YAMAMOTO TAKUYA 山本拓也

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Yamamoto Takuya 山本拓也

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Researcher Number	60752368
Other IDs
Affiliation (Current)	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所難病・免疫ゲノム研究センター, センター長
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所難病・免疫ゲノム研究センター, センター長 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所ワクチン・アジュバント研究センター, プロジェクトリーダー 2018 – 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所免疫老化プロジェクト, プロジェクトリーダー 2017: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所ワクチン・アジュバント研究センター, サブプロジェクトリーダー
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Studies on the Super-Aging Society / Infectious disease medicine Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 42020:Veterinary medical science-related / Bacteriology (including mycology)
Keywords	Principal Investigator 非ヒト霊長類 / 自然免疫 / CTL / SIV / HIV / アジュバント / 免疫療法 / 潜伏感染 / エイズ / SARS -CoV-2 … More / COVID-19 / CD8 T細胞 / mRNAワクチン / 記憶免疫 / ワクチン / 機能的治癒 / 高次元免疫学的解析 / テロメア / 老化 / 次世代シークエンス / フローサイトメーター / T細胞 / aging / 免疫老化 … More Except Principal Investigator 膵癌 / カニクイザル / ワクチン / 次世代フローサイトメーター / バイオマーカー / PBMC / 癌免疫微小環境 / 膵癌患者由来末梢血単核球細胞 / 腫瘍関連抗原特異的免疫反応 / フローサイトメトリー / Fc受容体 / インフルエンザ / 機械学習 / non-human primate / ハイパラメーターフローサイトメーター / 広範囲HA中和抗体 / Influenza / 免疫老化 / インフルエンザウイルス / ハイパラメーターフローサイトメトリー / 非ヒト霊長類 / Fc受容体依存的免疫応答 / ケモカイン / がん微小環境 / 癌周囲線維芽細胞 / 癌微小環境 / がん間質 / 膵がん / IL-6 / p53 / 悪性度 / SASP / 細胞老化 / 癌関連線維芽細胞 / ウイルス / 細菌 / 免疫学 / 感染症 / 組み換えウイルス / 感染防御 / 潜伏感染 / 結核 Less

COVID-19 mRNAワクチン接種による記憶CD8 T細胞反応誘導メカニズムの解明とその応用Principal Investigator
- Principal Investigator
  
  山本拓也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
膵癌における臨床応用を見据えた高次免疫学的解析手法を駆使した免疫微小環境の解析
- Principal Investigator
  
  秋田裕史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka International Cancer Institute
Establishment of a basic analytical platform for the development of a next-generation influenza vaccine considering immunosenescence
- Principal Investigator
  
  Takahama Shokichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Establishment of therapeutic strategies toward a functional cure for HIV by the adjuvant immunotherapyPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
The cellular senescence of cancer-associated fibroblast affect the malignant potential in pancreatic cancer
- Principal Investigator
  
  Akita Hirofumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka International Cancer Institute
  Osaka University
Development of the non-human primate model for studying the aging of the Immune SystemPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takuya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Study of tuberculosis and development of vaccine in latent infected cynomolgus monkeys.
- Principal Investigator
  
