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KAWASAKI Takumi  川崎 拓実

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Researcher Number 60584414
Other IDs
Affiliation (Current) 2025: 長崎大学, 高度感染症研究センター, 准教授
Affiliation (based on the past Project Information) *help 2024: 長崎大学, 高度感染症研究センター, 准教授
2018 – 2021: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教
2013 – 2017: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教
2013: 奈良先端科学技術大学院大学, バイオサイエンス研究科, その他
2011 – 2012: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤)
2010: 大阪大学, 免疫学フロンティア研究センター, 特任研究員
Review Section/Research Field
Principal Investigator
General medical chemistry / Basic Section 48040:Medical biochemistry-related / Basic Section 49070:Immunology-related / Biological Sciences / General pharmacology
Except Principal Investigator
Basic Section 49060:Virology-related
Keywords
Principal Investigator
自然免疫 / PIKfyve / マクロファージ / 肺胞マクロファージ / イノシトールリン脂質 / 抗原提示 / 肺 / ウイルス / キラーT細胞 / mRNAワクチン … More / インフルエンザウイルス / 分化 / 慢性炎症 / 肥満 / クロスプレゼンテーション / 自然免疫応答 / ウイルス感染 / 炎症 / アレルギー / 脂質代謝 / IRF3 / TBK1 / スクリーニング / ウィルス感染 / セリンスレオニンキナーゼ / ホスファチジルイノシトール5リン酸 / リン酸化 / シグナル伝達 / ホスファチジルイノシトール / T細胞 / カルシウム / イオンチャネル … More
Except Principal Investigator
T細胞免疫応答 / 重症化機構 / デング熱 / NGS / PBMC Less
  • Research Projects

    (8 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (6 People)
  •  Elucidation T cell-mediated "antigenic sin" and the mechanism behind the severity of dengue fever

    • Principal Investigator
      高松 由基
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Nagasaki University
  •  キラーT細胞を介した呼吸器感染ウイルスの制御メカニズムの解明と応用Principal Investigator

    • Principal Investigator
      川崎 拓実
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Nagasaki University
  •  Regulatory role of macrophage differentiation during obesityPrincipal Investigator

    • Principal Investigator
      Kawasaki Takumi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Nara Institute of Science and Technology
  •  Regulatory mechanism of Alveolar macrophagesPrincipal Investigator

    • Principal Investigator
      KAWASAKI Takumi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Nara Institute of Science and Technology
  •  ウイルス感染防御におけるイノシトールリン脂質の役割Principal Investigator

    • Principal Investigator
      川崎 拓実
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nara Institute of Science and Technology
  •  Regulatory role of PIKfyve in vivoPrincipal Investigator

    • Principal Investigator
      kawasaki takumi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Nara Institute of Science and Technology
  •  Investigation of TBK1 activation mechanismPrincipal Investigator

    • Principal Investigator
      KAWASAKI Takumi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Nara Institute of Science and Technology
      Osaka University
  •  T細胞の正負の選択に関わるカルシウムチャネルの同定Principal Investigator

    • Principal Investigator
      川崎 拓実
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University

All 2022 2021 2020 2019 2018 2017 2013 2012 Other

All Journal Article Presentation Patent

  • [Journal Article] Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site2022

    • Author(s)
      Lian Benedict Shi Xiang、Kawasaki Takumi、Kano Norisuke、Ori Daisuke、Ikegawa Moe、Isotani Ayako、Kawai Taro
    • Journal Title

      iScience

      Volume: 25 Issue: 4 Pages: 104118-104118

    • DOI

      10.1016/j.isci.2022.104118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-21K14817, KAKENHI-PROJECT-20H03468
  • [Journal Article] Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants2021

    • Author(s)
      Ong Guang Han、Lian Benedict Shi Xiang、Kawasaki Takumi、Kawai Taro
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 745016-745016

    • DOI

      10.3389/fcimb.2021.745016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-20H03468
  • [Journal Article] 1′-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression2021

    • Author(s)
      Sok Sophia P M、Ori Daisuke、Wada Ayana、Okude Haruna、Kawasaki Takumi、Momota Masatoshi、Nagoor Noor Hasima、Kawai Taro
    • Journal Title

      International Immunology

      Volume: 33 Issue: 7 Pages: 373-386

    • DOI

      10.1093/intimm/dxab016

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-21K14817
  • [Journal Article] The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-332020

    • Author(s)
      Momota Masatoshi、Nagayama Mizuka、Okude Haruna、Ishii Ken J.、Ori Daisuke、Kawasaki Takumi、Kawai Taro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 530 Issue: 4 Pages: 699-705

    • DOI

      10.1016/j.bbrc.2020.07.127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-20H03468, KAKENHI-PROJECT-19K22533
  • [Journal Article] Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses2020

    • Author(s)
      Monwan Warunthorn、Kawasaki Takumi、Hasan Md Zobaer、Ori Daisuke、Kawai Taro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 521 Issue: 4 Pages: 1077-1082

    • DOI

      10.1016/j.bbrc.2019.11.035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-19K22533, KAKENHI-PROJECT-17H04066
  • [Journal Article] Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System.2019

    • Author(s)
      Kawasaki T, Kawai T.
    • Journal Title

      Int Rev Cell Mol Biol.

