Okuyama Kazuki 奥山一生

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OKUYAMA Kazuki 奥山一生

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Researcher Number	60712750
Other IDs	https://orcid.org/0000-0002-0262-9326
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2015: 東海大学, 医学部, 客員准教授 2014: 東海大学, 医学部, 奨励研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 49030:Experimental pathology-related / Tumor therapeutics
Keywords	Principal Investigator 転写制御 / 血液細胞分化 / タンパク質間相互作用 / BioID法 / 分子間相互作用解析 / Runx転写因子 / 原発性免疫不全症 / ヒト原発性免疫不全症 / T細胞初期分化 / Bcl11b … More / T細胞分化 / 先天性免疫異常症 / B細胞分化 / T細胞性リンパ芽球性白血病 / Notch / miRNA / Notch1 / T-ALL Less

Interactomics of Runx family proteinsPrincipal Investigator
- Principal Investigator
  
  奥山一生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Institute of Physical and Chemical Research
Investigation of the impact of BCL11B p.N441K mutation on inborn errors of immunityPrincipal Investigator
- Principal Investigator
  
  Okuyama Kazuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Institute of Physical and Chemical Research
Investigation of miRNA targeting Notch1Principal Investigator
- Principal Investigator
  
  OKUYAMA Kazuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokai University

All 2023 2022 2021 2020 2015 2014

All Journal Article Presentation

[Journal Article] The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells2023
- Author(s)
  Okuyama Kazuki、Nomura Aneela、Nishino Kohei、Tanaka Hirokazu、Harly Christelle、Chihara Risa、Harada Yasuyo、Muroi Sawako、Kubo Masato、Kosako Hidetaka、Taniuchi Ichiro
- Journal Title
  
  The Journal of Immunology
  
  Volume: - Issue: 11 Pages: 1728-1739
- DOI
  10.4049/jimmunol.2200101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07459, KAKENHI-PLANNED-19H05747
[Journal Article] Three residues in the BTB domain promote a good partnership between NuRD and Thpok2022
- Author(s)
  Okuyama Kazuki、Taniuchi Ichiro
- Journal Title
  
  Science Immunology
  
  Volume: 7 Issue: 72
- DOI
  10.1126/sciimmunol.abq1408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07459, KAKENHI-PLANNED-19H05747
[Journal Article] A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS2021
- Author(s)
  Yamashita Motoi、Kuehn Hye Sun、Okuyama Kazuki、Okada Satoshi、Inoue Yuzaburo、Takagi Masatoshi、Kanegane Hirokazu、Takeuchi Masahiro、Shimojo Naoki、Tsumura Miyuki、Padhi Aditya K.、Zhang Kam Y. J.、Boisson Bertrand、Casanova Jean-Laurent、Ohara Osamu、Rosenzweig Sergio D.、Taniuchi Ichiro、Morio Tomohiro
- Journal Title
  
  Nature Immunology
  
  Volume: 22 Issue: 7 Pages: 893-903
- DOI
  10.1038/s41590-021-00951-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05747, KAKENHI-PROJECT-19H03614, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-21H02879, KAKENHI-PROJECT-20K07459, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K16884
[Journal Article] T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients2021
- Author(s)
  Kuehn Hye Sun、Chang Jingjie、Yamashita Motoi、Niemela Julie E.、Zou Chengcheng、Okuyama Kazuki、Harada Junji、Stoddard Jennifer L.、Nunes-Santos Cristiane J.、Boast Brigette、Baxter Ryan M.、Hsieh Elena W.Y.、Garofalo Mary、Fleisher Thomas A.、Morio Tomohiro、Taniuchi Ichiro、Dutmer Cullen M.、Rosenzweig Sergio D.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218 Issue: 12
- DOI
  10.1084/jem.20211118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05747, KAKENHI-PROJECT-21H02879, KAKENHI-PROJECT-20K07459, KAKENHI-PROJECT-20K16884
[Journal Article] EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene.2021
- Author(s)
  Somasundaram Rajesh、Jensen Christina T、Tingvall-Gustafsson Johanna、Ahsberg Josefine、Okuyama Kazuki、Prasad Mahadesh、Hagman James、Wang Xun、Soneji Shamit、Strid Tobias、Ungerback Jonas、Sigvardsson Mikael
- Journal Title
  
