Watanabe Akira 渡辺亮

Researcher Number	60738847
Other IDs
Affiliation (Current)	2025: 群馬県衛生環境研究所, 研究企画係, 研究員
Affiliation (based on the past Project Information) *help	2023: 群馬県衛生環境研究所, 研究企画係, 研究員 2021 – 2023: 群馬大学, 大学院医学系研究科, 助教 2018 – 2021: 群馬大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 58010:Medical management and medical sociology-related
Keywords	Principal Investigator PIP化合物 / STMN1 / シナジー効果 / 化学療法 / 温熱療法 / 膵癌 / STMN / ピロールイミダゾームポリアミド（PIP)化合物 / 肝胆膵癌細胞株 / 肝胆膵癌 / 増殖能 / 抗腫瘍効果 … More Except Principal Investigator … More 協働意思決定 / 共同意思決定 / 医療の質・安全 / レジリエンス・エンジニアリング / 会話分析 / インフォームド・コンセント / 肝臓外科 / 肝再生 / 肝細胞 / Galectin 3阻害剤 / マウス皮下腫瘍モデル / 肝胆膵癌 / M2BPGi / 癌関連線維芽細胞 / 肝胆膵がん Less

STMN1を標的とした化学療法・温熱療法とのシナジーによる膵癌新規治療法の開発Principal Investigator
- Principal Investigator
  
  渡辺亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma Institute of Public Health and Environmental Sciences
  Gunma University
会話分析を用いた協働意思決定過程の解明
- Principal Investigator
  
  滝沢牧子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Saitama Medical University
  Gunma University
Development of new therapeutic tools targeting microtubule dynamics of hepatobiliary pancreatic cancer with PIP compoundsPrincipal Investigator
- Principal Investigator
  
  Watanabe Akira
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor
- Principal Investigator
  
  Harimoto Norifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University

All 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021
- Author(s)
  Gantumur D, Harimoto N, Muranushi R, Hoshino K, Batbayar C, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Yokobori T, Aishima S, Shirabe K.
- Journal Title
  
  Hepatol Res .
  
  Volume: Online ahead of print. Issue: 10 Pages: 1058-1063
- DOI
  10.1111/hepr.13648
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021
- Author(s)
  Yamanaka T, Harimoto N, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Handa T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Umezawa K, Shirabe K.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: Online ahead of print. Issue: 6 Pages: 1019-1028
- DOI
  10.1158/1535-7163.mct-20-0150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16352
[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020
- Author(s)
  Dolgormaa Gantumur、Harimoto Norifumi、Ishii Norihiro、Yamanaka Takahiro、Hagiwara Kei、Tsukagoshi Mariko、Igarashi Takamichi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Handa Tadashi、Yokobori Takehiko、Oyama Tetsunari、Kuwano Hiroyuki、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 123 Issue: 7 Pages: 1145-1153
- DOI
  10.1038/s41416-020-0971-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16199, KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-18K07665
[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020
- Author(s)
  Yamanaka Takahiro、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Handa Tadashi、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 7 Pages: 986-994
- DOI
  10.1038/s41416-020-0744-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16199
[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019
- Author(s)
  Ishii Norihiro、Harimoto Norifumi、Araki Kenichiro、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Yamanaka Takahiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Shirabe Ken
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 12 Pages: 1398-1405
- DOI
  10.1111/hepr.13412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019
- Author(s)
  Hagiwara Kei、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Gantumur Dorgormaa、Yamanaka Takahiro、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Hosouchi Yasuo、Shirabe Ken
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 27 Issue: 3 Pages: 924-930
- DOI
  10.1245/s10434-019-07708-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Presentation] Development of a novel treatment for pancreatic cancer by synergizing chemotherapy and hyperthermia targeting STMN12023
- Author(s)
  渡辺　亮
- Organizer
  第34回日本癌発生学会
- Data Source
  KAKENHI-PROJECT-22K08792
[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020
- Author(s)
  山中崇弘、播本憲史、村主遼、星野弘毅、萩原慶、石井範洋、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、新木健一郎、梅澤一夫、調憲
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-18H02877

1. Shirabe Ken (70264025)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. 石井範洋 (00711508)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. Harimoto Norifumi (00419582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 五十嵐隆通 (20648472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 新木健一郎 (60431706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. 塚越真梨子 (60781317)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. 久保憲生 (10464744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 横堀武彦 (60420098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 滝沢牧子 (70613090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中島和江 (00324781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 野口怜 (50828861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 安部猛 (80621375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小松康宏 (60195849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 田中和美 (30526843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大石裕子 (90846924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 半田正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Akira 渡辺 亮

Research Projects

Research Products

Co-Researchers

STMN1を標的とした化学療法・温熱療法とのシナジーによる膵癌新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

会話分析を用いた協働意思決定過程の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic tools targeting microtubule dynamics of hepatobiliary pancreatic cancer with PIP compoundsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Development of a novel treatment for pancreatic cancer by synergizing chemotherapy and hyperthermia targeting STMN12023

Author(s)

Organizer

Data Source

[Presentation] 癌関連線維芽細胞が産生するサイトカインの制 御に基づく，肝癌の新たな治療戦略2020

Author(s)

Organizer

Data Source

Watanabe Akira 渡辺亮

[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020