Onishi Tomoko 大西智子

Researcher Number	60645589
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 奈良県立医科大学, 医学部, 助教 2023: 奈良県立医科大学, 医学部, 助教 2018 – 2022: 奈良県立医科大学, 医学部附属病院, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator CFWA / 凝固線溶波形解析 / 敗血症 / DIC / 播種性血管内凝固 / 線溶 / 凝固 / 血液腫瘍 / COVID-19 / 抗凝固療法 … More / 遺伝子組み換えトロンボモジュリン製剤 / テーラーメード治療 / トロンビン/プラスミン生成試験 / 凝固波形解析 / CFWAとT/P-GAの相関性 / 包括的凝固線溶動態 / 包括的凝固線溶動態３．研究課題名 / 新規病型分類 / トロンボモジュリン / トロンビンプラスミン生成試験 / DICの病型分類 / 包括的凝固線溶評価 / 出血 / 血栓 … More Except Principal Investigator 血栓性微小血管障害症 / 肝類洞閉塞症候群 / トロンビンプラスミン生成試験 / 凝固線溶波形解析 / トロンビン・プラスミン生成試験 / 線溶 / 凝固 / 播種性血管内凝固 / 血栓症 / 小児がん Less

血友病の年齢による凝血学的変化の解明と、「止血」と「抗血栓」併用の治療戦略の検討Principal Investigator
- Principal Investigator
  
  大西智子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
包括的凝固線溶解析を基盤とする播種性血管内凝固とCOVID-19の治療戦略の構築Principal Investigator
- Principal Investigator
  
  大西智子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nara Medical University
Establishment of the novel tailored therapy for the thrombosis of pediatric cancer based on the balance between coagulation and fibrinolysis
- Principal Investigator
  
  Takashi Ishihara
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University
Establishment of a new diagnostic method for disseminated intravascular coagulation based on comprehensive coagulation/fibrinolysis dynamics analysisPrincipal Investigator
- Principal Investigator
  
  Onishi Tomoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nara Medical University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] The effects of emicizumab on in vitro coagulation and fibrinolysis parameters in patients with disseminated intravascular coagulation with and without addition of anti‐FVIII antibody2024
- Author(s)
  Onishi Tomoko、Shimo Hanako、Harada Suguru、Nogami Keiji
- Journal Title
  
  Haemophilia
  
  Volume: 30 Issue: 3 Pages: 836-844
- DOI
  10.1111/hae.14997
- Data Source
  KAKENHI-PROJECT-22K16330
[Journal Article] The in vitro effect of anticoagulant agents on coagulation and fibrinolysis in the presence of emicizumab in the plasmas from patients with haemophilia A2023
- Author(s)
  Onishi Tomoko、Harada Suguru、Shimo Hanako、Tashiro Yoshihito、Soeda Tetsuhiro、Nogami Keiji
- Journal Title
  
  Haemophilia
  
  Volume: 29 Issue: 6 Pages: 1529-1538
- DOI
  10.1111/hae.14877
- Data Source
  KAKENHI-PROJECT-22K16330
[Journal Article] The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-192022
- Author(s)
  Onishi Tomoko、Kawaguchi Ryuji、Nishio Tomohisa、Nogami Keiji、et al
- Journal Title
  
  International Journal of Hematology
  
  Volume: 2 Issue: 6 Pages: 1-12
- DOI
  10.1007/s12185-022-03308-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10488, KAKENHI-PROJECT-22K16330, KAKENHI-PROJECT-20K08573
[Journal Article] Coagulation and fibrinolysis balance in disseminated intravascular coagulation2021
- Author(s)
  Ohnishi Tomoko、Ishihara Takashi、Nogami Keiji
- Journal Title
  
  Pediatrics International
  
  Volume: - Issue: 11 Pages: 1311-1318
- DOI
  10.1111/ped.14684
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
[Journal Article] A Pathological Clarification of Sepsis-Associated Disseminated Intravascular Coagulation Based on Comprehensive Coagulation and Fibrinolysis Function2020
- Author(s)
  Onishi Tomoko、Nogami Keiji、Ishihara Takashi、Inoue Satoki、Kawaguchi Masahiko、Nishio Kenji、Fukushima Hidetada、Kobayashi Hiroshi、Amano Itsuto、Nishikubo Toshiya、Yamasaki Masaharu、Kasahara Masato、Shima Midori
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 120 Issue: 09 Pages: 1257-1269
- DOI
  10.1055/s-0040-1713890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
[Journal Article] Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation2019
- Author(s)
  Ishihara Takashi、Nogami Keiji、Onishi Tomoko、Ogiwara Kenichi、Ochi Satoshi、Yamazaki Masaharu、Shima Midori
- Journal Title
  
