IWAKAWA HIROOKI 岩川弘宙

… Alternative Names

IWAKAWA Hiro-oki 岩川弘宙

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Researcher Number	60710415
Other IDs	https://orcid.org/0000-0002-2553-1196
Affiliation (Current)	2025: 立教大学, 理学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 立教大学, 理学部, 准教授 2021: 東京大学, 定量生命科学研究所, 講師 2017 – 2018: 東京大学, 定量生命科学研究所, 助教 2013 – 2017: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 43010:Molecular biology-related / Transformative Research Areas, Section (III) Except Principal Investigator Medium-sized Section 39:Agricultural and environmental biology and related fields / Basic Section 39040:Plant protection science-related / Biological Sciences
Keywords	Principal Investigator RNAサイレンシング / siRNA / miRNA / microRNA / 液-液相分離 / 相分離 / 二次的siRNA / 小分子RNA / リボソーム停滞 / RNA-DNA ハイブリッド … More / RNA-DNAハイブリッド / DNA-RNAハイブリッド / RNA依存性RNAポリメラーゼ / 自己・非自己認識 / 植物 / 発現制御 / 蛋白質 / 核酸 … More Except Principal Investigator RNAサイレンシング / ゲノム編集 / RNAサイレンシングサプレッサー / アグロインフィルトレーション / Nicotiana benthamiana / ウイルス抵抗性 / エフェクター / ARGONAUTE / 小分子RNA / サプレッサー / AGO1 / siRNA / 翻訳アレスト / mRNA品質管理 / mRNA分解 / タンパク質分解 / ユビキチン / RISC / 翻訳伸長制御 / peptidyl-tRNA / リボソーム動態 / 新生鎖 / 翻訳停滞 / クライオ電顕 / プロテアソーム / 翻訳停止 / 品質管理機構 / ストレス応答 / 異常リボソーム / 翻訳異常 / ユビキチン化 / リボソーム / 品質管理 Less

The role of liquid-liquid phase separation in the mechanism of small RNA amplificationPrincipal Investigator
- Principal Investigator
  
  岩川弘宙
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Rikkyo University
Molecular analyses of RNA silencing inhibition by suppressors from plant pathogens
- Principal Investigator
  
  吉川学
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 39040:Plant protection science-related
- Research Institution
  National Agriculture and Food Research Organization
ウイルス抵抗性研究の高度化に資するゲノム編集タバコプラットフォーム確立への挑戦
- Principal Investigator
  
  竹田篤史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 39:Agricultural and environmental biology and related fields
- Research Institution
  Ritsumeikan University
小分子RNA依存的リボソーム停滞機構の統合的理解Principal Investigator
- Principal Investigator
  
  岩川弘宙
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Rikkyo University
  The University of Tokyo
Analysis of the molecular mechanisms of RNA-directed DNA methylationPrincipal Investigator
- Principal Investigator
  
  Iwakawa Hiro-oki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Elucidation of the inter-modular communication in the secondary siRNA biogenesis in plantsPrincipal Investigator
- Principal Investigator
  
  Iwakawa Hiro-oki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Analysis of novel functions of nascent-chain in quality controls of mRNA and protein
- Principal Investigator
  
  Inada Toshifumi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Mechanism of miRNA-mediated translational repression in plantsPrincipal Investigator
- Principal Investigator
  
  IWAKAWA Hiro-oki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2022 2019 2018 2017 2016 2014 2013 Other

All Journal Article Presentation Book

[Book] Plant Argonaute Proteins: Methods and Protocols: In Vitro Analysis of ARGONAUTE-Mediated Target Cleavage and Translational Repression in Plants2017
- Author(s)
  Tomari Y, Iwakawa HO* Editor Carbonell, Alberto
- Total Pages
  297
- Publisher
  Springer
- ISBN
  9781493971640
- Data Source
  KAKENHI-PROJECT-15K14444
[Journal Article] Life of RISC: Formation, action, and degradation of RNA-induced silencing complex2022
- Author(s)
  Iwakawa Hiro-oki、Tomari Yukihide
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 1 Pages: 30-43
- DOI
  10.1016/j.molcel.2021.11.026
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21H05278, KAKENHI-PUBLICLY-21H05717, KAKENHI-PROJECT-18H05271
[Journal Article] In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR62018
- Author(s)
  Kyungmin Baeg, Yukihide Tomari, Hiro-oki Iwakawa
- Journal Title
  
