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Shimoyama Shuji  下山 修司

… Alternative Names

SHIMOYAMA Shuji  下山 修司

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Researcher Number 60736370
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6777-0438
Affiliation (Current) 2025: 弘前大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help 2019 – 2024: 弘前大学, 医学研究科, 助教
2017: 弘前大学, 医学研究科, 助教
2017: 弘前大学, 大学院医学研究科, 助教
2016: 弘前大学, 医学研究科, 研究機関研究員
2015: 弘前大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Basic Section 55050:Anesthesiology-related
Except Principal Investigator
Basic Section 52030:Psychiatry-related / Basic Section 52020:Neurology-related / Basic Section 59040:Nutrition science and health science-related / Anesthesiology / Psychiatric science
Keywords
Principal Investigator
細胞膜移行 / GABA-A受容体 / 薬剤耐性 / パルミトイル化 / ベンゾジアゼピン系化合物 / ジアゼパム / GABA受容体
Except Principal Investigator
自閉スペクトラム症 / 注意欠如・多動性障害 / シナプトタグミン13 … More / シナプス / 多系統萎縮症 / パーキンソン病 / αシヌクレイン / 老齢 / 運動由来分子 / 活動量 / exercise / プロテオーム解析 / 海馬 / 認知機能 / 老齢マウス / 運動 / 質量分析 / 神経発達障害 / 5歳児発達健診 / メタボローム解析 / 注意欠如・多動症 / 自閉症 / 神経発達症群 / ベンゾジアゼピン長期投与 / シナプス外GABA-A受容体 / GABA-A受容体細胞内分布 / 受容体リン酸化 / 受容体トラフィッキング / GABA / 麻酔薬 / 受容体リン酸化調節 / GABA-A受容体トラフィッキング / 麻酔作用調節 / 精神医学 / CNV / 自閉症スペクトラム / 児童・思春期精神医学 / ADHD / Autism Spectrum Disorder Less
  • Research Projects

    (7 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (23 People)
  •  新規伝播調節タンパク質SYT13の制御による異常αシヌクレインの伝播抑制

    • Principal Investigator
      三木 康生
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Hirosaki University
  •  GABA-A受容体パルミトイル化によるベンゾジアゼピン系薬剤耐性メカニズムの解明Principal Investigator

    • Principal Investigator
      下山 修司
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hirosaki University
  •  運動由来分子の個体間移行による認知機能向上効果の発現メカニズム解明

    • Principal Investigator
      古川 智範
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Hirosaki University
  •  Study on vulnerability and predictive factors for neurodevelopmental disorders

    • Principal Investigator
      Nakamura Kazuhiko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Hirosaki University
  •  ASD

    • Principal Investigator
      Kubo Kazutoshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Hirosaki University
  •  The clarification of pathophysiology in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

    • Principal Investigator
      Nakamura Kazuhiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Hirosaki University
  •  Novel regulatory mechanism of anesthetic efficay by GABA-A receptor trafficking

    • Principal Investigator
      UENO Shinya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Hirosaki University

All 2024 2023 2022 2020 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Benzodiazepin-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways2024

    • Author(s)
      Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno
    • Journal Title

      Hirosaki Med J

      Volume: 74 Pages: 52-60

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09086
  • [Journal Article] Sex-related differences in the effect of exercise on protein profiles of serum in mice2024

    • Author(s)
      Furukawa Tomonori, Shimoyama Shuji, Kobayashi Aogi, Tatara Yota, Nikaido Yoshikazu, Ueno Shinya.
    • Journal Title

      Hirosaki medical journal

      Volume: 74 Pages: 40-51

    • Data Source
      KAKENHI-PROJECT-22K11747
  • [Journal Article] Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO- independent pathways2024

    • Author(s)
      Shimoyama S, Furukawa T, Ueno S
    • Journal Title

      Hirosaki medical journal

      Volume: 74

    • Data Source
      KAKENHI-PROJECT-22K11747
  • [Journal Article] Effect of Ionizing Radiation on the Intercellular Network of Murine Cerebral Cortical Neurons2023

