Mori Takahiro 森貴裕

Researcher Number	60734564
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2019 – 2023: 東京大学, 大学院薬学系研究科(薬学部), 助教 2015 – 2017: 東京大学, 大学院薬学系研究科(薬学部), 助教 2014 – 2015: 東京大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Biomolecular chemistry / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Biomolecular chemistry
Keywords	Principal Investigator 生合成 / 酵素反応機構 / 酵素 / 結晶構造解析 / 酵素工学 / X線結晶構造解析 / 立体構造解析 / 天然物化学 / 異性化酵素 / 酸化酵素 … More Except Principal Investigator … More 酵素 / 合成生物学 / 生合成工学 / 生合成 / 薬用天然物 / 薬物代謝酵素活性化 / プロドラッグ / 立体構造基盤 / 薬物代謝活性化 / 腸内細菌 / 天然物化学 / 酵素工学 / 中国南西部 / 生物多様性 / 生合成マシナリー / 天然物生合成 / 創薬資源採集調査 / 反応機構 / 構造生物学 / 物質生産 / 遺伝子 Less

Metabolons in Natural Product BiosynthesisArea Organizer
- Area Organizer
  
  森貴裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
特化メタボロン・総括班Principal Investigator
- Principal Investigator
  
  森貴裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
微生物特化メタボロンの解明と酵素複合体立体構造解析Principal Investigator
- Principal Investigator
  
  森貴裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
薬用天然物の骨格構築に関わる新奇生合成酵素群の構造機能解明と合成生物学的利用Principal Investigator
- Principal Investigator
  
  森貴裕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokyo
Molecular Basis of Activation of Drug Metabolism by Intestinal Bacteria
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Survey for new drug discovery resources and exploration & elucidation of novel natural product biosynthetic machineries
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Structure-function studies of enzymes involved in natural product biosynthesis for drug discovery
- Principal Investigator
  
  ABE Ikuro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Structure-function analysis of biosynthetic enzymes in the biosynthesis of fungal meroterpenoidsPrincipal Investigator
- Principal Investigator
  
  Mori Takahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  The University of Tokyo
糸状菌由来テルペノイド合成酵素群の機能拡張と分子多様性の創出Principal Investigator
- Principal Investigator
  
  森貴裕
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo
Biosynthetic studies on complex natural products
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo
Functional analysis of bacterial stilbene synthasePrincipal Investigator
- Principal Investigator
  
  Mori Takahiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 Other

All Journal Article Presentation Other

[Journal Article] Lincosamide Antibiotics: Structure, Activity, and Biosynthesis2024
- Author(s)
  Mori Takahiro、Abe Ikuro
- Journal Title
  
  ChemBioChem
  
  Volume: 25 Issue: 6
- DOI
  10.1002/cbic.202300840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-23K27332
[Journal Article] Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes2023
- Author(s)
  Ushimaru Richiro、Cha Lide、Shimo Shotaro、Li Xiaojun、Paris Jared C.、Mori Takahiro、Miyamoto Kazunori、Coffer Lindsay、Uchiyama Masanobu、Guo Yisong、Chang Wei-chen、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 44 Pages: 24210-24217
- DOI
  10.1021/jacs.3c08413
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-23KJ0656, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H00320
[Journal Article] Structural and Mechanistic Insights into the C?C Bond-Forming Rearrangement Reaction Catalyzed by Heterodimeric Hinokiresinol Synthase2023
- Author(s)
  Ushimaru Richiro、Ding Yiling、Mori Takahiro、Miyamoto Kazunori、Uchiyama Masanobu、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 40 Pages: 21966-21973
- DOI
  10.1021/jacs.3c06762
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H00320
[Journal Article] Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis2023
- Author(s)
  Awakawa Takayoshi、Mori Takahiro、Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Natural Product Reports
  
  Volume: 40 Issue: 1 Pages: 46-61
- DOI
  10.1039/d2np00014h
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05123, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-23K21363, KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-20KK0173
[Journal Article] Structure‐Function Analysis of the S‐Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics2023
- Author(s)
  Mori Takahiro、Sun Xin、Kadlcik Stanislav、Janata Jiri、Abe Ikuro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 62 Issue: 29
- DOI
  10.1002/anie.202304989
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K27332
[Journal Article] Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics2023
- Author(s)
  Mori Takahiro、Kadlcik Stanislav、Lyu Shuang、Kamenik Zdenek、Sakurada Kosuke、Mazumdar Aninda、Wang Huibin、Janata Jiri、Abe Ikuro
- Journal Title
  
