NAKAHARA TOMOMI 中原知美

… Alternative Names

NAKAHARA Tomomi 中原知美

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Researcher Number	60601177
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2022: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2015: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2011 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Virology
Keywords	Principal Investigator 子宮頸がん / パピローマウイルス / ヒトパピローマウイルス / ゲノム複製 / HPV / p63 / FOXA2 / 発がんモデル / 腺がん / インターフェロン … More / ウイルスゲノム複製 / ATR / NFkB / ウイルス複製 / プロテオソーム / NFｋB / DNA損傷修復系 / 持続感染 / 細胞分化 / 角化細胞 / DNA損傷応答系 / がん / NFκB / NF-κB / ATM / 複製 Less

宿主細胞の分化に適合したHPVゲノム3相複製を制御するプロテオソーム機構の解明Principal Investigator
- Principal Investigator
  
  中原知美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  National Cancer Center Japan
Investigating viral and cellular factors defining histopathological features of cervical cancerPrincipal Investigator
- Principal Investigator
  
  NAKAHARA TOMOMI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  National Cancer Center Japan
Identification and characterization of the host factors involved in the genome replication of Human papillomaviruses associated with the viral persistencePrincipal Investigator
- Principal Investigator
  
  Nakahara Tomomi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  National Cancer Center Japan
Developing a new cell culture system for efficient production of infectious HPV virions to study molecular mechanisms of HPV infection cycles.Principal Investigator
- Principal Investigator
  
  NAKAHARA Tomomi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  National Cancer Center Japan

All 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Development of an in vitro carcinogenesis model of human papillomavirus‐induced cervical adenocarcinoma2021
- Author(s)
  Zhang Mengzhu、Kiyono Tohru、Aoki Kazunori、Goshima Naoki、Kobayashi Shin、Hiranuma Kengo、Shiraishi Kouya、Saya Hideyuki、Nakahara Tomomi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 3 Pages: 904-915
- DOI
  10.1111/cas.15246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09307
[Journal Article] Genomic Alterations in STK11 Can Predict Clinical Outcomes in Cervical Cancer Patients2020
- Author(s)
  Hirose S, Murakami N, Takahashi K, Kuno I, Takayanagi D, Asami Y, Matsuda M, Shimada Y, Yamano S, Sunami K, Yoshida K, Honda T, Nakahara T, Watanabe T, Komatsu M, Hamamoto R, Kato MK, Matsumoto K, Okuma K, Kuroda T, Okamoto A, Itami J, Kohno T, Kato T, Shiraishi K, Yoshida H.
- Journal Title
  
  Gynecologic Oncology
  
  Volume: 156 Pages: 203-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09307
[Journal Article] An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors2019
- Author(s)
  Farhana Ishrat Ghani, Kasumi Dendo, Reiko Watanabe, Kenji Yamada, Yuki Yoshimatsu, Takashi Yugawa, Tomomi Nakahara, Katsuyuki Tanaka, Hiroshi Yoshida, Masayuki Yoshida, Mitsuya Ishikawa, Naoki Goshima, Tomoyasu Kato, Tohru Kiyono
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 7 Pages: 644-644
- DOI
  10.3390/cells8070644
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09307
[Journal Article] Roles for E1-independent Replication and E6-mediated p53 Degradation During Low-Risk and High-Risk Human Papillomavirus Genome Maintenance2019
- Author(s)
  Isao Murakami, Nagayasu Egawa, Heather Griffin, Wen Yin, Christian Kranjec, Tomomi Nakahara, Tohru Kiyono , John Doorbar
- Journal Title
  
  PLOS Pathogens
  
  Volume: 15 Issue: 5 Pages: e1007755-e1007755
- DOI
  10.1371/journal.ppat.1007755
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09307, KAKENHI-PROJECT-17K16869
[Journal Article] Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation2018
- Author(s)
  Wakae Kousho、Nishiyama Tomoaki、Kondo Satoru、Izuka Takashi、Que Lusheng、Chen Cong、Kase Kina、Kitamura Kouichi、Mohiuddin Md、Wang Zhe、Ahasan Md Monjurul、Nakamura Mitsuhiro、Fujiwara Hiroshi、Yoshizaki Tomokazu、Hosomochi Kazuyoshi、Tajima Atsushi、Nakahara Tomomi、Kiyono Tohru、Muramatsu Masamichi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 9745-9745
- DOI
  10.1038/s41598-018-27930-z
- NAID
  120006602143
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09412, KAKENHI-PROJECT-18K09307, KAKENHI-PROJECT-17H01590, KAKENHI-PROJECT-16H05480, KAKENHI-PROJECT-16K15281, KAKENHI-PROJECT-17K16839
[Journal Article] Interplay between NFκB/Interferon (IFN) signaling and the genome replication of human papillomavirus2016
- Author(s)
  Nakahara T and Kiyono T.
- Journal Title
  