  Bio-protocol
  
  Volume: 8 Issue: 1
- DOI
  10.21769/bioprotoc.2673
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J07290, KAKENHI-PROJECT-15K14444, KAKENHI-PROJECT-16H06159
[Journal Article] ilencing messages in a unique way2017
- Author(s)
  Hiro-oki Iwakawa and Yukihide Tomari,
- Journal Title
  
  Nature Plants,
  
  Volume: 3 Issue: 10 Pages: 769-770
- DOI
  10.1038/s41477-017-0028-2
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-15K14444, KAKENHI-PLANNED-26113007, KAKENHI-PROJECT-16H06159
[Journal Article] Requirement for eukaryotic translation initiation factors in cap-independent translation differs between bipartite genomic RNAs of red clover necrotic mosaic virus.2017
- Author(s)
  Tajima Y, Iwakawa HO, Hyodo K, Kaido M, Mise K, Okuno T.
- Journal Title
  
  Virology
  
  Volume: 509 Pages: 152-158
- DOI
  10.1016/j.virol.2017.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15229, KAKENHI-PUBLICLY-17H05818, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-15H04456, KAKENHI-PROJECT-16H04881, KAKENHI-PROJECT-16H04882
[Journal Article] Biochemical and single-molecule analyses of the RNA silencing suppressing activity of CrPV-1A.2017
- Author(s)
  Watanabe M, Iwakawa HO, Tadakuma H, Tomari Y.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45(18) Issue: 18 Pages: 10837-10844
- DOI
  10.1093/nar/gkx748
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-26113001, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-15K14444, KAKENHI-PLANNED-26113007, KAKENHI-PROJECT-16KT0068
[Journal Article] In Vitro Analysis of ARGONAUTE-Mediated Target Cleavage and Translational Repression in Plants2017
- Author(s)
  Tomari Yukihide、Iwakawa Hiro-oki
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1640 Pages: 55-71
- DOI
  10.1007/978-1-4939-7165-7_4
- ISBN
  9781493971640, 9781493971657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06159
[Journal Article] The poly(A) tail blocks RDR6 from converting self mRNAs into substrates for gene silencing.2017
- Author(s)
  Baeg K, *Iwakawa HO, *Tomari Y.
- Journal Title
  
  Nature Plants
  
  Volume: 3 Issue: 4 Pages: 17036-17036
- DOI
  10.1038/nplants.2017.36
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26113007, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-16J07290, KAKENHI-PROJECT-15K14444, KAKENHI-PROJECT-16H06159, KAKENHI-ORGANIZER-26113001
[Journal Article] 植物のRNAサイレンシング機構が自己のmRNAを攻撃しないメカニズム2017
- Author(s)
  岩川　弘宙
- Journal Title
  
  BSJ-Review
  
  Volume: 8 Issue: B Pages: 58-70
- DOI
  10.24480/bsj-review.8b4.00114
- ISSN
  2432-9819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14444, KAKENHI-PROJECT-16H06159
[Journal Article] MicroRNAs block assembly of eIF4F translation initiation complex in Drosophila2014
- Author(s)
  #Takashi Fukaya, #Hiro-oki Iwakawa, *Yukihide Tomari, (#同等貢献)
- Journal Title
  
  Molecular Cell
  
  Volume: 56 Issue: 1 Pages: 67-78
- DOI
  10.1016/j.molcel.2014.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25891006, KAKENHI-PLANNED-26116003, KAKENHI-ORGANIZER-26113001, KAKENHI-PLANNED-26113007
[Journal Article] Molecular Insights into microRNA-Mediated Translational Repression in Plants.2013
- Author(s)
  Iwakawa HO, *Tomari Y.
- Journal Title
  
  Mol Cell.
  
