Sakurai Toshihiro 櫻井俊宏

Researcher Number	60707602
Other IDs
Affiliation (Current)	2025: 北海道大学, 保健科学研究院, 准教授
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 保健科学研究院, 准教授 2021 – 2023: 北海道大学, 保健科学研究院, 准教授 2018 – 2021: 北海道大学, 保健科学研究院, 講師 2017: 北海道大学, 保健科学研究院, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 52010:General internal medicine-related / Epidemiology and preventive medicine
Keywords	Principal Investigator 酸化HDL / NASH / ミトコンドリア / 酸化 / HDL / 脂肪滴 / 肝臓 / 非アルコール性脂肪性肝炎 / エネルギー / モノリゾカルジオリピン / カルジオリピン … More Except Principal Investigator … More 質量分析 / ミトコンドリア / モノリゾカルジオリピン / カルジオリピン / 生活習慣 / 脂質 / 低比重リポタンパク / 動脈硬化 / 高さ / 硬さ / ゼータ電位 / 粒径 / 低比重リポ蛋白 Less

健康維持戦略のための酸化変性apoAIと脂肪性肝炎との関連解明Principal Investigator
- Principal Investigator
  
  櫻井俊宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hokkaido University
Development and application of novel technique for evaluation of mitochondrial function
- Principal Investigator
  
  千葉仁志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Hokkaido University
Elucidation of oxidized HDL and NASH pathogenesis focusing on mitochondrial dysfunctionPrincipal Investigator
- Principal Investigator
  
  櫻井俊宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hokkaido University
Elucidation of pathogenic mechanism of NASH and developments for diagnostic markers focusing on oxidized HDLPrincipal Investigator
- Principal Investigator
  
  Sakurai Toshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hokkaido University
A community-based epidemiological study on the links between characteristics of low-density lipoprotein and lifestyles/metabolic disorders/arteriosclerosis.
- Principal Investigator
  
  Nakamura Koshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  University of the Ryukyus
  Hokkaido University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study2025
- Author(s)
  Nakamura K, Takeda S, Sakurai T, Ukawa S, Okada E, Nakagawa T, Imae A, Hui SP, Chiba H, Tamakoshi A.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 32 Issue: 1 Pages: 34-47
- DOI
  10.5551/jat.64961
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2025-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04120
[Journal Article] Kaempferol Improves Cardiolipin and ATP in Hepatic Cells: A Cellular Model Perspective in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease2024
- Author(s)
  Sakurai Akiko、Sakurai Toshihiro、Ho Hsin-Jung、Chiba Hitoshi、Hui Shu-Ping
- Journal Title
  
  Nutrients
  
  Volume: 16 Issue: 4 Pages: 508-508
- DOI
  10.3390/nu16040508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11797, KAKENHI-PROJECT-23K06881
[Journal Article] Oxidized Low-Density Lipoproteins Trigger Hepatocellular Oxidative Stress with the Formation of Cholesteryl Ester Hydroperoxide-Enriched Lipid Droplets2023
- Author(s)
  Sazaki Iku、Sakurai Toshihiro、Yamahata Arisa、Mogi Sumire、Inoue Nao、Ishida Koutaro、Kikkai Ami、Takeshita Hana、Sakurai Akiko、Takahashi Yuji、Chiba Hitoshi、Hui Shu-Ping
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 5 Pages: 4281-4281
- DOI
  10.3390/ijms24054281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11797, KAKENHI-PROJECT-23K06881
[Journal Article] Lysophosphatidylethanolamine Affects Lipid Accumulation and Metabolism in a Human Liver-Derived Cell Line2022
- Author(s)
  Yamamoto Yusuke、Sakurai Toshihiro、Chen Zhen、Inoue Nao、Chiba Hitoshi、Hui Shu-Ping
- Journal Title
  
