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OKUBO Koshu  大久保 光修

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Okubo Koshu  大久保 光修

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Researcher Number 60749125
Affiliation (based on the past Project Information) *help 2021 – 2023: 慶應義塾大学, 医学部(信濃町), 共同研究員
2016 – 2017: 慶應義塾大学, 医学部(信濃町), 共同研究員
2014: 慶應義塾大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related / Kidney internal medicine
Except Principal Investigator
膠原病・アレルギー・感染症内科学
Keywords
Principal Investigator
スフィンゴリン脂質 / 自己免疫性疾患 / 腎障害 / 活性酸素種 / NADPHオキシダーゼ / PKCδ / SHP-1 / Lyn / STIM1 / 好中球 … More / Fcγ受容体IIA / Fc受容体 / Mac-1 / 白血球細胞外トラップ / 急性腎障害 / 横紋筋融解症 … More
Except Principal Investigator
血栓 / NETs / 腎炎 / 血管炎 / 自己免疫 / 炎症 / ラクトフェリン / 好中球細胞外トラップ / 好中球 / vasculitis / autoimmune / lactoferrin / inflammation / neutrophil Less
  • Research Projects

    (3 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (6 People)
  •  Regulation in affinity of Fc receptor by sphingolipidsPrincipal Investigator

    • Principal Investigator
      OKUBO Koshu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Keio University
  •  Cytotoxicity of chromatin from macrophages in rhabdomyolysis-induced acute kidney injuryPrincipal Investigator

    • Principal Investigator
      Okubo Koshu
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Keio University
  •  Regulation of neutrophil extracellular traps via fenton reaction and its application to the treatment of refractory autoimmune vasculitis

    • Principal Investigator
      HIRAHASHI Junichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Keio University
      The University of Tokyo

All 2021 2018 2017 2016 2014 2013

All Journal Article Presentation Patent

  • [Journal Article] Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling2021

    • Author(s)
      Okubo Koshu、Brenner Michael D.、Cullere Xavier、Saggu Gurpanna、Patchen Myra L.、Bose Nandita、Mihori Saki、Yuan Zhou、Lowell Clifford A.、Zhu Cheng、Mayadas Tanya N.
    • Journal Title

      Cell Reports

      Volume: 35 Issue: 7 Pages: 109142-109142

    • DOI

      10.1016/j.celrep.2021.109142

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08283
  • [Journal Article] Macrophage extracellular chromatin release induced by Mac-1 mediated platelet-macrophage interactions triggers acute kidney injury in rhabdomyolysis.2018

    • Author(s)
      Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J.
    • Journal Title

      Nat. Med.

      Volume: 24 Issue: 2 Pages: 232-238

    • DOI

      10.1038/nm.4462

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-16H02606, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-15K09459, KAKENHI-PROJECT-16K15294, KAKENHI-PROJECT-16K19497, KAKENHI-PUBLICLY-16H01369
  • [Patent] 白血球の細胞外トラップ形成の阻害剤2013

    • Inventor(s)
      平橋淳一、浦野泰照、大久保光修、神谷真子、加賀谷伸治
    • Industrial Property Rights Holder
      国立大学法人東京大学、株式会社NRLファーマ
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24591461
  • [Presentation] Macrophage extracellular traps induced by Mac-1 (CD11b/CD18) dependent platelet-macrophage interactions progress acute kidney injury2017

    • Author(s)
      Koshu Okubo
    • Organizer
      The 18th International Vasculitis and ANCA Workshop
    • Place of Presentation
      伊藤国際学術研究センター (東京都文京区)
    • Year and Date
      2017-03-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19497
  • [Presentation] Macrophage Extracellular Traps Induced by Mac-1 (CD11b/CD18) Dependent Platelet-Macrophage Interactions Promotes Acute Kidney Injury in Rhabdomyolysis2016

    • Author(s)
      Koshu Okubo
    • Organizer
      ASN Kidney Week 2016 (American Society of Nephrology)
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2016-11-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19497
  • [Presentation] 好中球細胞外トラップ形成における活性酸素認識プローブを用いた新規イメージング技術の応用2016

    • Author(s)
      大久保光修
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市
    • Year and Date
      2016-09-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K19497
  • [Presentation] 好中球細胞外トラップ(NETs)を制御する物質:ラクトフェリン2014

    • Author(s)
      平橋 淳一、大久保 光修、神谷 真子、浦野 泰照、加賀谷 伸治
    • Organizer
      第19回日本血管病理研究会
    • Place of Presentation
      両国KFCビル(東京都墨田区)
    • Year and Date
      2014-10-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591461
  • [Presentation] 好中球細胞外トラップ(NETs)抑制物質ラクトフェリンの機能解析2014

    • Author(s)
      大久保 光修、林 松彦、神谷 真子、浦野 泰照、西 裕志、Tanya Mayadas、藤田 敏郎、南学 正臣、平橋 淳一
    • Organizer
      第5回分子腎臓フォーラム
    • Place of Presentation
      ベルサール八重洲(東京都中央区)
    • Year and Date
      2014-09-06
    • Data Source
      KAKENHI-PROJECT-24591461
  • [Presentation] Lactoferrin Is a Suppressor of Neutrophil Extracellular Traps in Inflammation2013

    • Author(s)
      Koshu Okubo, Masaomi Nangaku, Toshiro Fujita, Junichi Hirahashi
    • Organizer
      2013 American Society of Nephrology (Atlanta)
    • Place of Presentation
      アトランタ(アメリカ)
    • Data Source
      KAKENHI-PROJECT-24591461
  • [Presentation] Lactoferrin is a suppressor of neutrophil extracellular traps in inflammation2013

    • Author(s)
      Koshu Okubo, Mako Kamiya, Yasuteru Urano, Hiroshi Nishi, Jan Herter, Tanya Mayadas, Daigoro Hirohama, Kazuo Suzuki, Tomokazu Nagao, Mototsugu Tanaka, Miho Kurosawa, Shinji Kagaya, Keiichi Hishikawa, Masaomi Nangaku, Toshiro Fujita, and Junichi Hirahashi
    • Organizer
      XIth International Conference on Lactoferrin:Structure, Function, and Applications (2013 Rome)
    • Place of Presentation
      ローマ(イタリア)
    • Data Source
      KAKENHI-PROJECT-24591461
  • 1.  HIRAHASHI Junichi (70296573)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  URANO Yasuteru (20292956)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  KAMIYA Mako (90596462)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  KAWAKAMI Hiroshi (90458860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KUROSAWA Miho
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  長谷 耕二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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