Tsubouchi Hironobu 坪内拡伸

… Alternative Names

HIRONOBU Tsubouchi 坪内拡伸

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Researcher Number	60573988
Affiliation (Current)	2025: 宮崎大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2014 – 2025: 宮崎大学, 医学部, 助教 2010 – 2013: 宮崎大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 52010:General internal medicine-related / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 54030:Infectious disease medicine-related / Endocrinology / Basic Section 52010:General internal medicine-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Biological Sciences
Keywords	Principal Investigator 肺癌 / グレリン / 蛋白質断片化 / 酵素活性 / 骨格筋 / 肺炎 / サルコペニア / 癌 / 交感神経 / ARDS … More / 肺線維症 / 脂肪細胞 / ブレオマイシン / 悪液質 … More Except Principal Investigator Pten / グレリン / 細胞老化 / 肺癌 / アスペルギルス / 発癌 / 2型肺胞上皮 / シングルセル解析 / RhoA / 細胞骨格 / 急性肺損傷 / エネルギー代謝 / ペプチド / 視床下部 / インスリン分泌 / 肥満 / 糖尿病 / 真菌 / 自然発癌モデル / 腫瘍微小環境 / 末梢神経障害 / 日和見感染症 / 結核 / 感染症診断 / 癌関連線維芽細胞 / 間葉系細胞 / 1細胞解析 / 肺間葉細胞 / 間葉細胞 / シングルセルRNA解析 / 肺腺癌自然発癌モデル / 癌微小環境 / 発がん / 細胞ダイナミクス / 幹細胞 / 肺胞形成 / 肺発生 / 細胞運命決定 / 細胞移動調節機構 / 組織幹細胞ニッチ / 特発性肺線維症 / 慢性閉塞性肺疾患 / 内因性幹細胞ニッチ機構 / 肺胞微小環境 / 肺微小環境 / 肺線維症　肺リモデリング / Ror2 / 肺リモデリング / 肺線維症 / 内分泌学 / ペプチドホルモン / 糖脂質代謝 / 摂食中枢 / 生理活性ペプチド / 基底膜 / Ｐｔｅｎ / リモデリング / タイトジャンクション / 急性呼吸窮迫症候群 / 肺損傷 / 上皮統合性 / 交感神経 / 細胞内伝達情報 / 摂食調節 / ALI / 六君子湯 / トレンスレーショナルリサーチ / カヘキシア / QOL / 肺傷害 / 慢性呼吸不全 / 漢方薬 / 糖代謝 / 摂食 / 迷走神経 / 整理活性 / 膵β細胞 / トランスレーショナルリサーチ / 生理活性 / 医療 / 内科 Less

肺腺癌における過剰な酵素活性と蛋白質断片化の制御による新規治療法の開発Principal Investigator
- Principal Investigator
  
  坪内拡伸
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
グレリンシグナルを介した免疫賦活化作用による慢性肺アスペルギルス症の治療戦略開発
- Principal Investigator
  
  宮崎泰可
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  University of Miyazaki
担癌状態のパクリタキセルの神経毒性とグレリンシグナル活性化による神経保護の検討
- Principal Investigator
  
  塩見一剛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Miyazaki
Essentiality of mesenchymal subpopulations for carcinogenesis discovered by one-cell analysis of a mouse model of spontaneous lung adenocarcinoma.
- Principal Investigator
  
  柳重久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
グレリンシグナルの活性化による高齢者肺炎サルコペニアへの新規治療法の開発Principal Investigator
- Principal Investigator
  
  坪内拡伸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Miyazaki
尿中蛋白質断片の網羅的解析による日和見感染症の新規診断法の開発
- Principal Investigator
  
  宮崎泰可
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  University of Miyazaki
Determination of the mesenchymal subcluster responsible for carcinogenesis of lung cancer and origin of CAF based on the results of single-cell analysis
- Principal Investigator
  
  Yanagi Shigehisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
Investigetion of the pathomechanisims of smoking-related lung disease focusing on tissue stem cell niche
- Principal Investigator
  
  Yanagi Shigehisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
Clarification of the regulation system of cellular dynamics and senescence during lung development
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  University of Miyazaki
Investigation of new therapeutic strategies for ARDS and lung cancer focusing on the regulation of sympathetic overactivityPrincipal Investigator
- Principal Investigator
  
