TSUJIMURA Keita 辻村啓太

Researcher Number	60588474
Other IDs	https://orcid.org/0000-0002-7464-6133
Affiliation (based on the past Project Information) *help	2020 – 2023: 名古屋大学, 理学研究科, 特任講師 2016 – 2020: 名古屋大学, 医学系研究科, 特任助教 2015: 九州大学, 大学院医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Biological Sciences / Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 51:Brain sciences and related fields / Neuroscience in general
Keywords	Principal Investigator 発達障害 / レット症候群 / MECP2 / 遺伝子発現 / microRNA / miRNA / 神経発達 / ノンコーディングRNA / 脳発達 / 脳機能 … More / 進化 / 神経回路 / iPS細胞 / エピジェネティクス / 遺伝子発現解析 / 精神神経疾患 / MECP2重複 / RNAシークエンス / 疾患メカニズム / 精神疾患 / 極性 / 突起伸長 / 軸索形成 / MeCP2 … More Except Principal Investigator 既承認薬ライブラリー / GLUT1欠損症 / ドラッグリポジショング / 既承認薬 / モデルマウス / iPS細胞 / 治療 / 知的障害 / てんかん / グルコーストランスポーター / 生体内ゲノム編集技術 / HITI / 脳ゲノム / ゲノム編集 / ニューロン / miRNA / マイクロRNA / エピジェネティクス / MeCP2 / レット症候群 / 神経科学 Less

ハプロ不全で発症するGLUT1欠損症の治療薬開発：既承認薬ライブラリーからの選別
- Principal Investigator
  
  高橋悟
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Asahikawa Medical College
胎生期における超早期脳ゲノム編集治療法の開発
- Principal Investigator
  
  鈴木啓一郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka University
非翻訳RNAによる脳機能発達制御メカニズムの統合的理解Principal Investigator
- Principal Investigator
  
  辻村啓太
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Nagoya University
レット症候群におけるマルチスケール精神病態の構成的理解Principal Investigator
- Principal Investigator
  
  辻村啓太
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Elucidation of common mechanisms of MECP2 abnormal diseasesPrincipal Investigator
- Principal Investigator
  
  Tsujimura Keita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Nagoya University
Regulation of axon formation by Rett syndrome gene MeCP2Principal Investigator
- Principal Investigator
  
  Tsujimura Keita
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nagoya University
Elucidation of a novel mechanism relevant to disruption of microRNA biogenesis, explaining neurodevelopmental diseases.
- Principal Investigator
  
  Nakashima Kinichi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kyushu University
  Nara Institute of Science and Technology

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] MicroRNAs in neurological diseases,MicroRNA: From Bench to Beside. (CHAPTER 17)2022
- Author(s)
  Keita Tsujimura
- Total Pages
  8
- Publisher
  ELESEVIER (book)
- Data Source
  KAKENHI-PROJECT-21K06834
[Book] Rett syndrome and stem cell research2018
- Author(s)
  Keita Tsujimura and Nakashima Kinichi
- Total Pages
  15
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-18K06484
[Book] Rett syndrome and stem cell research2018
- Author(s)
  Keita Tsujimura, Kinichi Nakashima
- Total Pages
  14
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-16K18391
[Journal Article] miR-514a promotes neuronal development in human iPSC-derived neurons2023
- Author(s)
  Yuichi Akaba, Satoru Takahashi, Keiichiro Suzuki, Kenjiro Kosaki and Keita Tsujimura
- Journal Title
  
  Front. Cell Dev. Biol
  
  Volume: 11
- DOI
  10.3389/fcell.2023.1096463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06834
[Journal Article] MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling2021
- Author(s)
  Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A Trujillo, Masataka Ishiizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R Muotri, Nakashima Kinichi
- Journal Title
  
  Cell Reports
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05211
[Journal Article] MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling2021
- Author(s)
  Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A Trujillo, Masataka Ishiizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R Muotri, Nakashima Kinichi
- Journal Title
  
