KUWABARA Yasuhide 桑原康秀

Researcher Number	60632099
Other IDs
Affiliation (based on the past Project Information) *help	2016: 京都大学, 医学研究科, 特定助教 2014 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2012 – 2013: 京都大学, 医学(系)研究科(研究院), 医員
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine
Keywords	Principal Investigator 心不全 / 心肥大 / 長鎖非コードRNA / マイクロRNA / 非コードRNA / lincRNA / 非コーディングRNA / 分子細胞生物学 / 循環器内科学

心肥大で誘導される新規lincRNAの、筋組織における核内制御と核内機能の解明Principal Investigator
- Principal Investigator
  
  桑原康秀
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
Analysis of Non-coding RNA Functions in Heart DiseasesPrincipal Investigator
- Principal Investigator
  
  Yasuhide Kuwabara
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
Investigations for lincRNA functions involved in cardiac remodeling.Principal Investigator
- Principal Investigator
  
  KUWABARA Yasuhide
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model.2017
- Author(s)
  Izuhara M, Kuwabara Y, Saito N, Yamamoto E, Hakuno D, Nakashima Y, Horie T, Baba O, Nishiga M, Nakao T, Nishino T, Nakazeki F, Ide Y, Kimura M, Kimura T, Ono K.
- Journal Title
  
  PLoS One
  
  Volume: 12(3) Issue: 3 Pages: e0172798-e0172798
- DOI
  10.1371/journal.pone.0172798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-26293186, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-16K09497, KAKENHI-PROJECT-16K19400, KAKENHI-PROJECT-17K09860, KAKENHI-PROJECT-17H04177, KAKENHI-PROJECT-17K19590, KAKENHI-PUBLICLY-17H05599
[Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.2016
- Author(s)
  Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.
- Journal Title
  
  Circ Res.
  
  Volume: - Issue: 5 Pages: 835-847
- DOI
  10.1161/circresaha.116.309528
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05297, KAKENHI-PROJECT-16H06900, KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-26293186, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-16K09497, KAKENHI-PROJECT-16K19400, KAKENHI-PROJECT-17K09860, KAKENHI-PROJECT-17K19534, KAKENHI-PROJECT-16H05145, KAKENHI-PROJECT-17H04177, KAKENHI-PROJECT-15K09108, KAKENHI-PROJECT-17K19590, KAKENHI-PUBLICLY-17H05599
[Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.2015
- Author(s)
  Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.
- Journal Title
  
  Circulation Research
  
  Volume: 116 Issue: 2 Pages: 279-288
- DOI
  10.1161/circresaha.116.304707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26293186, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-26860556
[Journal Article] – Novel “Thrifty” Models –2015
- Author(s)
  Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 2 Pages: 278-284
- DOI
  10.1253/circj.CJ-14-1252
- NAID
  130004927073
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26293186, KAKENHI-PROJECT-26860556, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-25293182
[Journal Article] MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism2015
- Author(s)
  Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Kimura T.
- Journal Title
  
  Int. Heart J.
  
  Volume: 56 Issue: 4 Pages: 365-371
- DOI
  10.1536/ihj.15-019
- NAID
  130005087574
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461144, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-26860556
[Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.2015
- Author(s)
  Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.
- Journal Title
  
  PLoS One.
  
  Volume: 10(11) Issue: 11 Pages: e0142904-e0142904
- DOI
  10.1371/journal.pone.0142904
- NAID
  120005749912
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461144, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26893124, KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-26860556, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-26293186
[Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.2015
- Author(s)
  Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 242(2) Issue: 2 Pages: 632-8
- DOI
  10.1016/j.atherosclerosis.2015.05.010
- NAID
  120005678183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461144, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-14J05148, KAKENHI-PROJECT-26860556, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-26293186
[Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.2014
- Author(s)
  Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5312-5312
- DOI
  10.1038/srep05312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J05148, KAKENHI-PUBLICLY-25126701, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25461369, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-26670147, KAKENHI-PROJECT-26670448, KAKENHI-PROJECT-26860556, KAKENHI-PLANNED-23116006
[Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice2014
- Author(s)
  Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 9 Pages: e108201-e108201
- DOI
  10.1371/journal.pone.0108201
- NAID
  120005496630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300161, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26293186, KAKENHI-PROJECT-26461144, KAKENHI-PROJECT-26860556
[Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.2013
- Author(s)
  Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
- Journal Title
  
  Nat Commun.
  
