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Takeshita Takashi  竹下 卓志

… Alternative Names

Takashi Takeshita  竹下 卓志

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Researcher Number 60736289
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8559-8181
Affiliation (Current) 2025: 札幌医科大学, 医学部, 訪問研究員
Affiliation (based on the past Project Information) *help 2024: 札幌医科大学, 医学部, 訪問研究員
2021 – 2023: 北海道大学, 大学病院, 講師
2017 – 2018: 熊本大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Except Principal Investigator
Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
転移乳癌 / CDK4/6阻害薬 / ESR1変異 / ホルモン受容体陽性 / リキッドバイオプシー / 癌 / biomarker / PIK3CA mutation / ESR1 mutation / cell-free DNA … More / 内分泌抵抗性 / ER陽性乳癌 / cell-free DNA / 再発乳癌 / Liquid biopsy / ddPCR / HER2 / PIK3CA / ESR1 / metastatic breast cancer / liquid biopsy … More
Except Principal Investigator
テクスチャ解析 / FDG-PET / MRI / 乳癌 Less
  • Research Projects

    (3 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (9 People)
  •  Elucidation of the mechanism of resistance acquisition in 1st/2nd line treatment for metastatic breast cancer focusing on ESR1 mutationsPrincipal Investigator

    • Principal Investigator
      竹下 卓志
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Sapporo Medical University
  •  乳癌の再発転移予測に向けたMRIと半導体PETのバイオマーカーによる微小環境評価

    • Principal Investigator
      加藤 扶美
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Hokkaido University
  •  Development of liquid biopsy method for breast cancer clinical application.Principal Investigator

    • Principal Investigator
      Takashi Takeshita
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General surgery
    • Research Institution
      Kumamoto University

All 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] dPCR Mutational Analyses in Cell-Free DNA: A Comparison with Tissues2019

    • Author(s)
      Takeshita Takashi、Iwase Hirotaka
    • Journal Title

      Methods in molecular biology (Clifton, N.J.)

      Volume: 1909 Pages: 105-118

    • DOI

      10.1007/978-1-4939-8973-7_8

    • ISBN
      9781493989720, 9781493989737
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Journal Article] ESR1 and PIK3CA mutational status in serum and plasma from metastatic breast cancer patients: A comparative study2018

    • Author(s)
      Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Iwase Hirotaka
    • Journal Title

      Cancer Biomarkers

      Volume: 22 Issue: 2 Pages: 345-350

    • DOI

      10.3233/cbm-171161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Journal Article] Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer2018

    • Author(s)
      Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Murakami Keiichi、Iwase Hirotaka
    • Journal Title

      Molecular Cancer

      Volume: 17 Issue: 1 Pages: 67-72

    • DOI

      10.1186/s12943-018-0808-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10057, KAKENHI-PROJECT-17K16511
  • [Journal Article] Comparison of ESR1 Mutations in Tumor Tissue and Matched Plasma Samples from Metastatic Breast Cancer Patients2017

    • Author(s)
      Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Murakami Keiichi、Omoto Yoko、Iwase Hirotaka
    • Journal Title

      Translational Oncology

      Volume: 10 Issue: 5 Pages: 766-771

    • DOI

      10.1016/j.tranon.2017.07.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16511, KAKENHI-PROJECT-15K10057
  • [Journal Article] Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients2017

    • Author(s)
      Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Sueta Aiko、Tomiguchi Mai、Murakami Keiichi、Omoto Yoko、Iwase Hirotaka
    • Journal Title

      BMC Cancer

      Volume: 17 Issue: 1 Pages: 786-794

    • DOI

      10.1186/s12885-017-3779-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16511, KAKENHI-PROJECT-15K10057
  • [Journal Article] Analysis of <i>ESR1</i> and <i>PIK3CA</i> mutations in plasma cell-free DNA from ER-positive breast cancer patients2017

    • Author(s)
      Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Murakami Keiichi、Omoto Yoko、Iwase Hirotaka
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 32 Pages: 52142-52155

    • DOI

      10.18632/oncotarget.18479

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16511, KAKENHI-PROJECT-15K10057
  • [Presentation] リキッドバイオプシイ: ctDNA, CTC, microRNAなど ER陽性乳癌血漿cell-free DNA中 PIK3CA 、AKT1 、ESR1 mutationの治療ライン毎の臨床学的意義2018

    • Author(s)
      竹下卓志、藤木義敬、冨口麻衣、末田愛子、後藤理沙、指宿睦子、山本豊、岩瀬弘敬
    • Organizer
      第26回日本乳癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Presentation] Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer patients.2018

    • Author(s)
      Takashi Takeshita, Mai Tomiguchi, Aiko Sueta, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Hirotaka Iwase.
    • Organizer
      AACR Annual Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Presentation] ER陽性乳癌における治療ライン毎のcell-free DNA PIK3CA およびESR1突然変異の臨床学的意義2018

    • Author(s)
      竹下卓志、冨口麻衣、末田愛子、藤木義敬、後藤理沙、指宿睦子、山本豊、岩瀬弘敬
    • Organizer
      第118回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Presentation] ER陽性乳癌患者におけるESR1 mutationのスポットおよび連続検索の臨床学的意義2017

    • Author(s)
      竹下 卓志, 冨口 麻衣, 末田 愛子, 藤木 義敬, 指宿 睦子, 山本 豊, 岩瀬 弘敬
    • Organizer
      第76回日本癌学会総会記事
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Presentation] ER陽性転移・再発乳癌におけるESR1およびPIK3CA体細胞突然変異の臨床的意義に関する研究2017

    • Author(s)
      竹下卓志, 冨口麻衣, 末田愛子, 藤木義敬, 後藤理沙, 邱什, 西村純子, 指宿睦子, 山本豊, 岩瀬弘敬
    • Organizer
      第25回日本乳癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Presentation] Incidence and clinical relevance of ESR1 mutations in estrogen receptor positive breast cancer patients2017

    • Author(s)
      Takashi Takeshita, Mai Tomiguchi, Aiko Sueta, Keiichi Murakami, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Hirotaka Iwase
    • Organizer
      第15回日本臨床腫瘍学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K16511
  • [Presentation] ER陽性乳癌におけるDroplet Digital PCRを用いたcell‐free DNA内のESR1遺伝子変異のMultiplex検出2017

    • Author(s)
      竹下卓志, 冨口麻衣, 末田愛子, 西村純子, 指宿睦子, 山本豊, 岩瀬弘敬
    • Organizer
      第117回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K16511
  • 1.  加藤 扶美 (80399865)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  松野 吉宏 (00199829)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  平田 健司 (30431365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  高橋 將人 (50374343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  細田 充主 (40443931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  清水 亜衣 (60849123)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  鳥越 俊彦 (20301400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Iwase Hirotaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 9.  村上 敬一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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