sanada takahiro 真田崇弘

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SANADA Takahiro 真田崇弘

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Researcher Number	60721272
Other IDs	https://orcid.org/0000-0002-6362-7762
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 感染症医学研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員 2017 – 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology
Keywords	Principal Investigator B型肝炎ウイルス / ウイルス / HBV / 感染 / HBs抗原 / 粘膜免疫 / 経鼻接種 / 経鼻免疫 / HBs-L / ワクチン / B型肝炎 / エキソソーム

HBs抗原によるHBV感染増強機構の解明Principal Investigator
- Principal Investigator
  
  真田崇弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of HBs-L based vaccine against Hepatitis B virusPrincipal Investigator
- Principal Investigator
  
  SANADA Takahiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Characterization of HBV infection mediated by extracellular vesiclesPrincipal Investigator
- Principal Investigator
  
  SANADA Takahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Intranasal HBsAg/HBcAg-Containing Vaccine Induces Neutralizing Anti-HBs Production in Hepatitis B Vaccine Non-Responders2023
- Author(s)
  Shiraishi Kana、Yoshida Osamu、Imai Yusuke、Akbar Sheikh、Sanada Takahiro、Kohara Michinori、Miyazaki Takashi、Kamishita Taizou、Miyake Teruki、Hirooka Masashi、Tokumoto Yoshio、Abe Masanori、Rubido Julio、Nieto Gerardo、Hiasa Yoichi
- Journal Title
  
  Vaccines
  
  Volume: 11 Issue: 9 Pages: 1479-1479
- DOI
  10.3390/vaccines11091479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07096
[Journal Article] Hybrid large hepatitis B surface protein composed of two viral genotypes C and D induces strongly cross-neutralizing antibodies2023
- Author(s)
  Sanada Takahiro、Oda Yasunori、Ohashi Chinatsu、Isotani Kentaro、Goh Yasumasa、Kohara Michinori
- Journal Title
  
  Vaccine
  
  Volume: 41 Issue: 43 Pages: 6514-6521
- DOI
  10.1016/j.vaccine.2023.09.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07096
[Journal Article] Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18?months follow‐up results of phase IIa clinical study2022
- Author(s)
  Yoshida Osamu、Akbar Sheikh Mohammad Fazle、Imai Yusuke、Sanada Takahiro、Tsukiyama‐Kohara Kyoko、Miyazaki Takashi、Kamishita Taizou、Miyake Teruki、Tokumoto Yoshio、Hikita Hayato、Tsuge Masataka、Shimizu Masahito、Al Mahtab Mamun、Aguilar Julio Cesar、Guillen Gerardo、Kohara Michinori、Hiasa Yoichi
- Journal Title
  
  Hepatology Research
  
  Volume: 53 Issue: 3 Pages: 196-207
- DOI
  10.1111/hepr.13851
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07983, KAKENHI-PROJECT-21K08006, KAKENHI-PROJECT-22K07096, KAKENHI-PROJECT-19K16680
[Journal Article] HBs-S antigen-dependent enhancement of HBV infection2022
- Author(s)
  Sanada Takahiro、Yoshida Osamu、Hiasa Yoichi、Kohara Michinori
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.06.07.495222
- Open Access
- Data Source
  KAKENHI-PROJECT-22K07096, KAKENHI-PROJECT-19K16680
[Journal Article] Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model2022
- Author(s)
  Kayesh Mohammad Enamul Hoque、Hashem Md Abul、Sanada Takahiro、Kitab Bouchra、Rashid Md Haroon Or、Akter Lipi、Ezzikouri Sayeh、Murakami Shuko、Ogawa Shintaro、Tanaka Yasuhito、Kohara Michinori、Tsukiyama-Kohara Kyoko
- Journal Title
  
  Frontiers in Virology
  
  Volume: 2
- DOI
  10.3389/fviro.2022.926831
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07096, KAKENHI-PROJECT-19K16680
[Journal Article] Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies.2021
- Author(s)
  Honda T, Gomi S, Yamane D, Yasui F, Yamamoto T, Munakata T, Itoh Y, Ogasawara K, Sanada T, Yamaji K, Yasutomi Y, Tsukiyama-Kohara K, Kohara M.
- Journal Title
  
  mSphere
  
  Volume: 12 Issue: 3
- DOI
  10.1128/msphere.01342-20
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03164, KAKENHI-PROJECT-20K07531, KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-23K21382
[Journal Article] Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview2021
- Author(s)
  Kayesh Mohammad Enamul Hoque、Sanada Takahiro、Kohara Michinori、Tsukiyama-Kohara Kyoko
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 8 Pages: 1641-1641
- DOI
  10.3390/v13081641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16680
[Journal Article] Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew)2020
- Author(s)
  Chi Hai-Ying, Yuuki Tanaka, Tatsuro Hifumi, Ko-ichiro Shoji, Mohammad Enamu Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara
- Journal Title
  