  Volume: 4:2883 Issue: 1 Pages: 2883-2883
- DOI
  10.1038/ncomms3883
- NAID
  120005349007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-23390211, KAKENHI-PUBLICLY-24116512, KAKENHI-PROJECT-24390230, KAKENHI-PROJECT-24790753, KAKENHI-PROJECT-24890094, KAKENHI-PUBLICLY-25126701, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25461369, KAKENHI-PROJECT-25462136, KAKENHI-PROJECT-25670383
[Journal Article] MicroRNAs and Lipoprotein Metabolism2013
- Author(s)
  Horie T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T, Ono K
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 21 Pages: 17-22
- NAID
  130004845461
- Data Source
  KAKENHI-PROJECT-24890094
[Journal Article] MicroRNAs and Lipoprotein Metabolism.2013
- Author(s)
  Horie T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T, Ono K.
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 21 Pages: 17-22
- NAID
  130004845461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890094
[Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice2013
- Author(s)
  Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
- Journal Title
  
  Nat Commun.
  
  Volume: 4 Pages: 2883-2883
- NAID
  120005349007
- Data Source
  KAKENHI-PROJECT-24890094
[Journal Article] MicroRNA-33-deficiency reduces the progression of atherosclerotic plaque in apoE-/- mice2012
- Author(s)
  Horie T, Baba O, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, and Ono K
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 1
- Data Source
  KAKENHI-PROJECT-24890094
[Journal Article] MicroRNA 26b Encoded by the Intron of Small CTD Phosphatase (SCP) 1 Has an Antagonistic Effect on its Host Gene2012
- Author(s)
  Sowa N, Horie T, Kuwabara Y, Baba O, Watanabe S, Nishi H, Kinoshita M, Takanabe-Mori R, Wada H, Shimatsu A, Hasegawa K, Kimura T, and Ono K
- Journal Title
  
  J Cell Biochem.
  
