Takeshita Takashi 竹下卓志

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Takashi Takeshita 竹下卓志

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Researcher Number	60736289
Other IDs	https://orcid.org/0000-0002-8559-8181
Affiliation (Current)	2025: 札幌医科大学, 医学部, 訪問研究員
Affiliation (based on the past Project Information) *help	2024: 札幌医科大学, 医学部, 訪問研究員 2021 – 2023: 北海道大学, 大学病院, 講師 2017 – 2018: 熊本大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 転移乳癌 / CDK4/6阻害薬 / ESR1変異 / ホルモン受容体陽性 / リキッドバイオプシー / 癌 / biomarker / PIK3CA mutation / ESR1 mutation / cell-free DNA … More / 内分泌抵抗性 / ER陽性乳癌 / cell-free　DNA / 再発乳癌 / Liquid biopsy / ddPCR / HER2 / PIK3CA / ESR1 / metastatic breast cancer / liquid biopsy … More Except Principal Investigator テクスチャ解析 / FDG-PET / MRI / 乳癌 Less

Elucidation of the mechanism of resistance acquisition in 1st/2nd line treatment for metastatic breast cancer focusing on ESR1 mutationsPrincipal Investigator
- Principal Investigator
  
  竹下卓志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Sapporo Medical University
乳癌の再発転移予測に向けたMRIと半導体PETのバイオマーカーによる微小環境評価
- Principal Investigator
  
  加藤扶美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Development of liquid biopsy method for breast cancer clinical application.Principal Investigator
- Principal Investigator
  
  Takashi Takeshita
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University

All 2019 2018 2017

All Journal Article Presentation

[Journal Article] dPCR Mutational Analyses in Cell-Free DNA: A Comparison with Tissues2019
- Author(s)
  Takeshita Takashi、Iwase Hirotaka
- Journal Title
  
  Methods in molecular biology (Clifton, N.J.)
  
  Volume: 1909 Pages: 105-118
- DOI
  10.1007/978-1-4939-8973-7_8
- ISBN
  9781493989720, 9781493989737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16511
[Journal Article] ESR1 and PIK3CA mutational status in serum and plasma from metastatic breast cancer patients: A comparative study2018
- Author(s)
  Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Iwase Hirotaka
- Journal Title
  
  Cancer Biomarkers
  
  Volume: 22 Issue: 2 Pages: 345-350
- DOI
  10.3233/cbm-171161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16511
[Journal Article] Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer2018
- Author(s)
  Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Murakami Keiichi、Iwase Hirotaka
- Journal Title
  
  Molecular Cancer
  
  Volume: 17 Issue: 1 Pages: 67-72
- DOI
  10.1186/s12943-018-0808-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10057, KAKENHI-PROJECT-17K16511
[Journal Article] Comparison of ESR1 Mutations in Tumor Tissue and Matched Plasma Samples from Metastatic Breast Cancer Patients2017
- Author(s)
  Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Murakami Keiichi、Omoto Yoko、Iwase Hirotaka
- Journal Title
  
  Translational Oncology
  
  Volume: 10 Issue: 5 Pages: 766-771
- DOI
  10.1016/j.tranon.2017.07.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16511, KAKENHI-PROJECT-15K10057
[Journal Article] Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients2017
- Author(s)
  Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Sueta Aiko、Tomiguchi Mai、Murakami Keiichi、Omoto Yoko、Iwase Hirotaka
- Journal Title
  
