Okamoto Tsukasa 岡本師

Researcher Number	60724200
Other IDs
Affiliation (Current)	2025: 東京科学大学, 東京科学大学病院, 准教授
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 東京医科歯科大学病院, 准教授 2020 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 2019 – 2020: 東京医科歯科大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / 0803:Pathology, infection/immunology, and related fields Except Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator マウスモデル / 間質性肺炎 / 過敏性肺炎 / 炎症 / B細胞 / エクソーム解析 / 遺伝子変異 / Exome sequence / 遺伝性 / 疾患関連遺伝子 … More / 疾患感受性遺伝子 / CELSR3 / 全エクソン解析 / 家族性間質性肺炎 / 肺線維症 / 補体 / factor D / 好中球 / C3 / 補体活性化 … More Except Principal Investigator necroptosis / apoptosis / 遺伝子変異 / 線維性間質生肺炎 / RNA sequence / ネクロトーシス / サーファクタント関連遺伝子 / 網羅的エクソーム解析 / 線維性間質性肺炎 / エクソーム / テロメア / トランスクリプトーム / ネクロプトーシス / 細胞老化 / サーファクタント蛋白遺伝子 / 肺線維化 / 肺オルガノイド / iPS / トランスクリプトーム解析 / 遺伝性間質性肺炎 / 肺線維症 / 肺胞II型表皮細胞 / iPS細胞 / 細胞死 / 小胞体ストレス / エクソーム解析 / 遺伝子 / サーファクタント / 家族性間質性肺炎 Less

Elucidation of the molecular mechanism of activated B cells in the pathogenesis of hypersensitivity pneumonitis and its clinical significance.Principal Investigator
- Principal Investigator
  
  岡本師
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tokyo Medical and Dental University
Disease susceptibility genes for Japanese pulmonary fibrosis using whole exome sequencePrincipal Investigator
- Principal Investigator
  
  Okamoto Tsukasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tokyo Medical and Dental University
Identification of the gene responsible for pulmonary fibrosis, and exploration about the association between cell death and fibrosis through the disease-derived iPS cell-differentiated lung cells
- Principal Investigator
  
  Setoguchi Yasuhiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tokyo Medical and Dental University
Roles of complement system in development of hypersensitivity pneumonitisPrincipal Investigator
- Principal Investigator
  
  Okamoto Tsukasa
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Successful diagnosis of humidifier lung by individual provocation test to a responsible environment, a case report2022
- Author(s)
  Murakami T、Iijima Y、Ando T、Ejima M、Shirai Tsuyoshi、Furusawa H、Okamoto T、Tateishi T、Tamaoka M、Miyazaki Y
- Journal Title
  
  Respiratory Medicine Case Reports
  
  Volume: 37 Pages: 101639-101639
- DOI
  10.1016/j.rmcr.2022.101639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15920, KAKENHI-PROJECT-21K20895, KAKENHI-PROJECT-20K08515, KAKENHI-PROJECT-20K17211, KAKENHI-PROJECT-20H03687
[Journal Article] Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by<i>Saccharopolyspora rectivirgula</i>2022
- Author(s)
  Okamoto Tsukasa、Dobrinskikh Evgenia、Hennessy Corinne E.、Liu Naoko、Schwarz Marvin I.、Evans Christopher M.、Fontenot Andrew P.、Yang Ivana V.、Schwartz David A.
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: 323 Issue: 3 Pages: L329-L337
- DOI
  10.1152/ajplung.00061.2022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03687
[Journal Article] Role of serum surfactant protein-D as a prognostic predictor in fibrotic hypersensitivity pneumonitis.2022
- Author(s)
  Ejima M, Okamoto T, Suzuki T, Miyazaki Y
- Journal Title
  
  Respiratory investigation
  
  Volume: 60 Issue: 3 Pages: 369-378
- DOI
  10.1016/j.resinv.2021.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08515, KAKENHI-PROJECT-20H03687
[Journal Article] Alternative gene expression by TOLLIP variant is associated with lung function in chronic hypersensitivity pneumonitis.2021
- Author(s)
  Katayanagi S, Setoguchi Y, Kitagawa S, Okamoto T, Miyazaki Y
- Journal Title
  
