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Horikoshi Naoki  堀越 直樹

ORCIDConnect your ORCID iD *help
… Alternative Names

堀越 直樹  ホリコシ ナオキ

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Researcher Number 60732170
Other IDs
Affiliation (Current) 2022: 東京大学, 定量生命科学研究所, 准教授
Affiliation (based on the past Project Information) *help 2022: 東京大学, 定量生命科学研究所, 准教授
2019 – 2020: 筑波大学, 生存ダイナミクス研究センター, 助教
Review Section/Research Field
Principal Investigator
0701:Biology at molecular to cellular levels, and related fields / Basic Section 43030:Functional biochemistry-related / Basic Section 43010:Molecular biology-related
Except Principal Investigator
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords
Principal Investigator
G6PD / G6PD欠乏症 / NADPH / enzymopathy / 酵素異常症 / 構造解析 / NADP / structural defects / PPP / hemolysis … More / glucose metabolism / G6PD deficiency / redox signaling / ROS / クロマチン / エピジェネティクス / 細胞核 / クライオ電子顕微鏡 … More
Except Principal Investigator
滑膜肉腫 / 創薬 / 構造解析 Less
  • Research Projects

    (4 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (3 People)
  •  構造生物化学と定量解析を駆使した滑膜肉腫発生機構の解明と創薬

    • Principal Investigator
      岩崎 憲治
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      University of Tsukuba
  •  細胞核膜近傍におけるクロマチンの機能・構造解明Principal Investigator

    • Principal Investigator
      堀越 直樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      The University of Tokyo
  •  溶血性貧血の原因となる代謝疾患G6PD欠乏症における酵素活性化と活性化機構の解明Principal Investigator

    • Principal Investigator
      堀越 直樹
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      University of Tsukuba
  •  Structural basis of glucose-6-phosphate deficiencyPrincipal Investigator

    • Principal Investigator
      Horikoshi Naoki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0701:Biology at molecular to cellular levels, and related fields
    • Research Institution
      University of Tsukuba

All 2021 2019

All Journal Article Presentation

  • [Journal Article] Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency2021

    • Author(s)
      Horikoshi Naoki、Hwang Sunhee、Gati Cornelius、Matsui Tsutomu、Castillo-Orellana Carlos、Raub Andrew G.、Garcia Adriana A.、Jabbarpour Fatemeh、Batyuk Alexander、Broweleit Joshua、Xiang Xinyu、Chiang Andrew、Broweleit Rachel、Vohringer-Martinez Esteban、Mochly-Rosen Daria、Wakatsuki Soichi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118

    • DOI

      10.1073/pnas.2022790118

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15741, KAKENHI-PROJECT-19K23713
  • [Presentation] Structural basis of the glucose-6-phosphate dehydrogenase deficiency2019

    • Author(s)
      Horikoshi, N., Jabbarpour, F., Hwang, S., Raub, A.G., Mochly-Rosen, D., Wakatsuki Soichi.
    • Organizer
      The 92nd Annual meeting of the Japanese Biochemical Society
    • Data Source
      KAKENHI-PROJECT-19K23713
  • 1.  岩崎 憲治 (20342751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  竹中 聡 (00588379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  吉田 将人 (80511906)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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