  Blood
  
  Volume: 10(1) Issue: 22 Pages: 3037-3049
- DOI
  10.1182/blood.2020009564
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07459
[Journal Article] B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors2021
- Author(s)
  T. Strid, K. Okuyama, J. Tingvall-Gustafsson, J. Kuruvilla, C. Jensen, S. Lang, M. Prasad, R. Somasundaram, J. Ahsberg, S. Cristobal, S. Soneji, J Ungerback, and M. Sigvardsson
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 11 Pages: 2700-2713
- DOI
  10.4049/jimmunol.2100048
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07459
[Journal Article] PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma2020
- Author(s)
  Kawashima M, Carreras J, Higuchi H, Kotaki R, Hoshina T, Okuyama K, Suzuki N, Kakizaki M, Miyatake Y, Ando K, Nakayama M, Umezu S, Horie R, Higuchi Y, Katagiri K, Goyama S, Kitamura T, Chamoto K, Yano S,Nakamura N, and A Kotani
- Journal Title
  
  Leukemia
  
  Volume: - Issue: 9 Pages: 2405-2417
- DOI
  10.1038/s41375-020-0737-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-17H04212, KAKENHI-PROJECT-19H03880, KAKENHI-PROJECT-18K15100, KAKENHI-PROJECT-18K15131, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K07459, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716
[Journal Article] Overexpression of miR-669m inhibits erythroblast differentiation2020
- Author(s)
  Kotaki R., et.al. Kawashima M, Yamaguchi A, Suzuki N, Koyama-Nasu R, Ogiya D, Okuyama K, Yamamoto Y, Takamatsu M, Kurosaki N, Ando K, Murata A, Ohtsuka M, Nakagawa S, Katagiri K, Kotani A.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 13554-13554
- DOI
  10.1038/s41598-020-70442-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-20K07459, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716, KAKENHI-PROJECT-18K08297
[Journal Article] 白血病細胞の分化誘導と非コードRNA miR-1262015
- Author(s)
  奥山一生、幸谷愛
- Journal Title
  
  感染　免疫　炎症
  
  Volume: 45(2) Pages: 68-68
- Data Source
  KAKENHI-PROJECT-26830115
[Journal Article] マイクロRNAによる血液細胞分化制御2014
- Author(s)
  奥山一生, 幸谷愛
- Journal Title
  
