Shimoyama Shuji 下山修司

… Alternative Names

下山修司シモヤマシュウジ

SHIMOYAMA Shuji 下山修司

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Researcher Number	60736370
Other IDs	https://orcid.org/0000-0001-6777-0438
Affiliation (Current)	2024: 弘前大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2024: 弘前大学, 医学研究科, 助教 2019 – 2022: 弘前大学, 医学研究科, 助教 2017: 弘前大学, 医学研究科, 助教 2017: 弘前大学, 大学院医学研究科, 助教 2016: 弘前大学, 医学研究科, 研究機関研究員 2015: 弘前大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 52020:Neurology-related / Basic Section 59040:Nutrition science and health science-related / Anesthesiology / Psychiatric science
Keywords	Principal Investigator 細胞膜移行 / GABA-A受容体 / 薬剤耐性 / パルミトイル化 / ベンゾジアゼピン系化合物 / ジアゼパム / GABA受容体 Except Principal Investigator 自閉スペクトラム症 / 注意欠如・多動性障害 / シナプトタグミン13 … More / シナプス / 多系統萎縮症 / パーキンソン病 / αシヌクレイン / 老齢 / 運動由来分子 / プロテオーム解析 / 活動量 / 認知機能 / 老齢マウス / exercise / 質量分析 / 神経発達障害 / ベンゾジアゼピン長期投与 / シナプス外GABA-A受容体 / GABA-A受容体細胞内分布 / 受容体リン酸化 / 受容体トラフィッキング / GABA / 麻酔薬 / 受容体リン酸化調節 / GABA-A受容体トラフィッキング / 麻酔作用調節 / 精神医学 / CNV / 自閉症スペクトラム / 児童・思春期精神医学 / ADHD / Autism Spectrum Disorder Less

新規伝播調節タンパク質SYT13の制御による異常αシヌクレインの伝播抑制
- Principal Investigator
  
  三木康生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hirosaki University
GABA-A受容体パルミトイル化によるベンゾジアゼピン系薬剤耐性メカニズムの解明Principal Investigator
- Principal Investigator
  
  下山修司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hirosaki University
運動由来分子の個体間移行による認知機能向上効果の発現メカニズム解明
- Principal Investigator
  
  古川智範
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hirosaki University
神経発達障害の脆弱性と予測因子に関する研究
- Principal Investigator
  
  中村和彦
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hirosaki University
ASD
- Principal Investigator
  
  Kubo Kazutoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hirosaki University
The clarification of pathophysiology in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder
- Principal Investigator
  
  Nakamura Kazuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hirosaki University
Novel regulatory mechanism of anesthetic efficay by GABA-A receptor trafficking
- Principal Investigator
  
  UENO Shinya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Hirosaki University

All 2023 2022 2020 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons2023
- Author(s)
  Masaru Yamaguchi, Takakiyo Tsujiguchi, Tomonori Furukawa, Shuji Shimoyama, Toshiya Nakamura, Yasushi Mariya, Junko Yamada
- Journal Title
  
  Radiation Environment and Medicine
  
  Volume: 12 Issue: 1 Pages: 65-73
- DOI
  10.51083/radiatenvironmed.12.1_65
- ISSN
  2423-9097, 2432-163X
- Year and Date
  2023-02-27
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11747, KAKENHI-PROJECT-20K07270
[Journal Article] Pathological substrate of memory impairment in multiple system atrophy2022
- Author(s)
  Miki Yasuo、Tanji Kunikazu、Shinnai Kana、Tanaka Makoto T.、Altay Firat、et al.
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 48 Issue: 7
- DOI
  10.1111/nan.12844
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07452, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22K11747, KAKENHI-PROJECT-20K06887, KAKENHI-PROJECT-23K24209
[Journal Article] Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease2018
- Author(s)
  Miki Yasuo、Shimoyama Shuji、Kon Tomoya、Ueno Tatsuya、Hayakari Ryo、Tanji Kunikazu、Matsumiya Tomoh、Tsushima Eiki、Mori Fumiaki、Wakabayashi Koichi、Tomiyama Masahiko
- Journal Title
  
  Neurobiology of aging
  
  Volume: 63 Pages: 33-43
- DOI
  10.1016/j.neurobiolaging.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07088, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-16K15473, KAKENHI-PROJECT-16K19503
[Journal Article] Propofol anesthesia is reduced in Phospholipase C-related inactive protein type-1 knockout mice2017
- Author(s)
  Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S
- Journal Title
  
