Takado Yuhei 高堂裕平

Researcher Number	60593564
Other IDs
Affiliation (Current)	2023: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 主幹研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 主幹研究員 2021 – 2022: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 主幹研究員 2021: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 主幹研究員(定常) 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 主幹研究員(任常) 2016 – 2019: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 研究員(任常)
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Medium-sized Section 51:Brain sciences and related fields / Basic Section 08030:Family and consumer sciences, and culture and living-related
Keywords	Principal Investigator 磁気共鳴スペクトロスコピー / ポジトロン断層撮像法 / タウオパチー / バイオマーカー / MRS / アルツハイマー病 / アストロサイト / グルタミン酸 / 後部帯状回 / PET … More / 磁気共鳴スペクトロメトリー / タウ / 興奮抑制バランス / ポジトロン断層撮影 / 認知症 / 興奮・抑制バランス / 超偏極MRS … More Except Principal Investigator 中枢性感作 / MRスペクトロスコピー / 三叉神経 / 慢性疼痛 / 代謝産物 / MR spectroscopy / 安静時fMRI / 神経障害性疼痛 / 安静時機能的MRI / Infra-slow oscillation / オシレーション / fMRI / 視覚 / 可塑性 / 磁気共鳴分光法 / 興奮抑制バランス / ニューロフィードバック / 学習 / 脳イメージング / 口腔顔面痛 / 機能的MRI / Dynamic Causal Modeling / ペプチド / 認知機能 / 海馬 / ストレス Less

Effects of food peptide on cognitive function and the hippocampal mechanism
- Principal Investigator
  
  水重貴文
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Utsunomiya University
疼痛の中枢性感作における生体内情報の処理過程に対する動的因果モデルの検証
- Principal Investigator
  
  照光真
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Health Sciences University of Hokkaido
超偏極MRSとDREADDによるアストロサイトイメージングバイオマーカー開発Principal Investigator
- Principal Investigator
  
  高堂裕平
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  National Institutes for Quantum Science and Technology
E/I balance disruption in tau-related dementiaPrincipal Investigator
- Principal Investigator
  
  Takado Yuhei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Institutes for Quantum Science and Technology
興奮抑制バランス操作による脳の可塑性メカニズムの理解
- Principal Investigator
  
  柴田和久
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Institute of Physical and Chemical Research
Central Sensitization for Neuropathic Pain in Trigeminal Nerve-Modulation of Infra-slow Oscillation
- Principal Investigator
  
  TERUMITSU Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Health Sciences University of Hokkaido
Evaluation of tau protein related neural dysfunction: PET and 3T MRS studyPrincipal Investigator
- Principal Investigator
  
  Takado Yuhei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021
- Author(s)
  Sato H、Takado Y、Toyoda S、Tsukamoto-Yasui M、Minatohara K、Takuwa H、Urushihata T、Takahashi M、Shimojo M、Ono M、Maeda J、Orihara A、Sahara N、Aoki I、Karakawa S、Isokawa M、Kawasaki N、Kawasaki M、Ueno S、Kanda M、Nishimura M、Suzuki K、Mitsui A、Nagao K、Kitamura A、Higuchi M
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 43 Pages: 1-11
- DOI
  10.1126/sciadv.abd5046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-21H02818, KAKENHI-PROJECT-21K07580
[Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021
- Author(s)
  Takado Yuhei、Takuwa Hiroyuki、Sampei Kazuaki、Urushihata Takuya、Takahashi Manami、Shimojo Masafumi、Uchida Shoko、Nitta Nobuhiro、Shibata Sayaka、Nagashima Keisuke、Ochi Yoshihiro、Ono Maiko、Maeda Jun、Tomita Yutaka、Sahara Naruhiko、Near Jamie、Aoki Ichio、Shibata Kazuhisa、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 42 Issue: 1 Pages: 197-212
- DOI
  10.1177/0271678x211045449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-19H01041, KAKENHI-PROJECT-21H02818, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-21K07580
[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
- Journal Title
  
  J Neurosci.
  
