Ohgidani Masahiro 扇谷昌宏

Researcher Number	60636455
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 旭川医科大学, 医学部, 講師 2019 – 2021: 名古屋市立大学, 医薬学総合研究院(医学), 講師 2019: 名古屋市立大学, 医学部, 講師 2016 – 2018: 九州大学, 医学研究院, 学術研究員 2014 – 2015: 九州大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Health science and related fields / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator ミクログリア / iMG / 精神神経疾患 / 中枢免疫系 / 末梢免疫系 / 加齢性疾患 / 老化 / 神経内科 / 精神科 / トランスレーショナル研究 … More / microglia / HDLS / ALSP / TNF-α / 慢性疲労症候群 / 線維筋痛症 / ミクログリア様細胞 … More Except Principal Investigator ミクログリア / 神経炎症 / モデル動物 / 酸化ストレス / ミエリン鞘 / 認知機能障害 / CCL11 / ケモカイン / 統合失調症 / ミクログリア様細胞 / 抑うつ症状 / 閉塞性睡眠時無呼吸症候群 / 持続式陽圧呼吸療法 / 睡眠時無呼吸症候群 / 免疫ゲノム / 免疫免疫環境 / エクソソーム / 直接誘導ミクログリア様細胞 / 免疫微小環境 / リキッドバイオプシー / グリオーマ / フローサイトメトリー / Ca 2+ イメージング / Macrophage polarization / DAP12 / TREM2 / 神経炎症仮説 / 貪食能 / FCM / iMG / せん妄 Less

ヒトの末梢及び中枢免疫系から明らかにする加齢の正体と加齢性疾患治療への応用Principal Investigator
- Principal Investigator
  
  扇谷昌宏
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Asahikawa Medical College
What is microglial activation in neuropsychiatric disorders? A cross-disease study using human cells.Principal Investigator
- Principal Investigator
  
  扇谷昌宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Asahikawa Medical College
Elucidation of glioma immune microenvironment heterogeneity based on immunogenomics by liquid biopsy
- Principal Investigator
  
  Mizoguchi Masahiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kyushu University
dynamic analysis in induced-microglial cells from patients with major depression disorder and obstructive sleep apnea syndrome before and after treated with continuous positive airway pressure therapy
- Principal Investigator
  
  野上耕二郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saga University
Pathophysiology of cognitive dysfunction in schizophrenia focusing on the hypothesis of accelerated cerebral aging by CCL11
- Principal Investigator
  
  Kusumi Ichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hokkaido University
dynamic state analysis in induced-microglial cells from delirium population and non-delirium population
- Principal Investigator
  
  村川徹 (平地徹)
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saga University
Elucidation of the pathomechanisms of microglial diseases with severe neuropsychiatric symptoms and search for treatment options.Principal Investigator
- Principal Investigator
  
  Ohgidani Masahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Asahikawa Medical College
  Nagoya City University
Establishment of objective evaluation system for chronic fatigue syndrome using human peripheral blood induced microglia-like cellsPrincipal Investigator
- Principal Investigator
  
  Ohgidani Masahiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  Kyushu University
Establishment of humani microglial cells and application to psychiatric disordersPrincipal Investigator
- Principal Investigator
  
  Ohgidani Masahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter2023
- Author(s)
  Furube Eriko、Ohgidani Masahiro、Yoshida Shigetaka
- Journal Title
  
  Neurochemical Research
  
  Volume: - Issue: 9 Pages: 2645-2659
- DOI
  10.1007/s11064-023-03929-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24261
[Journal Article] Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease2023
- Author(s)
  Shirozu Noritoshi, et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 14842-14842
- DOI
  10.1038/s41598-023-41456-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07334, KAKENHI-PROJECT-23K08545, KAKENHI-PROJECT-23K10453, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H03044, KAKENHI-PROJECT-23K24261
[Journal Article] A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells2022
- Author(s)
  Ohgidani Masahiro、Kushima Itaru、Inamine Shogo、Kyuragi Sota、Sagata Noriaki、Nakao Tomohiro、Kanba Shigenobu、Ozaki Norio、Kato Takahiro A
- Journal Title
  