      Volume: 344 Pages: 1-30

    • DOI

      10.1016/bs.ircmb.2018.08.004

    • ISBN
      9780128159798
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15598
  • [Journal Article] Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization2019

    • Author(s)
      Zainol Mohd Izwan Bin、Kawasaki Takumi、Monwan Warunthorn、Murase Motoya、Sueyoshi Takuya、Kawai Taro
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 20406-20406

    • DOI

      10.1038/s41598-019-56914-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-19K22533, KAKENHI-PROJECT-17H04066
  • [Journal Article] PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking2019

    • Author(s)
      Putri DDP, Kawasaki T, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T.
    • Journal Title

      J Biol Chem

      Volume: - Issue: 21 Pages: 8412-8423

    • DOI

      10.1074/jbc.ra118.005731

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H06006, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-19K07608, KAKENHI-PROJECT-19K22533, KAKENHI-PROJECT-17K19529, KAKENHI-PROJECT-17K15598, KAKENHI-PROJECT-17H03674
  • [Journal Article] Intravesicular Acidification Regulates Lipopolysaccharide Inflammation and Tolerance through TLR4 Trafficking.2018

    • Author(s)
      Murase M, Kawasaki T, Hakozaki R, Sueyoshi T, Putri DDP, Kitai Y, Sato S, Ikawa M, Kawai T.
    • Journal Title

      J Immunol.

      Volume: -- Issue: 8 Pages: 2798-2808

    • DOI

      10.4049/jimmunol.1701390

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08836, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15598
  • [Journal Article] Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2.2018

    • Author(s)
      Sueyoshi T, Kawasaki T, Kitai Y, Ori D, Akira S, Kawai T.
    • Journal Title

      J Immunol.

      Volume: 200 Issue: 11 Pages: 3814-3824

    • DOI

      10.4049/jimmunol.1701282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-17K15598
  • [Journal Article] Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.2017

    • Author(s)
      Kawasaki T, Ito K, Miyata H, Akira S, Kawai T.
    • Journal Title

      EMBO J.

      Volume: 36 Issue: 12 Pages: 1707-1718

    • DOI

      10.15252/embj.201695528

    • NAID

      120006309714

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K15598
  • [Journal Article] DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity2017

    • Author(s)
      Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T.
    • Journal Title

      J. Immunol.

      Volume: 198 Issue: 4 Pages: 1649-1659

    • DOI

      10.4049/jimmunol.1601694

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01381, KAKENHI-PROJECT-15H05994, KAKENHI-PROJECT-26293107, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K15598
  • [Journal Article] The second messenger phosohatidylinositol-5-phosphate facilitates antiviral innate immune signaling2013

    • Author(s)
      Kawasaki T, Takemura N, Standley M D, Akira S, Kawai T
    • Journal Title

      Cell Host Microbe

      Volume: 14 Pages: 148-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790296
  • [Journal Article] The second messenger phosohatidylinositol-5-phosphate facilitates antiviral innate immune signaling2013

    • Author(s)
      Kawasaki T, Takemura N, Standley M D, Akira S, Kawai T.
    • Journal Title

      Cell Host Microbe.

      Volume: 14 Pages: 148158-148158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790296
  • [Patent] アジュバント及びそれを含むワクチン2012

    • Inventor(s)
      川崎 拓実
    • Industrial Property Rights Holder
      川崎 拓実
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-10-22
    • Data Source
      KAKENHI-PROJECT-23790296
  • [Presentation] 1'-acetoxychavicol acetate inhibit NLRP3-dependent inflammasome activation via mitochondrial ROS suppression2021

    • Author(s)
      Daisuke Ori, Sophia Sok, Takumi Kawasaki, Masatoshi Momota, Taro Kawai
    • Organizer
      第50回 日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K07608
  • [Presentation] Alveolar macrophages instruct CD103+CD8+ TRM cells formation via antigen cross-presentation2021

    • Author(s)
      Takumi Kawasaki, Moe Ikegawa, Taro Kawai
    • Organizer
      第50回 日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K07608
  • [Presentation] Identification of TXP as a molecule involved in antigen cross-presentation2021

    • Author(s)
      Moe Ikegawa, Takumi Kawasaki, Taro Kawai
    • Organizer
      第50回 日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K07608
  • [Presentation] Local CD8+ T cells expansion by tissue resident macrophages2020

    • Author(s)
      Takumi Kawasaki
    • Organizer
      Rising Stars in Cutting Edge Immunology Research
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07608
  • [Presentation] HuR controls cancer-microenviroment to suppress anti-cancer immune responses2019

    • Author(s)
      Takumi Kawasaki, Taro Kawai
    • Organizer
      第48回 日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K07608
  • [Presentation] Regulatory role of MTMR3/4 in innate immune signaling2018

    • Author(s)
      Takumi Kawasaki, Dyaningtyas Dewi Pamungkas Putri and Taro Kawai
    • Organizer
      日本免疫学会総会 第47回
    • Data Source
      KAKENHI-PROJECT-17K15598
  • [Presentation] Obesity regulation by PIKfyve, a lipid kinase, in macrophage2017

    • Author(s)
      Takumi Kawasaki, Mai Satake and Taro Kawai
    • Organizer
      日本免疫学会
    • Data Source
      KAKENHI-PROJECT-17K15598
  • [Presentation] PtdIns5P works as a new type of adjuvant2013

    • Author(s)
      Kawasaki T, Takemura N, Standley M D, Akira S, Kawai T
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-23790296
  • [Presentation] Identification and characterization of a cellular component that modulates TBK1-IRF3 signal axis2012

    • Author(s)
      川崎 拓実
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-23790296
  • [Presentation] Physiological role of the lipid kinase PIKfyve in innate immune responses

    • Author(s)
      Takumi Kawasaki, Rika Tanaka, Kosuke Ito, Shizuo Akira and Taro Kawai
    • Organizer
      第43回日本免疫学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26460368
  • 1.  高松 由基 (00750407)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  長谷部 太 (20253693)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  鍋島 武 (30546859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KAWAI Taro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 5.  SATO Shintaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  末次 志郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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