  Nutrients
  
  Volume: 14 Issue: 3 Pages: 579-579
- DOI
  10.3390/nu14030579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07434, KAKENHI-PROJECT-19K20174
[Patent] 非アルコール性脂肪性肝炎の診断方法2021
- Inventor(s)
  櫻井俊宏、惠淑萍、千葉仁志
- Industrial Property Rights Holder
  櫻井俊宏、惠淑萍、千葉仁志
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19K20174
[Patent] 非アルコール性脂肪性肝炎の診断方法2020
- Inventor(s)
  櫻井俊宏、惠淑萍、千葉仁志.
- Industrial Property Rights Holder
  櫻井俊宏、惠淑萍、千葉仁志.
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-149798
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] Kaempferol Improves Mitochondrial Respiratory Function in Human Liver-Derived Cell Line2023
- Author(s)
  Sakurai A, Sakurai T, Ho HJ, Chiba H, Hui SP.
- Organizer
  The 6th FHS International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] Enhancement of mitochondrial function with kaempferol, contained as glycoside in Aojiru2023
- Author(s)
  Sakurai A, Sakurai T, Ho HJ, Chiba H, Hui SP.
- Organizer
  The Indian Scientists Association in Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] 培養肝細胞から放出されるLDLの脂質プロフィール解析2023
- Author(s)
  櫻井俊宏, 陳震, 茂木すみれ, 千葉仁志, 惠淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] ケンペロールによるミトコンドリアへの作用2023
- Author(s)
  櫻井知子, 櫻井俊宏, 何欣蓉, 千葉仁志, 惠　淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] LDL添加による肝ミトコンドリア呼吸機能の変化は酸化により悪化する2023
- Author(s)
  佐﨑生, 櫻井俊宏, 千葉仁志, 惠淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 培養ヒト肝細胞から放出されるVLDL中のTG及びTG-OOHの解析2023
- Author(s)
  益子真明, 櫻井俊宏，山端ありさ，佐﨑生, 茂木すみれ, 千葉仁志，惠　淑萍.
- Organizer
  第48回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] 脂肪肝モデル細胞における12-EPAHSAのミトコンドリア形態への影響2023
- Author(s)
  竹下花, 櫻井俊宏, Siddabasave Gowda B. Gowda, 千葉仁志, 惠淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 脂肪肝モデル細胞におけるミトコンドリア膜脂質への酸化HDLの影響2023
- Author(s)
  石田航太郎, 櫻井俊宏, 茂木すみれ, 井上夏緒, 千葉仁志, 惠　淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] ケンペロールによるミトコンドリアへの作用2023
- Author(s)
  櫻井知子, 櫻井俊宏, 何欣蓉, 千葉仁志, 惠淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] LDL添加による肝ミトコンドリア呼吸機能の変化は酸化により悪化する2023
- Author(s)
  佐﨑　生, 櫻井俊宏, 千葉仁志, 惠　淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] 脂肪肝モデル細胞におけるミトコンドリア膜脂質への酸化HDLの影響2023
- Author(s)
  石田航太郎, 櫻井俊宏, 茂木すみれ, 井上夏緒, 千葉仁志, 惠淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] The effect of 12-EPAHSA on mitochondrial morphology in fatty liver model cells2023
- Author(s)
  Takeshita H, Sakurai T, Gowda SGB, Chiba H, Hui SP.
- Organizer
  The 6th FHS International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 肝細胞における酸化HDLの受容体の探索2023
- Author(s)
  笹真穂, 櫻井俊宏, 石田航太郎, 千葉仁志, 惠　淑萍.
- Organizer
  第57回日本臨床検査医学会北海道支部総会・第33回日本臨床化学会北海道支部例会
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] 培養ヒト肝細胞から放出されるVLDL中のTG及びTG-OOHの解析2023
- Author(s)
  益子真明, 櫻井俊宏，山端ありさ，佐﨑生, 茂木すみれ, 千葉仁志，惠淑萍.
- Organizer
  第48回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 培養肝細胞から放出されるLDLの脂質プロフィール解析2023
- Author(s)
  櫻井俊宏, 陳　震, 茂木すみれ, 千葉仁志, 惠　淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] Lipidomic Analysis of Very-Low Density Lipoprotein Released from Human Liver-Derived Cell Line2023
- Author(s)
  Masuko N, Sakurai T, Yamahata A, Sazaki I, Mogi S, Chiba H, Hui SP.
- Organizer
  The 6th FHS International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] Search for Oxidized High-Density Lipoprotein Receptor in Human Liver-Derived Cell Line2023
- Author(s)
  Sasa M, Sakurai T, Ishida K, Chiba H, Hui SP.
- Organizer
  The 6th FHS International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 肝細胞における酸化HDLの受容体の探索2023
- Author(s)
  笹真穂, 櫻井俊宏, 石田航太郎, 千葉仁志, 惠淑萍.
- Organizer
  第57回日本臨床検査医学会北海道支部総会・第33回日本臨床化学会北海道支部例会
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] Enhancement of mitochondrial function with kaempferol, contained as glycoside in Aojiru2023
- Author(s)
  Sakurai A, Sakurai T, Ho HJ, Chiba H, Hui SP.
- Organizer
  The Indian Scientists Association in Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 脂肪肝モデル細胞における12-EPAHSAのミトコンドリア形態への影響2023
- Author(s)
  竹下花, 櫻井俊宏, Siddabasave Gowda B. Gowda, 千葉仁志, 惠　淑萍.
- Organizer
  第63回日本臨床化学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06881
[Presentation] 酸化HDLによる肝細胞のミトコンドリア機能低下作用2022
- Author(s)
  櫻井俊宏, 山端ありさ, 関島将人, 井上夏緒, 上野朱音, 茂木すみれ, 何　欣蓉, 陳　震, 千葉仁志, 惠　淑萍.
- Organizer
  第62回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22K11797
[Presentation] 酸化HDL刺激による肝細胞中のリン脂質過酸化物の変動2020
- Author(s)
  茂木すみれ，櫻井俊宏，上野朱音，山端ありさ，陳震，千葉仁志，惠淑萍.
- Organizer
  第54回日本臨床検査医学会北海道支部総会・第30回日本臨床化会北海道支部例会
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] 酸化HDLの肝脂質代謝及びミトコンドリアへの影響2020
- Author(s)
  山端ありさ, 櫻井俊宏, 関島将人, 上野朱音, 千葉仁志, 惠　淑萍.
- Organizer
  第60回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] 酸化HDLにより誘導された肝細胞過酸化脂質プロフィールの変動2020
- Author(s)
  上野朱音, 櫻井俊宏, 関島将人, 山端ありさ, 陳震, 千葉仁志, 惠　淑萍.
- Organizer
  第60回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] 非アルコール性脂肪性肝炎発症に対する酸化HDLの関与2019
- Author(s)
  櫻井俊宏, 関島将人, 田村宥人, 仲門菜月, 津久井隆行, 布田博敏, 千葉仁志, 惠　淑萍
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] 酸化HDLに焦点を当てた非アルコール性脂肪性肝炎の発症機序の解明2019
- Author(s)
  櫻井俊宏, 関島将人, 田村宥人, 仲門菜月, 津久井隆行，布田博敏，千葉仁志, 惠　淑萍
- Organizer
  第4回北海道大学部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] ヒト肝培養細胞における酸化HDLの線維化促進作用2019
- Author(s)
  関島将人, 櫻井俊宏, 千葉仁志, 惠　淑萍
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] 肝細胞の脂質代謝とミトコンドリア代謝への酸化HDLの影響2019
- Author(s)
  山端ありさ, 櫻井俊宏, 関島将人, 上野朱音, 布田博敏, 千葉仁志, 惠淑萍
- Organizer
  第53回日本臨床検査医学会北海道支部総会・第29回日本臨床化会北海道支部例会
- Data Source
  KAKENHI-PROJECT-19K20174
[Presentation] Oxidized high-density lipoproteins promote fibrosis in hepatocytes2019
- Author(s)
  Sekijima M, Sakurai T, Chiba H, Hui SP
- Organizer
  FHS symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20174

