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IKUO Mariko  幾尾 真理子

ORCIDConnect your ORCID iD *help
Researcher Number 60713401
Other IDs
Affiliation (based on the past Project Information) *help 2019 – 2020: 広島大学, 医系科学研究科(薬), 助教
2018: 広島大学, 医歯薬保健学研究科(薬), 助教
2016: 徳島大学, 大学院医歯薬学研究部(薬学系), 特任助教
2015: 徳島大学, 大学院医歯薬学研究部, 特任助教
2014: 徳島大学, ヘルスバイオサイエンス研究部, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Biological pharmacy
Except Principal Investigator
Applied pharmacology
Keywords
Principal Investigator
BMP / Smad / エクソソーム / Extracellualr vesicle / 細胞外小胞 / 骨芽前駆細胞 / 骨分化 / 多発性骨髄腫 / Extracellular vesicles / 糖鎖 … More / 免疫 / 炎症 / 中枢神経疾患 / GM2蓄積症 / マクロファージ / ミクログリア / レクチン / リソソーム病 … More
Except Principal Investigator
ダイいレクトリプログラミング / トラフィキング / トラフィッキング / 蛍光イメージング / リソソーム病 / induced Neuron (iN細胞) / 疾患iPS細胞 / ダイレクトリプログラミング Less
  • Research Projects

    (3 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (3 People)
  •  多発性骨髄腫が分泌するエクソソームによる骨分化抑制機構の解明Principal Investigator

    • Principal Investigator
      幾尾 真理子
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Hiroshima University
  •  Establishment of induced neurons (iN cells) derived from lysosomal disease patients involving neurological symptoms and elucidation of regulatory mechanism of neurodegeneration

    • Principal Investigator
      ITOH Kohji
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      The University of Tokushima
  •  Comprehensive analysis of the pathogenic mechanism of GM2 gangliosidoses involving neurological symptoms by focusing on transcriptomes including ncRNAPrincipal Investigator

    • Principal Investigator
      IKUO Mariko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokushima

All 2019 2018 2016 2015 Other

All Journal Article Presentation Book

  • [Book] 臨床免疫・アレルギー科 Vol.72, No.1 特集II エクソソーム 細胞外小胞(エクソソーム)と細胞老化2019

    • Author(s)
      幾尾真理子、田原栄俊
    • Total Pages
      132
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-18K15213
  • [Journal Article] The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.2015

    • Author(s)
      Ling H, Pickard K, Ivan C, Isella C, Ikuo M, et al.
    • Journal Title

      Gut

      Volume: - Issue: 6 Pages: 1-13

    • DOI

      10.1136/gutjnl-2015-309372

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860037
  • [Presentation] 骨芽前駆細胞の骨分化経路BMP/Smadは、核内DNA結合Smadを標的とする多発性骨髄腫由来分泌小胞exosomeによって抑制される2018

    • Author(s)
      幾尾 真理子, 杉崎 圭, 寺町 順平, 田原 栄俊, 安倍 正博, 伊藤 孝司
    • Organizer
      第91回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K15213
  • [Presentation] The relationship between human aging and advanced glycation end products of extracellular vesicles in serum.2018

    • Author(s)
      韓 佳延,西山 有希,矢野 公義,幾尾 真理子,田原 栄俊
    • Organizer
      2018 JARI/JSEV
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15213
  • [Presentation] Extracellular vesicles derived from senescent cells repress tumor growth via miRNAs2018

    • Author(s)
      Mariko Ikuo, Megumi Okada, Shigeyuki Teranishi, Masaki Kinehara, Akira Shimamoto, and Hidetoshi Tahara
    • Organizer
      International Society for Extracellular Vesicles 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15213
  • [Presentation] 多発性骨髄腫によるExosome を介した骨分化抑制機構の発見と解析2016

    • Author(s)
      幾尾真理子、杉崎圭、伊藤孝司
    • Organizer
      The 8th JARI Annual Meeting/The 3rd JSDV Annual Meeting (日) 第8回日本RNAi研究会/3回日本細胞外小胞学会JSEV
    • Place of Presentation
      グランドプリンスホテル広島、広島県広島市
    • Year and Date
      2016-08-31
    • Data Source
      KAKENHI-PROJECT-26860037
  • [Presentation] 多発性骨髄腫が分泌する小胞exosomeは、骨芽前駆細胞において骨形成因子Bone Morphogenetic Protein 2が誘導する転写因子Smadによる転写活性化を阻害し、骨分化を抑制する2016

    • Author(s)
      幾尾真理子、杉崎圭、伊藤孝司
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター・東北大学川内北キャンパス、宮城県仙台市
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26860037
  • [Presentation] ザンドホッフ病モデルマウスの脳における補体経路活性化レクチンの異常発現2015

    • Author(s)
      幾尾 真理子
    • Organizer
      骨とCaクラスター ミニリトリート
    • Place of Presentation
      徳島大学 (徳島県徳島市)
    • Year and Date
      2015-01-25
    • Data Source
      KAKENHI-PROJECT-26860037
  • [Presentation] Development of protease-resistant modified human β-hexosaminidase B and evaluation of intracerebroventricular replacement effects on GM2 gangliosidosis model mice.2015

    • Author(s)
      Kitakaze, K., Tasaki, C., Mizutani,Y. Sugiyama, E., Ikuo, M., Kamiya, M., Setou, M., Urano, Y. and Itoh, K.
    • Organizer
      The 11th Annual World Symposium
    • Place of Presentation
      Hyatt Regency Orlando(USA,Orlando)
    • Year and Date
      2015-02-10
    • Data Source
      KAKENHI-PROJECT-26670269
  • [Presentation] 多発性骨髄腫由来エキソソームによる骨芽前駆細胞の分化抑制2015

    • Author(s)
      杉﨑 圭, 幾尾 真理子, 安倍 正博, 伊藤 孝司
    • Organizer
      第56回日本生化学会 中国四国支部例会
    • Place of Presentation
      島根県松江市(島根大学大学会館)
    • Year and Date
      2015-05-29
    • Data Source
      KAKENHI-PROJECT-26670269
  • [Presentation] Development of protease-resisitant modified human beta-hexosaminidase B and evaluation of intracerebroventricular replacement effects on GM2 gangliosidosis model mice.,

    • Author(s)
      Kitakaze Keisuke, Tasaki Chikako, Mizutani Yasumichi, Sugiyama Eiji, Mariko Ikuo, kamiya Mako, Setou Mitsutoshi, Urano Yasuteru and Kouji Itou
    • Organizer
      The 11th Annual World Symposium
    • Place of Presentation
      Hyatt Regency Orlando (Orlando, FL, USA)
    • Year and Date
      2015-02-09 – 2015-02-13
    • Data Source
      KAKENHI-PROJECT-26860037
  • 1.  ITOH Kohji (00184656)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  TSUJI Daisuke (00423400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  URANO Yasuteru (20292956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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