nakamura taishi 中村太志

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Nakamura Taishi 中村太志

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Researcher Number	60582947
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 教授
Affiliation (based on the past Project Information) *help	2024: 熊本大学, 病院, 教授 2019 – 2020: 熊本大学, 病院, 准教授 2018: 熊本大学, 大学病院, 准教授 2017: 熊本大学, 医療情報経営企画部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / Cardiovascular medicine
Keywords	Principal Investigator レドックス / プロテインキナーゼG / 生体情報 / 心肥大 / レドックス制御 / サイクリックGMP依存性プロテインキナーゼ / システイン酸化 / PKG / 病的心肥大 / サイクリックGMPシグナルの層別化 / システインレドックス / 心不全

Achieving precision medicine by visualizing sympathetic nerve activity leveraging the capture of structural changes in oxidized PKG and biological informationPrincipal Investigator
- Principal Investigator
  
  中村太志
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Kumamoto University
Therapeutic application of PKG-1alpha redox modulation and the disparate cGMP regulation in heart failurePrincipal Investigator
- Principal Investigator
  
  Nakamura Taishi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kumamoto University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Current trends and future perspectives for heart failure treatment leveraging cGMP modifiers and the practical effector PKG2021
- Author(s)
  Nakamura Taishi、Tsujita Kenichi
- Journal Title
  
  Journal of Cardiology
  
  Volume: in press Issue: 4 Pages: 261-268
- DOI
  10.1016/j.jjcc.2021.03.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Journal Article] PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy2020
- Author(s)
  Oeing Christian U.、Nakamura Taishi、Pan Shi、Mishra Sumita、Dunkerly-Eyring Brittany L.、Kokkonen-Simon Kristen M.、Lin Brian L.、Chen Anna、Zhu Guangshuo、Bedja Djahida、Lee Dong Ik.、Kass David A.、Ranek Mark J.
- Journal Title
  
  Circulation Research
  
  Volume: 127 Issue: 4 Pages: 522-533
- DOI
  10.1161/circresaha.119.315714
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Journal Article] PKG-mediated TSC2 regulates mTORC1 activity to counter adverse cardiac stress.2019
- Author(s)
  Ranek MJ, Kokkonen-Simon KM, Holewinski R, Lee DI, Chen A, Vera MP, Dunkerly-Eyring B, Patel C, Nakamura T, Zhu G, Bedja D, Sasaki M, Van Eyk J, Oeing C, Powel J, Kass DA.
- Journal Title
  
  Nature.
  
  Volume: 566 Issue: 7743 Pages: 264-269
- DOI
  10.1038/s41586-019-0895-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Journal Article] Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.2018
- Author(s)
  Kokkonen-Simon KM, Saberi A, Nakamura T, Ranek MJ, Zhu G, Bedja D, Kuhn M, Halushka MK, Lee DI, Kass DA.
- Journal Title
  
  JCI Insight.
  
  Volume: 3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Journal Article] Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation.2018
- Author(s)
  Nakamura T, Zhu G, Ranek MJ, Kokkonen-Simon K, Zhang M, Kim GE, Tsujita K, Kass DA
- Journal Title
  
  Circ Heart Fail.
  
