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Shiinoki Kikuko  椎木 幾久子 (阿望 幾久子)

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… Alternative Names

阿望幾久子

SHIINOKI Kikuko  椎木 幾久子

椎木 幾久子  シイノキ キクコ

阿望 幾久子

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Researcher Number 60609692
Other IDs
Affiliation (Current) 2025: 山口大学, 大学研究推進機構, 特命専門職員
Affiliation (based on the past Project Information) *help 2023: 山口大学, 大学院医学系研究科, 学術研究員(寄附金)
2022: 山口大学, 医学部, 助教(連携講座)
2019 – 2021: 山口大学, 医学部, 助教(寄附講座等)
2016 – 2017: 山口大学, 医学部, 助教(寄附講座等)
2014 – 2015: 山口大学, 医学部, 学術研究員
2013: 山口大学, 医学部, 特別医学研究員
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Basic Section 49030:Experimental pathology-related / Experimental pathology / Pathological medical chemistry
Keywords
Principal Investigator
β細胞脱分化 / 脱分化 / 膵β細胞 / 糖尿病 / 臓器間コミュニケーション / 膵α細胞 / 細胞内ストレス / β細胞不全 / 小胞体ストレス / WFS1 … More / 膵β細胞不全 / Wfs1 / 可溶性インスリン受容体 / インスリン抵抗性 / インスリン受容体切断 Less
  • Research Projects

    (4 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (5 People)
  •  神経ネットワークを介した肝臓-膵α細胞連関による栄養代謝調節の解明Principal Investigator

    • Principal Investigator
      椎木 幾久子 (阿望幾久子)
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Yamaguchi University
  •  The identification of therapeutic targets for pancreatic beta-cell dedifferentiation leading diabetesPrincipal Investigator

    • Principal Investigator
      Shiinoki Kikuko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Yamaguchi University
  •  The investigation of the mechanism of beta cell dedifferentiation aiming for new therapy of diabetes mellitusPrincipal Investigator

    • Principal Investigator
      SHIINOKI Kikuko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Yamaguchi University
  •  Dose calpain cleave insulin receptor, leading to the development of diabetes ?Principal Investigator

    • Principal Investigator
      SHIINOKI Kikuko
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Yamaguchi University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book

  • [Book] 月刊糖尿病 Vol.9 No.82017

    • Author(s)
      田部勝也、松永仁恵、椎木幾久子、谷澤幸生
    • Total Pages
      110
    • Publisher
      医学出版
    • ISBN
      9784287820988
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Book] 内分泌・糖尿病・代謝内科2017

    • Author(s)
      椎木幾久子、田部勝也、谷澤幸生
    • Total Pages
      174
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Book] 月刊糖尿病 Vol.9 No.72017

    • Author(s)
      椎木幾久子、田部勝也、谷澤幸生
    • Total Pages
      110
    • Publisher
      医学出版
    • ISBN
      9784287820971
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Journal Article] Hachimijiogan, a traditional herbal medicine, modulates adipose cell function and ameliorates diet-induced obesity and insulin resistance in mice2023

    • Author(s)
      Kagawa Syota、Tanabe Katsuya、Hiromura Makoto、Ogawa Kakuyou、Koga Takayuki、Maeda Takahiro、Amo-Shiinoki Kikuko、Ochi Hiroyuki、Ichiki Yui、Fukuyama Shogo、Suzuki Saori、Suizu Natsuki、Ohmine Takaaki、Hamachi Sakurako、Tsuneki Hiroshi、Okuya Shigeru、Sasaoka Toshiyasu、Tanizawa Yukio、Nagashima Fumihiro
    • Journal Title

      Frontiers in Pharmacology

      Volume: 14 Pages: 1167934-1167934

    • DOI

      10.3389/fphar.2023.1167934

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08581, KAKENHI-PROJECT-23K08011, KAKENHI-PROJECT-23K10862, KAKENHI-PROJECT-23K10960, KAKENHI-PROJECT-21K07332, KAKENHI-PROJECT-21K07382
  • [Journal Article] Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes.2021