1. 惠淑萍 (90337030)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. Nakamura Koshi (80422898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 武田晴治 (80374726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 千葉仁志 (70197622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

Sakurai Toshihiro 櫻井 俊宏

Research Projects

Research Products

Co-Researchers

健康維持戦略のための酸化変性apoAIと脂肪性肝炎との関連解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and application of novel technique for evaluation of mitochondrial function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of oxidized HDL and NASH pathogenesis focusing on mitochondrial dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenic mechanism of NASH and developments for diagnostic markers focusing on oxidized HDLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A community-based epidemiological study on the links between characteristics of low-density lipoprotein and lifestyles/metabolic disorders/arteriosclerosis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study2025

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Kaempferol Improves Cardiolipin and ATP in Hepatic Cells: A Cellular Model Perspective in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidized Low-Density Lipoproteins Trigger Hepatocellular Oxidative Stress with the Formation of Cholesteryl Ester Hydroperoxide-Enriched Lipid Droplets2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysophosphatidylethanolamine Affects Lipid Accumulation and Metabolism in a Human Liver-Derived Cell Line2022

Author(s)

Journal Title

DOI

Data Source

[Patent] 非アルコール性脂肪性肝炎の診断方法2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 非アルコール性脂肪性肝炎の診断方法2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Kaempferol Improves Mitochondrial Respiratory Function in Human Liver-Derived Cell Line2023

Author(s)

Organizer

Data Source

[Presentation] Enhancement of mitochondrial function with kaempferol, contained as glycoside in Aojiru2023

Author(s)

Organizer

Data Source

[Presentation] 培養肝細胞から放出されるLDLの脂質プロフィール解析2023

Author(s)

Sakurai Toshihiro 櫻井俊宏