Makiyama Tomohiro 牧山智彦

… Alternative Names

Makiyama Tomohiko 牧山智彦

MAKIYAMA TOMOHIKO 牧山智彦

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Researcher Number	60733102
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 昭和大学, 薬学部, 講師 2019 – 2021: 昭和大学, 薬学部, 助教 2018: 杏林大学, 医学部, 助教 2015 – 2016: 獨協医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 54040:Metabolism and endocrinology-related / Pathological medical chemistry Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 38050:Food sciences-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator トリグリセリド / NEK2 / PLIN2 / 細胞内脂肪滴 / ATP / 膵β細胞 / インスリン抵抗性 / インスリン分泌 / 細胞分化 / 炎症性メディエーター … More / Taxilin / マクロファージ / 分化 / 炎症性反応 … More Except Principal Investigator 好中球細胞外トラップ / LC-MS/MS / 動脈硬化症 / 膜融合 / 細胞内小胞輸送 / ステアリン酸 / 脂肪酸 / 中間比重粒子 / PLIN2 / COPⅡ小胞 / Sar1 / 細胞内脂肪滴 / リポタンパク質 / 血管内皮細胞 / LDL / NETs / 急性心筋梗塞 / HDL / 急性心筋後続 / 酸化HDL / 酸化LDL Less

Relationship between extracellular fatty acid balance and intracellular vesicular transport for prevention of lifestyle-related diseases
- Principal Investigator
  
  厚味厳一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Teikyo University
NEK2Aによる脂質代謝を介したがん細胞の特質変化制御機構の解明Principal Investigator
- Principal Investigator
  
  牧山智彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Showa University
Effects of neutrophil extracellular traps and lipoproteins on the function of vascular endothelial cells
- Principal Investigator
  
  小濱孝士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Showa University
Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.
- Principal Investigator
  
  板部洋之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Investigation of P2X7 purinergic receptor role contributing to the compensatory insulin secretionPrincipal Investigator
- Principal Investigator
  
  Makiyama Tomohiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Showa University
  Kyorin University
Analysis of the role of taxilin in release of inflammatory mediatorsPrincipal Investigator
- Principal Investigator
  
  MAKIYAMA TOMOHIKO
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Dokkyo Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells2023
- Author(s)
  Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Masahiro Chatani, Yuki Azetsu, Kosuke Kawaguchi, Tsuneo Imanaka, Hiroyuki Itabe
- Journal Title
  
  Exp Cell Res.
  
  Volume: 433 Issue: 2 Pages: 113855-113855
- DOI
  10.1016/j.yexcr.2023.113855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-22K06617, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-19KK0233
[Journal Article] Sar1 affects the localization of perilipin 2 to lipid droplets2022
- Author(s)
  Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Hiroyuki Itabe
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 2 Issue: 12 Pages: 6366-6366
- DOI
  10.3390/ijms23126366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06617
[Journal Article] Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein2021
- Author(s)
  Itabe Hiroyuki、Sawada Naoko、Makiyama Tomohiko、Obama Takashi
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 6 Pages: 655-655
- DOI
  10.3390/biomedicines9060655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069
[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Mirei Mizuno, Kiyoshi Fukuhara, Sanju Iwamoto, Toshihiro Aiuchi, Tomohiko Makiyama and Hiroyuki Itabe
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 11 Pages: 1045-1045
- DOI
  10.3390/antiox9111045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice2018
- Author(s)
  Aoyagi Kyota、Itakura Makoto、Fukutomi Toshiyuki、Nishiwaki Chiyono、Nakamichi Yoko、Torii Seiji、Makiyama Tomohiko、Harada Akihiro、Ohara-Imaizumi Mica
- Journal Title
  
  Endocrinology
  
  Volume: 159 Issue: 11 Pages: 3674-3688
- DOI
  10.1210/en.2018-00447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08528, KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09845, KAKENHI-PROJECT-18K16244, KAKENHI-PROJECT-18H02594
[Journal Article] β-Taxilin parcipipates in the differentiation of C2C12 myoblast into myotubes.2016
- Author(s)
  Sakane H, Makiyama T, Nogami S, Horii Y, Akasaki K, Shirataki H.
- Journal Title
  