    • Author(s)
      Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y.
    • Journal Title

      JCI Insight

      Volume: 6 Issue: 1 Pages: 143791-143791

    • DOI

      10.1172/jci.insight.143791

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09843, KAKENHI-PROJECT-19K07506, KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-20K08887, KAKENHI-PROJECT-20K08915, KAKENHI-PROJECT-20K21627, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-18K08516, KAKENHI-PROJECT-19H03710
  • [Journal Article] Interorgan Crosstalk Contributing to β-Cell Dysfunction.2017

    • Author(s)
      Tanabe K., Amo-Shiinoki K., Hatanaka M., Tanizawa Y.
    • Journal Title

      J Diabetes Res.

      Volume: 2017 Pages: 1-8

    • DOI

      10.1155/2017/3605178

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04849, KAKENHI-PROJECT-16K09752, KAKENHI-PROJECT-15K21198, KAKENHI-PROJECT-15K09390
  • [Presentation] 神経ネットワークを介した膵α細胞量の調節2023

    • Author(s)
      椎木幾久子、田部勝也、井泉知仁、吉村充弘、西村渉、今井淳太、奥屋茂、上田陽一、片桐秀樹、谷澤幸生
    • Organizer
      第66回日本糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K10960
  • [Presentation] グルカゴン受容体異常症の臨床像と病態2023

    • Author(s)
      田部 勝也、椎木 幾久子、奥屋 茂、谷澤 幸生
    • Organizer
      第66回日本糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K10960
  • [Presentation] Txnip preserves innate BAT thermogenic function in mice2023

    • Author(s)
      Zou Meng、田部 勝也、椎木 幾久子、河野 大輔、田口昭彦、奥屋 茂、北村 忠弘、増谷 弘、谷澤 幸生
    • Organizer
      第66回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-23K10960
  • [Presentation] 糖尿病における膵島細胞の可塑性と脱分化2022

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、奥屋茂、谷澤幸生
    • Organizer
      第65回日本糖尿病学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] Islet β-cell dedifferentiation is involved in progression of type 2 diabetes2020

    • Author(s)
      Kikuko Amo-Shiinoki, Katsuya Tanabe, Ryotaro Bouchi, Wataru Nishimura, Tetsuya Yamada, Yoshihiro Ogawa, Yukio Tanizawa
    • Organizer
      80th Scientific Sessions of American Diabetes Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] 膵β細胞脱分化は2型糖尿病の病態進展に関連する2020

    • Author(s)
      椎木幾久子,田部勝也,幡中雅行,奥屋茂,福田達也,竹内崇人,坊内良太郎,山田哲也,小川佳宏,谷澤幸生
    • Organizer
      第63回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] Islet beta-cell dedifferentiation is involved in progression of type 2 diabetes2020

    • Author(s)
      Kikuko Amo-Shiinoki, Katsuya Tanabe, Ryotaro Bouchi, Wataru Nishimura, Yoshihiro Ogawa, Yukio Tanizawa
    • Organizer
      80th Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] 膵β細胞脱分化は2型糖尿病の病態進展に関連する2020

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、奥屋茂、福田達也、竹内崇人、坊内良太郎、山田哲也、小川佳宏、谷澤幸生
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] Wolfram症候群をモデルとした細胞内ストレスによる膵β細胞可塑性制御の解明2019

    • Author(s)
      椎木幾久子,田部勝也,西村渉,幡中雅行,佐藤吉彦,駒津光久,増谷弘,谷澤幸生
    • Organizer
      第62回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] Metabolic dysregulation by cellular stress is implicated in the dedifferentiation and dysfunction of pancreatic β cells2019

    • Author(s)
      Yukio Tanizawa, Katsuya Tanabe, Kikuko Amo-Shiinoki
    • Organizer
      55th Annual Meeting of EASD
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] Activation of GLP-1 receptor signalling prevents beta cell dedifferentiation in a mouse model of Wolfram syndrome thorough modulating Txnip expression2019

