Horikoshi Naoki 堀越直樹

Researcher Number	60732170
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 定量生命科学研究所, 准教授 2019 – 2020: 筑波大学, 生存ダイナミクス研究センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Basic Section 43010:Molecular biology-related / Basic Section 43030:Functional biochemistry-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Transformative Research Areas, Section (III)
Keywords	Principal Investigator ヌクレオソーム / ヒストン / enzymopathy / NADPH / G6PD欠乏症 / G6PD / 構造解析 / Cryo-EM / クライオ電子顕微鏡 / 細胞核 … More / 核内高次構造 / エピジェネティクス / クロマチン / ROS / redox signaling / グルコース代謝 / 溶血性貧血 / G6PD deficiency / glucose metabolism / hemolysis / PPP / structural defects / NADP / 酵素異常症 … More Except Principal Investigator 構造生物化学 / 構造解析 / 創薬 / 滑膜肉腫 / クライオ電子顕微鏡 / ヒストン / ヌクレオソーム / エピジェネティクス / クロマチン Less

クロマチンの細胞核内配置制御機構の解明Principal Investigator
- Principal Investigator
  
  堀越直樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Tokyo
Elucidating the fundamental structures and operational principles of chromatin that define the epicode
- Principal Investigator
  
  胡桃坂仁志
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
細胞核膜近傍におけるクロマチンの機能・構造解明Principal Investigator
- Principal Investigator
  
  堀越直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of synovial sarcoma development and drug discovery using structural biochemistry and quantitative analysis
- Principal Investigator
  
  岩崎憲治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Tsukuba
Activation of dysfunctional metabolic enzymes in G6PD deficiency causing hemolytic anemiaPrincipal Investigator
- Principal Investigator
  
  Horikoshi Naoki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  The University of Tokyo
  University of Tsukuba
Structural basis of glucose-6-phosphate deficiencyPrincipal Investigator
- Principal Investigator
  
  Horikoshi Naoki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  University of Tsukuba

All 2024 2023 2022 2021 2019

All Journal Article Presentation Book

[Book] 実験医学増刊　あなたのラボから薬を生み出す　アカデミア創薬の実践「エピジェネティクスの構造基盤」2024
- Author(s)
  堀越直樹、胡桃坂仁志
- Total Pages
  243
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22K06076
[Journal Article] Chromatin structure related to oncogenesis2023
- Author(s)
  Matsumoto Syota、Horikoshi Naoki、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 8 Pages: 3068-3075
- DOI
  10.1111/cas.15850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06076, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-23H05475
[Journal Article] High-Speed Atomic Force Microscopy Reveals Spontaneous Nucleosome Sliding of H2A.Z at the Subsecond Time Scale2023
- Author(s)
  Morioka Shin、Sato Shoko、Horikoshi Naoki、Kujirai Tomoya、Tomita Takuya、Baba Yudai、Kakuta Takahiro、Ogoshi Tomoki、Puppulin Leonardo、Sumino Ayumi、Umeda Kenichi、Kodera Noriyuki、Kurumizaka Hitoshi、Shibata Mikihiro
- Journal Title
  
