ISHIHARA Makoto 石原誠人

Researcher Number	60581189
Affiliation (based on the past Project Information) *help	2015: 公益財団法人がん研究会, その他部局等, 研究員 2014: 東京大学, 新領域創成科学研究科, 客員共同研究員 2013: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 2011 – 2012: 独立行政法人理化学研究所, バイオマーカー探索・開発チーム, 特別研究員
Review Section/Research Field	Principal Investigator Tumor therapeutics / Tumor diagnosis
Keywords	Principal Investigator HTLV-1 / プロテオミクス / 腫瘍生物学 / 糖鎖 / 膜プロテオーム / プロテオミクス解析 / 治療標的 / 診断マーカー / 機械学習 / ATL / 質量分析

Research Projects
(3 results)
Research Products
(26 results)

成人Ｔ細胞性白血病新規治療標的分子の同定及びその機能解析Principal Investigator
- Principal Investigator
  
  石原誠人
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research
Quantitative membrane-proteome analysis to discover novel therapeutic targets for adult T-cell leukemia (ATL)Principal Investigator
- Principal Investigator
  
  ISHIHARA Makoto
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokyo
  Institute of Physical and Chemical Research
Quantitative proteome profiling to identify biomarkers and therapeutic targets for adult T-cell leukemia (ATL).Principal Investigator
- Principal Investigator
  
  ISHIHARA Makoto
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnosis
- Research Institution
  The Institute of Physical and Chemical Research

All 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent

[Journal Article] A plasma diagnostic model of human T-cell leukemia virus-1 associated myelopathy.2015
- Author(s)
  Makoto Ishihara, Natsumi Araya, Tomoo Sato, Naomi Saichi, Risa Fujii1 Yoshihisa Yamano, and Koji Ueda
- Journal Title
  
  Annals of clinical and translational neurology
  
  Volume: 2(3) Pages: 231-240
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830126
[Journal Article] Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia2013
- Author(s)
  Ishihara M., Araya N., Sato T., et al.
- Journal Title
  
  Blood
  
  Volume: in press Issue: 21 Pages: 4340-7
- DOI
  10.1182/blood-2012-08-446922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22680064, KAKENHI-PROJECT-23701090, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-25830126
[Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment2012
- Author(s)
  Ishihara M, Heissig B, Nishida C, Rosenkvist J, Tashiro Y, Ohki M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Hattori K
- Journal Title
  
