Maruhashi Takumi 丸橋拓海

Researcher Number	60743961
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京大学, 定量生命科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Transformative Research Areas, Section (III)
Keywords	Principal Investigator LAG-3 / 抑制性免疫補助受容体 / MHCII / 自己抗原 / がん免疫 / 免疫チェックポイント分子 / 自己反応性T細胞 / 構造多様性 / 主要組織適合遺伝子複合体クラスII / 自己抗原ペプチド … More / 自己免疫 / リガンド / 免疫チェックポイント / ヘルパーT細胞 Less

LAG-3によるself-pMHCII認識を起点とした恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  丸橋拓海
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
ペプチド－MHCII複合体の構造多様性の生物学的意義の解明Principal Investigator
- Principal Investigator
  
  丸橋拓海
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Tokyo
LAG-3によるself-pMHCII認識を起点とした恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  丸橋拓海
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Investigating the contribution of potential ligands to the inhibitory function of LAG-3Principal Investigator
- Principal Investigator
  
  Maruhashi Takumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Tokyo
Regulatory mechanisms of anti-tumor immunity by inhibitory coreceptor, LAG-3Principal Investigator
- Principal Investigator
  
  Maruhashi Takumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] LAG-3による自己免疫とがん免疫の抑制機構2023
- Author(s)
  丸橋拓海, 岡崎拓
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 53 Pages: 19-30
- Data Source
  KAKENHI-PROJECT-21K07076
[Journal Article] DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling2023
- Author(s)
  Kaifu Tomonori、Maruhashi Takumi、Chung Soo-Hyun、Shimizu Kenji、Nakamura Akira、Iwakura Yoichiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14
- DOI
  10.3389/fimmu.2023.1159058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07076
[Journal Article] PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity2022
- Author(s)
  Sugiura Daisuke、Okazaki Il-mi、Maeda Takeo K.、Maruhashi Takumi、Shimizu Kenji、Arakaki Rieko、Takemoto Tatsuya、Ishimaru Naozumi、Okazaki Taku
- Journal Title
  
  Nature Immunology
  
  Volume: 23 Issue: 3 Pages: 399-410
- DOI
  10.1038/s41590-021-01125-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09859, KAKENHI-PROJECT-17H03607, KAKENHI-PLANNED-18H05415, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-21K06526, KAKENHI-PROJECT-21K07076, KAKENHI-PROJECT-21K19270, KAKENHI-PROJECT-21K19605
[Journal Article] Binding of LAG-3 to stable peptide-MHC class II limits T?cell function and suppresses autoimmunity and anti-cancer immunity2022
- Author(s)
  Maruhashi Takumi、Sugiura Daisuke、Okazaki Il-mi、Shimizu Kenji、Maeda Takeo K.、Ikubo Jun、Yoshikawa Harunori、Maenaka Katsumi、Ishimaru Naozumi、Kosako Hidetaka、Takemoto Tatsuya、Okazaki Taku
- Journal Title
  
  Immunity
  
  Volume: - Issue: 5 Pages: 912-924
- DOI
  10.1016/j.immuni.2022.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-21K07076, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-21K19270, KAKENHI-PROJECT-21K19605, KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-21K06526
[Journal Article] PD-1 preferentially inhibits the activation of low-affinity T cells2021
- Author(s)
  Shimizu Kenji、Sugiura Daisuke、Okazaki Il-mi、Maruhashi Takumi、Takemoto Tatsuya、Okazaki Taku
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 35
- DOI
  10.1073/pnas.2107141118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03607, KAKENHI-PLANNED-18H05415, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-21K06526, KAKENHI-PROJECT-21K07076, KAKENHI-PROJECT-21K19270
[Journal Article] T-cell-intrinsic and -extrinsic regulation of PD-1 function2021
- Author(s)
  Sugiura Daisuke、Shimizu Kenji、Maruhashi Takumi、Okazaki Il-mi、Okazaki Taku
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 693-698
- DOI
  10.1093/intimm/dxab077
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-21K06526, KAKENHI-PROJECT-21K07076
[Journal Article] PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation2020
- Author(s)
  Shimizu Kenji、Sugiura Daisuke、Okazaki Il-mi、Maruhashi Takumi、Takegami Yujiro、Cheng Chaoyang、Ozaki Soichi、Okazaki Taku
- Journal Title
  
