Himeno Tatsuhito 姫野龍仁

Researcher Number	60753762
Other IDs	https://orcid.org/0000-0002-5677-1125
Affiliation (Current)	2025: 愛知医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 愛知医科大学, 医学部, 准教授 2018 – 2022: 愛知医科大学, 医学部, 講師 2015 – 2017: 愛知医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 47060:Clinical pharmacy-related / Metabolomics
Keywords	Principal Investigator Diabetic polyneuropathy / 糖尿病神経障害 / 糖尿病性合併症 / 糖尿病性多発神経障害 / 神経幹細胞 / Notch / Notch signaling / 糖尿病性神経障害 / 末梢神経系 / グルコース応答性 / KATP channel / グルコース応答性カリウムチャネル … More Except Principal Investigator … More 糖尿病性神経障害 / 糖尿病神経障害 / Diabetic polyneuropathy / 酸化ストレス / 糖尿病性多発神経障害 / イメグリミン / ミトコンドリア / オートファジー / グルコース応答性ATP感受性Kチャネル / NAD / ミトコンドリア機能改善薬 / ミトコンドリア機能異常 / 高血糖 / O-GlcNAc修飾 / O-GlcNAc / K-ATP channels / ω-3多価不飽和脂肪酸 / アポトーシス / 小胞体ストレス / ERストレス / ω3多価不飽和脂肪酸 / ヒト乳歯歯髄幹細胞 / 歯髄幹細胞 / 再生医療 / シュワン前駆細胞 / 皮膚由来神経堤幹細胞 / 神経終末グリア / GFAP / S100b / Nestin陽性神経前駆細胞 / 皮膚幹細胞 / 糖尿病多発神経障害 / NGF / サイトカイン産生 / 皮膚線維芽細胞 / 3次元凝集化多能性幹細胞 / シュワン細胞 / 血管再生 / サイトカイン / 幹細胞 / 細胞移植療法 Less

糖尿病性多発神経障害におけるinsulin-Notch連関の異常と再生機構の破綻Principal Investigator
- Principal Investigator
  
  姫野龍仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Development of the treatment of diabetic neuropathy by activating Schwann cell NAD targeting nerve function
- Principal Investigator
  
  加藤宏一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Aichi Gakuin University
糖尿病性多発神経障害におけるグルコース応答性ATP感受性Kチャネルの役割の解明
- Principal Investigator
  
  神谷英紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
糖尿病・前糖尿病状態における腸管神経系障害が迷走神経活動と腸管糖新生に及ぼす影響
- Principal Investigator
  
  中村二郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
糖尿病性多発神経障害におけるinsulin-Notch連関の異常と再生機構の破綻Principal Investigator
- Principal Investigator
  
  姫野龍仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Mitochondrial dysfunction and diabetic Neuropathy: the efficacy of mitochondrial function-improving agents.
- Principal Investigator
  
  Kato Koichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Aichi Gakuin University
The roles of ATP-sensitive potassium channels in diabetic polyneuropathy
- Principal Investigator
  
  Yoshiro Kato
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Roles of O-GlcNAc modification in diabetic polyneuropathy.
- Principal Investigator
  
  Jiro Nakamura
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Diabetic neuropathy, endoplasmic reticulum stress and autophagy.
- Principal Investigator
  
  KATO Koichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Aichi Gakuin University
The neuroregenerative crosstalk of Insulin-Notch signaling in diabetic polyneuropathyPrincipal Investigator
- Principal Investigator
  
  Himeno Tatsuhito
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Aichi Medical University
Development of the new treatment for diabetic neuropathy using somatic stem cells and their secreted factors
- Principal Investigator
  
  Hideki Kamiya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Aichi Medical University
Study of nerve terminal attraction and neuroprotective effect by Schwann cells on diabetic polyneuropathy
- Principal Investigator
  
  Nakamura Jiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Aichi Medical University
The Functions of Glucose-Responsive ATP-sensitive K (KATP) Channels in Peripheral Nervous SystemsPrincipal Investigator
- Principal Investigator
  
  Himeno Tatsuhito
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  Aichi Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Hyperglycaemia Aggravates Oxidised Low-Density Lipoprotein-Induced Schwann Cell Death via Hyperactivation of Toll-like Receptor 42024
- Author(s)
  Wataru Nihei, Ayako Kato, Tatsuhito Himeno, Masaki Kondo, Jiro Nakamura, Hideki Kamiya, Kazunori Sango, Koichi Kato
- Journal Title
  