  血液内科
  
  Volume: 68 Pages: 725-729
- Data Source
  KAKENHI-PROJECT-26830115
[Journal Article] An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules.2014
- Author(s)
  Akihiko Murata, Miya Yoshino, Mari Hikosaka, Kazuki Okuyama, Lan Zhou, Seiji Sakano, Hideo Yagita, Shin-Ichi Hayashi
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 9 Pages: e108535-e108535
- DOI
  10.1371/journal.pone.0108535
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860295, KAKENHI-PROJECT-26460488, KAKENHI-PROJECT-26830115
[Journal Article] Small RNA as a regulator of hematopoietic development, immune response in infection and tumorigenesis2014
- Author(s)
  Okuyama K, Ogata J, Yamakawa N, Chanda B, Kotani A.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 99 Issue: 5 Pages: 553-60
- DOI
  10.1007/s12185-014-1564-4
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118726, KAKENHI-PROJECT-25640070, KAKENHI-PROJECT-26830115
[Journal Article] Novel functional small RNAs are selectively loaded onto mammalian Ago12014
- Author(s)
  Yamakawa, N. Okuyama, K. Ogata, J. Kanai, A. Helwak, A. Takamatsu, M. Imadome, K. I. Takakura, K. Chanda, B. Kurosaki, N. Yamamoto, H. Ando, K. Matsui, H. Inaba, T. Kotani, A.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 未確定 Issue: 8 Pages: 5289-5301
- DOI
  10.1093/nar/gku137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PUBLICLY-25118726, KAKENHI-PROJECT-25640070, KAKENHI-PROJECT-26830115
[Presentation] マウス生体内AirID法の樹立と応用2023
- Author(s)
  奥山一生、谷内一郎
- Organizer
  第46回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07823
[Presentation] Interference of Bcl11a-Bcl11b heterodimer function by BCL11B p.N441K mutation during neurogenesis and thymopoiesis2022
- Author(s)
  K. Okuyama, M. Yamashita, H. Yoshida, and I. Taniuchi
- Organizer
  The 51st Annual Meeting of the Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-20K07459
[Presentation] A de novo missense mutation of Bcl11b gene causes an abnormal thymopoiesis2021
- Author(s)
  Kazuki Okuyama, Motoi Yamashita, Kazuaki Matsumoto, Michiko Ohno-Oishi, Satoshi Kojo, Tomohiro Morio, Hideyuki Yoshida, Ichiro Taniuchi
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K07459
[Presentation] 亜鉛フィンガー転写因子Bcl11bによる遺伝子発現制御とクロマチン再構成2021
- Author(s)
  奥山一生
- Organizer
  霊長類医科学フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07459
[Presentation] Identification of Notch-targeting miRNA that regulates B cell development and has therapeutic potential in T-ALL2015
- Author(s)
  那須亮、奥山一生、扇屋大輔、穂積勝人、村田暁彦、安藤潔、幸谷愛
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830115
[Presentation] 血液腫瘍におけるMicroRNA2014
- Author(s)
  奥山一生, 幸谷愛
- Organizer
  総合医学研究所・糖鎖科学研究所・創造科学技術研究機構第6回公開合同シンポジウム
- Place of Presentation
  神奈川　日本
- Year and Date
  2014-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-26830115
[Presentation] MicroRNAライブラリーを用いたNotch受容体標的MicroRNAの探索2014
- Author(s)
  奥山一生, 黒﨑なつみ, 水谷隆之, 大庭成喜, 恵口豊, 幸谷愛
- Organizer
  第6回日本RNAi研究会
- Place of Presentation
  広島　日本
- Year and Date
  2014-08-29
- Data Source
  KAKENHI-PROJECT-26830115
[Presentation] MicroRNA-126による転写因子非依存的？なB細胞運命決定制御機構2014
- Author(s)
  奥山一生
- Organizer
  第10回麒麟塾
- Place of Presentation
  東京　日本
- Year and Date
  2014-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-26830115
[Presentation] EBF deficient hematopoietic progenitor cells potentially differentiated into immature B cell: EBF1 dispensable for B cell lineage commitment from pro-B to pre-B stage2014
- Author(s)
  B. Chanda, T. Ikawa, K. Okuyama, K. Hozumi, K. Ando, A. Tojo, H. Kawamoto, A. Kotani
- Organizer
  56th ASH Annual Meeting
- Place of Presentation
  CA USA
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-26830115
[Presentation] Functional and comprehensive investigation of microRNA targeting Notch receptors2014
- Author(s)
  K. Okuyama, K. Hozumi, A. Murata, K. Ando, A. Kotani
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  京都　日本
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-26830115
[Presentation] The critical interaction between Epstein-Barr virus positive B-cells and tumor associated macrophages2014
- Author(s)
  A. Sato, N. Yamakawa, K. Okuyama, A. Kotani, N. Nakamura, K. Ando
- Organizer
  56th ASH Annual Meeting
- Place of Presentation
  CA USA
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-26830115

1. 片桐晃子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 村田暁彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 谷内一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 幸谷愛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuyama Kazuki 奥山 一生

OKUYAMA Kazuki 奥山 一生

Research Projects

Research Products

Co-Researchers

Interactomics of Runx family proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the impact of BCL11B p.N441K mutation on inborn errors of immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of miRNA targeting Notch1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three residues in the BTB domain promote a good partnership between NuRD and Thpok2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of miR-669m inhibits erythroblast differentiation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 白血病細胞の分化誘導と非コードRNA miR-1262015

Author(s)

Journal Title

Data Source

[Journal Article] マイクロRNAによる血液細胞分化制御2014

Author(s)

Journal Title

Data Source

[Journal Article] An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small RNA as a regulator of hematopoietic development, immune response in infection and tumorigenesis2014

Author(s)

Journal Title

DOI

Okuyama Kazuki 奥山一生

OKUYAMA Kazuki 奥山一生