  Volume: Mar Issue: 3 Pages: 11-13
- DOI
  10.1161/circheartfailure.117.004740
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] Single Cysteine Redox Sensor in PKG1α Controls Salt Sensitivity through Renal Sympathetic Nerve Activity2020
- Author(s)
  Taishi Nakamura, Nobuyuki Tokunaga, Shokei Kim-Mitsuyama, Kenichi Tsujita
- Organizer
  JCS2020
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] HFpEFをどのように考え、アプローチするか（基礎）2020
- Author(s)
  中村太志、辻田賢一
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] PKG1αの特異的なシステイン酸化による二量体化は腎交感神経を介し食塩感受性を誘導する2019
- Author(s)
  中村太志, 徳永信行, 長谷川雄, 光山勝慶, 宇宿功市郎, 辻田賢一
- Organizer
  第19回日本NO学会
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] The Oxidation of Cyclic GMP-dependent Protein Kinase-1α Induced Salt Sensitive Hypertension through Activated Sympathetic Nervous System.2019
- Author(s)
  Tokunaga N, Nakamura T, Tsujita K
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] プロテインキナーゼG(PKG) 1αのジスルフィド二量体化の予防は、腎交感神経を介して食塩感受性を緩和し心腎血管連関における有用な治療戦略である2019
- Author(s)
  中村太志, 徳永信行, 長谷川雄, 光山勝慶, 宇宿功市郎, 辻田賢一
- Organizer
  第42回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] サイクリックGMP依存性プロテインキナーゼ(PKG1α)の酸化は心臓交感神経系を介し、食塩感受性高血圧を惹起する2019
- Author(s)
  徳永信行, 中村太志, 山本英一郎, 光山勝慶, 辻田賢一
- Organizer
  第42回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] Single Cysteine Redox in PKG1α Controls Salt Sensitivity through Sympathetic Nervous System.2019
- Author(s)
  Nakamura T, Tokunaga N, Mitsuyama S, Tsujita K.
- Organizer
  The 83rd Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] Pharmacological Cyclic GMP Intervention and the Disparate MicroRNA Modulations in Heart Disease.2018
- Author(s)
  Nakamura T.
- Organizer
  The 10th Annual International Congress of Cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] PKG1α Disulfide Formation in the Stressed Heart -Differential Efficacy from cGMP Modulators-2018
- Author(s)
  Nakamura T, Tsujita K, Kass DA
- Organizer
  The 1st JCS Council Forum on Basic CardioVascular Research
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] PKG1α disulfide formation by oxidation facilitates anti-hypertrophic/anti-fibrotic effects from PDE5 inhibition but not sGC activation2018
- Author(s)
  Nakamura T, Kass DA, Tsujita K
- Organizer
  The 82nd Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-17K09583
[Presentation] PKG1α oxidation is required for cardiac anti-hypertrophic/fibrotic effects from PDE5 inhibition but not soluble guanylate cyclase activation.2017
- Author(s)
  Nakamura T, Zhu G, Ranek MJ, Tsujita K, Kass DA
- Organizer
  American Heart Association Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09583

1. 泉家康宏 (10515414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 勝田陽介 (50632460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

nakamura taishi 中村 太志

Nakamura Taishi 中村 太志

Research Projects

Research Products

Co-Researchers

Achieving precision medicine by visualizing sympathetic nerve activity leveraging the capture of structural changes in oxidized PKG and biological informationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic application of PKG-1alpha redox modulation and the disparate cGMP regulation in heart failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Current trends and future perspectives for heart failure treatment leveraging cGMP modifiers and the practical effector PKG2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PKG-mediated TSC2 regulates mTORC1 activity to counter adverse cardiac stress.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.2018

Author(s)

Journal Title

Data Source

[Journal Article] Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Single Cysteine Redox Sensor in PKG1α Controls Salt Sensitivity through Renal Sympathetic Nerve Activity2020

Author(s)

Organizer

Data Source

[Presentation] HFpEFをどのように考え、アプローチするか（基礎）2020

Author(s)

Organizer

Data Source

[Presentation] PKG1αの特異的なシステイン酸化による二量体化は腎交感神経を介し食塩感受性を誘導する2019

Author(s)

Organizer

Data Source

[Presentation] The Oxidation of Cyclic GMP-dependent Protein Kinase-1α Induced Salt Sensitive Hypertension through Activated Sympathetic Nervous System.2019

Author(s)

Organizer

Data Source

[Presentation] プロテインキナーゼG(PKG) 1αのジスルフィド二量体化の予防は、腎交感神経を介して食塩感受性を緩和し心腎血管連関における有用な治療戦略である2019

Author(s)

Organizer

Data Source

[Presentation] サイクリックGMP依存性プロテインキナーゼ(PKG1α)の酸化は心臓交感神経系を介し、食塩感受性高血圧を惹起する2019

Author(s)

Organizer

Data Source

[Presentation] Single Cysteine Redox in PKG1α Controls Salt Sensitivity through Sympathetic Nervous System.2019

Author(s)

Organizer

Data Source

[Presentation] Pharmacological Cyclic GMP Intervention and the Disparate MicroRNA Modulations in Heart Disease.2018

Author(s)

Organizer

Data Source

[Presentation] PKG1α Disulfide Formation in the Stressed Heart -Differential Efficacy from cGMP Modulators-2018

Author(s)

Organizer

Data Source

[Presentation] PKG1α disulfide formation by oxidation facilitates anti-hypertrophic/anti-fibrotic effects from PDE5 inhibition but not sGC activation2018

Author(s)

Organizer

nakamura taishi 中村太志

Nakamura Taishi 中村太志