  Hironobu Tsubouchi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
Identify the novel bioactive peptides and their role in feeding regulation
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  University of Miyazaki
Elucidation of the pathomechanism of lung fibrosis from the viewpoint of cellular senescence and cytoskeletal organization
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Exploratory research of adipocyte related pulmonary cachectic factor and investigation of ghrelin's effect on cachexiaPrincipal Investigator
- Principal Investigator
  
  Hironobu Tsubouchi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
The exploration of new therapeutic target and the investigation of the role of maintaining alveolar-epithelium cell integrity in acute respiratory distress syndrome
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Detection and functional analysis of the novel peptides regulating feeding and energy metabolic homeostasis
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  University of Miyazaki
上皮間葉転換早期相を焦点とする急性肺損傷発症機構の解明と新規治療法の探索
- Principal Investigator
  
  柳重久
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Investigation of the protective effects of ghrelin on the disease progression of acute lung injury and its clinical application
- Principal Investigator
  
  NAKAZATO Masamitsu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
The pathophysiological role of bioactive peptides regulating energy metabolism against obesity
- Principal Investigator
  
  NAKAZATO Masamitsu
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Miyazaki
Development research of ghrelin treatment against intractable respiratory diseases
- Principal Investigator
  
  NAKAZATO Masamitsu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2010 Other

All Journal Article Presentation Book

[Book] 別冊　医学のあゆみ2017
- Author(s)
  坪内拡伸、柳重久、中里雅光
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15K19424
[Book] 医学のあゆみ2016
- Author(s)
  坪内拡伸、柳重久、中里雅光
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15K19424
[Book] Annual Review 2015呼吸器，（分担）呼吸器疾患におけるPTENの役割2015
- Author(s)
  柳　重久、坪内拡伸、中里雅光
- Total Pages
  248
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26670419
[Book] Annual Review 2015呼吸器．（分担）呼吸器疾患におけるPTENの役割2015
- Author(s)
  柳　重久、坪内拡伸、中里雅光
- Total Pages
  248
- Publisher
  中外医学社
- Data Source
  KAKENHI-PLANNED-22126009
[Journal Article] GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity2022
- Author(s)
  Tanida Ryota、Tsubouchi Hironobu、Yanagi Shigehisa、Saito Yusuke、Toshinai Koji、Miyazaki Taiga、Takamura Toshinari、Nakazato Masamitsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 589 Pages: 260-266
- DOI
  10.1016/j.bbrc.2021.12.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-20K11499, KAKENHI-PROJECT-21K08159
[Journal Article] Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome2021
- Author(s)
  Matsuo Ayako、Tanida Ryota、Yanagi Shigehisa、Tsubouchi Hironobu、Miura Ayako、Shigekusa Takafumi、Matsumoto Nobuhiro、Nakazato Masamitsu
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 892 Pages: 173754-173754
- DOI
  10.1016/j.ejphar.2020.173754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08179, KAKENHI-PROJECT-17K16051
[Journal Article] Transition From Distinct Types of KRAS Mutation-Harboring Multifocal Lung Adenocarcinoma to Rhabdoid Tumor2021
- Author(s)
  Setoguchi K, Yanagi S, Gi T, Tsubouchi H, Uto K, Shigekusa T, Matsumoto N, Sato Y, Nakazato M.
- Journal Title
  
  Am J Case Rep.
  
  Volume: 22
- DOI
  10.12659/ajcr.932452
- Data Source
  KAKENHI-PROJECT-21K08159
[Journal Article] Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice.2017
- Author(s)
  Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 819 Pages: 35-42
- DOI
  10.1016/j.ejphar.2017.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-15K19424
[Journal Article] The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections2017
- Author(s)
  Shigehisa Yanagi, Hironobu Tsubouchi, Ayako Miura, Ayako Matsuo, Nobuhiro Matsumoto and Masamitsu Nakazato
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 3 Pages: 503-503
- DOI
  10.3390/ijms18030503
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860610, KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-16K15460
[Journal Article] Clinical application of ghrelin for chronic respiratory failure2017
- Author(s)
  Matsumoto N, Tsubouchi H, Imazu Y, Arimura Y, Yanagi S, Iiboshi H, Nakazato M.
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: Suppl. Pages: S1-S3
- DOI
  10.1507/endocrj.64.S1
- NAID
  130007307950
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15460, KAKENHI-PROJECT-15K19424
[Journal Article] Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line2017
- Author(s)
  Tsubouchi H, Onomura H, Saito Y, Yanagi S, Miura A, Matsuo A, Matsumoto N, Nakazato M.
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: Suppl. Pages: S41-S46
- DOI
  10.1507/endocrj.64.S41
- NAID
  130007307940
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-16K15460, KAKENHI-PROJECT-15K19424
[Journal Article] Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice2016
- Author(s)
  Naznin F, Sakoda H, Okada T, Tsubouchi H, Waise TM, Arakawa K, Nakazato M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 794 Pages: 37-44
- DOI
  10.1016/j.ejphar.2016.11.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-15K19424
[Journal Article] Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients2015
- Author(s)
  Tsuchimochi W, Ueno H, Yamashita E, Tsubouchi C, Sakoda H, Nakamura S, Nakazato M
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 1 Pages: 13-20
- DOI
  10.1507/endocrj.EJ14-0393
- NAID
  130004690934
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22126009, KAKENHI-PROJECT-25293216
[Journal Article] Ghrelin administration for chronic respiratory failure: a randomized dose-comparison trial2015
- Author(s)
  Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K
- Journal Title
  