  Neurol Int
  
  Volume: 16 Issue: 2 Pages: 370-379
- DOI
  10.3390/neurolint16020027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06718
[Journal Article] Docosahexaenoic acid suppresses oxidative stress-induced autophagy and cell death via the AMPK-dependent signaling pathway in the immortalized Fischer rat Schwann cells 12022
- Author(s)
  Tatsumi Y, Kato A, Niimi N, Yako H, Himeno T, Kondo M, Tsunekawa S, Kato Y, Kamiya H, Nakamura J, Higai K, Sango K, Kato K.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 8 Pages: 4405-4405
- DOI
  10.3390/ijms23084405
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07773, KAKENHI-PROJECT-21K06718
[Journal Article] Protocol to image and analyze the morphology of mouse peripheral nerves using transmission electron microscopy2022
- Author(s)
  Nakai-Shimoda H, Himeno T, Motegi M, Ozeki N, Inoue R, Hayami T, Miura-Yura E, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Kondo M, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H.
- Journal Title
  
  STAR Protoc.
  
  Volume: 3(3) Issue: 3 Pages: 101591-101591
- DOI
  10.1016/j.xpro.2022.101591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06718
[Journal Article] Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves2021
- Author(s)
  Nakai-Shimoda H,Himeno T,Okawa T, Miura-Yura E, Sasajima S, Kato M, Yamada Y, Morishita Y, Tsunekawa S, Kato Y, Seino Y, Inoue R, Kondo M, Seino S, Naruse K, Kato K, Mizukami H, Nakamura J, Kamiya H
- Journal Title
  
  iScience
  
  Volume: 25(1):103609 Issue: 1 Pages: 1-20
- DOI
  10.1016/j.isci.2021.103609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06718
[Journal Article] Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice.2020
- Author(s)
  Mikio Motegi, Tatsuhito Himeno, Hiromi Nakai-Shimoda, Rieko Inoue, Norio Ozeki, Keiko Naruse, Yusuke Seino, Yoshitaka Hayashi, Jiro Nakamura, Hideki Kamiya, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 532 Issue: 1 Pages: 47-53
- DOI
  10.1016/j.bbrc.2020.08.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10121, KAKENHI-PROJECT-18H03176, KAKENHI-PROJECT-18K06763
[Journal Article] Glucagon-like peptide-1 receptor agonist protects dorsal root ganglion neurons against oxidative insult2019
- Author(s)
  Mohiuddin MS, Himeno T, Inoue R, Miura-Yura E, Yamada Y, Nakai-Shimoda H, Asano S, Kato M, Motegi M, Kondo M, Seino Y, Tsunekawa S, Kato Y, Suzuki A, Naruse K, Kato K, Nakamura J, Kamiya H.
- Journal Title
  
  Journal of Diabetes Reserch
  
  Volume: 2019 Pages: 9426014-9426014
- DOI
  10.1155/2019/9426014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11846, KAKENHI-PROJECT-18K06763, KAKENHI-PROJECT-19K10121
[Journal Article] Omega-3 polyunsaturated fatty acids exert anti-oxidant effects through the nuclear factor (erythroid-derived 2)-related factor 2 pathway in immortalized mouse Schwann cells.2019
- Author(s)
  Tatsumi Y, Kato A, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakamura J,Kato K.
- Journal Title
  
  Journal of diabetes investigation
  
  Volume: 10 Issue: 3 Pages: 602-612
- DOI
  10.1111/jdi.12931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06763, KAKENHI-PROJECT-16K07048
[Journal Article] Secreted factors from cultured dental pulp stem cells promoted neurite outgrowth of dorsal root ganglion neurons and ameliorated neural functions in streptozotocin‐induced diabetic mice2019
- Author(s)
  Miura‐Yura Emiri、Tsunekawa Shin、Naruse Keiko、Nakamura Nobuhisa、Motegi Mikio、Nakai‐Shimoda Hiromi、Asano Saeko、Kato Makoto、Yamada Yuichiro、Izumoto‐Akita Takako、Yamamoto Akihito、Himeno Tatsuhito、Kondo Masaki、Kato Yoshiro、Nakamura Jiro、Kamiya Hideki
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 11 Issue: 1 Pages: 28-38
- DOI
  10.1111/jdi.13085
- NAID
  120006980549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10121, KAKENHI-PROJECT-17H04404, KAKENHI-PROJECT-17K09851
[Journal Article] Recurrent short-term hypoglycemia and hyperglycemia induce apoptosis and oxidative stress via the ER stress response in immortalized adult mouse Schwann (IMS32) cells.2019
- Author(s)
  Kato A, Tatsumi Y, Yako H, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakmura J, Kato K.
- Journal Title
  
