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Takado Yuhei  高堂 裕平

ORCIDConnect your ORCID iD *help
Researcher Number 60593564
Other IDs
Affiliation (Current) 2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 主幹研究員
Affiliation (based on the past Project Information) *help 2022 – 2024: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 主幹研究員
2021 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 脳機能イメージング研究部, 主幹研究員
2021: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 主幹研究員(定常)
2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 主幹研究員(任常)
2016 – 2019: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 研究員(任常)
Review Section/Research Field
Principal Investigator
Basic Section 52040:Radiological sciences-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 52020:Neurology-related / Neurology
Except Principal Investigator
Basic Section 57060:Surgical dentistry-related / Basic Section 08030:Family and consumer sciences, and culture and living-related / Basic Section 38050:Food sciences-related / Medium-sized Section 51:Brain sciences and related fields
Keywords
Principal Investigator
磁気共鳴スペクトロスコピー / 超偏極MRI / アストロサイト / ポジトロン断層撮影 / アルツハイマー病 / MRS / PET / バイオマーカー / タウオパチー / ポジトロン断層撮像法 … More / エネルギー代謝 / 空間トランスクリプトーム / 脳腫瘍モデルマウス / 超偏極MRS / DREADD / イメージングバイオマーカー / 脳エネルギー代謝 / 興奮・抑制バランス / 認知症 / 興奮抑制バランス / タウ / 磁気共鳴スペクトロメトリー / 後部帯状回 / グルタミン酸 … More
Except Principal Investigator
fMRI / MRスペクトロスコピー / MR spectroscopy / 中枢性感作 / 慢性疼痛 / ドーパミン / 体内動態 / 行動 / マウス / ストレス / 海馬 / 認知機能 / ペプチド / アミノ酸合成不全疾患 / 脳機能イメージング / ナノ粒子 / 認知症モデル / セリン / Dynamic Causal Modeling / 機能的MRI / 動的因果解析 / GABA / MEGA / MR Spectroscopy / fMRI / 内受容感覚 / 口腔顔面痛 / 興奮抑制バランス / 磁気共鳴分光法 / 脳イメージング / 学習 / ニューロフィードバック / 安定性 / 可塑性 / 運動 / 視覚 / オシレーション / Infra-slow oscillation / 安静時機能的MRI / 神経障害性疼痛 / 安静時fMRI / 代謝産物 / 三叉神経 Less
  • Research Projects

    (9 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (28 People)
  •  新規創成食品素材ナノ粒子化L-セリンによる加齢性認知症予防戦略の統合研究

    • Principal Investigator
      古屋 茂樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Kyushu University
  •  Multimodal evaluation of awake Hyperpolarized MRI and PET in brain tumor model micePrincipal Investigator

    • Principal Investigator
      高堂 裕平
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  Effects of food peptide on cognitive function and the hippocampal mechanism

    • Principal Investigator
      水重 貴文
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      Utsunomiya University
  •  疼痛の中枢性感作における生体内情報の処理過程に対する動的因果モデルの検証

    • Principal Investigator
      照光 真
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  Development of Astrocyte Imaging Biomarkers Using Hyperpolarized MRS and DREADDPrincipal Investigator

    • Principal Investigator
      Yuhei Takado
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  E/I balance disruption in tau-related dementiaPrincipal Investigator

    • Principal Investigator
      Takado Yuhei
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  Understanding the plasticity mechanisms of the brain through excitatory-inhibitory balance modulation.

    • Principal Investigator
      Shibata Kazuhisa
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 51:Brain sciences and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Central Sensitization for Neuropathic Pain in Trigeminal Nerve-Modulation of Infra-slow Oscillation

    • Principal Investigator
      TERUMITSU Makoto
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  Evaluation of tau protein related neural dysfunction: PET and 3T MRS studyPrincipal Investigator

    • Principal Investigator
      Takado Yuhei
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Institutes for Quantum and Radiological Science and Technology

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Investigating neural dysfunction with abnormal protein deposition in Alzheimer’s disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography2024

    • Author(s)
      Matsuoka Kiwamu、Hirata Kosei、Kokubo Naomi、Maeda Takamasa、Tagai Kenji、Endo Hironobu、Takahata Keisuke、Shinotoh Hitoshi、Ono Maiko、Seki Chie、Tatebe Harutsugu、Kawamura Kazunori、Zhang Ming-Rong、Shimada Hitoshi、Tokuda Takahiko、Higuchi Makoto、Takado Yuhei
    • Journal Title

