Yamada Daisaku 山田大作

… Alternative Names

YAMADA Daisaku 山田大作

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Researcher Number	60571396
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 助教 2022 – 2023: 大阪大学, 大学院医学系研究科, 助教 2020 – 2021: 大阪大学, 医学系研究科, 助教 2018 – 2019: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 消化器外科医長 2017: 大阪大学, 医学部附属病院, 医員 … More 2012: 大阪大学, 医学部附属病院, その他 2012: 大阪大学, 大学院・医学系研究科, 医員 2011: 大阪大学, 医学系研究科, 医員 2010: 大阪大学, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords	Principal Investigator バイオマーカー / microRNA / リキッドバイオプシー / 膵癌 / 門脈血 / 補助化学療法 / micro RNA / subclinical tumor / 集学的治療 / 耐性 / エクソソーム / 膵癌治療抵抗性 … More Except Principal Investigator … More 癌幹細胞 / 癌関連線維芽細胞 / microRNA / エクソソーム / 膵癌 / 腫瘍周囲環境 / IL-33 / 肝内胆管癌 / micro RNA / 肺転移 / 肝転移 / 癌周囲環境細胞 / 癌微小環境構成細胞 / 浸潤 / 癌 / 肝臓癌 / オルガノイド / 低酸素 / 膵臓癌 / 胆道癌 / 肝細胞癌 / ドラッグ・リポジショニング / 上皮間葉転換 / エピゲノム / c-Met / 放射線耐性 / 抗癌剤耐性 / proeniter gene / Pdx1 / Progenitor gene / 転写因子 / progenitor gene / 膵内分泌腫瘍 / 膵臓外科学 Less

肝内胆管癌におけるIL-33の癌促進作用と腫瘍内浸潤免疫細胞との関連についての研究Principal Investigator
- Principal Investigator
  
  山田大作
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Osaka
肝胆膵領域癌の浸潤過程における、周囲環境細胞との相互干渉の解析と制御
- Principal Investigator
  
  小林省吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
末梢血・門脈血中microRNA解析による臓器別転移機序の解明と個別化治療の開発
- Principal Investigator
  
  高橋秀典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
The impact of IL-33 on tumor microenvironment in intrahepatic cholangiocarcinoma
- Principal Investigator
  
  江口聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Molecular mechanism of metastasis, invasion, and resistance to chemo-/radiotherapy in hepato-biliary and pancreatic malignancies
- Principal Investigator
  
  和田浩志
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka International Cancer Institute
To investigate the exosomal microRNA within portal blood for the aim of individualization of the multimodal therapy for pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Yamada Daisaku
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
To investigate the useful biomarker gene for the management of pancreatic cancer.Principal Investigator
- Principal Investigator
  
  Yamada Daisaku
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka International Cancer Institute
Elucidation of drug-resistance induction mechanism and construction of the new therapy targeting epigenome change
- Principal Investigator
  
  Eguchi Hidetoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.
- Principal Investigator
  
  WADA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2019 2017

All Journal Article Presentation

[Journal Article] Automated Analysis for the Prevalence of Cancer-Associated Fibroblasts in Resected Specimens of Intrahepatic Cholangiocarcinoma is a Simple and Reliable Evaluation System.2023
- Author(s)
  Eguchi S, Yamada D, Kobayashi S, Sasaki K, Iwagami Y, Tomimaru Y, Noda T, Takahashi H, Asaoka T, Tanemura M, Doki Y, Eguchi H.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 30 Issue: 9 Pages: 5420-5428
- DOI
  10.1245/s10434-023-13633-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08799, KAKENHI-PROJECT-22K08869
[Journal Article] DUPAN-II normalisation as a biological indicator during preoperative chemoradiation therapy for resectable and borderline resectable pancreatic cancer2023
- Author(s)
  Hasegawa S, Takahashi H, Akita H, Mukai Y, Mikamori M, Asukai K, Yamada D, Wada H, Fujii Y, Sugase T, Yamamoto M, Takeoka T, Shinno N, Hara H, Kanemura T, Haraguchi N, Nishimura J, Matsuda C, Yasui M, Omori T, Miyata H, Ohue M, Ishikawa O, Sakon M.
- Journal Title
  
  BMC Cancer
  
  Volume: 23 Issue: 1 Pages: 63-63
- DOI
  10.1186/s12885-023-10512-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09069
[Journal Article] Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer2022
- Author(s)
  Takayama H, Kobayashi S, Gotoh K, Sasaki K, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Asaoka T, Noda T, Wada H, Takahashi H, Tanemura M, Doki Y, Eguchi H.
- Journal Title
  
  World J Surg Oncol.
  