  Psychiatry and Clinical Neurosciences
  
  Volume: 77 Issue: 2 Pages: 128-130
- DOI
  10.1111/pcn.13505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00494, KAKENHI-PROJECT-23K24261
[Journal Article] Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress2022
- Author(s)
  Enomoto Shingo、Ohgidani Masahiro、Sagata Noriaki、Inamine Shogo、Kato Takahiro A.
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 43 Issue: 1 Pages: 120-125
- DOI
  10.1002/npr2.12298
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00494, KAKENHI-PROJECT-23K24261
[Journal Article] CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma2021
- Author(s)
  Tanaka Shunya、Ohgidani Masahiro、Hata Nobuhiro、Inamine Shogo、Sagata Noriaki、Shirouzu Noritoshi、Mukae Nobutaka、Suzuki Satoshi O.、Hamasaki Hideomi、Hatae Ryusuke、Sangatsuda Yuhei、Fujioka Yutaka、Takigawa Kosuke、Funakoshi Yusuke、Iwaki Toru、Hosoi Masako、Iihara Koji、Mizoguchi Masahiro、Kato Takahiro A.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 670131-670131
- DOI
  10.3389/fimmu.2021.670131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04042, KAKENHI-PROJECT-21H03044, KAKENHI-PROJECT-20K09392, KAKENHI-PROJECT-19H03752
[Journal Article] 精神神経疾患のトランスレーショナル研究2020
- Author(s)
  扇谷昌宏
- Journal Title
  
  日本生物学的精神医学会誌
  
  Volume: 31 Pages: 186-186
- NAID
  130007961367
- Data Source
  KAKENHI-PROJECT-19K17065
[Journal Article] 精神疾患のミクログリア病態治療仮説　橋渡し研究による仮説解明をめざして2018
- Author(s)
  加藤隆弘, 扇谷昌宏, 神庭重信
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 69 Pages: 1007-1015
- Data Source
  KAKENHI-PROJECT-17K19915
[Journal Article] 線維筋痛症のトランスレーショナル研究 : ミクログリア過剰活性化とTNF-α2018
- Author(s)
  扇谷昌宏, 細井昌子, 加藤隆弘
- Journal Title
  