  Molecular Cell
  
  Volume: 77 Issue: 5 Pages: 937-950
- DOI
  10.1016/j.molcel.2019.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-19K16522, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029
[Journal Article] LAG-3: from molecular functions to clinical applications2020
- Author(s)
  Maruhashi Takumi、Sugiura Daisuke、Okazaki Il-mi、Okazaki Taku
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 8 Issue: 2 Pages: e001014-e001014
- DOI
  10.1136/jitc-2020-001014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-19K16694
[Journal Article] PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation2019
- Author(s)
  Mizuno Reina、Sugiura Daisuke、Shimizu Kenji、Maruhashi Takumi、Watada Mizuki、Okazaki Il-mi、Okazaki Taku
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 630-630
- DOI
  10.3389/fimmu.2019.00630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417
[Journal Article] Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation2019
- Author(s)
  Maeda Takeo K.、Sugiura Daisuke、Okazaki Il-mi、Maruhashi Takumi、Okazaki Taku
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 15 Pages: 6017-6026
- DOI
  10.1074/jbc.ra119.007455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417
[Journal Article] PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR2019
- Author(s)
  Mizuno Reina、Maruhashi Takumi、Sugiura Daisuke、Shimizu Kenji、Watada Mizuki、Okazaki Il-mi、Okazaki Taku
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 511 Issue: 3 Pages: 491-497
- DOI
  10.1016/j.bbrc.2019.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417
[Journal Article] Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells2019
- Author(s)
  Maeda Natsumi、Maruhashi Takumi、Sugiura Daisuke、Shimizu Kenji、Okazaki Il-mi、Okazaki Taku
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 52 Pages: 19896-19906
- DOI
  10.1074/jbc.ra119.010379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029
[Journal Article] Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses2019
- Author(s)
  Sugiura Daisuke、Maruhashi Takumi、Okazaki Il-mi、Shimizu Kenji、Maeda Takeo K.、Takemoto Tatsuya、Okazaki Taku
- Journal Title
  
  Science
  
  Volume: 364 Issue: 6440 Pages: 558-566
- DOI
  10.1126/science.aav7062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03607, KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-18KT0024, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029
[Journal Article] PD-1 aborts the activation trajectory of autoreactive CD8+ T cells to prohibit their acquisition of effector functions2019
- Author(s)
  Okamura Hikari、Okazaki Il-mi、Shimizu Kenji、Maruhashi Takumi、Sugiura Daisuke、Mizuno Reina、Okazaki Taku
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 105 Pages: 102296-102296
- DOI
  10.1016/j.jaut.2019.06.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03423, KAKENHI-PROJECT-18K19453, KAKENHI-PROJECT-19K16694, KAKENHI-PLANNED-18H05417, KAKENHI-PROJECT-19H01029
[Presentation] The requirement of dimer-forming ability for LAG-3 to inhibit T cell activation2024
- Author(s)
  Takumi Maruhashi, Dawei Chen, Il-mi Okazaki, Daisuke Sugiura, Kenji Shimizu, Taku Okazaki
- Organizer
  The 52th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] Identification of an MHC class II mutant lacking LAG-3-binding capacity while retaining antigen-presenting ability2024
- Author(s)
  Takumi Maruhashi, Taku okazaki
- Organizer
  The 1st AMED SCARDA Joint Symposium of Japan Initiative for World-leading Vaccine Research and Development Centers
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity2023
- Author(s)
  丸橋　拓海
- Organizer
  第18回血液若手研究者勉強会（麒麟塾）
- Invited
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] Immune regulation by LAG-3, an inhibitory co-receptor of a unique target selectivity2023
- Author(s)
  Takumi Maruhashi, Taku Okazaki
- Organizer
  The 32nd Hot Spring Harbor International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] LAG-3の免疫抑制機能作動原理の解明2022
- Author(s)
  丸橋　拓海
- Organizer
  第 31 回東京免疫フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] Stable pMHCII serves as the ligand of LAG-3 to trigger its inhibitory function2022
- Author(s)
  Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Kenji Shimizu, Taku Okazaki
- Organizer
  The 51th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] LAG-3 engagement with stable pMHCII is essential for the exertion of its inhibitory function2021
- Author(s)
  Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Kenji Shimizu, Taku Okazaki
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21K07076
[Presentation] Binding properties between LAG-3 and two potential ligands, stable pMHCII and FGL12019
- Author(s)
  Takumi Maruhashi, Jun Ikubo, Daisuke Sugiura, Il-mi Okazaki, Taku Okazaki
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16694
[Presentation] LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII2019
- Author(s)
  Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura, Suzuka Takahashi, Takeo K. Maeda, Kenji Shimizu, Taku Okazaki
- Organizer
  The 14th International Symposium of the Institute Network for Biomedical Sciences 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16694

1. ARAKAKI Rieko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. CHON Il-Mi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
3. TAKEMOTO Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 岡崎拓

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Maruhashi Takumi 丸橋 拓海

Research Projects

Research Products

Co-Researchers

LAG-3によるself-pMHCII認識を起点とした恒常性維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ペプチド－MHCII複合体の構造多様性の生物学的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

LAG-3によるself-pMHCII認識を起点とした恒常性維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating the contribution of potential ligands to the inhibitory function of LAG-3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of anti-tumor immunity by inhibitory coreceptor, LAG-3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] LAG-3による自己免疫とがん免疫の抑制機構2023

Author(s)

Journal Title

Data Source

[Journal Article] DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Binding of LAG-3 to stable peptide-MHC class II limits T?cell function and suppresses autoimmunity and anti-cancer immunity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 preferentially inhibits the activation of low-affinity T cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T-cell-intrinsic and -extrinsic regulation of PD-1 function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LAG-3: from molecular functions to clinical applications2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation2019

Author(s)

Maruhashi Takumi 丸橋拓海