Sou Yu-shin 曽友深

… Alternative Names

曽友深ソウユウシン

SOU Yu-shin 曽友深

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Researcher Number	60576221
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023: 順天堂大学, 医学部, 助教 2019 – 2021: 順天堂大学, 医学部, 助教 2015 – 2017: 順天堂大学, 医学部, 助教 2012 – 2013: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / Pathological medical chemistry
Keywords	Principal Investigator ゴルジ体 / GPHR / バスケット細胞 / プルキンエ細胞 / 膜接触部位 / 酸性オルガネラ / PI4P / SREBP / オルガネラ酸性環境 / N2A … More / 神経細胞 / コレステロール / SREBP2 / pH / 酸性環境 / 小脳回路 / 神経変性 / p62 / nbr1 / Nbr1 / オートファジー Less

オルガネラ酸性pHとPI4P局在の相関性の解明Principal Investigator
- Principal Investigator
  
  曽友深
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Juntendo University
Cellular cholesterol homeostasis and luminal pH of the Golgi apparatusPrincipal Investigator
- Principal Investigator
  
  Sou Yu-shin
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Juntendo University
Impairment of Golgi pH homeostasis cause neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Sou Yu-shin
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Juntendo University
pathophysiological analysis of autophagic substrate Nbr1.Principal Investigator
- Principal Investigator
  
  SOU Yu-shin
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2024 2022 2021 2019 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021
- Author(s)
  Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41467-020-20185-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-19K16344, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-16H06276
[Journal Article] Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity2021
- Author(s)
  Faruk MO, Ichimura Y, Kageyama S, Komatsu-Hirota S, El-Gowily AH, Sou YS, Koike M, Noda NN, Komatsu M.
- Journal Title
  
  J Biol Chem
  
  Volume: 297 Issue: 6 Pages: 101405-101405
- DOI
  10.1016/j.jbc.2021.101405
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-21H04163, KAKENHI-PROJECT-20K06549, KAKENHI-PROJECT-20K06644, KAKENHI-PROJECT-20K07743
[Journal Article] Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice2019
- Author(s)
  Sou Yu-shin、Kakuta Soichiro、Kamikubo Yuji、Niisato Kazue、Sakurai Takashi、Parajuli Laxmi Kumar、Tanida Isei、Saito Hiromitsu、Suzuki Noboru、Sakimura Kenji、Maeda Yusuke、Kinoshita Taroh、Uchiyama Yasuo、Koike Masato
- Journal Title
  
  eNeuro
  
  Volume: 6 Issue: 3 Pages: 0427-18
- DOI
  10.1523/eneuro.0427-18.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K15550, KAKENHI-PLANNED-17H06422
[Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.2019
- Author(s)
  Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
- Journal Title
  
  Life Sci Alliance.
  
  Volume: 3 Issue: 1 Pages: 201900513-201900513
- DOI
  10.26508/lsa.201900513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-16H06276
[Journal Article] Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation2017
- Author(s)
  van Wijk Sjoerd J. L.、Fricke Franziska、Herhaus Lina、Gupta Jalaj、H?tte Katharina、Pampaloni Francesco、Grumati Paolo、Kaulich Manuel、Sou Yu-shin、Komatsu Masaaki、Greten Florian R.、Fulda Simone、Heilemann Mike、Dikic Ivan
- Journal Title
  
  Nat Microbiol.
  
  Volume: 2 Issue: 7 Pages: 17066-17066
- DOI
  10.1038/nmicrobiol.2017.66
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-15K18961
[Journal Article] Phosphorylation of p62 activates the Keap1 - Nrf2 pathway during selective autophagy2014
- Author(s)
  ①Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M
- Journal Title
  
  Mol Cell
  
  Volume: 51 Pages: 618-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790332
[Journal Article] A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane2014
- Author(s)
  ③Uemura T, Yamamoto M, Kametaka A, Sou YS, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M, Waguri S
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34 Pages: 1695-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790332
[Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014
- Author(s)
  Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 446 Issue: 1 Pages: 309-315
- DOI
  10.1016/j.bbrc.2014.02.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790332, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-26000014
[Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy2014
- Author(s)
  ②Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 446 Pages: 309-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790332
[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013
- Author(s)
  Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
- Journal Title
  