  Nature Catalysis
  
  Volume: 6 Issue: 6 Pages: 531-542
- DOI
  10.1038/s41929-023-00971-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922
[Journal Article] Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL2022
- Author(s)
  Tao Hui、Ushimaru Richiro、Awakawa Takayoshi、Mori Takahiro、Uchiyama Masanobu、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 47 Pages: 21512-21520
- DOI
  10.1021/jacs.2c08116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05123, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-23K21363
[Journal Article] Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood2022
- Author(s)
  Wang Xiao-Hui、Gao Bo-Wen、Nakashima Yu、Mori Takahiro、Zhang Zhong-Xiu、Kodama Takeshi、Lee Yuan-E、Zhang Ze-Kun、Wong Chin-Piow、Liu Qian-Qian、Qi Bo-Wen、Wang Juan、Li Jun、Liu Xiao、Abe Ikuro、Morita Hiroyuki、Tu Peng-Fei、Shi She-Po
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 348-348
- DOI
  10.1038/s41467-022-27971-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16025, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490
[Journal Article] Rational Engineering of the Nonheme Iron- and 2-Oxoglutarate-Dependent Oxygenase SptF2022
- Author(s)
  Mori Takahiro、Yu Ziheng、Tao Hui、Abe Ikuro
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 8 Pages: 1737-1741
- DOI
  10.1021/acs.orglett.2c00409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-20H00490
[Journal Article] Structure-based redesign of Fe(<scp>ii</scp>)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation2022
- Author(s)
  Mori Takahiro、Nakashima Yu、Chen Heping、Hoshino Shotaro、Mitsuhashi Takaaki、Abe Ikuro
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 36 Pages: 5510-5513
- DOI
  10.1039/d2cc00736c
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490
[Journal Article] Discovery of non-squalene triterpenes2022
- Author(s)
  Tao Hui、Lauterbach Lukas、Bian Guangkai、Chen Rong、Hou Anwei、Mori Takahiro、Cheng Shu、Hu Ben、Lu Li、Mu Xin、Li Min、Adachi Naruhiko、Kawasaki Masato、Moriya Toshio、Senda Toshiya、Wang Xinghuan、Deng Zixin、Abe Ikuro、Dickschat Jeroen S.、Liu Tiangang
- Journal Title
  
  Nature
  
  Volume: 606 Issue: 7913 Pages: 414-419
- DOI
  10.1038/s41586-022-04773-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490
[Journal Article] Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF.2022
- Author(s)
  Tao, H., # Mori, T., # Chen, H., Lyu, S., Nonoyama, A., Lee, S., Abe, I. (#equall contribution)
- Journal Title
  
  Nature Commun
  
  Volume: 13 Issue: 1 Pages: 95-95
- DOI
  10.1038/s41467-021-27636-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490
[Journal Article] Cordycicadins A?D, Antifeedant Polyketides from the Entomopathogenic Fungus <i>Cordyceps cicadae</i> JXCH12022
- Author(s)
  Li Xinyang、Chen He-Ping、Zhou Lin、Fan Jing、Awakawa Takayoshi、Mori Takahiro、Ushimaru Richiro、Abe Ikuro、Liu Ji-Kai
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 47 Pages: 8627-8632
- DOI
  10.1021/acs.orglett.2c03432
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05123, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-23K21363
[Journal Article] Structural basis for endoperoxide-forming oxygenases2022
- Author(s)
  Mori Takahiro、Abe Ikuro
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 18 Pages: 707-721
- DOI
  10.3762/bjoc.18.71
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490
[Journal Article] Structural Basis for Isomerization Reactions in Fungal Tetrahydroxanthone Biosynthesis and Diversification2021
- Author(s)
  Yang Jiali、Mori Takahiro、Wei Xingxing、Matsuda Yudai、Abe Ikuro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 35 Pages: 19458-19465
- DOI
  10.1002/anie.202107884
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490
[Journal Article] Heterodimeric Non-heme Iron Enzymes in Fungal Meroterpenoid Biosynthesis2021
- Author(s)
  Li Xinyang、Awakawa Takayoshi、Mori Takahiro、Ling Meiqi、Hu Dan、Wu Bin、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 50 Pages: 21425-21432
- DOI
  10.1021/jacs.1c11548
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-23K21363
[Journal Article] One Polyketide Synthase, Two Distinct Products: Trans‐Acting Enzyme‐Controlled Product Divergence in Calbistrin Biosynthesis2021
- Author(s)
  Tao Hui、Mori Takahiro、Wei Xingxing、Matsuda Yudai、Abe Ikuro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 16 Pages: 8851-8858
- DOI
  10.1002/anie.202016525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-18F18404, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490
[Journal Article] Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021
- Author(s)
  Mori Takahiro、Zhai Rui、Ushimaru Richiro、Matsuda Yudai、Abe Ikuro
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4417-4417
- DOI
  10.1038/s41467-021-24685-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PROJECT-20K22700, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490
[Journal Article] Aziridine Formation by a Fe <sup>II</sup> /α‐Ketoglutarate Dependent Oxygenase and 2‐Aminoisobutyrate Biosynthesis in Fungi2021
- Author(s)
  Bunno Reito、Awakawa Takayoshi、Mori Takahiro、Abe Ikuro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 29 Pages: 15827-15831
- DOI
  10.1002/anie.202104644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-23K21363
[Journal Article] Insights into phosphatase-activated chemical defense in a marine sponge holobiont2021
- Author(s)
  Jomori Takahiro、Matsuda Kenichi、Egami Yoko、Abe Ikuro、Takai Akira、Wakimoto Toshiyuki
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 2 Issue: 6 Pages: 1600-1607
- DOI
  10.1039/d1cb00163a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PROJECT-21H02635, KAKENHI-PROJECT-20H00490
[Journal Article] C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes2021
- Author(s)
  Mori Takahiro、Kumano Takuto、He Haibing、Watanabe Satomi、Senda Miki、Moriya Toshio、Adachi Naruhiko、Hori Sanae、Terashita Yuzu、Kawasaki Masato、Hashimoto Yoshiteru、Awakawa Takayoshi、Senda Toshiya、Abe Ikuro、Kobayashi Michihiko
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6294-6294
- DOI
  10.1038/s41467-021-26585-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03197, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490, KAKENHI-ORGANIZER-19H05679, KAKENHI-PROJECT-23K21363
[Journal Article] Enzymatic Formation of Indolactam Scaffold by C-N Bond‐Forming Cytochrome P450 Oxidases in Teleocidin Biosynthesis2020
- Author(s)
  Morita Iori、Mori Takahiro、Abe Ikuro
- Journal Title
  