  Future Virology
  
  Volume: 11 Issue: 2 Pages: 141-155
- DOI
  10.2217/fvl.16.2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860349
[Journal Article] Activation of NF-κB by Human Papillomavirus 16 E1 Limits E1-Dependent Viral Replication through Degradation of E1.2015
- Author(s)
  Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T.
- Journal Title
  
  Journal of Virology
  
  Volume: 89 Issue: 9 Pages: 5040-5059
- DOI
  10.1128/jvi.00389-15
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860349, KAKENHI-PROJECT-26460406
[Journal Article] Regulation of Human papillomavirus (HPV) genome replication in the viral life cycle and its association with the viral persistence and cancer development.2014
- Author(s)
  中原　知美　清野　透
- Journal Title
  
  Uirusu
  
  Volume: 64 Issue: 1 Pages: 57-66
- DOI
  10.2222/jsv.64.57
- NAID
  130004922979
- ISSN
  0042-6857, 1884-3433
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-25860349
[Journal Article] Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.2013
- Author(s)
  Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 33(22) Issue: 22 Pages: 4434-4447
- DOI
  10.1128/mcb.00577-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590375, KAKENHI-PROJECT-23590908, KAKENHI-PROJECT-24650622, KAKENHI-PROJECT-25291027, KAKENHI-PROJECT-25860349
[Journal Article] Identification of TRAPPC8 as a Host Factor Required for Human Papillomavirus Cell Entry.2013
- Author(s)
  Ishii Y, Nakahara T, Kataoka M, Kusumoto-Matsuo R, Mori S, Takeuchi T, Kukimoto I.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e80297-e80297
- DOI
  10.1371/journal.pone.0080297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860349
[Journal Article] The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome2012
- Author(s)
  Egawa, N., et al
- Journal Title
  
  J.Virol.
  