  Mol Cell
  
  Volume: 51 Issue: 5 Pages: 618-631
- DOI
  10.1016/j.molcel.2013.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631
[Presentation] マンガン依存的なゴルジ体タンパク質TMEM165のリソソームによる分解機構の解析2024
- Author(s)
  曽　友深
- Organizer
  第129回日本解剖学会総会全国学術集会
- Data Source
  KAKENHI-PROJECT-23K06324
[Presentation] ゴルジ体酸性環境が担う適切な糖鎖修飾の変化がリソソームに与える影響2022
- Author(s)
  曽友深、前田祐輔、木下タロウ、小池正人
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K07276
[Presentation] ゴルジ体酸性環境による糖鎖修飾の制御メカニズム2021
- Author(s)
  曽友深
- Organizer
  第126回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K07276
[Presentation] 小脳神経系におけるゴルジ体酸性環境の重要性2019
- Author(s)
  曽友深
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-19K07276
[Presentation] An essential role for GPHR in cerebellar neurons2017
- Author(s)
  曽　友深、角田　宗一郎、前田　祐輔、木下　タロウ、内山安男、小池　正人
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K18961
[Presentation] ゴルジ体酸性環境不全に起因する病態発症機序の解明2017
- Author(s)
  曽友深、角田宗一郎、前田祐輔、木下タロウ、渡辺雅彦、崎村健司、内山安男、小池正人
- Organizer
  第122回日本解剖学会総会
- Place of Presentation
  長崎大学
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-15K18961
[Presentation] ゴルジ体の形態異常に起因する神経病態発症機序の解明2016
- Author(s)
  曽高　友深、角田　宗一郎、前田　祐輔、木下　タロウ、渡辺　雅彦、崎村　建司、内山　安男、小池　正人
- Organizer
  日本解剖学会
- Place of Presentation
  福島県ビックパレットふくしま
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K18961
[Presentation] オートファジー選択的基質p62およびNbr1の病態生理的意義2013
- Author(s)
  曽友深,和栗聡,田中啓二,小松雅明
- Organizer
  第1回オートファジー班会議(ポスター発表)
- Year and Date
  2013-12-20
- Data Source
  KAKENHI-PROJECT-24790332
[Presentation] Phenotypic analysis of liver specific Atg7 Nbr1-double knockout mice2012
- Author(s)
  Yu-shin Sou, Satoshi Waguri, Keiji Tanaka and Masaaki Komatsu
- Organizer
  6th International Symposium on Autophagy 2012
- Place of Presentation
  沖縄　ブセナテラス
- Data Source
  KAKENHI-PROJECT-24790332
[Presentation] Phenotypic analysis of liver specific Atg7 Nbr1 - double knockout mice2012
- Author(s)
  ②Yu-shin Sou, Satoshi Waguri, Keiji Tanaka, and Masaaki Komatsu
- Organizer
  6th International symposium on Autophagy(ポスター発表)
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-24790332
[Presentation] オートファジー選択的基質による凝集体形成制御機構
- Author(s)
  曽　友深、和栗　聡、 Caroline A Whitehouse、小松　雅明
- Organizer
  第２３回日本生体防御学会学術総会
- Place of Presentation
  東京　品川区総合区民会館
- Invited
- Data Source
  KAKENHI-PROJECT-24790332

1. KAMIKUBO Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sou Yu-shin 曽 友深

曽 友深 ソウ ユウシン

SOU Yu-shin 曽 友深

Research Projects

Research Products

Co-Researchers

オルガネラ酸性pHとPI4P局在の相関性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cellular cholesterol homeostasis and luminal pH of the Golgi apparatusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impairment of Golgi pH homeostasis cause neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

pathophysiological analysis of autophagic substrate Nbr1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of p62 activates the Keap1 - Nrf2 pathway during selective autophagy2014

Author(s)

Journal Title

Data Source

[Journal Article] A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane2014

Author(s)

Journal Title

Data Source

[Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LC3B is indispensable for selective autophagy of p62 but not basal autophagy2014

Author(s)

Journal Title

Data Source

[Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] マンガン依存的なゴルジ体タンパク質TMEM165のリソソームによる分解機構の解析2024

Author(s)

Organizer

Sou Yu-shin 曽友深

曽友深ソウユウシン

SOU Yu-shin 曽友深