  The Journal of pharmacology and experimental therapeutics
  
  Volume: 361(3) Issue: 3 Pages: 367-374
- DOI
  10.1124/jpet.116.239145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11503, KAKENHI-PROJECT-17K08562, KAKENHI-PROJECT-17K09050, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-17H01595, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-17H05074, KAKENHI-PROJECT-15K10503
[Journal Article] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017
- Author(s)
  Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi & Shinya Ueno
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 5(1) Issue: 1 Pages: 1-12
- DOI
  10.1002/prp2.283
- NAID
  120006576912
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-26284060, KAKENHI-PROJECT-15K10503, KAKENHI-PROJECT-26590161, KAKENHI-PROJECT-16K20888, KAKENHI-PROJECT-17H05074
[Journal Article] HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus.2016
- Author(s)
  Migita K, Ozaki T, Shimoyama S, Yamada J., Nikaido Y, Furukawa T, Shiba Y, Egan TM, Ueno S.
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 90 (2) Issue: 2 Pages: 116-126
- DOI
  10.1124/mol.115.102988
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460314, KAKENHI-PROJECT-15K10503
[Presentation] The effect of β 3 subunit phosphorylation on trafficking and function of GABAA receptor.2023
- Author(s)
  Aogi Kobayashi, Moeka Fujii, Tomonori Furukawa, Shuji Shimoyama, and Shinya Ueno
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-22K11747
[Presentation] "Plasma Oxytocin and Developmental Disorders in Japanese 5-year-old children"2020
- Author(s)
  "Yui Sakamoto*, Manabu Saito, Shuji Shimoyama, Ayako Osato, Ai Terui, Kazutaka Yoshida, Tamaki Mikami, Kazuhiko Nakamura"
- Organizer
  IACAPAP2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03595
[Presentation] The effect of chronic diazepam administration on hippocampal long-term potentiation and spine morphology.2018
- Author(s)
  T. Furukawa, Y. Nikaido, S. Shimoyama, Y. Ogata, K. Nakamura, S. Ueno.
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] The effect of chronic diazepam administration on hippocampal long-term potentiation and spine morphology2018
- Author(s)
  Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Yoshiki Ogata, Kazuhiko Nakamura and Shinya Ueno
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] 視線検出装置（Gazefinder）を用いた5歳児のASD傾向の検討2017
- Author(s)
  斉藤まなぶ、土屋賢治、吉田和貴、足立匡基、髙橋芳雄、下山修司、山田順子、上野伸哉、中村　和彦
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] The effect of chronic diazepam administration on Lcn2 expression and spine morphology2017
- Author(s)
  Tomonori Furukawa, Shuji Shimoyama, Yoshikazu Nikaido, Yasuo Miki, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
- Organizer
  第40回神経科学学会
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] Phospholipase C-related inactive protein type-1 deficiency alters anesthetic electroencephalogram induced by propofol in mice2017
- Author(s)
  Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata and Shinya Ueno
- Organizer
  第40回神経科学学会
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] IGF-1を標的とした自閉症スペクトラム治療薬候補の探索2017
- Author(s)
  下山修司
- Organizer
  第4回　脳研×高度先進×COI合同セミナー
- Place of Presentation
  弘前大学（青森県・弘前市）
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] 慢性社会的敗北ストレスによってうつ病様モデル化したラットは前頭前野の機能異常を起こす2017
- Author(s)
  二階堂義和, 古川智範, 下山修司, 櫛方哲也, 廣田和美, 上野伸哉
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017
- Author(s)
  Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
- Organizer
  第94回　日本生理学会
- Place of Presentation
  アクトシティ浜松（静岡県・浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] AP-1 complex induces mouse Tspo gene expression by lipopolysaccharide in microglial cell line, BV-22017
- Author(s)
  Shuji Shimoyama, Tomonori Furukawa, Yoshiki Ogata, Shinya Ueno and Kazuhiko Nakamura
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] The effect of chronic diazepam administration induced upregulation of Lcn2 expression on cognitive function2017
- Author(s)
  Yoshiki Ogata, Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Kazuhiko Nakamura and Shinya Ueno
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] The effect of chronic diazepam administration on Lcn2 expression and spine morphology.2017
- Author(s)
  T. Furukawa, S. Shimoyama, Y. Nikaido, Y. Miki, K. Koga, K. Nakamura, K. Wakabayashi, S. Ueno.
- Organizer
  第40回神経科学学会
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017
- Author(s)
  Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松(浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] Chronic diazepam administration impairs acquisition of spatial reference memory in aged mice2017
- Author(s)
  Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Kohei Koga, and Shinya Ueno
- Organizer
  第94回　日本生理学会
- Place of Presentation
  アクトシティ浜松（静岡県・浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] Phospholipase C-related inactive protein type-1 is involved in intravenous anesthetic-induced EEG changes in mice.2017
- Author(s)
  Y. Nikaido, T. Furukawa, S. Shimoyama, T. Kushikata, K. Hirota, T. Kanematsu, M. Hirata, S. Ueno.
- Organizer
  第40回神経科学学会
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] The effect of chronic diazepam administration induced upregulation of Lcn2 expression on cognitive function2017
- Author(s)
  Y. Ogata, T. Furukawa, Y. Nikaido, S. Shimoyama, K. Nakamura, S. Ueno.
- Organizer
  第44回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] ラット前帯状皮質は恐怖記憶の想起と消去では左右異なる活動を示す2016
- Author(s)
  古川智範、二階堂義和、右田啓介、下山修司、尾崎拓、古賀浩平、上野伸哉
- Organizer
  第93回　日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] 5歳児の自閉スペクトラム障害における VLDL、IGF-1、オキシトシンの診断有用性の検討2016
- Author(s)
  斉藤まなぶ、下山修司、吉田恵心、坂本由唯、大里絢子、高柳伸哉、足立匡基、安田小響、栗林理人、中村和彦
- Organizer
  第112回　日本精神神経学会総会
- Place of Presentation
  幕張メッセ（千葉県・千葉市）
- Year and Date
  2016-06-02
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] 遺伝子Tspo の発現調節メカニズムの解明2016
- Author(s)
  下山修司、中村和彦、上野伸哉
- Organizer
  日本生化学会東北支部　第82 回例会・シンポジウム
- Place of Presentation
  弘前大学(弘前市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K10503
[Presentation] 遺伝子Tspo の発現調節メカニズムの解明2016
- Author(s)
  下山修司、中村和彦、上野伸哉
- Organizer
  日本生化学会　東北支部　第82回例会
- Place of Presentation
  弘前大学（青森県・弘前市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15H04889
[Presentation] 某市5歳児発達健診における発達性協調運動障害の疫学2015
- Author(s)
  斉藤まなぶ、山田順子、下山修司、尾崎拓、上野伸哉、中村和彦
- Organizer
  第42回日本脳科学会
- Place of Presentation
  ANAホリデイ・インリゾート宮崎（宮崎県宮崎市）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15H04889