  Volume: 20 Pages: 291-291
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08774
[Journal Article] Preoperative FDG-Positive Lymph Nodes Predict the Postoperative Prognosis in Resectable Biliary Tract Cancers2022
- Author(s)
  Kubo M, Kobayashi S, Gotoh K, Takayama H, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Noda T, Kato H, Shimosegawa E, Doki Y, Eguchi H.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 29 Pages: 935-935
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08774
[Journal Article] ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer2022
- Author(s)
  Ueno G, Iwagami Y, Kobayashi S, Mitsufuji S, Yamada D, Tomimaru Y, Akita H, Asaoka T, Noda T, Gotoh K, Mori M, Doki Y, Eguchi H.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 29 Pages: 2899-2899
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08774
[Journal Article] A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma2019
- Author(s)
  Matsushita Katsunori、Konno Masamitsu、Eguchi Hidetoshi、Koseki Jun、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi、Obika Satoshi
- Journal Title
  
  ChemMedChem
  
  Volume: 14 Issue: 15 Pages: 1384-1391
- DOI
  10.1002/cmdc.201900324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08704, KAKENHI-PROJECT-19K07688, KAKENHI-PROJECT-19K09172, KAKENHI-PROJECT-19K22658, KAKENHI-PROJECT-18KK0251, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-17K10696, KAKENHI-PROJECT-18K16356
[Journal Article] Fatty Acid-Mediated Stromal Reprogramming of Pancreatic Stellate Cells Induces Inflammation and Fibrosis That Fuels Pancreatic Cancer.2017
- Author(s)
  Hata T, Kawamoto K, Eguchi H, Kamada Y, Takamatsu S, Maekawa T, Nagaoka S, Yamada D, Iwagami Y, Asaoka T, Noda T, Wada H, Gotoh K, Masamune A, Miyoshi E, Mori M, Doki Y.
- Journal Title
  
  Pancreas
  
  Volume: 46 Issue: 10 Pages: 1259-1266
- DOI
  10.1097/mpa.0000000000000943
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10696, KAKENHI-PROJECT-15H04810, KAKENHI-PROJECT-16H05226, KAKENHI-PROJECT-16K15428
[Presentation] IL-33 facilitates iCCA progression by increasing the secretion of IL-6 from CAFs2024
- Author(s)
  Satoshi Eguchi，Daisaku Yamada，Shogo Kobayashi，Kazuki Sasaki，Yoshifumi Iwagami，Yoshito Tomimaru，Takehiro Noda, Hidenori Takahashi，Yuichiro Doki，Hidetoshi Eguchi
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] IL-33 facilitates the intrahepatic cholangiocarcinoma progression by increasing inflammatory cytokine secretion from cancer associated fibroblasts2023
- Author(s)
  Satoshi Eguchi，Daisaku Yamada，Shogo Kobayashi，Kazuki Sasaki，Yoshifumi Iwagami，Yoshito Tomimaru，Takehiro Noda, Hidenori Takahashi，Yuichiro Doki，Hidetoshi Eguchi
- Organizer
  Asian Pacific Digestive Week (APDW) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] PROGNOSTIC IMPACT of IL-33 and CANCER ASSOCIATED FIBROBLAST in INTRAHEPATIC CHOLANGIOCARCINOMA2023
- Author(s)
  Satoshi Eguchi，Daisaku Yamada，Shogo Kobayashi，Kazuki Sasaki，Yoshifumi Iwagami，Yoshito Tomimaru，Takehiro Noda, Hidenori Takahashi，Yuichiro Doki，Hidetoshi Eguchi
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] 肝内胆管癌発育因子としてIL-33が癌関連線維芽細胞に与える影響の検討2023
- Author(s)
  江口聡，山田大作，小林省吾，佐々木一樹，岩上佳史，富丸慶人，野田剛広，高橋秀典，土岐祐一郎，江口英利
- Organizer
  第59回日本胆道学会
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] 肝切除時放出サイトカインIL-33と癌関連線維芽細胞が肝内胆管癌細胞株に与える影響についての検討2023
- Author(s)
  江口聡，山田大作，小林省吾，佐々木一樹，岩上佳史，富丸慶人，野田剛広，高橋秀典，土岐祐一郎，江口英利
- Organizer
  第78回消化器外科学会
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] 肝内胆管癌においてIL33と癌関連線維芽細胞が肝内再発に与える影響についての検討2022
- Author(s)
  江口聡，山田大作，小林省吾，佐々木一樹，岩上佳史，富丸慶人，野田剛広，高橋秀典，土岐祐一郎，江口英利
- Organizer
  第77回消化器外科学会
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] 肝内胆管癌切除標本における癌関連線維芽細胞数評価方法の検討2022
- Author(s)
  江口聡，山田大作，小林省吾，佐々木一樹，岩上佳史，富丸慶人，秋田裕史，野田剛広，後藤邦仁，高橋秀典，土岐祐一郎，江口英利
- Organizer
  第122回外科学会
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] 肝内胆管癌においてCAFが予後に与える影響についての検討2022
- Author(s)
  江口聡，山田大作，小林省吾，佐々木一樹，岩上佳史，富丸慶人，野田剛広，高橋秀典，土岐祐一郎，江口英利
- Organizer
  第58回日本胆道学会
- Data Source
  KAKENHI-PROJECT-22K08869
[Presentation] 膵癌集学的治療の個別化を目指した血中microRNA遺伝子の検討2021
- Author(s)
  竹田佑，山田大作，小林省吾，岩上佳史，富丸慶人，秋田裕史，野田剛広，後藤邦仁，土岐祐一郎，江口英利
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K17669
[Presentation] The investigation of new biomarkers for individualizing adjuvant chemotherapy for pancreatic cancers2021
- Author(s)
  Yu Takeda, Daisaku Yamada, Shogo Kobayashi, Yoshifumi Iwagami, Yoshito Tomimaru, Hirofumi Akita, Takehiro Noda, Kunihito Gotoh, Yuichiro Doki, Hidetoshi Eguchi
- Organizer
  日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K17669
[Presentation] The investigation of candidate biomarkers for individualizing cases of adjuvant chemotherapy resistance in pancreatic cancer.2021
- Author(s)
  Yu Takeda, Daisaku Yamada, Shogo Kobayashi, Yoshifumi Iwagami, Yoshito Tomimaru, Hirofumi Akita, Takehiro Noda, Kunihito Gotoh, Yuichiro Doki, Hidetoshi Eguchi
- Organizer
  日本肝胆膵外科学会
- Data Source
  KAKENHI-PROJECT-20K17669
[Presentation] 膵癌集学的治療の個別化を目指した血中microRNA遺伝子の検討2021
- Author(s)
  竹田佑，山田大作，小林省吾，岩上佳史，富丸慶人，秋田裕史，野田剛広，後藤邦仁，土岐祐一郎，江口英利
- Organizer
  日本外科学会
- Data Source
  KAKENHI-PROJECT-20K17669
[Presentation] Is the site of metastasis after surgery for pancreatic cancer predicted by the preoperative sample?2019
- Author(s)
  Go Shinke, Daisaku Yamada, Hidetoshi Eguchi, and Yuichiro Doki
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16354
[Presentation] 脈管浸潤陽性膵癌の術前療法は化学療法をすべきか、化学放射線療法をすべきか2017
- Author(s)
  江口英利, 後藤邦仁, 和田浩志, 浅岡忠史, 野田剛広, 山田大作, 岩上佳史, 川本弘一, 森正樹, 土岐祐一郎
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10696