  Chest
  
  Volume: 161 Issue: 2 Pages: 458-469
- DOI
  10.1016/j.chest.2021.08.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08515, KAKENHI-PROJECT-20H03687
[Journal Article] IL-17A-Secreting Memory γδ T Cells Play a Pivotal Role in Sensitization and Development of Hypersensitivity Pneumonitis.2021
- Author(s)
  Takashi Yamana, Tsukasa Okamoto, Masahiro Ishizuka, Satoshi Hanzawa, Masaru Ejima, Sho Shibata, Yasunari Miyazaki
- Journal Title
  
  Journal of immunology
  
  Volume: 206 Issue: 2 Pages: 355-365
- DOI
  10.4049/jimmunol.2000198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08515, KAKENHI-PROJECT-20H03687
[Journal Article] The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling2021
- Author(s)
  Gally Fabienne、Sasse Sarah K.、Kurche Jonathan S.、Gruca Margaret A.、Cardwell Jonathan H.、Okamoto Tsukasa、Chu Hong W.、Hou Xiaomeng、Poirion Olivier B.、Buchanan Justin、Preissl Sebastian、Ren Bing、Colgan Sean P.、Dowell Robin D.、Yang Ivana V.、Schwartz David A.、Gerber Anthony N.
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 2
- DOI
  10.1172/jci.insight.144294
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03687
[Journal Article] Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures2020
- Author(s)
  Furusawa Haruhiko、Cardwell Jonathan H.、Okamoto Tsukasa、Walts Avram D.、Konigsberg Iain R.、Kurche Jonathan S.、Bang Tami J.、Schwarz Marvin I.、Brown Kevin K.、Kropski Jonathan A.、Rojas Mauricio、Cool Carlyne D.、Lee Joyce S.、Wolters Paul J.、Yang Ivana V.、Schwartz David A.
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 202 Issue: 10 Pages: 1430-1444
- DOI
  10.1164/rccm.202001-0134oc
- Data Source
  KAKENHI-PROJECT-20H03687
[Presentation] TOLLIP rs5743899は慢性過敏性肺炎における肺線維化の予測因子となる可能性がある2021
- Author(s)
  片柳真司, 瀬戸口靖弘, 岡本師, 宮崎泰成
- Organizer
  日本アレルギー学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03687
[Presentation] 本邦の慢性過敏性肺炎におけるMUC5Bプロモーター多型の特徴と拘束性障害の進展の検討2021
- Author(s)
  片柳真司, 岡本師, 瀬戸口靖弘, 宮崎泰成
- Organizer
  日本肺サーファクタント・界面医学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03687

1. Setoguchi Yasuhiro (90206649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 宮崎泰成 (30396999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 後藤慎平 (50747219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIRAI Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamoto Tsukasa 岡本 師

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular mechanism of activated B cells in the pathogenesis of hypersensitivity pneumonitis and its clinical significance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Disease susceptibility genes for Japanese pulmonary fibrosis using whole exome sequencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the gene responsible for pulmonary fibrosis, and exploration about the association between cell death and fibrosis through the disease-derived iPS cell-differentiated lung cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of complement system in development of hypersensitivity pneumonitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Successful diagnosis of humidifier lung by individual provocation test to a responsible environment, a case report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by<i>Saccharopolyspora rectivirgula</i>2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of serum surfactant protein-D as a prognostic predictor in fibrotic hypersensitivity pneumonitis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alternative gene expression by TOLLIP variant is associated with lung function in chronic hypersensitivity pneumonitis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-17A-Secreting Memory γδ T Cells Play a Pivotal Role in Sensitization and Development of Hypersensitivity Pneumonitis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] TOLLIP rs5743899は慢性過敏性肺炎における肺線維化の予測因子となる可能性がある2021

Author(s)

Organizer

Data Source

[Presentation] 本邦の慢性過敏性肺炎におけるMUC5Bプロモーター多型の特徴と拘束性障害の進展の検討2021

Author(s)

Organizer

Data Source

Okamoto Tsukasa 岡本師