  Yasutomi Yasuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Development of new immunotherapy treatments toward a cure for HIVPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Infectious disease medicine
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 臨床免疫・アレルギー科 (免疫老化研究の展望)2023
- Author(s)
  髙濱正吉、山本拓也
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K06405
[Book] 新世代フローサイトメトリー活用スタンダード2021
- Author(s)
  清田純、山本拓也 (高濱正吉）
- Total Pages
  320
- Publisher
  羊土社
- ISBN
  9784758122542
- Data Source
  KAKENHI-PROJECT-20K06405
[Book] 新世代フローサイトメトリー活用スタンダード2021
- Author(s)
  清田　純、山本　拓也
- Total Pages
  320
- Publisher
  羊土社
- ISBN
  9784758122542
- Data Source
  KAKENHI-PROJECT-20H03728
[Journal Article] Model for predicting age-dependent safety and immunomodulatory effects of STING ligands in non-human primates2023
- Author(s)
  Takahama Shokichi、Ishige Kazuya、Nogimori Takuto、Yasutomi Yasuhiro、Appay Victor、Yamamoto Takuya
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 28 Pages: 99-115
- DOI
  10.1016/j.omtm.2022.12.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06405, KAKENHI-PROJECT-21K19395
[Journal Article] Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model2022
- Author(s)
  Masuta Yuji、Takahama Shokichi、Nogimori Takuto、Moriyama Saya、Takahashi Yoshimasa、Yamamoto Takuya
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 10 Pages: 105085-105085
- DOI
  10.1016/j.isci.2022.105085
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03728, KAKENHI-PROJECT-20K06405
[Journal Article] Up‐regulated LRRN2 expression as a marker for graft quality in living donor liver transplantation2022
- Author(s)
  Tomiyama Takahiro、Yamamoto Takuya、Takahama Shokichi、Toshima Takeo、Itoh Shinji、Harada Noboru、Shimokawa Mototsugu、Okuzaki Daisuke、Mori Masaki、Yoshizumi Tomoharu
- Journal Title
  
  Hepatology Communications
  
  Volume: 6 Issue: 10 Pages: 2836-2849
- DOI
  10.1002/hep4.2033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03728
[Journal Article] Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center.2021
- Author(s)
  3.Eslamizar L, Petrovas C, Leggat DJ, Furr K, Lifton ML, Levine G, Ma S, Fletez-Brant C, Hoyland W, Prabhakaran M, Narpala S, Boswell K, Yamamoto T, Liao HX, Pickup D, Ramsburg E, Sutherland L, McDermott A, Roederer M, Montefiori D, Koup RA, Haynes BF, Letvin NL, Santra S.
- Journal Title
  
  NPJ vaccines
  
  Volume: 6 Issue: 1 Pages: 15-15
- DOI
  10.1038/s41541-020-00277-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03728, KAKENHI-PROJECT-19K21601
[Journal Article] OMIP 075: A 22‐color panel for the measurement of antigen‐specific T‐cell responses in human and nonhuman primates2021
- Author(s)
  Nogimori Takuto、Moriishi Eiko、Ikeda Mami、Takahama Shokichi、Yamamoto Takuya
- Journal Title
  
  Cytometry Part A
  
  Volume: 99 Issue: 9 Pages: 884-887
- DOI
  10.1002/cyto.a.24460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03728
[Journal Article] OMIP 078: A 31‐parameter panel for comprehensive immunophenotyping of multiple immune cells in human peripheral blood mononuclear cells2021
- Author(s)
  Nogimori Takuto、Sugawara Yuko、Higashiguchi Masaya、Murakami Hirotomo、Akita Hirofumi、Takahama Shokichi、Tanaka Satoshi、Yamamoto Takuya
- Journal Title
  
  Cytometry Part A
  
  Volume: 99 Issue: 9 Pages: 893-898
- DOI
  10.1002/cyto.a.24490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03728
[Journal Article] Simultaneous monitoring assay for T-cell receptor stimulation-dependent activation of CD4 and CD8 T cells using inducible markers on the cell surface2021
- Author(s)
  Takahama Shokichi、Nogimori Takuto、Higashiguchi Masaya、Murakami Hirotomo、Akita Hirofumi、Yamamoto Takuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 571 Pages: 53-59
- DOI
  10.1016/j.bbrc.2021.07.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03728, KAKENHI-PROJECT-20K06405
[Journal Article] U.S.-Japan cooperative medical sciences program: 22nd International Conference on Emerging Infectious Diseases in the Pacific Rim.2020
- Author(s)
  5.Lu KT, Yamamoto T, McDonald D, Li W, Tan M, Moi ML, Park EC, Yoshimatsu K, Ricciardone M, Hildesheim A, Totsuka Y, Nanbo A, Putcharoen O, Suwanpimolkul G, Jantarabenjakul W, Paitoonpong L, Handley FG, Bernabe KG, Noda M, Sonoda M, Brennan P, Griffin DE, Kurane I.
- Journal Title
  