  Lung
  
  Volume: 193 Pages: 239-247
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293216
[Journal Article] Effects of miglitol, acarbose, and sitagliptin on plasma insulin and gut peptides in type 2 diabetes mellitus: A crossover study2015
- Author(s)
  Ueno H, Tsuchimochi W, Wang HW, Yamashita E, Tsubouchi C, Nagamine K, Sakoda H, Nakazato M
- Journal Title
  
  Diabetes Ther
  
  Volume: 6 Issue: 2 Pages: 187-196
- DOI
  10.1007/s13300-015-0113-3
- Open Access
- Data Source
  KAKENHI-PROJECT-25293216
[Journal Article] ARDSと肺線維症の病態機構における肺胞上皮細胞統合性の役割2015
- Author(s)
  柳　重久、坪内拡伸、松元信弘、中里雅光
- Journal Title
  
  呼吸
  
  Volume: 34 Pages: 554-559
- Data Source
  KAKENHI-PROJECT-26670419
[Journal Article] Breakdown of epithelial barrier integrity and overdrive activation of alveolar epithelial cells in the pathogenesis of acute respiratory distress syndrome and lung fibrosis.2015
- Author(s)
  Yanagi S, Tsubouchi H, Miura A, Matsumoto N, Nakazato M
- Journal Title
  
  Biomed Res Int
  
  Volume: 573210 Pages: 1-12
- DOI
  10.1155/2015/573210
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860610, KAKENHI-PROJECT-26670419
[Journal Article] Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial. Lung2015
- Author(s)
  Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K
- Journal Title
  
  Lung
  
  Volume: 193 Issue: 2 Pages: 239-247
- DOI
  10.1007/s00408-015-9685-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22126002, KAKENHI-PLANNED-22126009, KAKENHI-PROJECT-25293216, KAKENHI-PROJECT-26670419, KAKENHI-PROJECT-24591133
[Journal Article] Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice2014
- Author(s)
  Tsubouchi H, Yanagi S, Miura A, Matsumoto N, Kangawa K, Nakazato M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 743 Pages: 1-10
- DOI
  10.1016/j.ejphar.2014.09.025
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126002, KAKENHI-PLANNED-22126009, KAKENHI-PROJECT-25293216, KAKENHI-PROJECT-26670419
[Journal Article] Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.2014
- Author(s)
  Tsubouchi H, Yanagi S, Miura A, Iizuka S, Mogami S, Yamada C, Hattori T, Nakazato M
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 306 Issue: 3 Pages: 233-245
- DOI
  10.1152/ajplung.00096.2013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126009, KAKENHI-PROJECT-24659406, KAKENHI-PROJECT-25293216, KAKENHI-PROJECT-26670419
[Journal Article] Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion.2014
- Author(s)
  Tsubouchi H, , Yanagi S, Miura A, Mogami S, Yamada C, Iizuka S, Hattori T, Nakazato M
- Journal Title
  