  Leukemia
  
  Volume: 26 Issue: 2 Pages: 332-339
- DOI
  10.1038/leu.2011.203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00480, KAKENHI-PROJECT-21249059, KAKENHI-PROJECT-21591193, KAKENHI-PROJECT-21591234, KAKENHI-PUBLICLY-22019006, KAKENHI-PUBLICLY-22021013, KAKENHI-PLANNED-22112007, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590111, KAKENHI-PUBLICLY-23013009, KAKENHI-PROJECT-23591371, KAKENHI-PROJECT-23701090, KAKENHI-PUBLICLY-22117506
[Patent] ヒトTリンパ好性ウイルス-1 (HTLV-1)関連脊髄症(HAM/TSP)の検査方法、及び検査用キット2014
- Inventor(s)
  植田幸嗣、石原誠人、山野嘉久
- Industrial Property Rights Holder
  植田幸嗣、石原誠人、山野嘉久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-226719
- Filing Date
  2014-11-07
- Data Source
  KAKENHI-PROJECT-25830126
[Patent] ヒトTリンパ球向性ウイルスI型関連疾患検出用のポリペプチド、およびその利用2012
- Inventor(s)
  植田幸嗣、石原誠人、山野嘉久
- Industrial Property Rights Holder
  植田幸嗣、石原誠人、山野嘉久
- Filing Date
  2012-08-29
- Data Source
  KAKENHI-PROJECT-23701090
[Patent] ヒトＴリンパ球向性ウイルスＩ型関連疾患検出用のポリペプチド、およびその利用2012
- Inventor(s)
  植田幸嗣、石原誠人、山野嘉久
- Industrial Property Rights Holder
  植田幸嗣、石原誠人、山野嘉久
- Industrial Property Rights Type
  特許
- Filing Date
  2012-08-29
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] 定量膜プロテオーム解析によるヒトT細胞性白血病ウイルス1型(HTLV-1)関連疾患に対する新規治療標的の探索2015
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、藤井理沙、最知直美、宇都宮與、山野嘉久、植田幸嗣
- Organizer
  日本プロテオーム学会2015年会
- Place of Presentation
  くまもと森都心プラザ
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-15K06869
[Presentation] Membrane-proteome analysis to discover novel therapeutic targets for adult T-cell leukemia2015
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、藤井理沙、最知直美、宇都宮與、山野嘉久、植田幸嗣
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ホテル日航金沢
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-15K06869
[Presentation] Membrane Proteome Profiling to Discover Therapeutic Targets for HTLV-1 Associated Myelopathy2015
- Author(s)
  Makoto Ishihara, Natsumi Araya, Tomoo Sato, Ayako Tatsuguchi, Naomi Saichi Yoshihisa Yamano, Koji Ueda
- Organizer
  14th Annual World Congress of the Human Proteome Organization.
- Place of Presentation
  Vancouver Convention Centre
- Year and Date
  2015-09-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06869
[Presentation] 定量膜プロテオーム解析による成人Ｔ細胞性白血病に対する治療標的の探索2015
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、藤井理沙、最知直美、宇都宮與、山野嘉久、植田幸嗣
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K06869
[Presentation] Quantitative proteome profiling of CD4+CD25+CCR4+ T-cells to identify potential therapeutic targets for adult T-cell leukemia (ATL) and Human T-lymphotropic virus type-1 associated myelopathy (HAM).2012
- Author(s)
  Makoto Ishihara
- Organizer
  AACR 2012 Annual Meeting
- Place of Presentation
  McCormick Place (Chicago, Illinois, USA)
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] Quantitative proteome profiling of cerebrospinal fluid to identify potential diagnostic markers for human T-cell leukemia virus type 1 associated myelopathy2012
- Author(s)
  Makoto Ishihara
- Organizer
  HUPO 11th Annual World Congress
- Place of Presentation
  Hynes Convention Center (Boston, Massachusetts, USA)
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] Quantitative proteome profiling of cerebrospinal fluid to identify potential diagnostic markers for human T-cell leukemia virus type 1 associated myelopathy.2012
- Author(s)
  Makoto Ishihara
- Organizer
  HUPO 11th Annual World Congress
- Place of Presentation
  Hynes Convention Center (Boston, Massachusetts, USA)
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] Quantitative proteome profiling to identify biomarkers for Human T-lymphotropic virus type-1 associated disease2012
- Author(s)
  Makoto Ishihara
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌(北海道札幌市)
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] Quantitative proteome profiling to identify biomarkers for Human T-lymphotropic virus type-1 associated disease.2012
- Author(s)
  Makoto Ishihara
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] Quantitative proteome profiling of CD4^+CD25^+CCR4^+ T-cells to identify potential therapeutic targets for adult T-cell leukemia (ATL) and Human T-lymphotropic virus type-1 associated myelopathy (HAM)2012
- Author(s)
  Makoto Ishihara
- Organizer
  AACR 2012 Annual Meeting
- Place of Presentation
  McCormick Place (Chicago, Illinois, USA)
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] 成人T細胞白血病ウイルス関連疾患における新規マーカー同定を目的とした定量プロテオームプロファイリング2011
- Author(s)
  石原誠人
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] QUANTITATIVE PROTEOME PROFILING OF CD4+CD25+CCR4+ T-CELLS TO IDENTIFY POTENTIAL THERAPEUTIC TARGETS FOR HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 ASSOCIATED MYELOPATHY (HAM) AND ADULT T-CELL LEUKEMIA2011
- Author(s)
  Makoto Ishihara
- Organizer
  10th HUPO World Congress
- Place of Presentation
  Geneva palexp, Switzerland
- Data Source
  KAKENHI-PROJECT-23701090
[Presentation] Membrane proteome analysis to discover therapeutic targets for adult T-cell leukemia (ATL)
- Author(s)
  Makoto Ishihara, Natsumi Araya, Tomoo Sato, Ayako Tatsuguchi, Naomi Saichi Yoshihisa Yamano, Sumio Sugano, Koji Ueda
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] 脳脊髄液プロテオーム解析によるヒトTリンパ好性ウイルス関連脊髄症(HAM/TSP)に対する重症度診断アルゴリズムの構築
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、宇都宮與、山野嘉久、中川英刀、植田幸嗣
- Organizer
  第6回HTLV-1研究会
- Place of Presentation
  東京大学医科学研究所講堂
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] Quantitative membrane proteome profiling to discover therapeutic targets for HTLV-I associated diseases
- Author(s)
  Makoto Ishihara, Natsumi Araya, Tomoo Sato, Ayako Tatsuguchi, Naomi Saichi Yoshihisa Yamano, Koji Ueda
- Organizer
  13th Annual World Congress of the Human Proteome Organization
- Place of Presentation
  IFEMA Feria de Madrid
- Year and Date
  2014-10-05 – 2014-10-08
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] ＣＤ４陽性Ｔ細胞を用いた膜プロテオーム解析によるＨＴＬＶ－１関連脊髄症に対する新規治療標的分子の探索
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、藤井理沙、最知直美、宇都宮與、山野嘉久、菅野純夫、植田幸嗣
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2014-08-23 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] 成人T細胞白血病ウイルス関連疾患における新規治療標的同定を目的とした定量膜プロテオームプロファイリング
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、宇都宮與、中川英刀、山野嘉久、植田幸嗣
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] Label free quantitative proteome analysis on cerebrospinal fluid to discover severity grade markers for Human T-cell leukemia virus type 1 associated myelopathy/tropic spastic paraparesis (HAM/TSP)
- Author(s)
  Makoto Ishihara, Natsumi Araya, Tomoo Sato, Risa Fujii, Ayako Tatsuguchi, Naomi Saichi, Hidewaki Nakagawa, Yoshihisa Yamano, Koji Ueda
- Organizer
  HUPO 2013
- Place of Presentation
  Pacifico Yocohama, Kanagawa, Japan
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] 膜プロテオーム解析によるヒトT細胞白血病ウイルス－I型（HTLV-1）関連疾患に対する新規治療標的分子の探索
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、龍口文子、最知直美、宇都宮與、山野嘉久、菅野純夫、植田幸嗣
- Organizer
  日本プロテオーム学会2014 年会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25830126
[Presentation] Comprehensive membrane-proteomic analysis for discovery of novel therapeutic targets against adult T-cell leukemia
- Author(s)
  Makoto Ishihara, Natsumi Araya, Tomoo Sato, Risa Fujii, Ayako Tatsuguchi, Naomi Saichi, Atae Utsunomiya, Yoshihisa Yamano, Sumio Sugano, Koji Ueda
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830126