  Volume: 86 Issue: 6 Pages: 3276-3281
- DOI
  10.1128/jvi.06450-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370084, KAKENHI-PROJECT-22592084, KAKENHI-PUBLICLY-23114510, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23590375, KAKENHI-PROJECT-23790517, KAKENHI-PROJECT-23791303, KAKENHI-PROJECT-24650622
[Presentation] In vitro carcinogenesis model of HPV- induced cervical adenocarcinoma2022
- Author(s)
  Tomomi Nakahara
- Organizer
  he United States-Japan Cooperative Medical Sciences Program Virtual Meeting on Emerging Infectious Diseases (EID) in the Pacific Rim
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] Investigating viral and cellular factors that influence histopathological features of cervical cancer2021
- Author(s)
  Mengzhu Zhang, Tohru Kiyono, Kazunori Aoki, Tomomi Nakahara
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] Regulatory mechanisms of three phased papillomavirus genome replication in the viral life cycle: Potential roles of the proteasome in the viral latency.2020
- Author(s)
  中原　知美
- Organizer
  第22回汎太平洋新興・再興感染症国際会議
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] Development of a tissue culture system enabling real-time monitoring of the HPV genome maintenance and transcription by generating novel HPV16 based replicons.2019
- Author(s)
  中原　知美
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] Roles of SCFβTrCP-mediated degradation of HPV E1 in the establishment and/or sustenance of the viral persistency.2019
- Author(s)
  中原　知美
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] Activation of NFκB leads to phosphorylation-dependent degradation of HPV E1.2018
- Author(s)
  Tomomi Nakahara, Tohru Kiyono
- Organizer
  32st　International papillomavirus conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] ヒトパピローマウイルス持続感染におけるNFκB依存的E1タンパク分解機構の役割2018
- Author(s)
  中原知美、清野　透
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] NFκB活性化に依存したヒトパピローマウイルスE1タンパク質分解機構2018
- Author(s)
  中原知美、清野　透
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K09307
[Presentation] ヒトパピローマウイルスE1タンパク質の安定性を制御する機構2015
- Author(s)
  中原知美、温川恭至、清野透
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] HPV16の初期複製、維持複製、後期複製の切り替え機構2015
- Author(s)
  中原知美、田中克行、温川恭至、清野透
- Organizer
  「感染、免疫、炎症、発癌」研究集会
- Place of Presentation
  北海道大学遺伝子制御研究所
- Year and Date
  2015-12-18
- Invited
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] ヒトパピローマウイルス16型ゲノム複製を制御するE1-NFkB負のフィードバック機構に対するE6およびE7の効果2015
- Author(s)
  中原知美、田中克行、温川恭至、清野透
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] レポーター遺伝子を搭載したヒトパピローマウイルス16型(HPV16)ゲノムの作製と評価2013
- Author(s)
  中原　知美、江川長靖、大野真一、温川恭至、清野透
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] ヒトパピローマウイルス16型のゲノム複製に関与する宿主因子の解析2013
- Author(s)
  中原　知美、田中　克征、大野　真一、温川　恭至、清野　透
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] A cellular factor involved in suppression of E1-dependent replication of human papillomavirus 16 (HPV16) in proliferating keratinocytes2012
- Author(s)
  中原　知美
- Organizer
  28th International Papillomavirus Conference and Clinical Workshop
- Place of Presentation
  サンファン、プエルトリコ
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] ヒトパピローマウイルス16 型(HPV16)のE1ヘリカーゼ依存的ゲノム複製に対する細胞応答2012
- Author(s)
  中原知美、田中克幸、大野真一、江川長靖、温川恭至、清野透
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  グランキューブ大阪大阪市
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] The E1 protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of The Viral Genome2012
- Author(s)
  中原　知美
- Organizer
  遺伝子病制御研究所研究集会
- Place of Presentation
  北海道大学医学部フラテ会館
- Invited
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] ヒトパピローマウイルス16型(HPV16)のE1ヘリカーゼ依存的ゲノム複製に対する細胞応答2012
- Author(s)
  中原　知美
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  グランキューブ大阪
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] The E1 protein of Human papillomavirus type 16 is dispensable for maintenance replication of the viral genome2012
- Author(s)
  Nakahara, T
- Organizer
  遺伝病制御研究所研究集会
- Place of Presentation
  北海道大学医学部フラテ会館札幌市
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] A cellular factor involved in suppression of E1-depedent replication of Human papillomavirus type 16 (HPV16) in proliferating keratinocytes2012
- Author(s)
  Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T
- Organizer
  28^<th> International papillomavirus conference
- Place of Presentation
  San Juan, Puerto Rico
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] HPV16 E1 is not required for the viral genome maintenance2011
- Author(s)
  N Egawa, T Nakahara, S Ohno, T Yugawa, M Saito-Narisawa, T Kiyono
- Organizer
  27^<th> International Papillomavirus Conference
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23790517
[Presentation] NFκB活性化はヒトパピローマウイルス16型のゲノム複製を抑制する
- Author(s)
  中原　知美、田中　克征、大野　真一、温川　恭至、清野　透
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] Activation of NFkB induced by human papillmavirus 16 E1 through DNA damage response limits the E1-dependent viral replication
- Author(s)
  Tomomi Nakahara, Katsuyuiki Tanaka, Shin-ichi Ohno, Takashi Yugawa, Nagayasu Egawa, Tohru Kiyono
- Organizer
  Molecular Biology of DNA Tumor Viruses Conference
- Place of Presentation
  Madison (USA)
- Year and Date
  2014-07-21 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] Development of a novel HPV16 replicon that enables highly sensitive monitoring of the maintenance replication
- Author(s)
  Tomomi Nakahara, Nayagasu Egawa, Takashi Yugawa, Tohru Kiyono
- Organizer
  29th International Papillomavirus Conference and Clinical & Public Health Workshops
- Place of Presentation
  Seattle (USA)
- Year and Date
  2014-08-20 – 2014-08-25
- Data Source
  KAKENHI-PROJECT-25860349
[Presentation] ヒトパピローマウイルス16型のE1ヘリカーゼによるNFκB活性化は、E1の分解促進を介してE1依存性ウイルスゲノム複製を制限する
- Author(s)
  中原　知美、田中　克征、温川　恭至、清野　透
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860349

1. KITAMURA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 温川恭至

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAHARA TOMOMI 中原 知美

NAKAHARA Tomomi 中原 知美

Research Projects

Research Products

Co-Researchers

宿主細胞の分化に適合したHPVゲノム3相複製を制御するプロテオソーム機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating viral and cellular factors defining histopathological features of cervical cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and characterization of the host factors involved in the genome replication of Human papillomaviruses associated with the viral persistencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Developing a new cell culture system for efficient production of infectious HPV virions to study molecular mechanisms of HPV infection cycles.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of an in vitro carcinogenesis model of human papillomavirus‐induced cervical adenocarcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genomic Alterations in STK11 Can Predict Clinical Outcomes in Cervical Cancer Patients2020

Author(s)

Journal Title

Data Source

[Journal Article] An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles for E1-independent Replication and E6-mediated p53 Degradation During Low-Risk and High-Risk Human Papillomavirus Genome Maintenance2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Interplay between NFκB/Interferon (IFN) signaling and the genome replication of human papillomavirus2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of NF-κB by Human Papillomavirus 16 E1 Limits E1-Dependent Viral Replication through Degradation of E1.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Human papillomavirus (HPV) genome replication in the viral life cycle and its association with the viral persistence and cancer development.2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of TRAPPC8 as a Host Factor Required for Human Papillomavirus Cell Entry.2013

Author(s)

Journal Title

NAKAHARA TOMOMI 中原知美

NAKAHARA Tomomi 中原知美