    • Author(s)
      Katsuya Tanabe, Kikuko Amo-Shiinoki, Manabu Kondo, Masayuki Hatanaka, Hiroshi Masutani, Yukio Tanizawa
    • Organizer
      79th Scientific Sessions of American Diabetes Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] 膵β細胞脱分化は糖尿病患者の膵β細胞不全に関連する2019

    • Author(s)
      椎木幾久子,田部勝也,佐藤吉彦,駒津光久,谷澤幸生
    • Organizer
      第69回日本体質医学会総会
    • Data Source
      KAKENHI-PROJECT-19K07506
  • [Presentation] 膵β細胞脱分化・運命転換の成因解明に基づいた糖尿病治療の研究2018

    • Author(s)
      椎木幾久子
    • Organizer
      第61回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1欠損による膵β細胞のエネルギー代謝不全と脱分化2018

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、谷澤幸生
    • Organizer
      第21回日本病態栄養学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Txnip-mediated inhibition of pyruvate dehydrogenase is implicated to β cell dedifferentiation in the mouse model of Wolfram syndrome2018

    • Author(s)
      Kikuko Amo-Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Hiroshi Masutani, Yukio Tanizawa
    • Organizer
      American Diabetes Association's 78th Scientific Sessions
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Genetic deficiency of Txnip prevents diabetes progression in the mouse model of Wolfram syndrome2017

    • Author(s)
      Kikuko Amo-Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Risa Harano, Hiroshi Masutani, Yukio Tanizawa
    • Organizer
      American Diabetes Association's 77th Scientific Sessions
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wolfram症候群においてβ細胞脱分化は糖尿病の成因として重要である2017

    • Author(s)
      田部勝也、椎木幾久子、幡中雅行、谷澤幸生
    • Organizer
      第32回日本糖尿病合併症学会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] ER and oxidative stresses induce and Txnip knock-out prevents β-cell dedifferentiation and failure in Wolfram Syndrome2017

    • Author(s)
      Yukio Tanizawa, Kikuko Amo-Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Risa Harano, Hiroshi Masutani
    • Organizer
      International Diabetes Federation, IDF Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] ヒトの糖尿病においてβ細胞脱分化はβ細胞不全に関連する2017

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、近藤学、西村渉、木村徳宏、星井嘉信、池田栄二、水上浩哉、八木橋操六、佐藤吉彦、駒津光久、谷澤幸生
    • Organizer
      第60回日本糖尿病学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1欠損による膵β細胞のエネルギー代謝不全と脱分化2017

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、谷澤幸生
    • Organizer
      第67回日本体質医学会総会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1欠損マウスにおける膵β細胞不全の病態形成に対する代謝ストレスの意義2017

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、谷澤幸生
    • Organizer
      第38回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wolfram症候群において膵β細胞脱分化は糖尿病の成因として重要である2017

    • Author(s)
      田部勝也、椎木幾久子、幡中雅行、谷澤幸生
    • Organizer
      第90回日本内分泌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1欠損マウスにおける膵β細胞脱分化とその意義の解明2016

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、近藤学、谷澤幸生
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1欠損マウスにおける膵β細胞脱分化とその意義の解明2016

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、近藤学、谷澤幸生
    • Organizer
      第59回日本糖尿病学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府、京都市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] 膵島炎症に対するn-3 PUFAの抑制効果とその発現機構の解明2016

    • Author(s)
      椎木幾久子、田部勝也、谷澤幸生
    • Organizer
      第19回日本病態栄養学会年次学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2016-01-09
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wolfram症候群モデルマウスでは膵β細胞脱分化を来す2016

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、谷澤幸生
    • Organizer
      第66回日本体質医学会総会
    • Place of Presentation
      和歌山県JAビル(和歌山県、和歌山市)
    • Year and Date
      2016-09-03
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Beta cell dedifferentiation plays a central role in beta cell failure in a model of Wolfram syndrome2016

    • Author(s)
      Kikuko Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Manabu Kondo, Yukio Tanizawa
    • Organizer
      American Diabetes Association, 76th Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-06-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Beta cell dedifferentiation plays a central role in beta cell failure in a model of Wolfram syndrome2016