  Pediatrics International
  
  Volume: 61 Issue: 9 Pages: 872-881
- DOI
  10.1111/ped.13919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] 寛解導入療法時に包括的な凝固線溶動態解析を行ったKMT2A遺伝子再構成陽性急性リンパ性白血病（KMT2A-r ALL）の1乳児例2022
- Author(s)
  石原　卓、大西　智子、越智　聡史、秋定　直宏、渡壁　麻依、野上　恵嗣
- Organizer
  第113回近畿血液学地方会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] 凝固線溶波形解析を用いた小児敗血症性DICにおける包括的凝固線溶動態の経時的評価2021
- Author(s)
  大西　智子、石原　卓、渡壁　麻依、大前　隆志、野上　恵嗣
- Organizer
  第43回日本血栓止血学会学術集会学術集会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] 小児急性リンパ性白血病の先行治療相で発症した類洞閉塞症候群では凝固能および線溶能が抑制傾向を来す2021
- Author(s)
  秋定　直宏、石原　卓、越智　聡史、大西　智子、髙田　晃司、長谷川菜摘、野上　恵嗣
- Organizer
  第63回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] A new classification of sepsis-associated disseminated intravascular coagulation (DIC): comprehensive evaluation of coagulation and fibrinolysis2020
- Author(s)
  Tomoko Onishi
- Organizer
  ISTH 2020(International Society on Thrombosis and Haemostasis)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15726
[Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019
- Author(s)
  大西　智子、野上　恵嗣、伊藤　陽子、大前　隆志、石原　卓、嶋　緑倫
- Organizer
  第122回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019
- Author(s)
  大西智子
- Organizer
  第122回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15726
[Presentation] 凝固線溶均衡/不均衡パターンにより分類したDIC各病型におけるトロンビン・プラスミンの動態2019
- Author(s)
  大西智子
- Organizer
  第41回　日本血栓止血学会　学術集会
- Data Source
  KAKENHI-PROJECT-18K15726
[Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019
- Author(s)
  大西智子
- Organizer
  第122回　日本小児科学会　学術集会
- Data Source
  KAKENHI-PROJECT-18K15726
[Presentation] トロンビン・プラスミン生成の低下がみられた肝類洞閉塞症候群（SOS）の1例2019
- Author(s)
  石原　卓、野上　恵嗣、越智　聡史、水町　邦義、大西　智子、嶋　緑倫
- Organizer
  第41回日本造血細胞移植学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08304
[Presentation] 凝固/線溶動態絡みた播種性血管内凝固（DIC）の新規分類法2018
- Author(s)
  大西智子
- Organizer
  第80回　日本血液学会　学術集会
- Data Source
  KAKENHI-PROJECT-18K15726

1. Takashi Ishihara (00533712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 野上恵嗣 (50326328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 嶋緑倫 (30162663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. KAWAGUCHI Ryuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Onishi Tomoko 大西 智子

Research Projects

Research Products

Co-Researchers

血友病の年齢による凝血学的変化の解明と、「止血」と「抗血栓」併用の治療戦略の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

包括的凝固線溶解析を基盤とする播種性血管内凝固とCOVID-19の治療戦略の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of the novel tailored therapy for the thrombosis of pediatric cancer based on the balance between coagulation and fibrinolysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a new diagnostic method for disseminated intravascular coagulation based on comprehensive coagulation/fibrinolysis dynamics analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The effects of emicizumab on in vitro coagulation and fibrinolysis parameters in patients with disseminated intravascular coagulation with and without addition of anti‐FVIII antibody2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The in vitro effect of anticoagulant agents on coagulation and fibrinolysis in the presence of emicizumab in the plasmas from patients with haemophilia A2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The balance of comprehensive coagulation and fibrinolytic potential is disrupted in patients with moderate to severe COVID-192022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coagulation and fibrinolysis balance in disseminated intravascular coagulation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Pathological Clarification of Sepsis-Associated Disseminated Intravascular Coagulation Based on Comprehensive Coagulation and Fibrinolysis Function2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 寛解導入療法時に包括的な凝固線溶動態解析を行ったKMT2A遺伝子再構成陽性急性リンパ性白血病（KMT2A-r ALL）の1乳児例2022

Author(s)

Organizer

Data Source

[Presentation] 凝固線溶波形解析を用いた小児敗血症性DICにおける包括的凝固線溶動態の経時的評価2021

Author(s)

Organizer

Data Source

[Presentation] 小児急性リンパ性白血病の先行治療相で発症した類洞閉塞症候群では凝固能および線溶能が抑制傾向を来す2021

Author(s)

Organizer

Data Source

[Presentation] A new classification of sepsis-associated disseminated intravascular coagulation (DIC): comprehensive evaluation of coagulation and fibrinolysis2020

Author(s)

Organizer

Data Source

[Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019

Author(s)

Organizer

Data Source

[Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019

Author(s)

Onishi Tomoko 大西智子

[Presentation] 凝固線溶均衡/不均衡パターンにより分類したDIC各病型におけるトロンビン・プラスミンの動態2019