  Nano Letters
  
  Volume: 23 Issue: 5 Pages: 1696-1704
- DOI
  10.1021/acs.nanolett.2c04346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K04849, KAKENHI-PROJECT-22K19290, KAKENHI-PROJECT-21H01771, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-21H00247, KAKENHI-PROJECT-23K23187, KAKENHI-PROJECT-22K06076, KAKENHI-PROJECT-20H00327
[Journal Article] Structural insight into replicative helicase loading in Escherichia coli2022
- Author(s)
  Horikoshi Naoki、Kurumizaka Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 6 Pages: 605-607
- DOI
  10.1093/jb/mvac023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-20H00449, KAKENHI-PROJECT-22K06076
[Journal Article] Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical?variants2022
- Author(s)
  Garcia Adriana Ann、Mathews Irimpan I.、Horikoshi Naoki、Matsui Tsutomu、Kaur Manat、Wakatsuki Soichi、Mochly-Rosen Daria
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 3 Pages: 101610-101610
- DOI
  10.1016/j.jbc.2022.101610
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15741
[Journal Article] Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency2021
- Author(s)
  Horikoshi Naoki、Hwang Sunhee、Gati Cornelius、Matsui Tsutomu、Castillo-Orellana Carlos、Raub Andrew G.、Garcia Adriana A.、Jabbarpour Fatemeh、Batyuk Alexander、Broweleit Joshua、Xiang Xinyu、Chiang Andrew、Broweleit Rachel、Vohringer-Martinez Esteban、Mochly-Rosen Daria、Wakatsuki Soichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 4
- DOI
  10.1073/pnas.2022790118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15741, KAKENHI-PROJECT-19K23713
[Presentation] 核ラミナ構成因子によるクロマチン制御機構の生化学的及び構造生物学的解析2024
- Author(s)
  堀越直樹、三宅諒祐、曽川-藤原千鶴、小笠原光雄、滝沢由政、胡桃坂仁志
- Organizer
  第４１回染色体ワークショップ、第２２回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-22K06076
[Presentation] 天然性変性領域SSXとDNAの相互作用様式を決定づけているアミノ酸残基2023
- Author(s)
  韓叡佳,高橋花南,吉永匡希,堀越直樹,胡桃坂仁志,竹中聡,岩崎憲治
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] 核膜近傍のクロマチン構造解析2023
- Author(s)
  堀越直樹、三宅諒祐、曽川-藤原千鶴、小笠原光雄、滝沢由政、胡桃坂仁志
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06076
[Presentation] 核内における高次クロマチン形成の構造基盤2023
- Author(s)
  堀越直樹、三宅諒祐、曽川-藤原千鶴、小笠原光雄、滝沢由政、胡桃坂仁志
- Organizer
  第１６回エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-22K06076
[Presentation] 天然変性領域SSXとSMARCB c末端 α-ヘリックスによる競合的なヌクレオソーム酸性パッチターゲッティング2023
- Author(s)
  鈴木理惠,高橋花南,堀越直樹,小淵里恵,重田育照,Kowit Hengphasatporn,権藤花奈,竹中聡,胡桃坂仁志, 岩崎憲治
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] クライオ電子顕微鏡単粒子解析法による天然変性領域SSX２RDとヌクレオソーム複合体の機能・構造解析2023
- Author(s)
  渋谷綾音,谷一寿,高橋花南,堀越直樹,宮ノ入洋平,吉永匡希,小淵里恵,原田彩佳,吉田尚史,竹中聡,胡桃坂仁志,岩崎憲治
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] 天然変性タンパク質SSX1の新規機能が引き起こすクロマチンリモデリング異常のメカニズム2022
- Author(s)
  高橋花南, 堀越直樹, 谷一寿, 宮ノ入洋平, 古寺哲幸, 西村正宏, 加藤広介, 竹中聡, 胡桃坂仁志, 岩崎憲治
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] 核内タンパク質による高次クロマチン形成機構の構造生物学的解析2022
- Author(s)
  堀越直樹、三宅諒祐、曽川-藤原千鶴、胡桃坂仁志
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06076
[Presentation] 天然変性タンパク質SSX1の新規機能が引き起こす滑膜肉腫発生メカニズム2022
- Author(s)
  高橋花南, 堀越直樹, 谷一寿, 宮ノ入洋平, 古寺哲幸, 西村正宏, 加藤広介, 竹中聡, 胡桃坂仁志, 岩崎憲治
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] 腫瘍性融合タンパク質 SS18-SSX1 における C 末端領域のヌクレオソームへの結合様式2022
- Author(s)
  小淵里恵, 堀越直樹, 谷一寿, 吉永匡希, 吉田尚史, 竹中聡, 胡桃坂仁志, 岩崎憲治
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] SSX1 に示唆される新規の DNA 結合ドメインとその溶液中構造解析2022
- Author(s)
  高橋花南, 古寺哲幸, 宮ノ入洋平, 加藤広介, 西村正宏, 堀越直樹, 胡桃坂仁志, 竹中聡, 岩崎憲治.
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24013
[Presentation] Structural basis of the glucose-6-phosphate dehydrogenase deficiency2019
- Author(s)
  Horikoshi, N., Jabbarpour, F., Hwang, S., Raub, A.G., Mochly-Rosen, D., Wakatsuki Soichi.
- Organizer
  The 92nd Annual meeting of the Japanese Biochemical Society
- Data Source
  KAKENHI-PROJECT-19K23713

1. 胡桃坂仁志 (80300870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 高橋達郎 (50452420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩崎憲治 (20342751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 竹中聡 (00588379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. 吉田将人 (80511906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 梅田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horikoshi Naoki 堀越 直樹

Research Projects

Research Products

Co-Researchers

クロマチンの細胞核内配置制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the fundamental structures and operational principles of chromatin that define the epicode

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞核膜近傍におけるクロマチンの機能・構造解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of synovial sarcoma development and drug discovery using structural biochemistry and quantitative analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activation of dysfunctional metabolic enzymes in G6PD deficiency causing hemolytic anemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis of glucose-6-phosphate deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学増刊 あなたのラボから薬を生み出す アカデミア創薬の実践「エピジェネティクスの構造基盤」2024

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Chromatin structure related to oncogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-Speed Atomic Force Microscopy Reveals Spontaneous Nucleosome Sliding of H2A.Z at the Subsecond Time Scale2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insight into replicative helicase loading in Escherichia coli2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical?variants2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 核ラミナ構成因子によるクロマチン制御機構の生化学的及び構造生物学的解析2024

Author(s)

Organizer

Data Source

[Presentation] 天然性変性領域SSXとDNAの相互作用様式を決定づけているアミノ酸残基2023

Author(s)

Organizer

Data Source

[Presentation] 核膜近傍のクロマチン構造解析2023

Author(s)

Horikoshi Naoki 堀越直樹

[Book] 実験医学増刊　あなたのラボから薬を生み出す　アカデミア創薬の実践「エピジェネティクスの構造基盤」2024