  日本臨牀
  
  Volume: 76 Pages: 1937-1942
- Data Source
  KAKENHI-PROJECT-17K19915
[Journal Article] Microglial CD206Gene Has Potential as a State Marker of Bipolar Disorder2017
- Author(s)
  M. Ohgidani, T.A. Kato, Y. Haraguchi, T. Matsushima, Y. Mizoguchi, T. Murakawa-Hirachi, N. Sagata, A. Monji, S. Kanba
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 7 Pages: 1-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860933
[Journal Article] Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells2017
- Author(s)
  Ohgidani Masahiro、Kato Takahiro A.、Hosoi Masako、Tsuda Makoto、Hayakawa Kohei、Hayaki Chie、Iwaki Rie、Sagata Noriaki、Hashimoto Ryota、Inoue Kazuhide、Sudo Nobuyuki、Kanba Shigenobu
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1-6
- DOI
  10.1038/s41598-017-11506-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09304, KAKENHI-PROJECT-26713039, KAKENHI-ORGANIZER-25117001, KAKENHI-PLANNED-25117011, KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-17K19915
[Journal Article] Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders2015
- Author(s)
  Ohgidani M, Kato TA*, Kanba S.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: in press Pages: 184-184
- DOI
  10.3389/fncel.2015.00184
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-25117001, KAKENHI-PROJECT-26860933, KAKENHI-PLANNED-25117011
[Journal Article] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease.2014
- Author(s)
  Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 4957-4957
- DOI
  10.1038/srep04957
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24650227, KAKENHI-ORGANIZER-25117001, KAKENHI-PROJECT-25253005, KAKENHI-PROJECT-26670541, KAKENHI-PROJECT-26713039, KAKENHI-PROJECT-26860933
[Patent] ALSP等の程度の判定方法2020
- Inventor(s)
  加藤隆弘、扇谷昌宏
- Industrial Property Rights Holder
  加藤隆弘、扇谷昌宏
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K17065
[Presentation] ミクログリアに着目した精神神経疾患研究2023
- Author(s)
  扇谷昌宏、加藤隆弘、古部瑛莉子、吉田成孝
- Organizer
  第128回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-23K24261
[Presentation] 神経毒性評価におけるグリア細胞の重要性：マウス由来の株化細胞を用いた基礎的検討2022
- Author(s)
  扇谷昌宏
- Organizer
  BPCNPNPPP4学会合同年会
- Data Source
  KAKENHI-PROJECT-21H02845
[Presentation] ヒト血液由来誘導ミクログリア様細胞の貪食能についての検討2022
- Author(s)
  前原直喜, 白水寛理, 田中俊也, 扇谷昌宏, 三月田祐平, 藤岡寛, 空閑太亮, 秦暢宏, 溝口昌弘, 加藤隆弘, 吉本幸司
- Organizer
  一般社団法人日本脳神経外科学会第81回学術総会
- Data Source
  KAKENHI-PROJECT-21H03044
[Presentation] Direct induction of microglia-like cells from human monocytes: A novel cellular tool for predicting the inflammatory state of an individual’s central nervous system.2021
- Author(s)
  扇谷昌宏
- Organizer
  第25回グリア研究会
- Data Source
  KAKENHI-PROJECT-19K17065
[Presentation] Gliomaの免疫微小環境バイオマーカーとしてのヒト血液由来ミクログリア様(iMG)細胞の有用性の検討2021
- Author(s)
  田中俊也、扇谷昌宏、秦暢宏、稲嶺翔吾、佐方功明、迎伸孝、波多江龍亮、三月田祐平、岩城徹、細井昌子、溝口昌弘、加藤隆弘
- Organizer
  日本脳神経外科学会第80回学術総会
- Data Source
  KAKENHI-PROJECT-21H03044
[Presentation] 精神神経疾患のトランスレーショナル研究ツールとしてのiMG(induced microglia-like)細胞の開発と応用2019
- Author(s)
  扇谷昌宏、加藤隆弘、神庭重信
- Organizer
  日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K17065
[Presentation] Direct induction of microglia-like cells from human monocytes: A novel cellular tool for translational research of neuropsychiatric disorders2019
- Author(s)
  扇谷昌宏、加藤隆弘
- Organizer
  AsCNP2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17065
[Presentation] 精神神経疾患のトランスレーショナル研究ツールとしてのiMG(induced microglia-like)細胞2019
- Author(s)
  扇谷昌宏、加藤隆弘
- Organizer
  日本精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-19K17065
[Presentation] 患者由来直接誘導ニューロン・ミクログリア様細胞による精神疾患の病態解明研究2018
- Author(s)
  扇谷昌宏
- Organizer
  第5回サイコグリア研究会
- Data Source
  KAKENHI-PROJECT-17K19915
[Presentation] Direct induction of microglia-like cells from human monocytes: A novel cellular tool for translational research of neuropsychiatric disorders2018
- Author(s)
  Masahiro Ohgidani
- Organizer
  ASCB EMBO 2018 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19915
[Presentation] 精神神経疾患のトランスレーショナル研究ツールとしてのiMG(induced microglia-like)細胞2018
- Author(s)
  扇谷昌宏
- Organizer
  第31回動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-17K19915
[Presentation] Psychiatric translational research using human blood-induced microglial (iMG) cells2017
- Author(s)
  M. Ohgidani, T.A. Kato, S. Kanba
- Organizer
  5th AsCNP
- Place of Presentation
  インドネシア、バリ
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860933
[Presentation] ヒト血液由来直接誘導ミクログリア様（iMG）細胞による痛みの客観的評価法の開発2017
- Author(s)
  扇谷昌宏、加藤隆弘、神庭重信
- Organizer
  痛みの研究会
- Data Source
  KAKENHI-PROJECT-17K19915
[Presentation] Translational research of chronic pain patients using human blood-induced microglia-like (iMG) cells2015
- Author(s)
  Ohgidani M, Kato TA, Hosoi M, Tsuda M, Hayakarwa K, Sudo N, Kanba S
- Organizer
  The 58th Annual meeting of the japanese society for neurochemistry
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26860933
[Presentation] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
- Author(s)
  Ohgidani M, Kato TA, Kanba S
- Organizer
  Shared Pathways to Novel Treatment Strategies Beyond Boundaries in Psychiatry and Neurology
- Place of Presentation
  Munich, GERMANY
- Year and Date
  2014-06-29 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26860933
[Presentation] Modeling brain diseases with direct induction technology of ramified microglia-like (iMG) cells from human monocytes
- Author(s)
  Ohgidani, M. Kato, T. A. Kanba, S.
- Organizer
  12th International Congress of Neuroimmunology (ISNI)
- Place of Presentation
  Mainz, GERMANY
- Year and Date
  2014-11-09 – 2014-11-13
- Data Source
  KAKENHI-PROJECT-26860933

