒド由来終末糖化産物の関与2018
- Author(s)
  逆井(逆井)亜紀子、高田尊信、竹内正義
- Organizer
  第28回日本メイラード学会年会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] NAFLD/ALDの発症・進展におけるToxic AGEs (TAGE) の関与2018
- Author(s)
  逆井(逆井)亜紀子、高田尊信、瀧野純一、堤幹宏、竹内正義
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 非アルコール性及びアルコール性肝疾患の発症・進展に共通する新規ターゲット分子Toxic AGEs (TAGE)2018
- Author(s)
  高田尊信、逆井亜紀子、瀧野純一、堤幹宏、竹内正義
- Organizer
  第18回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] Toxic AGEs (TAGE) は生活習慣病の新規バイオマーカーである2018
- Author(s)
  竹内正義、高田尊信、逆井(逆井)亜紀子
- Organizer
  第25回日本未病システム学会学術総会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] NASHの発症・進展における新規ターゲットToxic AGEs (TAGE)2018
- Author(s)
  竹内正義、瀧野純一、逆井(逆井)亜紀子、高田尊信
- Organizer
  第33回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 生活習慣病の発症・進展における新規バイオマーカー Toxic AGEs (TAGE)2018
- Author(s)
  竹内正義、逆井亜紀子、高田尊信
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] NAFLD/ALDの発症・進展におけるToxic AGEs (TAGE) 病因説2018
- Author(s)
  竹内正義、逆井亜紀子、高田尊信、瀧野純一、堤　幹宏
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] ヒト株化膵管上皮癌培養細胞におけるTAGE生成／蓄積と膵癌促進の可能性2018
- Author(s)
  高田尊信、逆井（坂井）亜紀子、竹内正義
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 膵癌細胞内におけるグリセルアルデヒド由来終末糖化産物の生成・蓄積と膵癌促進の可能性2018
- Author(s)
  高田尊信、逆井(逆井)亜紀子、竹内正義
- Organizer
  第28回日本メイラード学会年会
- Data Source
  KAKENHI-PROJECT-18K11003
[Presentation] 生活習慣病の発症・進展におけるToxic AGEs (TAGE) の関与－新たな予防概念－2017
- Author(s)
  高田尊信、逆井（坂井）亜紀子、瀧野純一、竹内正義
- Organizer
  第17回日本抗加齢医学会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 生活習慣病の発症・進展における新規バイオマーカーとしてのToxic AGEs (TAGE)2017
- Author(s)
  竹内正義、瀧野純一、逆井（坂井）亜紀子、高田尊信、上田忠司
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] NAFLDとALDの発症・進展におけるToxic AGEs（TAGE）の関与2017
- Author(s)
  逆井（坂井）亜紀子、瀧野純一、高田尊信、堤幹宏、竹内正義
- Organizer
  第24回日本未病システム学会学術総会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 糖尿病の発症・進展におけるTAGEの関与－新たな予防概念－2017
- Author(s)
  逆井（坂井）亜紀子、高田尊信、竹内正義
- Organizer
  日本糖尿病学会第91回中部地方会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 生活習慣病の発症・進展における新規バイオマーカーとしてのToxic AGEs (TAGE)2017
- Author(s)
  高田尊信、逆井（坂井）亜紀子、竹内正義
- Organizer
  第24回日本未病システム学会学術総会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] ヒト株化膵管上皮癌培養細胞におけるTAGE生成／蓄積と膵癌促進の可能性2017
- Author(s)
  高田尊信、逆井（坂井）亜紀子、竹内正義
- Organizer
  日本糖尿病学会第91回中部地方会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 肝実質細胞死におけるグリセルアルデヒド由来終末糖化産物の関与2017
- Author(s)
  逆井（坂井）亜紀子、高田尊信、竹内正義
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 糖尿病の発症・進展におけるToxic AGEs (TAGE) の関与－新たな予防概念－2017
- Author(s)
  逆井（坂井）亜紀子、高田尊信、瀧野純一、竹内正義
- Organizer
  第60回日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] 非アルコール性脂肪性肝障害（NAFLD）の発症・進展におけるToxic AGEs(TAGE)の関与2016
- Author(s)
  竹内正義、逆井（坂井）亜紀子、高田尊信、上田忠司、瀧野純一
- Organizer
  第23回日本未病システム学会総会学術総会
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] ヒト膵管癌培養細胞における細胞内TAGE蓄積と細胞障害関連蛋白質の探索2016
- Author(s)
  高田尊信、逆井（坂井）亜紀子、上田忠司、竹内正義
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] PANC-1における細胞内TAGE生成とTAGE化蛋白質の探索2016
- Author(s)
  高田尊信、逆井（坂井）亜紀子、上田忠司、竹内正義
- Organizer
  第31回日本糖尿病合併症学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] Glycer-AGEsに関連したNASHの非侵襲的バイオマーカー探索2016
- Author(s)
  瀧野純一、長嶺憲太郎、永井真也、山根惇、平石勇、逆井（坂井）亜紀子、竹内正義、堀隆光
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  就実大学（岡山県岡山市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K16239
[Presentation] NASHの発症・進展予防におけるToxic AGEs（TAGE）の関与2016
- Author(s)
  逆井（坂井）亜紀子、竹内正義、瀧野純一
- Organizer
  第3回肝臓と糖尿病・代謝研究会
- Place of Presentation
  石川県立音楽堂邦楽ホール・交流ホール（石川県金沢市）
- Year and Date
  2016-07-16
- Data Source
  KAKENHI-PROJECT-15K16239

1. TAKEUCHI Masayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
2. KORIYAMA Yoshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. FURUKAWA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TAKEDA Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 瀧野純一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 梶波康二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 高田尊信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 上田忠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 長嶺憲太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKASAI AKIKO 坂井 亜紀子

SAKASAI-SAKAI Akiko 逆井 亜紀子

坂井亜紀子

Research Projects

Research Products

Co-Researchers

AGEsがつなぐ「糖の代謝―細胞老化―生活習慣病」の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

毎日の食生活により徐々に蓄積される毒性終末糖化産物に対する除去機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intracellular toxic advanced glycation end-products promote the production of reactive oxygen species in HepG2 cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of new advanced glycation end-products and food ingredients to diagnose and prevent lifestyle diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Toxic advanced glycation end-products (TAGE) are major structures of cytotoxic AGEs derived from glyceraldehyde2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structures of Toxic Advanced Glycation End-Products Derived from Glyceraldehyde, A Sugar Metabolite2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of Intracellular TAGE and the TAGE?RAGE?ROS Axis in the Onset and Progression of NAFLD/NASH2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Toxic AGEs (TAGE)と健康:I. 細胞障害因子としてのTAGE2023

Author(s)

Journal Title

Data Source

[Journal Article] Toxic AGEs (TAGE)と健康:II. 生活習慣病予測マーカーとしてのTAGE2023

Author(s)

Journal Title

Data Source

[Journal Article] Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Microtubule-Associated Protein 1 Light Chain 3 and p622022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Toxic AGEs (TAGE) on Human Health2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

SAKASAI AKIKO 坂井亜紀子

SAKASAI-SAKAI Akiko 逆井亜紀子