ISHIHARA Makoto 石原 誠人

Research Projects

Research Products

成人Ｔ細胞性白血病新規治療標的分子の同定及びその機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative membrane-proteome analysis to discover novel therapeutic targets for adult T-cell leukemia (ATL)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative proteome profiling to identify biomarkers and therapeutic targets for adult T-cell leukemia (ATL).Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A plasma diagnostic model of human T-cell leukemia virus-1 associated myelopathy.2015

Author(s)

Journal Title

Data Source

[Journal Article] Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrixmetallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment2012

Author(s)

Journal Title

DOI

Data Source

[Patent] ヒトTリンパ好性ウイルス-1 (HTLV-1)関連脊髄症(HAM/TSP)の検査方法、及び検査用キット2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ヒトTリンパ球向性ウイルスI型関連疾患検出用のポリペプチド、およびその利用2012

Inventor(s)

Industrial Property Rights Holder

Filing Date

Data Source

[Patent] ヒトＴリンパ球向性ウイルスＩ型関連疾患検出用のポリペプチド、およびその利用2012

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 定量膜プロテオーム解析によるヒトT細胞性白血病ウイルス1型(HTLV-1)関連疾患に対する新規治療標的の探索2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Membrane-proteome analysis to discover novel therapeutic targets for adult T-cell leukemia2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Membrane Proteome Profiling to Discover Therapeutic Targets for HTLV-1 Associated Myelopathy2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 定量膜プロテオーム解析による成人Ｔ細胞性白血病に対する治療標的の探索2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Quantitative proteome profiling of CD4+CD25+CCR4+ T-cells to identify potential therapeutic targets for adult T-cell leukemia (ATL) and Human T-lymphotropic virus type-1 associated myelopathy (HAM).2012

Author(s)

Organizer

ISHIHARA Makoto 石原誠人