  PLoS One
  
  Volume: 15(5) Issue: 5 Pages: e0233232-e0233232
- DOI
  10.1371/journal.pone.0233232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19277, KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-16H02587, KAKENHI-PROJECT-20H03164
[Journal Article] Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri)2019
- Author(s)
  Takahiro Sanada, Fumihiko Yasui, Tomoko Honda, Mohammad Enamul Hoque Kayesh, Jun-ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Kyoko Tsukiyama-Kohara, and Michinori Kohara
- Journal Title
  
  Virology
  
  Volume: 529 Pages: 101-110
- DOI
  10.1016/j.virol.2019.01.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19277, KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-17H04079
[Journal Article] Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response2019
- Author(s)
  Sanada Takahiro、Yamamoto Naoki、Kayesh Mohammad Enamul Hoque、Tsukiyama-Kohara Kyoko、Hasegawa Hideki、Miyazaki Takashi、Takano Jun-ichiro、Shiogama Yumiko、Yasutomi Yasuhiro、Goh Yasumasa、Yoshida Osamu、Hiasa Yoichi、Kohara Michinori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 520 Issue: 1 Pages: 86-92
- DOI
  10.1016/j.bbrc.2019.09.072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-17H04079
[Journal Article] Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing2019
- Author(s)
  Sanada Takahiro、Tsukiyama-Kohara Kyoko、Shin-I Tadasu、Yamamoto Naoki、Kayesh Mohammad Enamul Hoque、Yamane Daisuke、Takano Jun-ichiro、Shiogama Yumiko、Yasutomi Yasuhiro、Ikeo Kazuho、Gojobori Takashi、Mizokami Masashi、Kohara Michinori
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12372-12372
- DOI
  10.1038/s41598-019-48867-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-17H04079
[Journal Article] Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri2017
- Author(s)
  Kayesh Mohammad Enamul Hoque、Ezzikouri Sayeh、Sanada Takahiro、Chi Haiying、Hayashi Yukiko、Rebbani Khadija、Kitab Bouchra、Matsuu Aya、Miyoshi Noriaki、Hishima Tsunekazu、Kohara Michinori、Tsukiyama-Kohara Kyoko
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 9848-9848
- DOI
  10.1038/s41598-017-10329-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-15H04739
[Journal Article] Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection2017
- Author(s)
  Kayesh MEH, Kitab B, Sanada T, Hayasaka D, Morita K, Kohara M, *Tsukiyama-Kohara K.
- Journal Title
  
  Infect Genet Evol.
  
  Volume: 51 Pages: 203-210
- DOI
  10.1016/j.meegid.2017.04.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-15K14871, KAKENHI-PROJECT-15K15146, KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-16H05174
[Journal Article] Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri2017
- Author(s)
  Kayesh MEH, Ezzikouri S, Chi H, Sanada T, Yamamoto N, Kitab B, Haraguchi T, Matsuyama R, Nkogue CN, Hatai H, Miyoshi N, Murakami S, Tanaka Y, Takano JI, Shiogama Y, Yasutomi Y, Kohara M, Tsukiyama-Kohara K
- Journal Title
  
