Nomura Wataru 野村亘

Researcher Number	60724292
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院農学系, 助教
Affiliation (based on the past Project Information) *help	2025: 信州大学, 学術研究院農学系, 助教 2021 – 2023: 京都大学, 農学研究科, 研究員 2017 – 2020: 京都大学, 農学研究科, 特定助教 2015: 京都大学, (連合)農学研究科(研究院), その他 2015: 京都大学, (連合)農学研究科(研究院), 助教 2014: 京都大学, (連合)農学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 38060:Applied molecular and cellular biology-related / Applied molecular and cellular biology / Applied health science
Keywords	Principal Investigator シグナル伝達 / Pkc1 / TORC2 / PKC / yeast / 酵母 / sphingolipid / eisosome / edelfosine / 脂肪細胞 … More / エルゴステロール / Ypk1/2 / エデルホシン / 細胞膜 / ホスファチジルセリン / Rho1 / mTORC1 / IRS-1 / インスリン抵抗性 / インスリンシグナル / メチルグリオキサール Less

Research Projects
(5 results)
Research Products
(35 results)

細胞膜動態を感知するTORC2シグナルの制御機構：２段階制御モデルの実証Principal Investigator
- Principal Investigator
  
  野村亘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Shinshu University
酵母におけるプロテインキナーゼCによるTORC2シグナルの負の制御Principal Investigator
- Principal Investigator
  
  野村亘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kyoto University
Study on the mechanism of action of plasma membrane lipids that contribute to the activation of TORC2 signalingPrincipal Investigator
- Principal Investigator
  
  NOMURA Wataru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kyoto University
Analysis of the regulation of TORC2 signaling by phosphatidylserinePrincipal Investigator
- Principal Investigator
  
  Nomura Wataru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Kyoto University
Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance developmentPrincipal Investigator
- Principal Investigator
  
  Nomura Wataru
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation Book

[Book] The Yeast Role in Medical Applications (Chapter 4; TOR signaling in budding yeast.)2018
- Author(s)
  Inoue, Y., and Nomura, W.
- Total Pages
  24
- Publisher
  InTechOpen
- Data Source
  KAKENHI-PROJECT-17K15414
[Journal Article] Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae2023
- Author(s)
  Hayashida Momoko、Nomura Wataru、Shiojiri Atsushi、Inoue Yoshiharu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 685 Pages: 149157-149157
- DOI
  10.1016/j.bbrc.2023.149157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05559, KAKENHI-PROJECT-21K19079
[Journal Article] Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in <i>Saccharomyces cerevisiae</i>2022
- Author(s)
  Nomura Wataru、Ng Su-Ping、Takahara Terunao、Maeda Tatsuya、Kawada Teruo、Goto Tsuyoshi、Inoue Yoshiharu
- Journal Title
  
