KAWASAKI Takumi 川崎拓実

Researcher Number	60584414
Other IDs
Affiliation (Current)	2025: 長崎大学, 高度感染症研究センター, 准教授
Affiliation (based on the past Project Information) *help	2024: 長崎大学, 高度感染症研究センター, 准教授 2018 – 2021: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 2013 – 2017: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 2013: 奈良先端科学技術大学院大学, バイオサイエンス研究科, その他 2011 – 2012: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) 2010: 大阪大学, 免疫学フロンティア研究センター, 特任研究員
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 48040:Medical biochemistry-related / Basic Section 49070:Immunology-related / Biological Sciences / General pharmacology Except Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator 自然免疫 / PIKfyve / マクロファージ / 肺胞マクロファージ / イノシトールリン脂質 / 抗原提示 / 肺 / ウイルス / キラーT細胞 / mRNAワクチン … More / インフルエンザウイルス / 分化 / 慢性炎症 / 肥満 / クロスプレゼンテーション / 自然免疫応答 / ウイルス感染 / 炎症 / アレルギー / 脂質代謝 / IRF3 / TBK1 / スクリーニング / ウィルス感染 / セリンスレオニンキナーゼ / ホスファチジルイノシトール５リン酸 / リン酸化 / シグナル伝達 / ホスファチジルイノシトール / T細胞 / カルシウム / イオンチャネル … More Except Principal Investigator T細胞免疫応答 / 重症化機構 / デング熱 / NGS / PBMC Less

Elucidation T cell-mediated "antigenic sin" and the mechanism behind the severity of dengue fever
- Principal Investigator
  
  高松由基
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagasaki University
キラーT細胞を介した呼吸器感染ウイルスの制御メカニズムの解明と応用Principal Investigator
- Principal Investigator
  
  川崎拓実
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Nagasaki University
Regulatory role of macrophage differentiation during obesityPrincipal Investigator
- Principal Investigator
  
  Kawasaki Takumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Nara Institute of Science and Technology
Regulatory mechanism of Alveolar macrophagesPrincipal Investigator
- Principal Investigator
  
  KAWASAKI Takumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nara Institute of Science and Technology
ウイルス感染防御におけるイノシトールリン脂質の役割Principal Investigator
- Principal Investigator
  
  川崎拓実
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
Regulatory role of PIKfyve in vivoPrincipal Investigator
- Principal Investigator
  
  kawasaki takumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nara Institute of Science and Technology
Investigation of TBK1 activation mechanismPrincipal Investigator
- Principal Investigator
  
  KAWASAKI Takumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nara Institute of Science and Technology
  Osaka University
T細胞の正負の選択に関わるカルシウムチャネルの同定Principal Investigator
- Principal Investigator
  
  川崎拓実
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site2022
- Author(s)
  Lian Benedict Shi Xiang、Kawasaki Takumi、Kano Norisuke、Ori Daisuke、Ikegawa Moe、Isotani Ayako、Kawai Taro
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 4 Pages: 104118-104118
- DOI
  10.1016/j.isci.2022.104118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-21K14817, KAKENHI-PROJECT-20H03468
[Journal Article] Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants2021
- Author(s)
  Ong Guang Han、Lian Benedict Shi Xiang、Kawasaki Takumi、Kawai Taro
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 745016-745016
- DOI
  10.3389/fcimb.2021.745016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-20H03468
[Journal Article] 1′-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression2021
- Author(s)
  Sok Sophia P M、Ori Daisuke、Wada Ayana、Okude Haruna、Kawasaki Takumi、Momota Masatoshi、Nagoor Noor Hasima、Kawai Taro
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 7 Pages: 373-386
- DOI
  10.1093/intimm/dxab016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-21K14817
[Journal Article] The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-332020
- Author(s)
  Momota Masatoshi、Nagayama Mizuka、Okude Haruna、Ishii Ken J.、Ori Daisuke、Kawasaki Takumi、Kawai Taro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 4 Pages: 699-705
- DOI
  10.1016/j.bbrc.2020.07.127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-20H03468, KAKENHI-PROJECT-19K22533
[Journal Article] Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses2020
- Author(s)
  Monwan Warunthorn、Kawasaki Takumi、Hasan Md Zobaer、Ori Daisuke、Kawai Taro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 4 Pages: 1077-1082
- DOI
  10.1016/j.bbrc.2019.11.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-19K22533, KAKENHI-PROJECT-17H04066
[Journal Article] Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System.2019
- Author(s)
  Kawasaki T, Kawai T.
- Journal Title
  
  Int Rev Cell Mol Biol.
  
  Volume: 344 Pages: 1-30
- DOI
  10.1016/bs.ircmb.2018.08.004
- ISBN
  9780128159798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15598
[Journal Article] Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization2019
- Author(s)
  Zainol Mohd Izwan Bin、Kawasaki Takumi、Monwan Warunthorn、Murase Motoya、Sueyoshi Takuya、Kawai Taro
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 20406-20406
- DOI
  10.1038/s41598-019-56914-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-19K22533, KAKENHI-PROJECT-17H04066
[Journal Article] PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking2019
- Author(s)
  Putri DDP, Kawasaki T, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T.
- Journal Title
  
  J Biol Chem
  
  Volume: - Issue: 21 Pages: 8412-8423
- DOI
  10.1074/jbc.ra118.005731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H06006, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-19K22533, KAKENHI-PROJECT-17K19529, KAKENHI-PROJECT-17K15598, KAKENHI-PROJECT-17H03674
[Journal Article] Intravesicular Acidification Regulates Lipopolysaccharide Inflammation and Tolerance through TLR4 Trafficking.2018
- Author(s)
  Murase M, Kawasaki T, Hakozaki R, Sueyoshi T, Putri DDP, Kitai Y, Sato S, Ikawa M, Kawai T.
- Journal Title
  
  J Immunol.
  