  Volume: 40 Issue: 17 Pages: 3491-3501
- DOI
  10.1523/jneurosci.2880-19.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
[Presentation] The association between plasma and brain Glutamine and Glutamate in healthy twenties probed by LC-MS and 1H-MRS2019
- Author(s)
  Naoto Sato, Yuhei Takado, Yuta Kanbe, Moyoko Tomiyasu, Jamie Near, Xin Lijing, Tatsuya Higashi, Tetsuya Suhara, Makoto Higuchi and Takayuki Obata
- Organizer
  ISMRM 27TH ANNUAL MEETING & EXHIBITION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09733
[Presentation] Tau protein accumulation and neurodegeneration in tauopathy model mice detected by PET and MRS2019
- Author(s)
  Yuhei Takado, Hiroyuki Takuwa, Takuya Urushihata, Manami Takahashi, Maiko Ono, Jun Maeda, Masafumi Shimojo, Nobuhiro Nitta, Sayaka Shibata, Ichio Aoki, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
- Organizer
  BRAIN & BRAIN PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08005
[Presentation] MRSを用いたin vivo脳内タウリン濃度測定：マウスからヒトまで2018
- Author(s)
  高堂　裕平 , 田桑　弘之 , 下條　雅文 , 小野　麻衣子 , 塚本　智史 , 青木　伊知男 , 小畠　隆行 , 東　達也 , 佐原　成彦 , 須原　哲也 , 樋口　真人
- Organizer
  第4回国際タウリン研究会日本部会学術集会
- Data Source
  KAKENHI-PROJECT-16K09733
[Presentation] SNR comparison of 1H-MRS sequences: SPECIAL vs PRESS2017
- Author(s)
  佐藤直人，高堂裕平，富安もよこ，Lijing Xin, Jamie Near，吉川宏起，樋口真人，小畠隆行
- Organizer
  第45回日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-16K09733
[Presentation] 1H-MRS 用シーケンス SPECIAL と PRESS における信号雑音比の比較2017
- Author(s)
  佐藤　直人, 高堂　裕平, 富安　もよこ, Hyerin Oh, Jamie Near, 吉川宏起, 樋口　真人, 小畠　隆行
- Organizer
  第 29 回臨床 MR 脳機能研究会
- Place of Presentation
  損保会館（東京都・千代田区）
- Year and Date
  2017-04-08
- Data Source
  KAKENHI-PROJECT-16K09733

1. TERUMITSU Makoto (60401767)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 福田謙一 (80228907)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 瀬尾憲司 (40242440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大塚有紀子 (30815767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 倉田行伸 (20464018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吉本裕代 (40453287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金澤香 (40453279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大桶華子 (90295907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 柴田和久 (20505979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高野正行 (50197117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 梅田聡 (90317272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 水重貴文 (70571008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鈴木智大 (10649601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 蕪山由己人 (20285042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SUHARA Tetsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. SHIMADA Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. IKOMA Yoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OBATA Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. TAKUWA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 佐原成彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Takado Yuhei 高堂 裕平

Research Projects

Research Products

Co-Researchers

Effects of food peptide on cognitive function and the hippocampal mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疼痛の中枢性感作における生体内情報の処理過程に対する動的因果モデルの検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

超偏極MRSとDREADDによるアストロサイトイメージングバイオマーカー開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

E/I balance disruption in tau-related dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

興奮抑制バランス操作による脳の可塑性メカニズムの理解

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Central Sensitization for Neuropathic Pain in Trigeminal Nerve-Modulation of Infra-slow Oscillation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of tau protein related neural dysfunction: PET and 3T MRS studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] The association between plasma and brain Glutamine and Glutamate in healthy twenties probed by LC-MS and 1H-MRS2019

Author(s)

Organizer

Data Source

[Presentation] Tau protein accumulation and neurodegeneration in tauopathy model mice detected by PET and MRS2019

Author(s)

Organizer

Data Source

[Presentation] MRSを用いたin vivo脳内タウリン濃度測定：マウスからヒトまで2018

Author(s)

Organizer

Data Source

[Presentation] SNR comparison of 1H-MRS sequences: SPECIAL vs PRESS2017

Author(s)

Organizer

Data Source

[Presentation] 1H-MRS 用シーケンス SPECIAL と PRESS における信号雑音比の比較2017

Author(s)

Organizer

Takado Yuhei 高堂裕平