Kimura Hirokazu 木村公一

Researcher Number	60595370
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 助教 2016 – 2019: 大阪大学, 医学系研究科, 特任助教(常勤)
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 49010:Pathological biochemistry-related / General medical chemistry
Keywords	Principal Investigator DKK1 / エクソソーム / CKAP4 / 腫瘍マーカー / コンパニオン診断 / Dkk1 / がん / Clathrin / エンドサイトーシス / クラスリン

Functional characterization of variants in FAT1 and FAT4, novel pancreatic cancer susceptibility genes in JapanesePrincipal Investigator
- Principal Investigator
  
  木村公一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Osaka
Analysis of translocation mechanism and function of cell membrane receptor CKAP4 to exosomePrincipal Investigator
- Principal Investigator
  
  KIMURA HIROKAZU
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka University
Analysis of the translocation mechanism of CKAP4 to exosomePrincipal Investigator
- Principal Investigator
  
  Kimura Hirokazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University

All 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy2019
- Author(s)
  Kimura Hirokazu、Yamamoto Hideki、Harada Takeshi、Fumoto Katsumi、Osugi Yoshihito、Sada Ryota、Maehara Natsumi、Hikita Hayato、Mori Soichiro、Eguchi Hidetoshi、Ikawa Masahito、Takehara Tetsuo、Kikuchi Akira
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 25 Issue: 6 Pages: 1936-1947
- DOI
  10.1158/1078-0432.ccr-18-2124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-18K06930, KAKENHI-PROJECT-18K15064, KAKENHI-PUBLICLY-18H04861, KAKENHI-PUBLICLY-18H05101, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22563, KAKENHI-PROJECT-16H06374
[Journal Article] Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth2019
- Author(s)
  Harada Takeshi、Matsumoto Shinji、Hirota Suguru、Kimura Hirokazu、Fujii Shinsuke、Kasahara Yuuya、Gon Hidetoshi、Yoshida Toshihiko、Itoh Tomoo、Haraguchi Naotsugu、Mizushima Tsunekazu、Noda Takehiro、Eguchi Hidetoshi、Nojima Satoshi、Morii Eiichi、Fukumoto Takumi、Obika Satoshi、Kikuchi Akira
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 18 Issue: 3 Pages: 602-612
- DOI
  10.1158/1535-7163.mct-18-0824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-18K06956, KAKENHI-PUBLICLY-18H05101, KAKENHI-PROJECT-15K08272, KAKENHI-PROJECT-16K11501, KAKENHI-PROJECT-18K15064, KAKENHI-PROJECT-16H06374
[Journal Article] Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP62019
- Author(s)
  Sada Ryota、Kimura Hirokazu、Fukata Yuko、Fukata Masaki、Yamamoto Hideki、Kikuchi Akira
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 608 Pages: 9519-9519
- DOI
  10.1126/scisignal.aat9519
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PROJECT-19K22563, KAKENHI-PUBLICLY-18H04861, KAKENHI-PUBLICLY-18H04873, KAKENHI-PUBLICLY-18H05101, KAKENHI-PUBLICLY-19H04974, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-18K15064, KAKENHI-PROJECT-16H06374
[Journal Article] Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.2018
- Author(s)
  Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A.
- Journal Title
  
  Oncogene
  
  Volume: 未確定 Issue: 26 Pages: 602-612
- DOI
  10.1038/s41388-018-0179-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06944, KAKENHI-PUBLICLY-18H04861, KAKENHI-PROJECT-16H06374
[Journal Article] The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.2017
- Author(s)
  Kikuchi A, Fumoto K, Kimura H.
- Journal Title
  
  Br J Pharmacol
  
  Volume: 174(24) Issue: 24 Pages: 4651-4665
- DOI
  10.1111/bph.13863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06944, KAKENHI-PROJECT-16H06374
[Presentation] 肝腫瘍に対するARL4Cを標的としたアンチセンス核酸を用いた新規がん治療法の開発2019
- Author(s)
  原田武志、松本真司、廣田傑、木村公一、藤井慎介、菊池章
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15064
[Presentation] CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy.2019
- Author(s)
  山本英樹、木村公一、菊池章
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15064
[Presentation] DKK1-CKAP4シグナルと転写因子FOXM1のpositive feedback loopの形成機構2019
- Author(s)
  高田直季、木村公一、菊池章
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15064
[Presentation] DKK1 signal-dependent cellular functions through two receptors, LRP6 and CKAP4.2019
- Author(s)
  菊池章、佐田遼太、木村公一、山本英樹
- Organizer
  第71回日本細胞生物学会大会合同年次大会・第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K15064
[Presentation] DKK1の新規受容体であるCKAP４のエクソソームへの移行機構の解析2018
- Author(s)
  木村公一
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K15064
[Presentation] 膵癌の新規治療標的であるDkk1新規受容体CKAP42017
- Author(s)
  木村　公一
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-16H06944
[Presentation] 食道扁平上皮癌の新規治療標的であるDKK1-CKAP4シグナル2017
- Author(s)
  木村　公一
- Organizer
  第76回癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H06944
[Presentation] Dkk1-CKAP4 signaling pathway represents a novel therapeutic2016
- Author(s)
  Hirokau Kimura
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H06944

1. 原田武志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 深田優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Hirokazu 木村 公一

Research Projects

Research Products

Co-Researchers

Functional characterization of variants in FAT1 and FAT4, novel pancreatic cancer susceptibility genes in JapanesePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of translocation mechanism and function of cell membrane receptor CKAP4 to exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the translocation mechanism of CKAP4 to exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP62019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 肝腫瘍に対するARL4Cを標的としたアンチセンス核酸を用いた新規がん治療法の開発2019

Author(s)

Organizer

Data Source

[Presentation] CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy.2019

Author(s)

Organizer

Data Source

[Presentation] DKK1-CKAP4シグナルと転写因子FOXM1のpositive feedback loopの形成機構2019

Author(s)

Organizer

Data Source

[Presentation] DKK1 signal-dependent cellular functions through two receptors, LRP6 and CKAP4.2019

Author(s)

Organizer

Data Source

[Presentation] DKK1の新規受容体であるCKAP４のエクソソームへの移行機構の解析2018

Author(s)

Organizer

Data Source

[Presentation] 膵癌の新規治療標的であるDkk1新規受容体CKAP42017

Author(s)

Organizer

Data Source

[Presentation] 食道扁平上皮癌の新規治療標的であるDKK1-CKAP4シグナル2017

Author(s)

Organizer

Data Source

[Presentation] Dkk1-CKAP4 signaling pathway represents a novel therapeutic2016

Author(s)

Organizer

Place of Presentation

Year and Date

Kimura Hirokazu 木村公一