Kashiwagi Kazuhiro 柏木一宏

… Alternative Names

柏木一宏カシワギカズヒロ

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Researcher Number	60732980
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2022 – 2023: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2018 – 2020: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Transformative Research Areas, Section (III) Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator 統合的ストレス応答 / クライオ電子顕微鏡 / 翻訳調節 / 試験管内翻訳 / 反応場 / 局所翻訳調節 / 翻訳開始 / 翻訳 / X線結晶構造解析 Except Principal Investigator タンパク質 … More / mRNA / 蛋白質 / 反応場 / 翻訳 Less

翻訳と反応場から考える蛋白質の新しい社会像の領域推進
- Principal Investigator
  
  小林穂高
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokushima
ミトコンドリア上での局所翻訳調節による「反応場」再編成の理解Principal Investigator
- Principal Investigator
  
  柏木一宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
アミノ酸枯渇下での翻訳に伴う、リボソーム上でのGCN2活性化機構の解明Principal Investigator
- Principal Investigator
  
  柏木一宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
細胞変性過程における統合的ストレス応答活性化の分子基盤Principal Investigator
- Principal Investigator
  
  柏木一宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Molecular basis of the inhibition of eIF2B under stressPrincipal Investigator
- Principal Investigator
  
  Kashiwagi Kazuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2021 2019

All Journal Article Presentation

[Journal Article] Switching on stress2023
- Author(s)
  Kashiwagi Kazuhiro、Ito Takuhiro
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 20 Issue: 4 Pages: 394-395
- DOI
  10.1038/s41589-023-01436-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06118, KAKENHI-PLANNED-21H05281, KAKENHI-PROJECT-23K23813
[Journal Article] ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B2021
- Author(s)
  Zyryanova Alisa F.、Kashiwagi Kazuhiro、Rato Claudia、Harding Heather P.、Crespillo-Casado Ana、Perera Luke A.、Sakamoto Ayako、Nishimoto Madoka、Yonemochi Mayumi、Shirouzu Mikako、Ito Takuhiro、Ron David
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 1 Pages: 88-103
- DOI
  10.1016/j.molcel.2020.10.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03172, KAKENHI-PROJECT-18K14644
[Journal Article] Structural basis for eIF2B inhibition in integrated stress response2019
- Author(s)
  Kashiwagi Kazuhiro、Yokoyama Takeshi、Nishimoto Madoka、Takahashi Mari、Sakamoto Ayako、Yonemochi Mayumi、Shirouzu Mikako、Ito Takuhiro
- Journal Title
  
  Science
  
  Volume: 364 Issue: 6439 Pages: 495-499
- DOI
  10.1126/science.aaw4104
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05677, KAKENHI-PROJECT-16H04756, KAKENHI-PROJECT-18K14644, KAKENHI-PROJECT-19H03172
[Presentation] Inhibition of eIF2B activity by eIF2 phosphorylation2019
- Author(s)
  Kazuhiro Kashiwagi, Takeshi Yokoyama,Madoka Nishimoto, Mari Takahashi, Ayako Sakamoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito
- Organizer
  第21回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K14644
[Presentation] Structural basis of eIF2B regulation by eIF2 phosphorylation2019
- Author(s)
  Kazuhiro Kashiwagi, Takeshi Yokoyama,Madoka Nishimoto, Mari Takahashi, Ayako Sakamoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito
- Organizer
  EMBO Workshop: Protein Synthesis and Translational Control
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14644

1. 小林穂高 (80802975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 七野悠一 (40748365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松尾芳隆 (00725252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 伊藤桜子 (60597152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ITO Takuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kashiwagi Kazuhiro 柏木 一宏

柏木 一宏 カシワギ カズヒロ

Research Projects

Research Products

Co-Researchers

翻訳と反応場から考える蛋白質の新しい社会像の領域推進

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミトコンドリア上での局所翻訳調節による「反応場」再編成の理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミノ酸枯渇下での翻訳に伴う、リボソーム上でのGCN2活性化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞変性過程における統合的ストレス応答活性化の分子基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of the inhibition of eIF2B under stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Switching on stress2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for eIF2B inhibition in integrated stress response2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Inhibition of eIF2B activity by eIF2 phosphorylation2019

Author(s)

Organizer

Data Source

[Presentation] Structural basis of eIF2B regulation by eIF2 phosphorylation2019

Author(s)

Organizer

Data Source

Kashiwagi Kazuhiro 柏木一宏

柏木一宏カシワギカズヒロ