      NeuroImage: Clinical

      Volume: 41 Pages: 103560-103560

    • DOI

      10.1016/j.nicl.2023.103560

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K18268, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22K19393, KAKENHI-PROJECT-20K16681
  • [Journal Article] Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease2023

    • Author(s)
      Hirata Kosei、Matsuoka Kiwamu、Tagai Kenji、Endo Hironobu、Tatebe Harutsugu、Ono Maiko、Kokubo Naomi、Oyama Asaka、Shinotoh Hitoshi、Takahata Keisuke、Obata Takayuki、Dehghani Masoumeh、Near Jamie、Kawamura Kazunori、Zhang Ming‐Rong、Shimada Hitoshi、Yokota Takanori、Tokuda Takahiko、Higuchi Makoto、Takado Yuhei
    • Journal Title

      Annals of Neurology

      Volume: 95 Issue: 1 Pages: 104-115

    • DOI

      10.1002/ana.26797

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18268, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393
  • [Journal Article] A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model2022

    • Author(s)
      Kimura Taeko、Ono Maiko、Seki Chie、Sampei Kazuaki、Shimojo Masafumi、Kawamura Kazunori、Zhang Ming-Rong、Sahara Naruhiko、Takado Yuhei、Higuchi Makoto
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 49 Issue: 13 Pages: 4298-4311

    • DOI

      10.1007/s00259-022-05898-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393, KAKENHI-PUBLICLY-21H05705, KAKENHI-PUBLICLY-21H00446
  • [Journal Article] Neurometabolite Levels and Relevance to Central Sensitization in Chronic Orofacial Pain Patients: A Magnetic Resonance Spectroscopy Study2022

    • Author(s)
      Terumitsu Makoto、Takado Yuhei、Fukuda Ken-Ichi、Kato Eisuke、Tanaka Sei
    • Journal Title

      Journal of Pain Research

      Volume: Volume 15 Pages: 1421-1432

    • DOI

      10.2147/jpr.s362793

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021

    • Author(s)
      Sato H、Takado Y、Toyoda S、Tsukamoto-Yasui M、Minatohara K、Takuwa H、Urushihata T、Takahashi M、Shimojo M、Ono M、Maeda J、Orihara A、Sahara N、Aoki I、Karakawa S、Isokawa M、Kawasaki N、Kawasaki M、Ueno S、Kanda M、Nishimura M、Suzuki K、Mitsui A、Nagao K、Kitamura A、Higuchi M
    • Journal Title

      Science Advances

      Volume: 7 Issue: 43 Pages: 1-11

    • DOI

      10.1126/sciadv.abd5046

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
  • [Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021

    • Author(s)
      Takado Yuhei、Takuwa Hiroyuki、Sampei Kazuaki、Urushihata Takuya、Takahashi Manami、Shimojo Masafumi、Uchida Shoko、Nitta Nobuhiro、Shibata Sayaka、Nagashima Keisuke、Ochi Yoshihiro、Ono Maiko、Maeda Jun、Tomita Yutaka、Sahara Naruhiko、Near Jamie、Aoki Ichio、Shibata Kazuhisa、Higuchi Makoto
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: 42 Issue: 1 Pages: 197-212

    • DOI

      10.1177/0271678x211045449

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-19H01041, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-23K21399
  • [Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020

    • Author(s)
      Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
    • Journal Title

      J Neurosci.

      Volume: 40 Issue: 17 Pages: 3491-3501

    • DOI

      10.1523/jneurosci.2880-19.2020

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
  • [Presentation] MRSによる脳代謝計測から脳病態を探る2024

    • Author(s)
      高堂裕平
    • Organizer
      第26回日本ヒト脳機能マッピング学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] Can functional MRS distinguish Glu and GABA during brain activation?2023

    • Author(s)
      高堂裕平
    • Organizer
      fMRS symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] シンポジウム概要とアルツハイマー病における脳エネルギー代謝評価2023

    • Author(s)
      高堂裕平
    • Organizer
      第34回 臨床MR脳機能研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 加齢・認知症病態の理解につなげる脳代謝MRS/超偏極イメージング2023

    • Author(s)
      高堂裕平
    • Organizer
      第25回日本ヒト脳機能マッピング学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 認知症とアストロサイト機能不全:脳エネルギー代謝イメージングによる検討2023

    • Author(s)
      高堂裕平
    • Organizer
      第64回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 脳病態における脳エネルギー代謝障害:MRS/超偏極MRSによる評価2023