  Virology
  
  Volume: 555 Pages: 71-77
- DOI
  10.1016/j.virol.2020.12.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03728, KAKENHI-PROJECT-18K07136, KAKENHI-PROJECT-19K21601
[Journal Article] Pattern Recognition Receptor Ligands as an Emerging Therapeutic Agent for Latent HIV-1 Infection2020
- Author(s)
  Takahama Shokichi, Yamamoto Takuya
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 10 Pages: 216-216
- DOI
  10.3389/fcimb.2020.00216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03728, KAKENHI-PROJECT-19K21601
[Journal Article] Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies2019
- Author(s)
  Adachi Yu、Tonouchi Keisuke、Nithichanon Arnone、Kuraoka Masayuki、Watanabe Akiko、Shinnakasu Ryo、Asanuma Hideki、Ainai Akira、Ohmi Yusuke、Yamamoto Takuya、Ishii Ken J.、Hasegawa Hideki、Takeyama Haruko、Lertmemongkolchai Ganjana、Kurosaki Tomohiro、Ato Manabu、Kelsoe Garnett、Takahashi Yoshimasa
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-019-11821-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17656, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-18K19447
[Journal Article] Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response2019
- Author(s)
  Sanada Takahiro、Yamamoto Naoki、Kayesh Mohammad Enamul Hoque、Tsukiyama-Kohara Kyoko、Hasegawa Hideki、Miyazaki Takashi、Takano Jun-ichiro、Shiogama Yumiko、Yasutomi Yasuhiro、Goh Yasumasa、Yoshida Osamu、Hiasa Yoichi、Kohara Michinori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 520 Issue: 1 Pages: 86-92
- DOI
  10.1016/j.bbrc.2019.09.072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-17H04079
[Journal Article] STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques2019
- Author(s)
  Yamamoto Takuya、Kanuma Tomohiro、Takahama Shokichi、Okamura Tomotaka、Moriishi Eiko、Ishii Ken J.、Terahara Kazutaka、Yasutomi Yasuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-019-42253-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04079, KAKENHI-PROJECT-17H05087
[Journal Article] Priming of HIV-1-specific CD8+ T cells with strong functional properties from naive T cells2019
- Author(s)
  Kuse Nozomi、Sun Xiaoming、Akahoshi Tomohiro、Lissina Anna、Yamamoto Takuya、Appay Victor、Takiguchi Masafumi
- Journal Title
  