  Virus Research
  
  Volume: 237 Pages: 47-57
- DOI
  10.1016/j.virusres.2017.05.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709
[Patent] Ｂ型肝炎ウイルスの複製阻害組成物2018
- Inventor(s)
  棟方翼、小原道法、真田崇弘
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K15709
[Patent] 経鼻B型肝炎ワクチン組成物およびその製造方法2017
- Inventor(s)
  上下泰造、宮崎隆、小原道法、真田崇弘、日浅陽一、吉田理他
- Industrial Property Rights Holder
  上下泰造、宮崎隆、小原道法、真田崇弘、日浅陽一、吉田理他
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K15709
[Patent] B型肝炎ワクチン2017
- Inventor(s)
  日浅陽一、小原恭子、小原道法、真田崇弘、郷保正、織田康則
- Industrial Property Rights Holder
  日浅陽一、小原恭子、小原道法、真田崇弘、郷保正、織田康則
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] ツパイヘパシウイルスの全配列決定および性状解析2023
- Author(s)
  真田崇弘、小原道法
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07096
[Presentation] Construction of genomic and transcriptomic database of the tree shrew (Tupaia belangeri), which is a small animal model of HBV infection.2019
- Author(s)
  Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Kohara M.
- Organizer
  2019 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16680
[Presentation] Construction of genomic and transcriptomic database of the tree shrew (Tupaia belangeri), which is a small animal model of HBV infection.2019
- Author(s)
  Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Kohara M.
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] Construction of genomic and transcriptomic database of the tree shrew (Tupaia belangeri), which is a small animal model of HBV infection.2019
- Author(s)
  Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Kohara M.
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16680
[Presentation] Construction of genomic and transcriptomic database of the tree shrew (Tupaia belangeri), which is a small animal model of HBV infection.2019
- Author(s)
  Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Kohara M.
- Organizer
  2019 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] HBs-large hybrid protein vaccination via intranasal route with carboxyl vinyl polymer rapidly induced strong neutralizing antibody and anti-HBs IgA.2019
- Author(s)
  Sanada T, Kayesh MEH, Tsukiyama-Kohara K, Hasegawa H, Goh Y, Miyazaki T, Kohara M.
- Organizer
  2019 AASLD THE LIVER MEETING.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] HBs-large hybrid protein vaccination via intranasal route with carboxyl vinyl polymer rapidly induced strong neutralizing antibody and anti-HBs IgA.2019
- Author(s)
  Sanada T, Kayesh MEH, Tsukiyama-Kohara K, Hasegawa H, Goh Y, Miyazaki T, Kohara M.
- Organizer
  2019 AASLD THE LIVER MEETING.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16680
[Presentation] HBs-large protein vaccination via intranasal route with carboxyl vinyl polymer induces strong neutralizing antibody and anti-HBs IgA2018
- Author(s)
  SanadaT, Kayesh MEH, Chi H, Yamamoto N, Tsukiyama-Kohara K, Yoshida O, Hiasa Y, Hasegawa H, Sugiyama M, Mizokami M, Oda Y, Goh Y, Miyazaki T, Kamishita T, Kohara M.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] HBs-large protein vaccination via intranasal route with carboxyl vinyl polymer induces strong neutralizing antibody and anti-HBs IgA2018
- Author(s)
  SanadaT, Kayesh MEH, Chi H, Yamamoto N, Tsukiyama-Kohara K, Yoshida O, Hiasa Y, Hasegawa H, Sugiyama M, Mizokami M, Oda Y, Goh Y, Miyazaki T, Kamishita T, Kohara M.
- Organizer
  2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] Transmission of HBV genomic DNA mediated by extracellular vesicles2017
- Author(s)
  Sanada T, Hirata Y, Naito Y, Yamamoto N, Kikkawa Y, Ishida Y, Yamasaki C, Tateno C, Ochiya T, Kohara M.
- Organizer
  XVII International Congress of Virology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709
[Presentation] Transmission of HBV mediated by extracellular vesicles2017
- Author(s)
  Sanada T, Hirata Y, Naito Y, Yamamoto N, Kikkawa Y, Ishida Y, Yamasaki C, Tateno C, Ochiya T, Kohara M.
- Organizer
  2017 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15709

1. 吉田理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 小原道法

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 小原恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sanada takahiro 真田 崇弘

SANADA Takahiro 真田 崇弘

Research Projects

Research Products

Co-Researchers

HBs抗原によるHBV感染増強機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of HBs-L based vaccine against Hepatitis B virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of HBV infection mediated by extracellular vesiclesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intranasal HBsAg/HBcAg-Containing Vaccine Induces Neutralizing Anti-HBs Production in Hepatitis B Vaccine Non-Responders2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hybrid large hepatitis B surface protein composed of two viral genotypes C and D induces strongly cross-neutralizing antibodies2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18?months follow‐up results of phase IIa clinical study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HBs-S antigen-dependent enhancement of HBV infection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew)2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri)2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri2017

Author(s)

sanada takahiro 真田崇弘

SANADA Takahiro 真田崇弘