  Experimental Cell Research
  
  Volume: 345 Issue: 2 Pages: 230-238
- DOI
  10.1016/j.yexcr.2016.05.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19030
[Journal Article] TSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression2015
- Author(s)
  Xu Bin Sai, Tomohiko Makiyama, Hiroshi Sakane, Yukimi Horii, Hideyuki Hiraishi, Hiromichi Shirataki
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Issue: 1
- DOI
  10.1186/s12885-015-1942-1
- NAID
  120006373204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19030
[Presentation] 細胞分裂期における脂肪滴の挙動2023
- Author(s)
  牧山智彦、小濵孝士、渡邉雄一、板部洋之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] 細胞分裂期の細胞内脂肪滴は、構成タンパク質が変動し他のオルガネラと異なる細胞内局在を示す2023
- Author(s)
  牧山　智彦, 小濵　孝士, 渡邉　雄一, 板部　洋之
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] 細胞内脂肪滴は細胞分裂期において他のオルガネラと異なる局在を示す2023
- Author(s)
  牧山　智彦, 小濵　孝士, 渡邉　雄一, 茶谷　昌弘, 畔津　祐希, 川口　甲介, 今中　常雄, 板部　洋之
- Organizer
  第96回日本生化学会
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] 細胞内脂肪滴形成機構と小胞輸送の関り2022
- Author(s)
  牧山智彦、板部洋之
- Organizer
  第64回日本脂質生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06617
[Presentation] HDLを伴った血中酸化リポタンパク質粒子の生成と動脈硬化症2020
- Author(s)
  澤田直子、板部洋之、小濵孝士、木庭新治、巖本三壽、髙木孝士、Wirapol Phimarn、牧山智彦、相内敏弘
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] 妊娠期膵β細胞でのP2X7受容体によるインスリン分泌亢進機構2019
- Author(s)
  牧山　智彦、青柳　共太、中道　洋子、西脇　知世乃、小泉　修一、今泉　美佳
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-18K16244
[Presentation] VAMP7 regulates autophagosome formation by supporting Atg9a functions in pancreatic beta-cells2018
- Author(s)
  青柳　共太、西脇　知世乃、中道　洋子、福冨　俊之、鳥居　征司、牧山　智彦、櫻井裕之、今泉　美佳
- Organizer
  第91回生化学会
- Data Source
  KAKENHI-PROJECT-18K16244
[Presentation] C2C12筋芽細胞の筋管細胞への分化におけるbeta-Taxilinの機能解析2017
- Author(s)
  坂根　洋, 牧山　智彦, 野上　識, 堀井　幸美, 赤崎　健司, 白瀧　博通
- Organizer
  第137回日本薬学会年会
- Place of Presentation
  東北大学 (宮城県, 仙台市)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K19030
[Presentation] TSG101によるMMP-9 mRNAの発現調節を介したがん細胞浸潤制御2016
- Author(s)
  牧山　智彦、賽　序斌、坂根　洋、堀井　幸美、平石　秀幸、白瀧　博通
- Organizer
  第89回日本生化学会
- Place of Presentation
  東北大学 (宮城県, 仙台市)
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K19030
[Presentation] C2C12筋芽細胞の金管細胞への分化におけるbeta-Taxilinの機能解析2015
- Author(s)
  坂根洋, 牧山智彦, 野上識, 堀井幸美, 赤崎健司, 白瀧博通
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K19030

1. ITABE Hiroyuki (30203079)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. 小濱孝士 (60395647)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 澤田直子 (50643566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高木孝士 (10774820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 渡邉雄一 (70792729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 厚味厳一 (70276608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 石橋賢一 (00707458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 斎藤将樹 (50400271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 鳥居征司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 笹部直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 畔津佑季

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 茶谷昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Makiyama Tomohiro 牧山 智彦

Makiyama Tomohiko 牧山 智彦

MAKIYAMA TOMOHIKO 牧山 智彦

Research Projects

Research Products

Co-Researchers

Relationship between extracellular fatty acid balance and intracellular vesicular transport for prevention of lifestyle-related diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NEK2Aによる脂質代謝を介したがん細胞の特質変化制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of neutrophil extracellular traps and lipoproteins on the function of vascular endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of P2X7 purinergic receptor role contributing to the compensatory insulin secretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the role of taxilin in release of inflammatory mediatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sar1 affects the localization of perilipin 2 to lipid droplets2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] β-Taxilin parcipipates in the differentiation of C2C12 myoblast into myotubes.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression2015

Author(s)

Makiyama Tomohiro 牧山智彦

Makiyama Tomohiko 牧山智彦

MAKIYAMA TOMOHIKO 牧山智彦

[Presentation] 細胞分裂期の細胞内脂肪滴は、構成タンパク質が変動し他のオルガネラと異なる細胞内局在を示す2023