  EBioMedicine
  
  Volume: 42 Pages: 109-119
- DOI
  10.1016/j.ebiom.2019.03.078
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05087
[Journal Article] Requirement for memory B-cell activation in protection from heterologous influenza virus reinfection2019
- Author(s)
  Leach Sarah、Shinnakasu Ryo、Adachi Yu、Momota Masatoshi、Makino-Okamura Chieko、Yamamoto Takuya、Ishii Ken J、Fukuyama Hidehiro、Takahashi Yoshimasa、Kurosaki Tomohiro
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 12 Pages: 771-779
- DOI
  10.1093/intimm/dxz049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17656, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-18K19447
[Journal Article] The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T cells2019
- Author(s)
  Gutjahr Alice、Papagno Laura、Nicoli Francesco、Kanuma Tomohiro、Kuse Nozomi、Cabral-Piccin Mariela Pires、Rochereau Nicolas、Gostick Emma、Lioux Thierry、Perouzel Eric、Price David A.、Takiguchi Masafumi、Verrier Bernard、Yamamoto Takuya、Paul Stephane、Appay Victor
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 7 Pages: 1-11
- DOI
  10.1172/jci.insight.125107
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05087
[Journal Article] Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing2019
- Author(s)
  Sanada Takahiro、Tsukiyama-Kohara Kyoko、Shin-I Tadasu、Yamamoto Naoki、Kayesh Mohammad Enamul Hoque、Yamane Daisuke、Takano Jun-ichiro、Shiogama Yumiko、Yasutomi Yasuhiro、Ikeo Kazuho、Gojobori Takashi、Mizokami Masashi、Kohara Michinori
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12372-12372
- DOI
  10.1038/s41598-019-48867-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16680, KAKENHI-PROJECT-17K15709, KAKENHI-PROJECT-17H04079
[Journal Article] Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread2019
- Author(s)
  Hataye Jason M.、Casazza Joseph P.、Best Katharine、Liang C. Jason、Immonen Taina T.、Ambrozak David R.、Darko Samuel、Henry Amy R.、Laboune Farida、Maldarelli Frank、Douek Daniel C.、Hengartner Nicolas W.、Yamamoto Takuya、Keele Brandon F.、Perelson Alan S.、Koup Richard A.
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 26 Issue: 6 Pages: 748-763.e20
- DOI
  10.1016/j.chom.2019.10.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05087
[Journal Article] Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases2019
- Author(s)
  Fujimoto Kosuke、Kawaguchi Yunosuke、Shimohigoshi Masaki、Gotoh Yoshiyuki、Nakano Yoshiko、Usui Yuki、Hayashi Tetsuya、Kimura Yasumasa、Uematsu Miho、Yamamoto Takuya、Akeda Yukihiro、Rhee Joon Haeng、Yuki Yoshikazu、Ishii Ken J.、Crowe Sheila E.、Ernst Peter B.、Kiyono Hiroshi、Uematsu Satoshi
- Journal Title
  
  Gastroenterology
  
  Volume: 157 Issue: 6 Pages: 1530-1543
- DOI
  10.1053/j.gastro.2019.08.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17028, KAKENHI-PROJECT-19K17932, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-19H03465, KAKENHI-PROJECT-18H05280
[Journal Article] An Antigen-Free, Plasmacytoid Dendritic Cell-Targeting Immunotherapy To Bolster Memory CD8+ T Cells in Nonhuman Primates.2018
- Author(s)
  Masuta Y, Yamamoto T, Natsume-Kitatani Y, Kanuma T, Moriishi E, Kobiyama K, Mizuguchi K, Yasutomi Y, Ishii KJ.
- Journal Title
  
  J Immunol.
  