  Cell Reports
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06484
[Journal Article] Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression2018
- Author(s)
  Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Masataka Ishizu, Miao Pan, Tomonori Kameda, Kinichi Nakashima
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 38 Issue: 20 Pages: 4791-4810
- DOI
  10.1523/jneurosci.2423-17.2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06484, KAKENHI-PROJECT-17H01390, KAKENHI-PROJECT-18J21142
[Journal Article] Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression2018
- Author(s)
  Hideyuki Nakashima1, Keita Tsujimura1,2,3*, Koichiro Irie1, Masataka Ishizu1, Pan Miao1, Tomonori Kameda1, Kinichi Nakashima1*
- Journal Title
  
  Journal of neuroscience
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18391
[Journal Article] Emerging roles for miRNA-based post-transcriptional regulation in neuronal morphogenesis and neurodevelopment disorders2016
- Author(s)
  Keita Tsujimura, Hideyuki Nakashima, Koichiro Irie, Kinichi Nakashima
- Journal Title
  
  RNA & DISEASE
  
  Volume: 3
- DOI
  10.14800/rd.1456
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18391
[Journal Article] miR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett Syndrome phenotypes.2015
- Author(s)
  Tsujimura K, Irie K, Nakashima H, Egashira Y, Fukao Y, Fujiwara M, Itoh M, Uesaka M, Imamura T, Nakahata Y, Yamashita Y, Abe T, Takamori S, Nakashima K.
- Journal Title
  
  Cell Rep
  
  Volume: 12 Issue: 11 Pages: 1887-1901
- DOI
  10.1016/j.celrep.2015.08.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26115716, KAKENHI-PROJECT-24240051, KAKENHI-PROJECT-15J06414, KAKENHI-PROJECT-26830074, KAKENHI-PROJECT-24390270
[Journal Article] VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome2014
- Author(s)
  Guo W, Tsujimura K, Otsuka I M, Irie K, Igarashi K, Nakashima K, Zhao X.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 6 Pages: e100215-e100215
- DOI
  10.1371/journal.pone.0100215
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24240051, KAKENHI-PUBLICLY-25110721, KAKENHI-PROJECT-25281028
[Presentation] Regulation of neuronal development by Rett syndrome causative gene MeCP22021
- Author(s)
  Keita Tsujimura
- Organizer
  The 14th Annual Meeting for Japanese Developmental Neuroscientists Korea Japan Joint Symposium
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05211
[Presentation] Regulation of functional neural circuit development by Rett syndrome causative factor MeCP22021
- Author(s)
  Keita Tsujimura
- Organizer
  The 43rd Annual Meeting of the Japan Neuroscience Society 第43回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05211
[Presentation] 治療法開発とMRI研究2021
- Author(s)
  辻村啓太
- Organizer
  2021 レット症候群とMECP2重複症候群合同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06484
[Presentation] 発達障害の脳細胞系譜病態と神経幹細胞運命決定機構2021
- Author(s)
  辻村啓太
- Organizer
  若手新分野創成ワークショップ脳を知り、疾患を理解する
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05211
[Presentation] 治療法開発とMRI研究2021
- Author(s)
  辻村啓太
- Organizer
  2021レット症候群とMECP2重複症候群合同シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05211
[Presentation] 発達障害の脳細胞系譜病態と神経幹細胞運命決定機構2021
- Author(s)
  辻村啓太
- Organizer
  若手新分野創成ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-18K06484
[Presentation] Deciphering the molecular mechanisms underlying neurodevelopmental disorder Rett syndrome2021
- Author(s)
  Keita Tsujimura
- Organizer
  Seminar; Special Lecture of Biological Science 2・5, Nagoya University
- Invited
- Data Source
  KAKENHI-PROJECT-21K06834
[Presentation] Regulation of neuronal development by Rett syndrome causative gene MeCP22021
- Author(s)
  Keita Tsujimura
- Organizer
  The 14th Annual Meeting for Japanese Developmental Neuroscientists Korea Japan Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-18K06484
[Presentation] Regulation of functional neural circuit development by Rett syndrome causative factor MeCP22020
- Author(s)
  Keita Tsujimura
- Organizer
  The 43rd Annual Meeting of the Japan Neuroscience Society 第43回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06484
[Presentation] Rett症候群における神経回路病態の解明と治療法開発2020
- Author(s)
  辻村啓太
- Organizer
  「2020レット症候群とMECP2重複症候群合同」シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05211
[Presentation] Rett症候群における神経回路病態の解明と治療法開発2020
- Author(s)
  辻村啓太
- Organizer
  「2020レット症候群とMECP2重複症候群合同」シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06484
[Presentation] Rett症候群原因因子MeCP2によるmicroRNAプロセシングを起点とした神経機能制御のその応用2018
- Author(s)
  辻村啓太
- Organizer
  名古屋大学研究大学強化促進事業若手新分野フロンティアシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K18391
[Presentation] Rett症候群原因因子MeCP2によるmicroRNAプロセシングを起点とした神経機能制御とその応用2018
- Author(s)
  辻村　啓太
- Organizer
  名古屋大学　研究大学強化促進事業　若手新分野フロンティア　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06484
[Presentation] レット症候群の新たな分子メカニズム2017
- Author(s)
  辻村啓太
- Organizer
  愛知県心身障害者コロニー発達障害研究所公開セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K18391
[Presentation] 神経発達障害原因因子MeCP2による神経機能制御の分子基盤2017
- Author(s)
  辻村啓太
- Organizer
  日本薬学会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-16K18391
[Presentation] Functional analysis of MeCP2, the Rett syndrome responsible factor, mediated by microRNA in neural stem cells fate specification2015
- Author(s)
  中嶋秀行、辻村啓太、入江浩一郎、中島欽一
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-24240051
[Presentation] Analysis of the molecular mechanism of dendritic formation by MeCP2 through miR-199a processing2015
- Author(s)
  入江浩一郎、辻村啓太、中嶋秀行、中島欽一
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-24240051
[Presentation] レット症候群原因因子MeCP2による興奮性シナプス伝達制御の分子基盤
- Author(s)
  辻村啓太、入江浩一郎、中嶋秀行、江頭良明、深尾陽一朗、藤原正幸、伊藤雅之、高森茂雄、中島欽一
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24240051
[Presentation] Rett syndrome responsible factor MeCP2 regulates specific miRNA processing
- Author(s)
  Keita Tsujimura
- Organizer
  第8回神経発生討論会
- Place of Presentation
  九州大学
- Year and Date
  2015-03-19 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24240051
[Presentation] Functional analysis of MeCP2,the Rett syndrome responsible factor in neural stem cells
- Author(s)
  中嶋秀行、辻村啓太、入江浩一郎、中島欽一
- Organizer
  第１２回幹細胞シンポジウム
- Place of Presentation
  九州大学
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24240051