  Neuroscience research
  
  Volume: in press Pages: 26-32
- DOI
  10.1016/j.neures.2018.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06763, KAKENHI-PROJECT-16K07048
[Journal Article] Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy2019
- Author(s)
  Asano Saeko、Himeno Tatsuhito、Hayami Tomohide、Motegi Mikio、Inoue Rieko、Nakai-Shimoda Hiromi、Miura-Yura Emiri、Morishita Yoshiaki、Kondo Masaki、Tsunekawa Shin、Kato Yoshiro、Kato Koichi、Naruse Keiko、Nakamura Jiro、Kamiya Hideki
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: 2019 Pages: 1-7
- DOI
  10.1155/2019/2756020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06763, KAKENHI-PROJECT-19K10121
[Journal Article] Secreted factors from cultured dental pulp stem cells promoted neurite outgrowth of dorsal root ganglion neurons and ameliorated neural functions in streptozotocin-induced diabetic mice.2019
- Author(s)
  Miura-Yura E, Tsunekawa S, Naruse K, Nakamura N, Motegi M, Nakai-Shimoda H, Asano S, Kato M, Yamada Y, Izumoto-Akita T, Yamamoto A, Himeno T, Kondo M, Kato Y, Nakamura J, Kamiya H.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 印刷中
- NAID
  120006980549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09768
[Journal Article] Novel mechanism for counter-regulatory responses to hypoglycemia.2017
- Author(s)
  Tatsuhito Himeno, Jiro Nakamura.
- Journal Title
  