  Volume: 200(6) Issue: 6 Pages: 2067-2075
- DOI
  10.4049/jimmunol.1701183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05087
[Journal Article] Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis2018
- Author(s)
  Fali T, Fabre-Mersseman V, Yamamoto T, Bayard C, Papagno L, Fastenackels S, Zoorab R, Koup RA, Boddaert J, Sauce D, Appay V.
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 13 Pages: 1-14
- DOI
  10.1172/jci.insight.95319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05087
[Journal Article] A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection2018
- Author(s)
  Yamamoto Takuya、Masuta Yuji、Momota Masatoshi、Kanekiyo Masaru、Kanuma Tomohiro、Takahama Shoukichi、Moriishi Eiko、Yasutomi Yasuhiro、Saito Takashi、Graham Barney S、Takahashi Yoshimasa、Ishii Ken J
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 2 Pages: 81-90
- DOI
  10.1093/intimm/dxy069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19576, KAKENHI-PROJECT-18K15162, KAKENHI-PUBLICLY-17H05806, KAKENHI-PROJECT-18H02672, KAKENHI-PROJECT-17H05087, KAKENHI-PROJECT-17H04079
[Journal Article] CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8+T Cell Responses2017
- Author(s)
  Kanuma Tomohiro、Yamamoto Takuya、Kobiyama Kouji、Moriishi Eiko、Masuta Yuji、Kusakabe Takato、Ozasa Koji、Kuroda Etsushi、Jounai Nao、Ishii Ken J.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 198 Issue: 12 Pages: 4707-4715
- DOI
  10.4049/jimmunol.1600731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05256, KAKENHI-PROJECT-17H05087
[Presentation] Analysis of Fcγ receptor-mediated target-effector cells binding via influenza vaccine-induced antibodies in a non-human primate model.2022
- Author(s)
  Yuji Masuta, Shokichi Takahama, Takuto Nogimori, Saya Moriyama, Yoshimasa Takahashi, Takuya Yamamoto.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06405
[Presentation] 霊長類モデルにおけるインフルエンザワクチンにより誘導される抗体Fcγ受容体依存的免疫応答の評価2022
- Author(s)
  升田雄士、髙濱正吉、野木森拓人、森山彩野、高橋宜聖、山本拓也.
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06405
[Presentation] Prediction of the safety and efficacy of STING ligands administration in the nonhuman primate model.2022
- Author(s)
  Shokichi Takahama, Kazuya Ishige, Takuto Nogimori, Yasuhiro Yasutomi, Victor Appay, Takuya Yamamoto.
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] Analysis of follicular CD8 T cells to control SIV replication under cART,2022
- Author(s)
  Ayaka Washizaki, Shokichi Takahama, Tomotaka Okamura, Takuto Nogimori, Yuji Masuta, Yasuhiro Yasutomi, Yorifumi Satou, Takuya Yamamoto.
- Organizer
  23rd Kumamoto AIDS Seminar
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] Prediction of the safety and efficacy of STING ligands administration in the nonhuman primate model.2022
- Author(s)
  Shokichi Takahama, Kazuya Ishige, Takuto Nogimori, Yasuhiro Yasutomi, Victor Appay, Takuya Yamamoto.
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K06405
[Presentation] Investigation of the role of follicular CD8 T cells for reducing viral reservoirs under cART treatment.2022
- Author(s)
  Ayaka Washizaki, Shokichi Takahama, Tomotaka Okamura, Takuto Nogimori, Yuji Masuta, Yasuhiro Yasutomi, Yorifumi Satou, Takuya Yamamoto.
- Organizer
  The 51st Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] Characterization of follicular CD8 T cells in SIV-infected cynomolgus monkeys under cART.2022
- Author(s)
  Takuya Yamamoto
- Organizer
  第2回日仏HIV/AIDS & 感染症基礎研究シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] カニクイザルSIVコントローラーモデルにおけるfCD8細胞の遺伝子発現プロファイル2022
- Author(s)
  髙濱正吉、鷲﨑彩夏、野木森拓人、升田雄士、岡村智崇、保富康宏、山本拓也.
- Organizer
  第35回近畿エイズ研究会学術集会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] 非ヒト霊長類モデルを用いた造血幹細胞の免疫老化現象の解析2021
- Author(s)
  升田　雄士, 野木森　拓人, 髙濱　正吉, 山本　拓也
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] 非ヒト霊長類モデルを用いたワクチン・アジュバントの免疫毒性研究2021
- Author(s)
  山本　拓也
- Organizer
  第48回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] The non-human primate model for studying immunosenescence2021
- Author(s)
  山本　拓也
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] 非ヒト霊長類モデルを用いたT細胞老化を基軸とする免疫老化現象の本質的解明2021
- Author(s)
  野木森　拓人,升田　雄士, 髙濱　正吉, 山本　拓也
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] SIV抗原特異的CD4T細胞、及びCD8T細胞の高感度同時分取法の樹立2020
- Author(s)
  髙濱正吉、岡村智崇、保富康宏、山本拓也
- Organizer
  第34回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] 次世代型フローサイトメーターを用いた膵癌微小環境の解析2020
- Author(s)
  村上弘大、秋田裕史、東口公哉、野木森拓人、高濱正吉、小林省吾、土岐祐一郎、江口英利、山本拓也
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] ケモカイン/ケモカイン受容体を介した膵癌細胞と癌関連線維芽細胞間相互作用の解析2020
- Author(s)
  東口公哉、秋田裕史、高濱正吉、村上弘大、小林省吾、土岐祐一郎、江口英利、山本拓也
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] 消化器癌における癌抗原特異亭 CD8T 細胞反応の量的・質的評価2020