1. FURUKAWA Tomonori (60402369)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. Nakamura Kazuhiko (80263911)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. UENO Shinya (00312158)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
4. 斉藤まなぶ (40568846)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 尾崎拓 (70621069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 坂本由唯 (60770386)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 三木康生 (30709142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. NIKAIDOU Yoshikazu (50613478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. Kubo Kazutoshi (80716910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三上達也 (70344611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中根明夫 (30164239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 足立匡基 (50637329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高橋芳雄 (70760891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 西嶌春生 (90858177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小枝周平 (00455734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 多田羅洋太 (00443995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 若林孝一 (50240768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. MIGITA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. OZAKI Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 山田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 兼松隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 森文秋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 丹治邦和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimoyama Shuji 下山 修司

下山 修司 シモヤマ シュウジ

SHIMOYAMA Shuji 下山 修司

Research Projects

Research Products

Co-Researchers

新規伝播調節タンパク質SYT13の制御による異常αシヌクレインの伝播抑制

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GABA-A受容体パルミトイル化によるベンゾジアゼピン系薬剤耐性メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

運動由来分子の個体間移行による認知機能向上効果の発現メカニズム解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経発達障害の脆弱性と予測因子に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ASD

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The clarification of pathophysiology in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel regulatory mechanism of anesthetic efficay by GABA-A receptor trafficking

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Pathological substrate of memory impairment in multiple system atrophy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Propofol anesthesia is reduced in Phospholipase C-related inactive protein type-1 knockout mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus.2016

Author(s)

Journal Title

Shimoyama Shuji 下山修司

下山修司シモヤマシュウジ

SHIMOYAMA Shuji 下山修司