  Volume: 52(4) Issue: 4 Pages: 591-601
- DOI
  10.1016/j.molcel.2013.10.033
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115002, KAKENHI-PROJECT-25891006
[Journal Article] Arabidopsis ARGONAUTE7 selects miR390 through multiple checkpoints during RISC assembly.2013
- Author(s)
  Endo Y, *Iwakawa HO, *Tomari Y.
- Journal Title
  
  EMBO Rep.
  
  Volume: 14(7) Issue: 7 Pages: 652-658
- DOI
  10.1038/embor.2013.73
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115002, KAKENHI-PROJECT-25891006
[Presentation] 小分子RNA依存的なリボソーム停滞部位の網羅的解析2022
- Author(s)
  古和田凌佑、泊幸秀、岩崎信太郎、岩川弘宙
- Organizer
  第10回植物RNA研究ネットワークシンポジウム
- Data Source
  KAKENHI-PUBLICLY-21H05717
[Presentation] 植物の二次的小分子 RNA が作られるしくみ2022
- Author(s)
  岩川弘宙
- Organizer
  第63回日本植物生理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H05717
[Presentation] In vitro recapitulation of the secondary siRNA biogenesis in plants2019
- Author(s)
  Kyungmin Baeg, Yuriki Sakurai, Andy Lam, Keisuke Shoji, Manabu Yoshikawa, Yukihide Tomari, Hiro-oki Iwakawa
- Organizer
  POST-TRANSCRIPTIONAL GENE REGULATION IN PLANTS (PGRP) 2019 Nara
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] In vitro recapitulation of the secondary siRNA biogenesis in plants2019
- Author(s)
  Hiro-oki Iwakawa, Kyungmin Baeg, Yuriki Sakurai, Manabu Yoshikawa, Yukihide Tomari
- Organizer
  第20回武田科学振興財団生命科学シンポジウム RNAネオバイオロジー
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] The PIWI domain of RdDM Argonautes in plants plays a critical role for sensing the identity of the 5′-base of small RNAs2019
- Author(s)
  Wei Liu, Yukihide Tomari, Hiro-oki Iwakawa
- Organizer
  POST-TRANSCRIPTIONAL GENE REGULATION IN PLANTS (PGRP) 2019 Nara
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] 植物における二次的小分子RNA生成の試験管内再現2018
- Author(s)
  Baeg Kyungmin、櫻井友理希、吉川学、泊幸秀、岩川弘宙
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] In vitro analysis of small RNA preference of ARGONAUTE 4 in Arabidopsis thaliana2018
- Author(s)
  Wei Liu, Yukihide Tomari, Hiro-oki Iwakawa
- Organizer
  第59回日本植物生理学会年会
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] 植物のRNAサイレンシング機構2018
- Author(s)
  岩川弘宙
- Organizer
  第53回植物感染生理談話会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] 非自己核酸と防御2017
- Author(s)
  岩川　弘宙
- Organizer
  分生研シンポジウム「生命科学の若手フロンティア」
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] The poly(A) tail blocks RDR6 from converting self mRNAs into the substrates for gene silencing2017
- Author(s)
  Baeg K, Iwakawa HO, Tomari Y
- Organizer
  12th Microsymposium on small RNA biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] Plant ARGONAUTE4 family proteins prefer to bind to DNA targets in vitro2017
- Author(s)
  Iwakawa HO, Tomari Y
- Organizer
  12th Microsymposium on small RNA biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] Plant ARGONAUTE4 family proteins prefer to bind to DNA targets in vitro2017
- Author(s)
  Iwakawa HO, Tomari Y
- Organizer
  The 22nd Annual Meeting of the RNA Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] The poly(A) tail blocks RDR6 from converting self mRNAs into the substrates for gene silencing2017
- Author(s)
  Kyungmin Baeg, Hiro-oki Iwakawa, Yukihide Tomari
- Organizer
  12th Microsymposium on small RNA biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] The poly(A) tail blocks RDR6 from converting self mRNAs into the substrates for gene silencing2017
- Author(s)
  Baeg K, Iwakawa HO, Tomari Y
- Organizer
  The 22nd Annual Meeting of the RNA Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] 生化学で迫る植物の RNA サイレンシング2016
- Author(s)
  岩川　弘宙
- Organizer
  日本植物学会　第80回大会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Invited
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] The substrate specificity of RNA DEPENDENT RNA POLYMERASE 62016
- Author(s)
  Kyungmin Baeg, Hiro-oki Iwakawa, Yukihide Tomari
- Organizer
  Keystone Symposia Small RNA Silencing Meeting
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2016-01-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] RNA依存性RNAポリメラーゼ6の鋳型特異性2016
- Author(s)
  Kyungmin Baeg, 岩川弘宙, 泊幸秀
- Organizer
  平成28年度日本植物病理学会大会
- Place of Presentation
  岡山コンベンションセンター (岡山県・岡山市)
- Year and Date
  2016-03-21
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] 植物のRNAサイレンシング機構2016
- Author(s)
  岩川　弘宙
- Organizer
  第39回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] Plant ARGONAUTE4 family proteins prefer to bind to DNA targets in vitro2016
- Author(s)
  Hiro-oki Iwakawa, Yukihide Tomari
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] 植物のRNAサイレンシング機構2016
- Author(s)
  岩川　弘宙
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Invited
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] The substrate specificity of RNA DEPENDENT RNA POLYMERASE 62016
- Author(s)
  Kyungmin Baeg, Hiro-oki Iwakawa, Yukihide Tomari
- Organizer
  第5回植物RNA研究ネットワークシンポジウム
- Place of Presentation
  東京大学駒場キャンパス 21 KOMCEE (東京都・目黒区)
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-15K14444
[Presentation] 生化学で迫る植物の RNA サイレンシング2016
- Author(s)
  岩川　弘宙
- Organizer
  日本植物学会第80回大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06159
[Presentation] 植物におけるmicroRNAを介した翻訳抑制機構
- Author(s)
  岩川弘宙, 泊幸秀
- Organizer
  RNAフロンティアミーティング 2014
- Place of Presentation
  和歌山
- Year and Date
  2014-09-16 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-25891006
[Presentation] 植物microRNAによる翻訳抑制機構
- Author(s)
  岩川弘宙, 泊幸秀
- Organizer
  第16回 RNA学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25891006
[Presentation] The mechanistic bases for microRNA-mediated translational repression in plants
- Author(s)
  岩川弘宙, 泊幸秀
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11 – 2013-09-13
- Data Source
  KAKENHI-PROJECT-25891006