1. 村川徹 (00813049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 門司晃 (00294942)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 溝口義人 (60467892)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 加藤隆弘 (70546465)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. Mizoguchi Masahiro (50380621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Kusumi Ichiro (30250426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 阪本雄一郎 (20366678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤岡寛 (10914252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 秦暢宏 (10596034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 空閑太亮 (40759932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 三月田祐平 (00848640)

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# of Collaborated Products: 2 results
12. 中溝玲 (80529800)

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13. 野上耕二郎 (60891265)

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14. 野出孝一 (80359950)

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15. 白木綾 (50638252)

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16. 夏秋政浩 (20816318)

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17. 西原正志 (50516557)

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18. 立石洋 (50457470)

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19. 國武裕 (30404148)

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20. 松島淳 (90773151)

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21. 白石匠 (80990168)

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22. 石川修平 (30880091)

# of Collaborated Projects: 1 results

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23. 橋本直樹 (40615895)

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24. 豊巻敦人 (70515494)

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25. 古賀農人 (70744936)

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26. 山崎亮 (10467946)

# of Collaborated Projects: 1 results

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27. HOSOI Masako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 神庭重信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohgidani Masahiro 扇谷 昌宏

Research Projects

Research Products

Co-Researchers

ヒトの末梢及び中枢免疫系から明らかにする加齢の正体と加齢性疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

What is microglial activation in neuropsychiatric disorders? A cross-disease study using human cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of glioma immune microenvironment heterogeneity based on immunogenomics by liquid biopsy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

dynamic analysis in induced-microglial cells from patients with major depression disorder and obstructive sleep apnea syndrome before and after treated with continuous positive airway pressure therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiology of cognitive dysfunction in schizophrenia focusing on the hypothesis of accelerated cerebral aging by CCL11

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

dynamic state analysis in induced-microglial cells from delirium population and non-delirium population

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathomechanisms of microglial diseases with severe neuropsychiatric symptoms and search for treatment options.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of objective evaluation system for chronic fatigue syndrome using human peripheral blood induced microglia-like cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of humani microglial cells and application to psychiatric disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma2021

Author(s)

Ohgidani Masahiro 扇谷昌宏

[Journal Article] 精神疾患のミクログリア病態治療仮説　橋渡し研究による仮説解明をめざして2018