  Chemistry A European Journal
  
  Volume: 27 Issue: 9 Pages: 2963-2972
- DOI
  10.1002/chem.202003899
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-20H00490
[Journal Article] Heterochiral coupling in non-ribosomal peptide macrolactamization2020
- Author(s)
  Matsuda Kenichi、Zhai Rui、Mori Takahiro、Kobayashi Masakazu、Sano Ayae、Abe Ikuro、Wakimoto Toshiyuki
- Journal Title
  
  Nature Catalysis
  
  Volume: 3 Issue: 6 Pages: 507-515
- DOI
  10.1038/s41929-020-0456-7
- NAID
  120006941707
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-20H00490
[Journal Article] αKG‐Dependent Enzyme AndA Involved in Anditomin Biosynthesis2020
- Author(s)
  Nakashima Yu、Mori Takahiro、Abe Ikuro
- Journal Title
  
  Encyclopedia of Inorganic and Bioinorganic Chemistry
  
  Volume: 1 Pages: 1-8
- DOI
  10.1002/9781119951438.eibc2735
- Data Source
  KAKENHI-PROJECT-19K15703
[Journal Article] Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis2020
- Author(s)
  Wang Juan、Zhang Ze-Kun、Jiang Fang-Fang、Qi Bo-Wen、Ding Ning、Hnin Saw Yu Yu、Liu Xiao、Li Jun、Wang Xiao-hui、Tu Peng-Fei、Abe Ikuro、Morita Hiroyuki、Shi She-Po
- Journal Title
  
  Organic Letters
  
  Volume: 22 Issue: 21 Pages: 8725-8729
- DOI
  10.1021/acs.orglett.0c03339
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-20H00490
[Journal Article] Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases2020
- Author(s)
  Bai Tongxuan、Matsuda Yudai、Tao Hui、Mori Takahiro、Zhang Yonghui、Abe Ikuro
- Journal Title
  