  Journal of Cell Science
  
  Volume: 135 Issue: 17
- DOI
  10.1242/jcs.259988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05559, KAKENHI-PROJECT-21K19079, KAKENHI-PROJECT-20H03251, KAKENHI-PROJECT-21H02103, KAKENHI-PROJECT-20J23198
[Journal Article] Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes2022
- Author(s)
  Ng Su-Ping、Nomura Wataru、Takahashi Haruya、Inoue Kazuo、Kawada Teruo、Goto Tsuyoshi、Inoue Yoshiharu
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 21 Pages: 2279-2296
- DOI
  10.1042/bcj20220271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05559, KAKENHI-PROJECT-21K19079, KAKENHI-PROJECT-21H02103, KAKENHI-PROJECT-20J23198
[Journal Article] Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae2021
- Author(s)
  Nomura Wataru、Futamata Ryota、Inoue Yoshiharu
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1865 Issue: 5 Pages: 129853-129853
- DOI
  10.1016/j.bbagen.2021.129853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05949, KAKENHI-PROJECT-18H02168
[Journal Article] Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes2021
- Author(s)
  Ng Su-Ping、Nomura Wataru、Takahashi Haruya、Inoue Kazuo、Kawada Teruo、Goto Tsuyoshi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 28 Pages: 101127-101127
- DOI
  10.1016/j.bbrep.2021.101127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05949, KAKENHI-PROJECT-20J23198
[Journal Article] Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae2020
- Author(s)
  Nomura Wataru、Aoki Miho、Inoue Yoshiharu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13887-13887
- DOI
  10.1038/s41598-020-70802-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05949, KAKENHI-PROJECT-18H02168
[Journal Article] Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes2019
- Author(s)
  Ng Su-Ping、Nomura Wataru、Mohri Shinsuke、Takahashi Haruya、Jheng Huei-Fen、Ara Takeshi、Nagai Hiroyuki、Ito Tetsuro、Kawada Teruo、Goto Tsuyoshi
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 83 Issue: 9 Pages: 1782-1789
- DOI
  10.1080/09168451.2019.1611413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05949, KAKENHI-PROJECT-18K14420
[Journal Article] Toxicity of dihydroxyacetone is exerted through the formation of methylglyoxal inSaccharomyces cerevisiae: effects on actin polarity and nuclear division2018
- Author(s)
  Nomura Wataru、Aoki Miho、Inoue Yoshiharu
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Issue: 16 Pages: 2637-2652
- DOI
  10.1042/bcj20180234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15414
[Journal Article] Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade inSaccharomyces cerevisiae2017
- Author(s)
  Nomura Wataru、Maeta Kazuhiro、Inoue Yoshiharu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 36 Pages: 15039-15048
- DOI
  10.1074/jbc.m117.791590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15414
[Journal Article] Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae2017
- Author(s)
  Nomura Wataru、Inoue Yoshiharu
- Journal Title
  