    • Author(s)
      Masaru Yamaguchi, Takakiyo Tsujiguchi, Tomonori Furukawa, Shuji Shimoyama, Toshiya Nakamura, Yasushi Mariya, Junko Yamada
    • Journal Title

      Radiation Environment and Medicine

      Volume: 12 Issue: 1 Pages: 65-73

    • DOI

      10.51083/radiatenvironmed.12.1_65

    • ISSN
      2423-9097, 2432-163X
    • Year and Date
      2023-02-27
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K11747, KAKENHI-PROJECT-20K07270
  • [Journal Article] Pathological substrate of memory impairment in multiple system atrophy2022

    • Author(s)
      Miki Yasuo、Tanji Kunikazu、Shinnai Kana、Tanaka Makoto T.、Altay Firat、et al.
    • Journal Title

      Neuropathology and Applied Neurobiology

      Volume: 48 Issue: 7

    • DOI

      10.1111/nan.12844

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07452, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22K11747, KAKENHI-PROJECT-20K06887, KAKENHI-PROJECT-23K24209
  • [Journal Article] Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease2018

    • Author(s)
      Miki Yasuo、Shimoyama Shuji、Kon Tomoya、Ueno Tatsuya、Hayakari Ryo、Tanji Kunikazu、Matsumiya Tomoh、Tsushima Eiki、Mori Fumiaki、Wakabayashi Koichi、Tomiyama Masahiko
    • Journal Title

      Neurobiology of aging

      Volume: 63 Pages: 33-43

    • DOI

      10.1016/j.neurobiolaging.2017.11.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07088, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-16K15473, KAKENHI-PROJECT-16K19503
  • [Journal Article] Propofol anesthesia is reduced in Phospholipase C-related inactive protein type-1 knockout mice2017

    • Author(s)
      Nikaido Y, Furukawa T, Shimoyama S, Yamada J, Migita K, Koga K, Kushikata T, Hirota K, Kanematsu T, Hirata M, Ueno S
    • Journal Title

      The Journal of pharmacology and experimental therapeutics

      Volume: 361(3) Issue: 3 Pages: 367-374

    • DOI

      10.1124/jpet.116.239145

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11503, KAKENHI-PROJECT-17K08562, KAKENHI-PROJECT-17K09050, KAKENHI-PROJECT-17K19766, KAKENHI-PROJECT-17H01595, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-17H05074, KAKENHI-PROJECT-15K10503
  • [Journal Article] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017

    • Author(s)
      Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi & Shinya Ueno
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 5(1) Issue: 1 Pages: 1-12

    • DOI

      10.1002/prp2.283

    • NAID

      120006576912

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-26284060, KAKENHI-PROJECT-15K10503, KAKENHI-PROJECT-26590161, KAKENHI-PROJECT-16K20888, KAKENHI-PROJECT-17H05074
  • [Journal Article] HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus.2016

    • Author(s)
      Migita K, Ozaki T, Shimoyama S, Yamada J., Nikaido Y, Furukawa T, Shiba Y, Egan TM, Ueno S.
    • Journal Title

      Molecular Pharmacology

      Volume: 90 (2) Issue: 2 Pages: 116-126

    • DOI

      10.1124/mol.115.102988

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460314, KAKENHI-PROJECT-15K10503
  • [Presentation] The modulation of functional and trafficking properties of GABAA receptor by phosphorylation of β3 subunit2024

    • Author(s)
      Aogi Kobayashi, Tomonori Furukawa, Shuji Shimoyama and Shinya Ueno
    • Organizer
      The Annual Meeting of the Physiological Society of Japan
    • Data Source
      KAKENHI-PROJECT-22K11747
  • [Presentation] Palmitoylation regulates GABAA receptor distribution and function2023