- Author(s)
  東口公哉、秋田裕史、村上弘大、野木森拓人、高濱正吉、小林省吾、土岐祐一郎、江口英利、山本拓也
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] 次世代型フローサイトメーターを用いた膵癌微小環境の解析2020
- Author(s)
  村上弘大、秋田裕史、東口公哉、野木森拓人、高濱正吉、小林省吾、土岐祐一郎、江口英利、山本拓也
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] 消化器癌における癌抗原特異亭 CD8T 細胞反応の量的・質的評価2020
- Author(s)
  東口公哉、秋田裕史、村上弘大、野木森拓人、高濱正吉、小林省吾、土岐祐一郎、江口英利、山本拓也
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] SIV抗原特異的CD4T細胞、及びCD8T細胞の高感度同時分取法の樹立2020
- Author(s)
  髙濱正吉、岡村智崇、保富康宏、山本拓也
- Organizer
  第34回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] SIV慢性感染期抗ウイルス薬治療下カニクイザルを用いた免疫学的マルチオミクス解析2020
- Author(s)
  山本拓也
- Organizer
  第34回日本エイズ学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] ケモカイン/ケモカイン受容体を介した膵癌細胞と癌関連線維芽細胞間相互作用の解析2020
- Author(s)
  東口公哉、秋田裕史、高濱正吉、村上弘大、小林省吾、土岐祐一郎、江口英利、山本拓也
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] SIV慢性感染期抗ウイルス薬治療下カニクイザルを用いた免疫学的マルチオミクス解析2020
- Author(s)
  山本拓也
- Organizer
  第34回日本エイズ学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03728
[Presentation] リンパ組織におけるSIV潜伏感染細胞排除の可能性.2019
- Author(s)
  升田　雄士、髙濱正吉、岡村智崇、伊勢知子、永田諭志、保富康宏、山本拓也
- Organizer
  第33回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] HIV治癒を目指したSIV潜伏感染cARTモデルの構築.2019
- Author(s)
  髙濱正吉、神沼智裕、升田雄士、岡村智崇、保富康宏、山本拓也
- Organizer
  第33回近畿エイズ研究会学術集会
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] Analysis of immunosenescence in the non-human primates.2019
- Author(s)
  Masuta Y, Tanaka M, Takahama S,Sugawara Y, Okamura T,Tanaka S, Yasutomi Y and Yamamoto T.
- Organizer
  The 42nd Annual Meeting of the Molecular Biology Society of Japan.
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] The non-human primate model of immunosenescence.2019
- Author(s)
  Yamamoto T.
- Organizer
  France-Japan Symposium Implication of senescence in age related disorders: Toward health aging.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] The challenges of high-dimensional single-cell flowcytometric analysis for the study of immune aging.2019
- Author(s)
  Yamamoto T.
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology.
- Invited
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] 非ヒト霊長類におけるFc受容体依存免疫応答評価系の樹立.2019
- Author(s)
  高濱正吉、神沼智裕、升田雄士、保富康宏、高橋宜聖、山本拓也
- Organizer
  第23回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K21601
[Presentation] Evaluating broadly neutralizing antibodies for targeted ADCC cure strategies in the Asia Pacific region.2019
- Author(s)
  Yamamoto T., and Lynch RM.
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 22nd International Conference on Emerging Infectious Diseases in the Pacific Rim.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] 機能的治癒を目指したSIV潜伏感染cARTモデルの構築2019
- Author(s)
  高濱正吉、升田雄士、岡村智崇、保富康宏、山本拓也
- Organizer
  第33回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] Effects of cART interruption during the chronic phase of SIV Infection on T-cell responses.2019
- Author(s)
  Yamamoto T.
- Organizer
  United States-Japan Cooperative Medical Sciences Program (AIDS Panel)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] Establishment of a new strategy to eradicate SIV-latently infected cells for a cure treatment.2019
- Author(s)
  Kanuma T, Takahama S, Okamura T, Masuta1 Y, Ise T, Nagata S, Yasutomi Y, and Yamamoto T.
- Organizer
  17th International Congress of Immunology (IUIS 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] STING ligand re-activates latently SIV infected cells and enhances SIV-specific CTL responses.2018
- Author(s)
  Kanuma T, Takahama S, Okamura T, Yasutomi Y, Yamamoto T.
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] Adjuvant effect of a nanoparticulate TLR9 agonist for protection against heterologous influenza challenge through FcRγ-mediated effector functions.2018
- Author(s)
  Yamamoto T, Masuta Y, Momota M, Takahashi Y, Ishii KJ.
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] SIV潜伏感染細胞排除を目指した自然免疫賦活化剤の応用2018
- Author(s)
  髙濱正吉、神沼智裕、岡村智崇、保富康宏、山本拓也
- Organizer
  第32回日本エイズ学会
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] 免疫賦活化剤によるSIV潜伏感染細胞排除の可能性2018
- Author(s)
  髙濱正吉、岡村智崇、神沼智裕、滝口雅文、保富康宏、山本拓也
- Organizer
  第32回近畿エイズ研究会学術集会
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] ユニバーサルインフルエンザワクチン開発に向けたK3-SPGアジュバントの応用2018
- Author(s)
  3.升田雄士, 山本拓也, 百田匡寿, 高橋宜聖, 石井健
- Organizer
  第22回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] How can we improve CTL functions during cART?2017
- Author(s)
  Takuya Yamamoto
- Organizer
  18th Kumamoto AIDS seminar
- Invited
- Data Source
  KAKENHI-PROJECT-17H05087
[Presentation] ART開始時期の違いによるHIV特異的CD8T細胞機能変化2017
- Author(s)
  山本拓也
- Organizer
  第31会日本エイズ学会
- Data Source
  KAKENHI-PROJECT-17H05087