  Small GTPases
  
  Volume: - Issue: 6 Pages: 449-455
- DOI
  10.1080/21541248.2017.1339766
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15414, KAKENHI-PROJECT-18H02168
[Presentation] 細胞壁ストレス応答とTORC2シグナルの機能的関連性2023
- Author(s)
  野村亘、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第56回研究報告会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] 酵母の細胞壁ストレスを感知するCWI経路は細胞膜健全性に寄与するTORC2シグナルを負に制御する2023
- Author(s)
  野村亘、井上善晴
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] 酵母TORC2-Ypk1/2シグナルはcell wall integrity経路による負の制御を受ける2023
- Author(s)
  野村亘、井上善晴
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] メチルグリオキサールはDNA損傷チェックポイントを介して出芽酵母のスピンドル極体におけるKar9の非対称性分布を崩壊させる2023
- Author(s)
  林田ももこ、野村亘、井上善晴
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] 合成脂質edelfosineを用いた酵母TORC2シグナルの制御機構解析2023
- Author(s)
  野村亘、井上善晴
- Organizer
  日本農芸化学会 2023年度大会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] 出芽酵母CWI経路はeisosome依存的にTOR複合体2シグナルを負に制御する2022
- Author(s)
  野村亘、井上善晴
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] Saccharomyces cerevisiaeにおけるピルビン酸デカルボキシラーゼI欠損は2-デオキシグルコース感受性を高める2022
- Author(s)
  宇田竜成、向山佳歩、井上善晴、野村亘
- Organizer
  日本農芸化学会 2022年度大会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] Saccharomyces cerevisiaeのプロテインキナーゼCにおけるHR1領域の機能解析2022
- Author(s)
  井澗和也、野村亘、井上善晴
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K05559
[Presentation] Methylglyoxal inhibits isoproterenol-induced Ucp1 expression in beige adipocytes2021
- Author(s)
  Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] 酢酸由来アセチルCoA産生経路が脂肪細胞の分化と機能に及ぼす影響2021
- Author(s)
  造田みな美、野村亘、高橋春弥、井上和生、後藤剛
- Organizer
  日本農芸化学会関西支部第514回講演会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] Methylglyoxal is Involved in Insulin Resistance via Activation of mTORC1/S6K Pathway in Adipocytes2021
- Author(s)
  Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Tsuyoshi Goto, Teruo Kawada, Yoshiharu Inoue
- Organizer
  日本農芸化学会 2021年度大会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] 出芽酵母ピルビン酸デカルボキシラーゼIの機能と細胞内局在性の関連2021
- Author(s)
  宇田竜成、向山佳歩、野村亘、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第54回研究報告会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] CWI経路が関わるTORC2シグナル制御機構の解析2020
- Author(s)
  野村亘、後藤剛、高原照直、前田達哉、河田照雄、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第53回研究報告会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] メチルグリオキサールによる出芽酵母の核分裂阻害機構の解析2020
- Author(s)
  野村亘、青木美穂、後藤剛、河田照雄、井上善晴
- Organizer
  日本農芸化学会 2020年度大会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] 出芽酵母cell wall integrity経路が関わるTOR複合体2シグナル制御機構の解析2019
- Author(s)
  野村亘、後藤剛、高原照直、前田達哉、河田照雄、井上善晴
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] Edelfosineを用いたTOR複合体2シグナル制御機構の解析2019
- Author(s)
  野村亘、後藤剛、高原照直、前田達哉、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第52回研究報告会
- Data Source
  KAKENHI-PROJECT-19K05949
[Presentation] 出芽酵母PKCのリン酸化状態が安定性に及ぼす影響2018
- Author(s)
  野村　亘、今井杏里沙、後藤　剛、河田照雄、井上善晴
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15414
[Presentation] Pkc1安定性とリン酸化状態との関連性2018
- Author(s)
  野村　亘、今井杏里沙、後藤　剛、河田照雄、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第51回研究報告会
- Data Source
  KAKENHI-PROJECT-17K15414
[Presentation] 出芽酵母のストレス応答におけるPKCシグナルの制御機構2018
- Author(s)
  野村　亘
- Organizer
  第85回酵母研究会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15414
[Presentation] Contribution of Phosphatidylserine to Protein Kinase C Signaling in Saccharomyces cerevisiae.2017
- Author(s)
  Wataru Nomura, Teruo Kawada, Yoshiharu Inoue
- Organizer
  28th International Conference on Yeast Genetics and Molecular Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15414
[Presentation] Cdc42が関与する出芽酵母TOR複合体2シグナルの解析2017
- Author(s)
  野村　亘、後藤　剛、高原照直、前田達哉、河田照雄、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第50回研究報告会
- Data Source
  KAKENHI-PROJECT-17K15414
[Presentation] ホスファチジルセリンが関与する酵母Cキナーゼの制御機構2017
- Author(s)
  野村　亘，河田照雄，井上善晴
- Organizer
  第64回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-17K15414
[Presentation] Pkc1のリン酸化状態におけるturn motifの役割2015
- Author(s)
  野村　亘、井上善晴
- Organizer
  酵母遺伝学フォ－ラム　第47回研究報告会
- Place of Presentation
  広島大学
- Year and Date
  2015-08-31
- Data Source
  KAKENHI-PROJECT-26560397
[Presentation] Protein kinase C-dependent phosphorylation of Rho GTPase-activating protein Rgd1 in yeast2015
- Author(s)
  野村　亘、井上善晴
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26560397

Nomura Wataru 野村 亘

Research Projects

Research Products

細胞膜動態を感知するTORC2シグナルの制御機構：２段階制御モデルの実証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酵母におけるプロテインキナーゼCによるTORC2シグナルの負の制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the mechanism of action of plasma membrane lipids that contribute to the activation of TORC2 signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the regulation of TORC2 signaling by phosphatidylserinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] The Yeast Role in Medical Applications (Chapter 4; TOR signaling in budding yeast.)2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in <i>Saccharomyces cerevisiae</i>2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Toxicity of dihydroxyacetone is exerted through the formation of methylglyoxal inSaccharomyces cerevisiae: effects on actin polarity and nuclear division2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade inSaccharomyces cerevisiae2017

Author(s)

Nomura Wataru 野村亘