    • Author(s)
      Shuji Shimoyama, Tomonori Furukawa, Nasa Majima and Shinya Ueno
    • Organizer
      The 46th Annual Meeting of the Japan Neuroscience Society
    • Data Source
      KAKENHI-PROJECT-22K11747
  • [Presentation] Palmitoylation regulates GABAA receptor distribution and function2023

    • Author(s)
      Nasa Majima, Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno
    • Organizer
      第46回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-22K09086
  • [Presentation] The effect of β 3 subunit phosphorylation on trafficking and function of GABAA receptor.2023

    • Author(s)
      Aogi Kobayashi, Moeka Fujii, Tomonori Furukawa, Shuji Shimoyama, and Shinya Ueno
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-22K11747
  • [Presentation] Sex-related differences in the effect of exercise on protein profiles of serum2023

    • Author(s)
      Tomonori Furukawa, Shuji Shimoyama and Shinya Ueno
    • Organizer
      The 46th Annual Meeting of the Japan Neuroscience Society
    • Data Source
      KAKENHI-PROJECT-22K11747
  • [Presentation] "Plasma Oxytocin and Developmental Disorders in Japanese 5-year-old children"2020

    • Author(s)
      "Yui Sakamoto*, Manabu Saito, Shuji Shimoyama, Ayako Osato, Ai Terui, Kazutaka Yoshida, Tamaki Mikami, Kazuhiko Nakamura"
    • Organizer
      IACAPAP2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03595
  • [Presentation] The effect of chronic diazepam administration on hippocampal long-term potentiation and spine morphology.2018

    • Author(s)
      T. Furukawa, Y. Nikaido, S. Shimoyama, Y. Ogata, K. Nakamura, S. Ueno.
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] The effect of chronic diazepam administration on hippocampal long-term potentiation and spine morphology2018

    • Author(s)
      Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Yoshiki Ogata, Kazuhiko Nakamura and Shinya Ueno
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] 視線検出装置(Gazefinder)を用いた5歳児のASD傾向の検討2017

    • Author(s)
      斉藤まなぶ、土屋賢治、吉田和貴、足立匡基、髙橋芳雄、下山修司、山田 順子、上野 伸哉、中村 和彦
    • Organizer
      第44回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] The effect of chronic diazepam administration on Lcn2 expression and spine morphology2017

    • Author(s)
      Tomonori Furukawa, Shuji Shimoyama, Yoshikazu Nikaido, Yasuo Miki, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] Phospholipase C-related inactive protein type-1 deficiency alters anesthetic electroencephalogram induced by propofol in mice2017

    • Author(s)
      Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Tetsuya Kushikata, Kazuyoshi Hirota, Takashi Kanematsu, Masato Hirata and Shinya Ueno
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] IGF-1を標的とした自閉症スペクトラム治療薬候補の探索2017

    • Author(s)
      下山修司
    • Organizer
      第4回 脳研×高度先進×COI合同セミナー
    • Place of Presentation
      弘前大学(青森県・弘前市)
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] 慢性社会的敗北ストレスによってうつ病様モデル化したラットは前頭前野の機能異常を起こす2017

    • Author(s)
      二階堂義和, 古川智範, 下山修司, 櫛方哲也, 廣田和美, 上野伸哉
    • Organizer
      第44回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017

    • Author(s)
      Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
    • Organizer
      第94回 日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] AP-1 complex induces mouse Tspo gene expression by lipopolysaccharide in microglial cell line, BV-22017

    • Author(s)
      Shuji Shimoyama, Tomonori Furukawa, Yoshiki Ogata, Shinya Ueno and Kazuhiko Nakamura
    • Organizer
      第44回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] The effect of chronic diazepam administration induced upregulation of Lcn2 expression on cognitive function2017

    • Author(s)
      Yoshiki Ogata, Tomonori Furukawa, Yoshikazu Nikaido, Shuji Shimoyama, Kazuhiko Nakamura and Shinya Ueno
    • Organizer
      第44回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] The effect of chronic diazepam administration on Lcn2 expression and spine morphology.2017