1. WADA Hiroshi (00572554)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. 高橋秀典 (90601120)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. EGUCHI Hidetoshi (90542118)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 岩上佳史 (60597441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 小林省吾 (30452436)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 富丸慶人 (70528570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. NAGANO Hiroaki (10294050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKIUCHI Daisuke (30571351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 後藤邦仁 (10362716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 長谷川慎一郎 (60621026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 野田剛広 (50528594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 佐々木一樹 (20745442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 秋田裕史 (70528463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 江口聡 (00912007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. HIDESHI Ishii

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 佐藤太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 小関準

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 種村匡弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamada Daisaku 山田 大作

YAMADA Daisaku 山田 大作

Research Projects

Research Products

Co-Researchers

肝内胆管癌におけるIL-33の癌促進作用と腫瘍内浸潤免疫細胞との関連についての研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝胆膵領域癌の浸潤過程における、周囲環境細胞との相互干渉の解析と制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

末梢血・門脈血中microRNA解析による臓器別転移機序の解明と個別化治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The impact of IL-33 on tumor microenvironment in intrahepatic cholangiocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of metastasis, invasion, and resistance to chemo-/radiotherapy in hepato-biliary and pancreatic malignancies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To investigate the exosomal microRNA within portal blood for the aim of individualization of the multimodal therapy for pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To investigate the useful biomarker gene for the management of pancreatic cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of drug-resistance induction mechanism and construction of the new therapy targeting epigenome change

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Automated Analysis for the Prevalence of Cancer-Associated Fibroblasts in Resected Specimens of Intrahepatic Cholangiocarcinoma is a Simple and Reliable Evaluation System.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DUPAN-II normalisation as a biological indicator during preoperative chemoradiation therapy for resectable and borderline resectable pancreatic cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer2022

Author(s)

Journal Title

Data Source

[Journal Article] Preoperative FDG-Positive Lymph Nodes Predict the Postoperative Prognosis in Resectable Biliary Tract Cancers2022

Author(s)

Journal Title

Data Source

[Journal Article] ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer2022

Author(s)

Journal Title

Yamada Daisaku 山田大作

YAMADA Daisaku 山田大作