  Organic Letters
  
  Volume: 22 Issue: 11 Pages: 4311-4315
- DOI
  10.1021/acs.orglett.0c01358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-20J22522, KAKENHI-PROJECT-20H00490
[Journal Article] Exploiting a C-N Bond Forming Cytochrome?P450 Monooxygenase for C?S Bond Formation2020
- Author(s)
  Morita Iori、Mori Takahiro、Mitsuhashi Takaaki、Hoshino Shotaro、Taniguchi Yoshimasa、Kikuchi Takashi、Nagae Kei、Nasu Norihiro、Fujita Makoto、Ohwada Tomohiko、Abe Ikuro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 10 Pages: 3988-3993
- DOI
  10.1002/anie.201916269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-18H02552, KAKENHI-PROJECT-19H05461, KAKENHI-PROJECT-20H00490
[Journal Article] Enzymatic studies on aromatic prenyltransferases2020
- Author(s)
  Mori Takahiro
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 74 Issue: 3 Pages: 501-512
- DOI
  10.1007/s11418-020-01393-x
- NAID
  40022252768
- Data Source
  KAKENHI-PROJECT-19K15703
[Journal Article] Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases2020
- Author(s)
  He Haibing、Bian Guangkai、Herbst-Gervasoni Corey J.、Mori Takahiro、Shinsky Stephen A.、Hou Anwei、Mu Xin、Huang Minjian、Cheng Shu、Deng Zixin、Christianson David W.、Abe Ikuro、Liu Tiangang
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 3958-3958
- DOI
  10.1038/s41467-020-17642-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-20H00490
[Journal Article] Molecular insights into the Mg2+-dependent allosteric control of indole prenylation by aromatic prenyltransferase AmbP12018
- Author(s)
  Abe Ikuro、Awakawa Takayoshi、Mori Takahiro、Nakashima Yu、Zhai Rui、Wong Chin Piow、Hillwig Matthew、Liu Xinyu
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 印刷中 Issue: 23 Pages: 6810-6813
- DOI
  10.1002/anie.201800855
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0095, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-17H04763, KAKENHI-PROJECT-15J12340, KAKENHI-PROJECT-16F16410
[Journal Article] Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis2018
- Author(s)
  Nakashima Yu、Mori Takahiro、Nakamura Hitomi、Awakawa Takayoshi、Hoshino Shotaro、Senda Miki、Senda Toshiya、Abe Ikuro
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-017-02371-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0095, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-17H04763, KAKENHI-PROJECT-15J12340, KAKENHI-PROJECT-16J01117, KAKENHI-PROJECT-17H06264
[Journal Article] Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis2017
- Author(s)
  Mori Takahiro、Iwabuchi Taiki、Hoshino Shotaro、Wang Hang、Matsuda Yudai、Abe Ikuro
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 13 Issue: 10 Pages: 1066-1073
- DOI
  10.1038/nchembio.2443
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-16J01117
[Journal Article] Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP32017
- Author(s)
  Wong Chin Piow、Awakawa Takayoshi、Nakashima Yu、Mori Takahiro、Zhu Qin、Liu Xinyu、Abe Ikuro
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 57 Issue: 2 Pages: 560-563
- DOI
  10.1002/anie.201710682
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0095, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-17H04763, KAKENHI-PROJECT-15J12340, KAKENHI-PROJECT-16F16410
[Journal Article] 2-Alkylquinolone alkaloid biosynthesis in the medicinal plantEvodia rutaecarpainvolves collaboration of two novel type III polyketide synthases2017
- Author(s)
  Matsui Takashi、Kodama Takeshi、Mori Takahiro、Tadakoshi Tetsuhiro、Noguchi Hiroshi、Abe Ikuro、Morita Hiroyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 22 Pages: 9117-9135
- DOI
  10.1074/jbc.m117.778977
- NAID
  120006559815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00397, KAKENHI-PROJECT-16K18501, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-16H05840
[Journal Article] Structural insight into the enzymatic formation of bacterial stilbene2016
- Author(s)
  Mori, T., Awakawa, T., Shimomura, K., Saito, Y., Yang, D., Morita, H., Abe, I.
- Journal Title
  
  Cell Chem. Biol.
  
  Volume: 23 Issue: 12 Pages: 1468-1479
- DOI
  10.1016/j.chembiol.2016.10.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-26282210
[Journal Article] Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases2016
- Author(s)
  T. Mori, L. Zhang, T. Awakawa, S. Hoshino, M. Okada, H. Morita, I. Abe
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 10849-10851
- DOI
  10.1038/ncomms10849
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-26560435, KAKENHI-PROJECT-26282210, KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-16J01117, KAKENHI-PROJECT-24688011
[Journal Article] Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum2016
- Author(s)
  Matsuda, Y., Iwabuchi,T., Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 138 Issue: 38 Pages: 12671-12677
- DOI
  10.1021/jacs.6b08424
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-15J12340
[Journal Article] An unusual chimeric diterpene synthase from Emericella varicolor and its functional conversion into a sesterterpene synthase by domain swapping2016
- Author(s)
  B. Qin, Y. Matsuda, T. Mori, M. Okada, Z. Quan, T. Mitsuhashi, T. Wakimoto, I. Abe
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55 Issue: 5 Pages: 1658-1661
- DOI
  10.1002/anie.201509263
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-24688011
[Journal Article] Unusual chemistries in fungal meroterpenoid biosynthesis2016
- Author(s)
  Matsuda, Y., Awakawa, T., Mori, T., Abe, I.
- Journal Title
  
  Curr. Opin. Chem. Biol.
  