    • Author(s)
      T. Furukawa, S. Shimoyama, Y. Nikaido, Y. Miki, K. Koga, K. Nakamura, K. Wakabayashi, S. Ueno.
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] Chronic diazepam administration increases the expression of Lcn2 in the CNS2017

    • Author(s)
      Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, and Shinya Ueno
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(浜松市)
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] Chronic diazepam administration impairs acquisition of spatial reference memory in aged mice2017

    • Author(s)
      Yoshikazu Nikaido, Tomonori Furukawa, Shuji Shimoyama, Kohei Koga, and Shinya Ueno
    • Organizer
      第94回 日本生理学会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] Phospholipase C-related inactive protein type-1 is involved in intravenous anesthetic-induced EEG changes in mice.2017

    • Author(s)
      Y. Nikaido, T. Furukawa, S. Shimoyama, T. Kushikata, K. Hirota, T. Kanematsu, M. Hirata, S. Ueno.
    • Organizer
      第40回神経科学学会
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] The effect of chronic diazepam administration induced upregulation of Lcn2 expression on cognitive function2017

    • Author(s)
      Y. Ogata, T. Furukawa, Y. Nikaido, S. Shimoyama, K. Nakamura, S. Ueno.
    • Organizer
      第44回日本脳科学会
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] ラット前帯状皮質は恐怖記憶の想起と消去では左右異なる活動を示す2016

    • Author(s)
      古川智範、二階堂義和、右田啓介、下山修司、尾崎拓、古賀浩平、上野伸哉
    • Organizer
      第93回 日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] 5歳児の自閉スペクトラム障害における VLDL、IGF-1、オキシトシンの診断有用性の検討2016

    • Author(s)
      斉藤 まなぶ 、 下山 修司 、 吉田 恵心 、坂本 由唯 、大里 絢子 、 高柳 伸哉 、 足立 匡基 、 安田 小響 、 栗林 理人 、 中村 和彦
    • Organizer
      第112回 日本精神神経学会総会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2016-06-02
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] 遺伝子Tspo の発現調節メカニズムの解明2016

    • Author(s)
      下山修司、中村和彦、上野伸哉
    • Organizer
      日本生化学会 東北支部 第82 回例会・シンポジウム
    • Place of Presentation
      弘前大学(弘前市)
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-15K10503
  • [Presentation] 遺伝子Tspo の発現調節メカニズムの解明2016

    • Author(s)
      下山修司、中村和彦、上野伸哉
    • Organizer
      日本生化学会 東北支部 第82回例会
    • Place of Presentation
      弘前大学(青森県・弘前市)
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-15H04889
  • [Presentation] 某市5歳児発達健診における発達性協調運動障害の疫学2015

    • Author(s)
      斉藤まなぶ、山田順子、下山修司、尾崎拓、上野伸哉、中村和彦
    • Organizer
      第42回日本脳科学会
    • Place of Presentation
      ANAホリデイ・イン リゾート宮崎 (宮崎県宮崎市)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-15H04889
  • 1.  FURUKAWA Tomonori (60402369)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 23 results
  • 2.  Nakamura Kazuhiko (80263911)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 3.  UENO Shinya (00312158)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 19 results
  • 4.  斉藤 まなぶ (40568846)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 5.  尾崎 拓 (70621069)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  坂本 由唯 (60770386)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  三木 康生 (30709142)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 8.  NIKAIDOU Yoshikazu (50613478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 9.  Kubo Kazutoshi (80716910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  三上 達也 (70344611)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  中根 明夫 (30164239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  足立 匡基 (50637329)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  高橋 芳雄 (70760891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  西嶌 春生 (90858177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  小枝 周平 (00455734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  多田羅 洋太 (00443995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  若林 孝一 (50240768)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  MIGITA Keisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  OZAKI Taku
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  山田 順子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  兼松 隆
    # of Collaborated Projects: 0 results
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  • 22.  森 文秋
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  • 23.  丹治 邦和
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