  Volume: 113 Pages: 3455-65
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] LincRNA Upregulated by Pressure Overload Induces Hypertrophy in Neonatal Mouse Cardiac Myocytes by Binding with Multiple Partners2017
- Author(s)
  Kuwabara Y, Horie T, Watanabe S, Nishiga M, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Kimura T, Ono K.
- Organizer
  第81回　日本循環器学会学術集会
- Place of Presentation
  石川県立音楽堂、金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K19400
[Presentation] 筋肉特異的な新規長鎖非コードRNAは筋芽細胞分化を制御する2016
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村剛、尾野亘
- Organizer
  Molecular Cardiovascular Conference II 2016
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-16K19400
[Presentation] ある循環器内科医の基礎研究と臨床2016
- Author(s)
  桑原康秀
- Organizer
  第14回　愛媛大学医学部医科学研究発表会　特別講演
- Place of Presentation
  東温、愛媛
- Year and Date
  2016-09-20
- Invited
- Data Source
  KAKENHI-PROJECT-16K19400
[Presentation] Long Intergenic Noncoding RNA and Myogenin Circuitry Promotes Myoblast Differentiation.2016
- Author(s)
  Yasuhide Kuwabara, Takahiro Horie, Shin Watanabe, Osamu Baba, Takeshi Kimura, Koh Ono.
- Organizer
  Keystone Symposia, Noncoding RNAs in Health and Disease
- Place of Presentation
  Santa Fe, New Mexico, USA
- Year and Date
  2016-02-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] Overexpression of the LincRNA Regulated by Pressure-Overload Leads to Cardiomyocyte Hypertrophy2016
- Author(s)
  桑原康秀、堀江貴裕、馬場理、西賀雅隆、中尾哲史、西野共達、中関典子、小山智史、木村剛、尾野亘
- Organizer
  第20回　日本心不全学会学術集会
- Place of Presentation
  ロイトン札幌、北海道
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K19400
[Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Cardiac Myocytes.2016
- Author(s)
  Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Koyama S, Kita T, Kimura T, Ono K.
- Organizer
  The 80th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Sendai, Japan
- Year and Date
  2016-03-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] 肥大刺激によって誘導されるlincRNAの心臓と骨格筋における機能解析2015
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村剛、尾野亘
- Organizer
  平成27年度　新学術領域班会議　生命素子による転写環境とエネルギー代謝のクロストーク制御「転写代謝システム」
- Place of Presentation
  菊南温泉ユウベルホテル　熊本市　熊本
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] MicroRNA-451 Aggravates Lipotoxic Cardiomyopathy through Suppression of the LKB1/AMP Pathway.2015
- Author(s)
  Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Toru Kita, Takeshi Kimura, Koh Ono.
- Organizer
  Basic Cardiovascular Sciences 2015
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2015-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] MicroRNA-451 Induced by Palmitate Aggravates Diabetic Cardiomyopathy via Suppression of the LKB1/AMPK Signaling Pathway.2015
- Author(s)
  Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Masayasu Izuhara, Shunsuke Usami, Tetsushi Nakao, Masataka Nishiga, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Koji Hasegawa, Toru Kita, Takeshi Kimura, Koh Ono.
- Organizer
  20th Asian Pacific Society of Cardiology Congress
- Place of Presentation
  Abu Dhabi, UAE
- Year and Date
  2015-04-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] 虚血性心疾患の新規バイオマーカーとして、非コードRNAの可能性を探る2015
- Author(s)
  桑原康秀
- Organizer
  第１回　Cardiac Biomarker研究会
- Place of Presentation
  神戸シェラトン&タワーズ　神戸　兵庫
- Year and Date
  2015-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する2015
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、北徹、木村剛、尾野亘
- Organizer
  第52回日本臨床分子医学会学術集会
- Place of Presentation
  みやこめっせ　京都
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] MicroRNA-451 is Involved in Diabetic Cardiomyopathy through LKB1/AMPK Pathway.2015
- Author(s)
  Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Yuya Ide, Fumiko Nakazeki, Kimura T, Ono K.
- Organizer
  The 79th Annual Scientific Meeting of the Japanese Circulation Society,
- Place of Presentation
  Osaka, Japan
- Year and Date
  2015-04-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] マウス大動脈縮窄モデルにより増加するlincRNAはマウス心筋細胞において心肥大を誘導する2015
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、西賀雅隆、西野共達、北徹、木村剛、尾野亘
- Organizer
  第19回　日本心不全学術集会　ワーックショップ(6)
- Place of Presentation
  グランフロント大阪　ナレッジキャピタル　コングレコンベンションセンター　大阪
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] 肥満を伴う糖尿病性心筋症における、microRNA-451の機能解析2014
- Author(s)
  桑原康秀、堀江貴裕、馬場理、木村剛、尾野亘
- Organizer
  第九回　高血圧と冠動脈疾患研究会
- Place of Presentation
  大手町サンケイプラザ
- Year and Date
  2014-12-20
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する2014
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、木村剛、尾野亘
- Organizer
  新学術領域転写代謝システム冬の若手ワークショップ2014
- Place of Presentation
  磯部、群馬
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する。2014
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、木村剛、尾野亘.
- Organizer
  新学術領域　転写代謝システム　冬の若手ワークショップ　2014.
- Place of Presentation
  群馬
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Caridomyocytes and High Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway.2014
- Author(s)
  Kuwabara Y, Horie T, Baba O, Watanabe Shin, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Yuya Ide, Fumiko Nakazeki, Kimura T, Ono K.
- Organizer
  The 78th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Caridomyocytes and High Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway2014
- Author(s)
  Kuwabara Y, Horie T, Baba O, Watanabe Shin, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Yuya Ide, Fumiko Nakazeki, Kimura T, Ono K
- Organizer
  The 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム、東京
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Ventricular Cardiomyocytes.2013
- Author(s)
  Kuwabara Y, Izuhara M, Horie T, Watanabe S, Baba O, Usami S, Nakao T, Nishiga M, Nishino T, Kita T, Kimura T, Ono K.
- Organizer
  American Heart Association Annual Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, U.S.A.
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Ventricular Cardiomyocytes2013
- Author(s)
  Kuwabara Y, Izuhara M, Horie T, Watanabe S, Baba O, Usami S, Nakao T, Nishiga M, Nishino T, Kita T, Kimura T, Ono K
- Organizer
  Cold Spring Harbor Laboratory Meeting. Metabolic Signaling & Disease : From Cell to Organism
- Place of Presentation
  Cold Spring Harbor, New York, U.S.A.
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Caridomyocytes and High Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway2013
- Author(s)
  Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Kimura T, Ono K
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  Awaji, Hyogo
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Caridomyocytes and High Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway.2013