1. Akita Hirofumi (70528463)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Yasutomi Yasuhiro (90281724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Takahama Shokichi (60510287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 辻村祐佑 (30512404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 東口公哉 (80804450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 江口英利 (90542118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 野木森拓人 (20870653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 黒田悦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 真田崇弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 保富康弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 斉藤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO TAKUYA 山本 拓也

Yamamoto Takuya 山本 拓也

Research Projects

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COVID-19 mRNAワクチン接種による記憶CD8 T細胞反応誘導メカニズムの解明とその応用Principal Investigator

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膵癌における臨床応用を見据えた高次免疫学的解析手法を駆使した免疫微小環境の解析

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Establishment of a basic analytical platform for the development of a next-generation influenza vaccine considering immunosenescence

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Establishment of therapeutic strategies toward a functional cure for HIV by the adjuvant immunotherapyPrincipal Investigator

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The cellular senescence of cancer-associated fibroblast affect the malignant potential in pancreatic cancer

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Development of the non-human primate model for studying the aging of the Immune SystemPrincipal Investigator

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Study of tuberculosis and development of vaccine in latent infected cynomolgus monkeys.

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Development of new immunotherapy treatments toward a cure for HIVPrincipal Investigator

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[Book] 臨床免疫・アレルギー科 (免疫老化研究の展望)2023

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[Book] 新世代フローサイトメトリー活用スタンダード2021

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[Book] 新世代フローサイトメトリー活用スタンダード2021

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[Journal Article] Model for predicting age-dependent safety and immunomodulatory effects of STING ligands in non-human primates2023

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[Journal Article] Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model2022

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YAMAMOTO TAKUYA 山本拓也

Yamamoto Takuya 山本拓也