  Nutr Res
  
  Volume: 34 Issue: 10 Pages: 876-885
- DOI
  10.1016/j.nutres.2014.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126009, KAKENHI-PROJECT-25293216, KAKENHI-PROJECT-26670419
[Journal Article] Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity2013
- Author(s)
  Miyoshi K, Yanagi S, Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita S, Suzuki A, Nakazato M
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 187 Issue: 3 Pages: 262-275
- DOI
  10.1164/rccm.201205-0851oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592132, KAKENHI-PUBLICLY-24111536, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-24591171, KAKENHI-PROJECT-24650201, KAKENHI-PROJECT-24659406, KAKENHI-PUBLICLY-24112515
[Journal Article] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation2010
- Author(s)
  Imazu Y, Yanagi S, Miyoshi K, Tsubouchi H, Yamashita S, Matsumoto N, Ashitani J, Kangawa K, Nakazato M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 672 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659161
[Presentation] 2型肺胞上皮細胞内因子による肺間葉細胞の摂動で出現する発癌責任間葉サブクラスター2022
- Author(s)
  柳重久、坪内拡伸、宮崎泰可
- Organizer
  日本肺サーファクタント・界面医学会第58回学術研究会
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] 2型肺胞上皮でのPten欠損は細胞老化を加速し、ミトコンドリア恒常性とニッチ恒常性を破綻させ、加齢性の肺気腫を誘導する.2021
- Author(s)
  堀口崇典、柳　重久、坪内拡伸、松尾彩子、重草貴文、松元信弘、中里雅光.
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] Ghrelin attenuates lipopolysaccharide-Induced acute lung injury independently of vagus nerve circuit2019
- Author(s)
  Hironobu Tsubouchi
- Organizer
  The 24th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15929
[Presentation] 尿中微量蛋白質断片解析による新規肺腺癌診断マーカーの探索2018
- Author(s)
  坪内　拡伸
- Organizer
  第55回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15929
[Presentation] 肥満関連喘息におけるグレリンの役割の検討2018
- Author(s)
  坪内　拡伸
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15929
[Presentation] Ghrelin Protects Against Airway Eosinophilic Inflammation in Asthma2017
- Author(s)
  H. Tsubouchi, S. Yanagi, A Miura, et al.
- Organizer
  The 22st Congress of Asian Pacific Society of Respirology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19424
[Presentation] グレリンによる肺腺癌の増殖への影響と抗悪液質作用の検討2017
- Author(s)
  坪内拡伸, 柳重久, 三浦綾子, 松尾彩子, 松元信弘, 中里雅光
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19424
[Presentation] 肺癌悪液質における摂食関連分子の発現の検討2016
- Author(s)
  小野村仁美、坪内拡伸、三浦綾子、他
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-15K19424
[Presentation] Ghrelin attenuates lung cancer cachexia through mediating the expression of energy homeostasis related molecules.2016
- Author(s)
  H. Tsubouchi, S. Yanagi, A. Miura, et al.
- Organizer
  21nd Congress of the Asia Pacific Society of Respirology 2016
- Place of Presentation
  Bangkok (Thailand)
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-15K19424
[Presentation] The role of Pten in the cell-fate determination of epithelial cells in lung development.2016
- Author(s)
  Ayako Miura, Hironobu Tsubouch Shigehisa Yanagi, Nobuhiro Matsumoto, and Masamitsu Nakazato
- Organizer
  European Respiratory Society International Congress 2016
- Place of Presentation
  United Kingdom, London EXCEL
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K15460
[Presentation] マウス肺腺癌悪液質モデルにおいてGhrelin投与は癌悪液質を抑制する.2015
- Author(s)
  坪内拡伸、柳重久、松元信弘、中里雅光
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム (東京都千代田区)
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-15K19424
[Presentation] Ghrelin Ameliorates Cancer Cachexia Associated with the Development of Lung Adenocarcinoma in Mice.2015
- Author(s)
  11)Tsubouchi H, Yanagi S, Miura A, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society International Congres, 2015.
- Place of Presentation
  amsterdam (Nederland)
- Year and Date
  2015-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19424
[Presentation] Ghrelin ameliorates cachectic status in the mouse model of lung cancer model2013
- Author(s)
  Tsubouchi H, Yanagi S, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society
- Place of Presentation
  バルセロナ　スペイン
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] Lung epithelial Pten controls epithelial barrier integrity in vitro and in vivo2013
- Author(s)
  Yanagi S, Miyoshi K, Tsubouchi H, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society
- Place of Presentation
  バルセロナ　スペイン
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] ブレオマイシン急性肺傷害モデルによる六君子湯投与の効果2013
- Author(s)
  坪内拡伸
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2013-04-21
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] Ghrelin ameliorates cachectic status in the mouse model of lung cancer model2013
- Author(s)
  坪内拡伸
- Organizer
  European Respiratory Society
- Place of Presentation
  バルセロナ
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] Rikkunshito ameliorates bleomycin-induced lung injury in mice.2012
- Author(s)
  Tsubouchi H, Yanagi S, Iizuka S, Mogami S, Miyoshi K, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Epithelial Pten controls acute lung injury and fibrosis by regulatiug intercellular junctional integrity and EMT.2012
- Author(s)
  Yanagi S, Miyoshi K, Tsubouchi H, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation.2012
- Author(s)
  Yanagi S, Imazu Y, Miyoshi K, Tsubouchi H, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Epithelial Pten controls acute lung injury and fibrosis by regulating intercellular junctional integrity and EMT.2012
- Author(s)
  Yanagi S, Miyoshi K,　Kawahara K, Tsubouchi H, Matsumoto N, Yamashita S, Suzuki A, Nakazato M
- Organizer
  17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine
- Place of Presentation
  Hersonissos, Crete , Greece
- Invited
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] ブレオマイシン肺傷害モデルにおける六君子湯のグレリン分泌を介したcachexia改善効果
- Author(s)
  坪内拡伸，柳　重久，松元信弘，中里雅光
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PLANNED-22126009
[Presentation] ブレオマイシン誘発肺線維症モデルにおけるグレリンを介した六君子湯の摂食調節作用
- Author(s)
  飯塚正一，柳　重久，坪内拡伸，十枝内厚次，最上祥子，山田ちひろ，服部智久，中里雅光
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25293216
[Presentation] ブレオマイシン誘発肺線維症モデルにおけるグレリンを介した六君子湯の摂食調節作用
- Author(s)
  飯塚正一，柳　重久，坪内拡伸，十枝内厚次，最上祥子，山田ちひろ，服部智久，中里雅光
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-26670419
[Presentation] ブレオマイシン肺傷害モデルにおける六君子湯のグレリン分泌を介したcachexia改善効果
- Author(s)
  坪内拡伸，柳　重久，松元信弘，中里雅光
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26670419
[Presentation] ブレオマイシン肺傷害モデルにおける六君子湯のグレリン分泌を介したcachexia改善効果
- Author(s)
  坪内拡伸，柳　重久，松元信弘，中里雅光
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-25293216
[Presentation] ブレオマイシン誘発肺線維症モデルにおけるグレリンを介した六君子湯の摂食調節作用
- Author(s)
  飯塚正一，柳　重久，坪内拡伸，十枝内厚次，最上祥子，山田ちひろ，服部智久，中里雅光
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PLANNED-22126009