    • Author(s)
      Kikuko Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Manabu Kondo, Yukio Tanizawa
    • Organizer
      American Diabetes Association 76th Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-06-10
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1-deficiency causes beta-cell dedifferentiation associated with enhanced ER stress and oxidative stress, independently of hyperglycemia2015

    • Author(s)
      Yukio Tanizawa, Kikuko Shiinoki, Katsuya Tanabe, Masayuki Hatanaka
    • Organizer
      7th AASD Scientific Meeting and Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction
    • Place of Presentation
      Hong Kong Convention and Exhibition Centre, China
    • Year and Date
      2015-11-21
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1 deficiency compromises beta cell identity and results in loss of beta cell failure2015

    • Author(s)
      Kikuko Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Yasuharu Ohta, Yukio Tanizawa
    • Organizer
      The 2nd Japan-Korea Diabetes Forum
    • Place of Presentation
      海峡メッセ下関、山口県
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1-deficiency causes beta-cell dedifferentiation associated with enhanced ER stress and oxidative stress, independently of hyperglycemia2015

    • Author(s)
      Kikuko Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Yasuharu Ohta, Yukio Tanizawa
    • Organizer
      American Diabetes Association 75th Scientific Sessions
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-06-05
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1欠損マウスにおける膵β細胞脱分化とその意義の解明2015

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、秋山優、谷澤幸生
    • Organizer
      第27回分子糖尿病学シンポジウム
    • Place of Presentation
      丸ビルホール&コンファレンススクエア、東京都
    • Year and Date
      2015-12-05
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] Wfs1-deficiency causes β-cell dedifferentiation associated with enhanced ER stress and oxidative stress, independently of hyperglycemia2015

    • Author(s)
      Katsuya Tanabe, Kikuko Amo-Shiinoki, Masayuki Hatanaka, Syota Kagawa, Yukio Tanizawa
    • Organizer
      KEYSTONE SYMPOSIA on Molecular and Cellular Biology
    • Place of Presentation
      Westin Miyako Kyoto, Kyoto, Japan
    • Year and Date
      2015-10-25
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] WFS1欠損膵島における膵β細胞脱分化機構の解析2015

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、永尾優子、太田康晴、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関、山口県
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K21198
  • [Presentation] WFS1欠損膵島における膵β細胞脱分化機構の解析

    • Author(s)
      椎木幾久子、田部勝也、幡中雅行、永尾優子、太田康晴、谷澤幸生
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2015-05-21 – 2015-05-24
    • Data Source
      KAKENHI-PROJECT-25870483
  • [Presentation] Wfs1-deficiency causes beta-cell dedifferentiation associated with enhanced ER stress and oxidative stress, independently of hyperglycemia

    • Author(s)
      Kikuko Shiinoki, Katsuya Tanabe, Masayuki Hatanaka, Yasuharu Ohta, Yukio Tanizawa
    • Organizer
      American Diabetes Association 75th Scientific Sessions
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2015-06-05 – 2015-06-09
    • Data Source
      KAKENHI-PROJECT-25870483
  • [Presentation] 膵島炎症に対するn-3 PUFAの抑制効果とその発現機構の解明

    • Author(s)
      椎木幾久子、田部勝也、永尾優子、秋山優、太田康晴、谷澤幸生
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-25870483
  • [Presentation] GLP-1受容体作動薬はWfs1欠損マウスにおけるインスリン分泌障害を改善する

    • Author(s)
      椎木幾久子、田部勝也、近藤学、永尾優子、秋山優、太田康晴、谷澤幸生
    • Organizer
      第64回日本体質医学会総会
    • Place of Presentation
      中央電気倶楽部(大阪府)
    • Year and Date
      2014-09-06 – 2014-09-07
    • Data Source
      KAKENHI-PROJECT-25870483
  • 1.  TANABE Katsuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 2.  NISHIMURA Wataru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  幡中 雅行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  谷沢 幸生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  奥屋 茂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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