    • Author(s)
      高堂裕平
    • Organizer
      第46回日本神経科学大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] Overview of Hyperpolarization2023

    • Author(s)
      高堂裕平
    • Organizer
      2023 ISMRM & ISMRT Annual Meeting & Exhibition, ISMRM
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 超偏極MRSによる脳エネルギー代謝評価系を用いた精神疾患の病態研究への展望2023

    • Author(s)
      高堂裕平
    • Organizer
      日本生物学的精神医学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 超偏極MRSおよびH-MRSによるトランスレーショナルリサーチ2022

    • Author(s)
      高堂裕平
    • Organizer
      第5回基礎と臨床をつなぐMR研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] Brain energy metabolism and glial cells in dementia2022

    • Author(s)
      高堂裕平
    • Organizer
      NEURO2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 超偏極MRによるエネルギー代謝イメージング:From mice to Human2022

    • Author(s)
      高堂裕平
    • Organizer
      DNP研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] Combining MRS and PET to elucidate the pathophysiology of Aging brain2022

    • Author(s)
      Yuhei Takado
    • Organizer
      International Society for Neurochemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] 13C同位体を用いたイメージング手法による脳エネルギー代謝研究2022

    • Author(s)
      高堂裕平
    • Organizer
      第13回日本安定同位体・生体ガス医学応用学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19393
  • [Presentation] The association between plasma and brain Glutamine and Glutamate in healthy twenties probed by LC-MS and 1H-MRS2019

    • Author(s)
      Naoto Sato, Yuhei Takado, Yuta Kanbe, Moyoko Tomiyasu, Jamie Near, Xin Lijing, Tatsuya Higashi, Tetsuya Suhara, Makoto Higuchi and Takayuki Obata
    • Organizer
      ISMRM 27TH ANNUAL MEETING & EXHIBITION
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09733
  • [Presentation] Tau protein accumulation and neurodegeneration in tauopathy model mice detected by PET and MRS2019

    • Author(s)
      Yuhei Takado, Hiroyuki Takuwa, Takuya Urushihata, Manami Takahashi, Maiko Ono, Jun Maeda, Masafumi Shimojo, Nobuhiro Nitta, Sayaka Shibata, Ichio Aoki, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
    • Organizer
      BRAIN & BRAIN PET 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08005
  • [Presentation] MRSを用いたin vivo脳内タウリン濃度測定:マウスからヒトまで2018

    • Author(s)
      高堂 裕平 , 田桑 弘之 , 下條 雅文 , 小野 麻衣子 , 塚本 智史 , 青木 伊知男 , 小畠 隆行 , 東 達也 , 佐原 成彦 , 須原 哲也 , 樋口 真人
    • Organizer
      第4回国際タウリン研究会日本部会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09733
  • [Presentation] SNR comparison of 1H-MRS sequences: SPECIAL vs PRESS2017

    • Author(s)
      佐藤直人,高堂裕平,富安もよこ,Lijing Xin, Jamie Near,吉川宏起,樋口真人,小畠隆行
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Data Source
      KAKENHI-PROJECT-16K09733
  • [Presentation] 1H-MRS 用シーケンス SPECIAL と PRESS における信号雑音比の比較2017

    • Author(s)
      佐藤 直人, 高堂 裕平, 富安 もよこ, Hyerin Oh, Jamie Near, 吉川 宏起, 樋口 真人, 小畠 隆行
    • Organizer
      第 29 回 臨床 MR 脳機能研究会
    • Place of Presentation
      損保会館(東京都・千代田区)
    • Year and Date
      2017-04-08
    • Data Source
      KAKENHI-PROJECT-16K09733
  • 1.  TERUMITSU Makoto (60401767)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  福田 謙一 (80228907)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  Shibata Kazuhisa (20505979)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  瀬尾 憲司 (40242440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  大塚 有紀子 (30815767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  倉田 行伸 (20464018)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  吉本 裕代 (40453287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  金澤 香 (40453279)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  大桶 華子 (90295907)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高野 正行 (50197117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  梅田 聡 (90317272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  古屋 茂樹 (00222274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  濱野 桃子 (40717336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  甲田 優太 (90759325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  棗田 学 (00515728)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  山崎 友照 (80627563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  水重 貴文 (70571008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  鈴木 智大 (10649601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  蕪山 由己人 (20285042)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SUHARA Tetsuya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 21.  SHIMADA Hitoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  IKOMA Yoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  OBATA Takayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 24.  TAKUWA Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  平田 浩聖
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 26.  横田 隆徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  下條 雅文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  佐原 成彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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