1. YANAGI Shigehisa (60404422)

# of Collaborated Projects: 10 results

# of Collaborated Products: 12 results
2. NAKAZATO Masamitsu (10180267)

# of Collaborated Projects: 8 results

# of Collaborated Products: 18 results
3. MATSUMOTO Nobuhiro (70418838)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
4. HIDEKI Yamaguchi (10305097)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HIROAKI Ueno (00381062)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 高尾敏文 (10197048)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KOJI Toshinai (80381101)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. Tsuchimochi Wakaba (90573303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. MIYOSHI Kahori (50573375)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
10. Sakota Hideyuki (50376464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. Shimizu Kouichirou (90711292)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. Miura Ayako (70710903)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
13. 松尾彩子 (40776332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 小田康晴 (90843235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 宮崎泰可 (60448496)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. Naznin Farhana

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. AKIKO Taguchi (80517186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ARIMURA Yasuji (70534080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 今井光一 (00404426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 重草貴文 (90867730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 平山達朗 (40836269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 岩見真吾 (90518119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 塩見一剛 (40305082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 酒井克也 (00839491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 北村瑛子 (20985171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Waise Zaved T.M

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. Moin Abu Saleh MD

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Waise T. M. Zaved

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 張維東

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. KAWAHARA Kohichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 寒川賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tsubouchi Hironobu 坪内 拡伸

HIRONOBU Tsubouchi 坪内 拡伸

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肺腺癌における過剰な酵素活性と蛋白質断片化の制御による新規治療法の開発Principal Investigator

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グレリンシグナルの活性化による高齢者肺炎サルコペニアへの新規治療法の開発Principal Investigator

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Investigation of new therapeutic strategies for ARDS and lung cancer focusing on the regulation of sympathetic overactivityPrincipal Investigator

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Exploratory research of adipocyte related pulmonary cachectic factor and investigation of ghrelin's effect on cachexiaPrincipal Investigator

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Tsubouchi Hironobu 坪内拡伸

HIRONOBU Tsubouchi 坪内拡伸

[Book] 別冊　医学のあゆみ2017