1. 吉川学 (80391564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Inada Toshifumi (40242812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Tadakuma Hisashi (10339707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 長尾翌手可 (30588017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 韓龍雲 (50566297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 向原隆文 (80344406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 竹田篤史 (60560779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Tsuboyama Kotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Kyungmin Baeg

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. TOMARI Yukihide

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
11. BAEG KYUNGMIN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 兵頭究

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IWAKAWA HIROOKI 岩川 弘宙

IWAKAWA Hiro-oki 岩川 弘宙

Research Projects

Research Products

Co-Researchers

The role of liquid-liquid phase separation in the mechanism of small RNA amplificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular analyses of RNA silencing inhibition by suppressors from plant pathogens

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ウイルス抵抗性研究の高度化に資するゲノム編集タバコプラットフォーム確立への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小分子RNA依存的リボソーム停滞機構の統合的理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the molecular mechanisms of RNA-directed DNA methylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the inter-modular communication in the secondary siRNA biogenesis in plantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of novel functions of nascent-chain in quality controls of mRNA and protein

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of miRNA-mediated translational repression in plantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Plant Argonaute Proteins: Methods and Protocols: In Vitro Analysis of ARGONAUTE-Mediated Target Cleavage and Translational Repression in Plants2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Life of RISC: Formation, action, and degradation of RNA-induced silencing complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR62018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ilencing messages in a unique way2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Requirement for eukaryotic translation initiation factors in cap-independent translation differs between bipartite genomic RNAs of red clover necrotic mosaic virus.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical and single-molecule analyses of the RNA silencing suppressing activity of CrPV-1A.2017

IWAKAWA HIROOKI 岩川弘宙

IWAKAWA Hiro-oki 岩川弘宙