Horikoshi Naoki 堀越直樹

… Alternative Names

堀越直樹ホリコシナオキ

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Researcher Number	60732170
Other IDs
Affiliation (Current)	2022: 東京大学, 定量生命科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022: 東京大学, 定量生命科学研究所, 准教授 2019 – 2020: 筑波大学, 生存ダイナミクス研究センター, 助教
Review Section/Research Field	Principal Investigator 0701:Biology at molecular to cellular levels, and related fields / Basic Section 43030:Functional biochemistry-related / Basic Section 43010:Molecular biology-related Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator G6PD / G6PD欠乏症 / NADPH / enzymopathy / 酵素異常症 / 構造解析 / NADP / structural defects / PPP / hemolysis … More / glucose metabolism / G6PD deficiency / redox signaling / ROS / クロマチン / エピジェネティクス / 細胞核 / クライオ電子顕微鏡 … More Except Principal Investigator 滑膜肉腫 / 創薬 / 構造解析 Less

構造生物化学と定量解析を駆使した滑膜肉腫発生機構の解明と創薬
- Principal Investigator
  
  岩崎憲治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Tsukuba
細胞核膜近傍におけるクロマチンの機能・構造解明Principal Investigator
- Principal Investigator
  
  堀越直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Tokyo
溶血性貧血の原因となる代謝疾患G6PD欠乏症における酵素活性化と活性化機構の解明Principal Investigator
- Principal Investigator
  
  堀越直樹
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  University of Tsukuba
Structural basis of glucose-6-phosphate deficiencyPrincipal Investigator
- Principal Investigator
  
  Horikoshi Naoki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  University of Tsukuba

All 2021 2019

All Journal Article Presentation

[Journal Article] Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency2021
- Author(s)
  Horikoshi Naoki、Hwang Sunhee、Gati Cornelius、Matsui Tsutomu、Castillo-Orellana Carlos、Raub Andrew G.、Garcia Adriana A.、Jabbarpour Fatemeh、Batyuk Alexander、Broweleit Joshua、Xiang Xinyu、Chiang Andrew、Broweleit Rachel、Vohringer-Martinez Esteban、Mochly-Rosen Daria、Wakatsuki Soichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118
- DOI
  10.1073/pnas.2022790118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15741, KAKENHI-PROJECT-19K23713
[Presentation] Structural basis of the glucose-6-phosphate dehydrogenase deficiency2019
- Author(s)
  Horikoshi, N., Jabbarpour, F., Hwang, S., Raub, A.G., Mochly-Rosen, D., Wakatsuki Soichi.
- Organizer
  The 92nd Annual meeting of the Japanese Biochemical Society
- Data Source
  KAKENHI-PROJECT-19K23713

1. 岩崎憲治 (20342751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 竹中聡 (00588379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 吉田将人 (80511906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Horikoshi Naoki 堀越直樹

堀越直樹ホリコシナオキ

Research Projects

Research Products

Co-Researchers

構造生物化学と定量解析を駆使した滑膜肉腫発生機構の解明と創薬

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞核膜近傍におけるクロマチンの機能・構造解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

溶血性貧血の原因となる代謝疾患G6PD欠乏症における酵素活性化と活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis of glucose-6-phosphate deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Structural basis of the glucose-6-phosphate dehydrogenase deficiency2019

Author(s)

Organizer

Data Source

Horikoshi Naoki 堀越 直樹

堀越 直樹 ホリコシ ナオキ

Research Projects

Research Products

Co-Researchers

構造生物化学と定量解析を駆使した滑膜肉腫発生機構の解明と創薬

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞核膜近傍におけるクロマチンの機能・構造解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

溶血性貧血の原因となる代謝疾患G6PD欠乏症における酵素活性化と活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis of glucose-6-phosphate deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Structural basis of the glucose-6-phosphate dehydrogenase deficiency2019

Author(s)

Organizer

Data Source

Horikoshi Naoki 堀越直樹

堀越直樹ホリコシナオキ