- Author(s)
  Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Kimura T, Ono K.
- Organizer
  International Symposium on Transcription and Metabolism, 2013
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] 循環器疾患におけるバイオマーカーとしての血清中microRNA2013
- Author(s)
  桑原康秀、尾野亘、堀江貴裕、ガーボル•バジョー、渡邉真、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、木村剛
- Organizer
  第115回日本循環器学会近畿地方会
- Place of Presentation
  京都
- Year and Date
  2013-06-15
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Caridomyocytes and High Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway.2013
- Author(s)
  Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Kimura T, Ono K.
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  Awaji, Hyogo.
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] Elevated MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients with Acute Coronary Syndrome Indicate the Myocardial Damage2013
- Author(s)
  Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nagao K, Baba O, Kita T, Kimura T
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Ventricular Cardiomyocytes. Cold Spring Harbor Laboratory Meeting.2013
- Author(s)
  Kuwabara Y, Izuhara M, Horie T, Watanabe S, Baba O, Usami S, Nakao T, Nishiga M, Nishino T, Kita T, Kimura T, Ono K.
- Organizer
  Cold Spring Harbor Laboratory Meeting. Metabolic Signaling & Disease: From Cell to Organism
- Place of Presentation
  Cold Spring Harbor, New York, U.S.A.
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Ventricular Cardiomyocytes2013
- Author(s)
  Kuwabara Y, Izuhara M, Horie T, Watanabe S, Baba O, Usami S, Nakao T, Nishiga M, Nishino T, Kita T, Kimura T, Ono K
- Organizer
  American Heart Association Annual Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, U.S.A.
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] MicroRNA 26b encoded by the introns of small CTD Phosphatases (SCPs) 1 has an antagonistic effect on its host gene and suppresses cardiac hypertrophy2012
- Author(s)
  Kuwabara Y, Sowa N, Takahiro H, Baba O, Watanabe S, Nishi H, Hasegawa K, Kimura T, Ono K
- Organizer
  Cold Spring Harbor Laboratory Meeting. Regulatory and non-coding RNA
- Place of Presentation
  Cold Spring Harbor, New York, U.S.A.
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] 心血管疾患患者血清におけるmicroRNA-1とmicroRNA-133aの上昇は心筋傷害を示唆する2012
- Author(s)
  桑原康秀
- Organizer
  第49回日本臨床分子医学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] 飽和脂肪酸により誘導されるmicroRNA-451は、糖尿病性心筋症の増悪因子である。
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村剛、尾野亘
- Organizer
  第５回　Molecular Cardiovascular Conference II
- Place of Presentation
  神戸ベイシェラトンホテル＆タワーズ
- Year and Date
  2014-09-05 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] MicroRNA-451 is Involved in Diabetic Cardiomyopathy through Suppression of the LKB1/AMPK Pathway.
- Author(s)
  Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Masataka Nishiga, Shunsuke Usami, Masayasu Izuhara, Tetsushi Nakao, Tomohiro Nishino, Toru Kita, Takeshi Kimura, Koh Ono.
- Organizer
  9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress.
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-09-12 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する。
- Author(s)
  桑原康秀、堀江貴裕、馬場理、渡邉真、西賀雅隆、宇佐美俊輔、出原正康、中尾哲史、西野共達、木村剛、尾野亘
- Organizer
  第51回　日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] 循環器疾患におけるバイオマーカーとしての血清中microRNA.
- Author(s)
  桑原康秀、尾野亘、堀江貴裕、ガーボルバジョー、渡邉真、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、木村剛.
- Organizer
  第115回日本循環器学会近畿地方会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24890094
[Presentation] 心肥大・心不全におけるlincRNAの機能解析
- Author(s)
  桑原康秀、堀江貴裕、中島康弘、伯野大彦、馬場理、出原正康、宇佐美俊輔、西賀雅隆、西野共達、中尾哲史、井手裕也、中関典子、小山智史、北徹、木村剛、尾野亘
- Organizer
  新学術領域研究　転写研究会＆転写サイクル＆転写代謝システム共催　若手ワークショップ
- Place of Presentation
  ホテル松本楼、渋川市伊香保町、群馬
- Year and Date
  2015-02-05 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway.
- Author(s)
  Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Shin Watanabe, Toru Kita, Takeshi Kimura, Koh Ono.
- Organizer
  Keystone Symposia, Mitochondria, Metabolism and Heart Failure joint with Diabetes and Metabolic Dysfunction.
- Place of Presentation
  Santa Fe, New Mexico, USA
- Year and Date
  2015-01-27 – 2015-02-01
- Data Source
  KAKENHI-PROJECT-26860556
[Presentation] 飽和脂肪酸により誘導されるmicroRNA-451は、糖尿病性心筋症の増悪因子である。
- Author(s)
  桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村剛、尾野亘
- Organizer
  第37回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26860556

1. HORIE Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. KIMURA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 矢作直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 伯野大彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 尾野亘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 西英一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUWABARA Yasuhide 桑原 康秀

Research Projects

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心肥大で誘導される新規lincRNAの、筋組織における核内制御と核内機能の解明Principal Investigator

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Analysis of Non-coding RNA Functions in Heart DiseasesPrincipal Investigator

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Investigations for lincRNA functions involved in cardiac remodeling.Principal Investigator

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[Journal Article] Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model.2017

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[Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.2016

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[Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.2015

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[Journal Article] – Novel “Thrifty” Models –2015

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[Journal Article] MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism2015

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[Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.2015

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[Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.2015

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[Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.2014

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[Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice2014

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[Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.2013

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KUWABARA Yasuhide 桑原康秀