  Volume: 31 Pages: 1-7
- DOI
  10.1016/j.cbpa.2015.11.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836
[Journal Article] Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis2016
- Author(s)
  Okada, M., Matsuda, Y., Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 138 Issue: 31 Pages: 10011-10018
- DOI
  10.1021/jacs.6b05799
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-16J01117, KAKENHI-PROJECT-24688011
[Journal Article] Structural basis for the β-carboline alkaloids production by the microbial homodimeric enzyme McbB2015
- Author(s)
  T. Mori, S. Hoshino, S. Sahashi, T. Wakimoto, T. Matsui, H. Morita, I. Abe
- Journal Title
  
  Chem. Biol.
  
  Volume: 17 Issue: 7 Pages: 1501-1504
- DOI
  10.1016/j.chembiol.2015.06.006
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-26282210, KAKENHI-PROJECT-15H01836
[Journal Article] Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB2015
- Author(s)
  Mori, T., Yang, D., Matsui, T, Hashimoto, M., Morita, H., Fujii, I., Abe, I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 8 Pages: 5214-5225
- DOI
  10.1074/jbc.m114.626416
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23241068, KAKENHI-PROJECT-24770088, KAKENHI-PUBLICLY-25108710, KAKENHI-PUBLICLY-25108722, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-26282210, KAKENHI-PROJECT-26560435, KAKENHI-PROJECT-15H01836
[Journal Article] Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/ reductase in antimycin biosynthesis2015
- Author(s)
  Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.,
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 54 Issue: 45 Pages: 13462-13465
- DOI
  10.1002/anie.201506899
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J12365, KAKENHI-PROJECT-26560428, KAKENHI-PROJECT-15H01836
[Presentation] 酵素立体構造を基盤とした二次代謝産物生合成酵素の酵素工学2022
- Author(s)
  森貴裕
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K15703
[Presentation] Molecular basis for the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021
- Author(s)
  Takahiro Mori, Rui Zhai, Richiro Ushimaru, Ikuro Abe
- Organizer
  3rd Aachen Protein Engineering Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703
[Presentation] 非ヘム鉄α-ケトグルタル酸要求性オキシゲナーゼによるエンドペルオキシド形成機構の解明2021
- Author(s)
  森貴裕、Rui Zhai、牛丸理一郎、阿部郁朗
- Organizer
  第63回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K15703
[Presentation] Molecular basis for the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021
- Author(s)
  Takahiro Mori, Rui Zhai, Richiro Ushimaru, Ikuro Abe
- Organizer
  4th European Conference on Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703
[Presentation] 新規ジアルキル縮合酵素のX線結晶構造解析
- Author(s)
  森貴裕
- Organizer
  第２０回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-11-05 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-26882018
[Presentation] 新規ジアルキル縮合酵素のX線結晶構造解析
- Author(s)
  森貴裕
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-26882018
[]

1. Abe Ikuro (40305496)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
2. 淡川孝義 (80609834)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. 牛丸理一郎 (10873648)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. MORITA Hiroyuki (20416663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SENDA Toshiya (30272868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中村仁美 (90800657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岡田正弘 (40377792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松田侑大 (10720766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KODAMA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. WAKIMOTO Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. ABE Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松田研一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 野口博司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 安達成彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mori Takahiro 森 貴裕

Research Projects

Research Products

Co-Researchers

Metabolons in Natural Product BiosynthesisArea Organizer

Area Organizer

Project Period (FY)

Research Category

特化メタボロン・総括班Principal Investigator

Principal Investigator

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微生物特化メタボロンの解明と酵素複合体立体構造解析Principal Investigator

Principal Investigator

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Review Section

Research Institution

薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

薬用天然物の骨格構築に関わる新奇生合成酵素群の構造機能解明と合成生物学的利用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular Basis of Activation of Drug Metabolism by Intestinal Bacteria

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Survey for new drug discovery resources and exploration & elucidation of novel natural product biosynthetic machineries

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-function studies of enzymes involved in natural product biosynthesis for drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-function analysis of biosynthetic enzymes in the biosynthesis of fungal meroterpenoidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

糸状菌由来テルペノイド合成酵素群の機能拡張と分子多様性の創出Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Biosynthetic studies on complex natural products

Principal Investigator

Project Period (FY)

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Research Institution

Functional analysis of bacterial stilbene synthasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lincosamide Antibiotics: Structure, Activity, and Biosynthesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes2023

Mori Takahiro 森貴裕