1. Nakashima Kinichi (80302892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. FUKAO Yoichiro (80432590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 鈴木啓一郎 (70433654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小野大輔 (30634224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋悟 (10431404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 高森茂雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUJIMURA Keita 辻村 啓太

Research Projects

Research Products

Co-Researchers

ハプロ不全で発症するGLUT1欠損症の治療薬開発：既承認薬ライブラリーからの選別

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胎生期における超早期脳ゲノム編集治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

非翻訳RNAによる脳機能発達制御メカニズムの統合的理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

レット症候群におけるマルチスケール精神病態の構成的理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of common mechanisms of MECP2 abnormal diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of axon formation by Rett syndrome gene MeCP2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a novel mechanism relevant to disruption of microRNA biogenesis, explaining neurodevelopmental diseases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] MicroRNAs in neurological diseases,MicroRNA: From Bench to Beside. (CHAPTER 17)2022

Author(s)

Total Pages

Publisher

Data Source

[Book] Rett syndrome and stem cell research2018

Author(s)

Total Pages

Publisher

Data Source

[Book] Rett syndrome and stem cell research2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] miR-514a promotes neuronal development in human iPSC-derived neurons2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling2021

Author(s)

Journal Title

Data Source

[Journal Article] MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling2021

Author(s)

Journal Title

Data Source

[Journal Article] Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression2018

TSUJIMURA Keita 辻村啓太