  BMC Cancer
  
  Volume: 17 Issue: 1 Pages: 786-794
- DOI
  10.1186/s12885-017-3779-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16511, KAKENHI-PROJECT-15K10057
[Journal Article] Analysis of <i>ESR1</i> and <i>PIK3CA</i> mutations in plasma cell-free DNA from ER-positive breast cancer patients2017
- Author(s)
  Takeshita Takashi、Yamamoto Yutaka、Yamamoto-Ibusuki Mutsuko、Tomiguchi Mai、Sueta Aiko、Murakami Keiichi、Omoto Yoko、Iwase Hirotaka
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 32 Pages: 52142-52155
- DOI
  10.18632/oncotarget.18479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16511, KAKENHI-PROJECT-15K10057
[Presentation] リキッドバイオプシイ: ctDNA, CTC, microRNAなど　ER陽性乳癌血漿cell-free DNA中 PIK3CA 、AKT1 、ESR1 mutationの治療ライン毎の臨床学的意義2018
- Author(s)
  竹下卓志、藤木義敬、冨口麻衣、末田愛子、後藤理沙、指宿睦子、山本豊、岩瀬弘敬
- Organizer
  第26回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16511
[Presentation] Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer patients.2018
- Author(s)
  Takashi Takeshita, Mai Tomiguchi, Aiko Sueta, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Hirotaka Iwase.
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16511
[Presentation] ER陽性乳癌における治療ライン毎のcell-free DNA PIK3CA およびESR1突然変異の臨床学的意義2018
- Author(s)
  竹下卓志、冨口麻衣、末田愛子、藤木義敬、後藤理沙、指宿睦子、山本豊、岩瀬弘敬
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16511
[Presentation] ER陽性乳癌患者におけるESR1 mutationのスポットおよび連続検索の臨床学的意義2017
- Author(s)
  竹下卓志, 冨口麻衣, 末田愛子, 藤木義敬, 指宿睦子, 山本豊, 岩瀬弘敬
- Organizer
  第76回日本癌学会総会記事
- Data Source
  KAKENHI-PROJECT-17K16511
[Presentation] ER陽性転移・再発乳癌におけるESR1およびPIK3CA体細胞突然変異の臨床的意義に関する研究2017
- Author(s)
  竹下卓志, 冨口麻衣, 末田愛子, 藤木義敬, 後藤理沙, 邱什, 西村純子, 指宿睦子, 山本豊, 岩瀬弘敬
- Organizer
  第25回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16511
[Presentation] Incidence and clinical relevance of ESR1 mutations in estrogen receptor positive breast cancer patients2017
- Author(s)
  Takashi Takeshita, Mai Tomiguchi, Aiko Sueta, Keiichi Murakami, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Hirotaka Iwase
- Organizer
  第15回日本臨床腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16511
[Presentation] ER陽性乳癌におけるDroplet Digital PCRを用いたcell‐free DNA内のESR1遺伝子変異のMultiplex検出2017
- Author(s)
  竹下卓志, 冨口麻衣, 末田愛子, 西村純子, 指宿睦子, 山本豊, 岩瀬弘敬
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16511

1. 加藤扶美 (80399865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 松野吉宏 (00199829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 平田健司 (30431365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高橋將人 (50374343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 細田充主 (40443931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 清水亜衣 (60849123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鳥越俊彦 (20301400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Iwase Hirotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
9. 村上敬一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshita Takashi 竹下 卓志

Takashi Takeshita 竹下 卓志

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of resistance acquisition in 1st/2nd line treatment for metastatic breast cancer focusing on ESR1 mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乳癌の再発転移予測に向けたMRIと半導体PETのバイオマーカーによる微小環境評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of liquid biopsy method for breast cancer clinical application.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] dPCR Mutational Analyses in Cell-Free DNA: A Comparison with Tissues2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] ESR1 and PIK3CA mutational status in serum and plasma from metastatic breast cancer patients: A comparative study2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of ESR1 Mutations in Tumor Tissue and Matched Plasma Samples from Metastatic Breast Cancer Patients2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of <i>ESR1</i> and <i>PIK3CA</i> mutations in plasma cell-free DNA from ER-positive breast cancer patients2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] リキッドバイオプシイ: ctDNA, CTC, microRNAなど ER陽性乳癌血漿cell-free DNA中 PIK3CA 、AKT1 、ESR1 mutationの治療ライン毎の臨床学的意義2018

Author(s)

Organizer

Data Source

[Presentation] Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer patients.2018

Author(s)

Organizer

Data Source

[Presentation] ER陽性乳癌における治療ライン毎のcell-free DNA PIK3CA およびESR1突然変異の臨床学的意義2018

Author(s)

Organizer

Data Source

[Presentation] ER陽性乳癌患者におけるESR1 mutationのスポットおよび連続検索の臨床学的意義2017

Author(s)

Organizer

Data Source

[Presentation] ER陽性転移・再発乳癌におけるESR1およびPIK3CA体細胞突然変異の臨床的意義に関する研究2017

Author(s)

Organizer

Data Source

[Presentation] Incidence and clinical relevance of ESR1 mutations in estrogen receptor positive breast cancer patients2017

Author(s)

Organizer

Data Source

[Presentation] ER陽性乳癌におけるDroplet Digital PCRを用いたcell‐free DNA内のESR1遺伝子変異のMultiplex検出2017

Author(s)

Takeshita Takashi 竹下卓志

Takashi Takeshita 竹下卓志

[Presentation] リキッドバイオプシイ: ctDNA, CTC, microRNAなど　ER陽性乳癌血漿cell-free DNA中 PIK3CA 、AKT1 、ESR1 mutationの治療ライン毎の臨床学的意義2018