  Volume: -- Issue: 8 Pages: 2798-2808
- DOI
  10.4049/jimmunol.1701390
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08836, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15598
[Journal Article] Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2.2018
- Author(s)
  Sueyoshi T, Kawasaki T, Kitai Y, Ori D, Akira S, Kawai T.
- Journal Title
  
  J Immunol.
  
  Volume: 200 Issue: 11 Pages: 3814-3824
- DOI
  10.4049/jimmunol.1701282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-17K15598
[Journal Article] Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.2017
- Author(s)
  Kawasaki T, Ito K, Miyata H, Akira S, Kawai T.
- Journal Title
  
  EMBO J.
  
  Volume: 36 Issue: 12 Pages: 1707-1718
- DOI
  10.15252/embj.201695528
- NAID
  120006309714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K15598
[Journal Article] DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity2017
- Author(s)
  Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T.
- Journal Title
  
  J. Immunol.
  
  Volume: 198 Issue: 4 Pages: 1649-1659
- DOI
  10.4049/jimmunol.1601694
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01381, KAKENHI-PROJECT-15H05994, KAKENHI-PROJECT-26293107, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K15598
[Journal Article] The second messenger phosohatidylinositol-5-phosphate facilitates antiviral innate immune signaling2013
- Author(s)
  Kawasaki T, Takemura N, Standley M D, Akira S, Kawai T
- Journal Title
  
  Cell Host Microbe
  
  Volume: 14 Pages: 148-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790296
[Journal Article] The second messenger phosohatidylinositol-5-phosphate facilitates antiviral innate immune signaling2013
- Author(s)
  Kawasaki T, Takemura N, Standley M D, Akira S, Kawai T.
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 14 Pages: 148158-148158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790296
[Patent] アジュバント及びそれを含むワクチン2012
- Inventor(s)
  川崎　拓実
- Industrial Property Rights Holder
  川崎　拓実
- Industrial Property Rights Type
  特許
- Filing Date
  2012-10-22
- Data Source
  KAKENHI-PROJECT-23790296
[Presentation] 1'-acetoxychavicol acetate inhibit NLRP3-dependent inflammasome activation via mitochondrial ROS suppression2021
- Author(s)
  Daisuke Ori, Sophia Sok, Takumi Kawasaki, Masatoshi Momota, Taro Kawai
- Organizer
  第50回　日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07608
[Presentation] Alveolar macrophages instruct CD103+CD8+ TRM cells formation via antigen cross-presentation2021
- Author(s)
  Takumi Kawasaki, Moe Ikegawa, Taro Kawai
- Organizer
  第50回　日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07608
[Presentation] Identification of TXP as a molecule involved in antigen cross-presentation2021
- Author(s)
  Moe Ikegawa, Takumi Kawasaki, Taro Kawai
- Organizer
  第50回　日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07608
[Presentation] Local CD8+ T cells expansion by tissue resident macrophages2020
- Author(s)
  Takumi Kawasaki
- Organizer
  Rising Stars in Cutting Edge Immunology Research
- Invited
- Data Source
  KAKENHI-PROJECT-19K07608
[Presentation] HuR controls cancer-microenviroment to suppress anti-cancer immune responses2019
- Author(s)
  Takumi Kawasaki, Taro Kawai
- Organizer
  第48回　日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07608
[Presentation] Regulatory role of MTMR3/4 in innate immune signaling2018
- Author(s)
  Takumi Kawasaki, Dyaningtyas Dewi Pamungkas Putri and Taro Kawai
- Organizer
  日本免疫学会総会　第４７回
- Data Source
  KAKENHI-PROJECT-17K15598
[Presentation] Obesity regulation by PIKfyve, a lipid kinase, in macrophage2017
- Author(s)
  Takumi Kawasaki, Mai Satake and Taro Kawai
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K15598
[Presentation] PtdIns5P works as a new type of adjuvant2013
- Author(s)
  Kawasaki T, Takemura N, Standley M D, Akira S, Kawai T
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-23790296
[Presentation] Identification and characterization of a cellular component that modulates TBK1-IRF3 signal axis2012
- Author(s)
  川崎　拓実
- Organizer
  第４１回日本免疫学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23790296
[Presentation] Physiological role of the lipid kinase PIKfyve in innate immune responses
- Author(s)
  Takumi Kawasaki, Rika Tanaka, Kosuke Ito, Shizuo Akira and Taro Kawai
- Organizer
  第４３回日本免疫学会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26460368

1. 高松由基 (00750407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 長谷部太 (20253693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鍋島武 (30546859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWAI Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. SATO Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 末次志郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWASAKI Takumi 川崎 拓実

Research Projects

Research Products

Co-Researchers

Elucidation T cell-mediated "antigenic sin" and the mechanism behind the severity of dengue fever

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

キラーT細胞を介した呼吸器感染ウイルスの制御メカニズムの解明と応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory role of macrophage differentiation during obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of Alveolar macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ウイルス感染防御におけるイノシトールリン脂質の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory role of PIKfyve in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of TBK1 activation mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

T細胞の正負の選択に関わるカルシウムチャネルの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1′-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-332020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System.2019

Author(s)

Journal Title

KAWASAKI Takumi 川崎拓実