  Journal of Diabetes Investigations
  
  Volume: 8 Issue: 1 Pages: 29-31
- DOI
  10.1111/jdi.12527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06720
[Presentation] イメグリミンはシュワン細胞において高血糖・低血糖によるミトコンドリア機能障害を改善しNAD+産生およびNAMPT活性を亢進する2023
- Author(s)
  加藤文子、二瓶渉、八子英司、巽康彰、姫野龍仁、近藤正樹、加藤義郎、中村二郎、神谷英紀、三五一憲、加藤宏一
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] Synergistic Effects of Hyperglycemia and Dyslipidemia on Diabetic Neuropathy-High Glucose Aggravates Oxidized LDL-Induced Schwann Cell Death via Hyperactivation of TLR42023
- Author(s)
  Wataru Nihei, Ayako Kato, Tatsuhito Himeno, Masaki Kondo, Jiro Nakamura, Hideki Kamiya, Kazunori Sango, Koichi Kato
- Organizer
  American Diabetes Association 83rd scientific sessions.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] 糖尿病性神経障害におけるTLR4発現・遺伝子変異の病態生理学的意義の解析2023
- Author(s)
  二瓶渉、加藤文子、上田純礼、姫野龍仁、近藤正樹、中村二郎、神谷英紀、三五一憲、加藤宏一
- Organizer
  第38回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] 脂質異常症を合併した糖尿病性神経障害の発症・進展メカニズム-酸化LDLによるTLR4活性化、炎症性サイトカインとシュワン細胞死2023
- Author(s)
  二瓶渉、加藤文子、姫野龍仁、近藤正樹、中村二郎、神谷英紀、三五一憲、加藤宏一
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] IMEGLIMIN, A NEW ORAL HYPOGLYCEMIC AGENT, IMPROVES HYPERGLYCEMIA AND HYPOGLYCEMIA-INDUCED CELL DEATH AND MITOCHONDRIAL DYSFUNCTION IN SCHWANN CELLS2023
- Author(s)
  Koichi Kato, Ayako Kato, Wataru Nihei, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Kazunori Sango, Jiro Nakamura, Hideki Kamiya.
- Organizer
  33rd annual meeting of the diabetic neuropathy study group of the European Association for the Study of Diabetes (EASD), Neurodiab 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] Effects of imeglimin, a new oral hyperglycemic agent, on high glucose and low glucose-induced cell death and mitochondrial dysfunction in Schwann cells2022
- Author(s)
  Ayako Kato, Hideji Yako, Yasuaki Tatsumi, Wataru Nihei, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Kazunori Sango, Koichi Kato.
- Organizer
  The American Diabetes Association's 82nd Scientific Sessions（ADA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] 末梢神経系におけるグルコース応答性ATP感受性Kチャネルの生理的役割の解明2022
- Author(s)
  水野翼, 茂木幹雄, 姫野龍仁, 速水智英, 浅野紗恵子, 下田博美, 山田祐一郎, 三浦絵美梨, 森下啓明, 近藤正樹, 恒川新, 加藤義郎, 中村二郎, 大西正文, 神谷英紀
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K08873
[Presentation] シュワン細胞における高・低グルコースによる酸化ストレス亢進に対するミトコンドリア機能改善薬の効果2022
- Author(s)
  加藤文子、八子英司、巽康彰、二瓶渉、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] DHAはラット不死化シュワン細胞においてAMPK依存性シグナル経路を介して酸化ストレス誘導オートファジーと細胞死を抑制する2021
- Author(s)
  巽康彰、加藤文子、新見直子、八子英司、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、三五一憲、加藤宏一
- Organizer
  第64回日本糖尿病学会年次学術総会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] 糖尿病性神経障害における高グルコース・低グルコースの神経ミトコンドリア機能に対する影響―ミトコンドリア機能改善薬の効果―2021
- Author(s)
  加藤文子、巽康彰、二瓶渉、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第36回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] イメグリミンはシュワン細胞において高・低グルコースによるミトコンドリア機能障害を改善し細胞死を抑制する2021
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第64回日本糖尿病学会年次学術総会
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] Docosahexaenoic Acid Suppresses Oxidative Stress-Induced Autophagy and Cell Death through the AMPKDependent Signaling Pathway in Immortalized Adult Rat Schwann (IFRS1) Cells.2021
- Author(s)
  Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Kazunori Sango, Koichi Kato
- Organizer
  The American Diabetes Association's 81st Scientific Sessions（ADA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06718
[Presentation] Docosahexaenoic acid attenuates oxidative stress-induced autophagy and cell death in immortalized adult rat Schwann (IFRS1) cells2020
- Author(s)
  Yasuaki Tatsumi, Ayako Kato, Takahiro Banno, Naoko Niimi, Kazunori Sango, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koichi Kato
- Organizer
  American Diabetes Association 80th scientific sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] イメグリミンはシュワン細胞において高・低グルコースのミトコンドリア酸化ストレスの亢進を改善し細胞死を抑制する由来活性酸素に対する影響：脂肪酸酸化およびポリオール代謝の関与2020
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第63回　日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] ラット不死化シュワン細胞におけるDHAの酸化ストレス誘導オートファジーの抑制と細胞死改善効果2020
- Author(s)
  巽康彰、加藤文子、坂野崇宏、新見直子、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第35回　日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] DHAはラット不死化シュワン細胞における酸化ストレス誘導オートファジーを抑制し細胞死を改善する2020
- Author(s)
  巽康彰、加藤文子、坂野崇宏、新見直子、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第63回　日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] シュワン細胞における高・低グルコースによる細胞死の増加とミトコンドリア機能障害に対するイメグリミンの効果2020
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第35回　日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] 短時間の低血糖および血糖変動はシュワン細胞において酸化ストレスを亢進させアポトーシスを誘導する―ポリオール代謝、小胞体ストレスおよびミトコンドリア由来酸化ストレスの関与―2019
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  令和元年度糖尿病神経障害を考える会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] HYPOGLYCEMIA AND HYPERGLYCEMIA ENHANCE OXIDATIVE STRESS THROUGH POLYOL PATHWAY IN SCHWANN CELLS: NOVEL ANTIOXIDATIVE MECHANISMS OF ALDOSE REDUCTASE INHIBITORS.2019
- Author(s)
  Koichi Kato, Ayako Kato, Yasuaki Tatsumi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Hideki Kamiya, Kazunori Sango and Jiro Nakamura
- Organizer
  29th annual meeting of the diabetic neuropathy study group of the European Association for the Study of Diabetes(EASD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] Secreted Factors from Dental Pulp Stem Cells Ameliorated neural functions in Streptozotocin-Induced Diabetic Mice2019
- Author(s)
  EMIRI MIURA-YURA, SHIN TSUNEKAWA, KEIKO NARUSE, MIYUKA KAWAI, MAKOTO KATO, HIROMI SHIMODA, YUICHIRO YAMADA, MIKIO MOTEGI, SAEKO ASANO, TATSUHITO HIMENO, MASAKI KONDO, YOSHIRO KATO, JIRO NAKAMURA, HIDEKI KAMIYA
- Organizer
  The American Diabetes Association's 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09851
[Presentation] 末梢神経系の Notchシグナリングおよび神経幹細胞・前駆細胞のマウス糖尿病多発神経障害の発症機序に及ぼす影響の検討2019
- Author(s)
  姫野龍仁、John M Hayes、Carey Backus、Jacqueline R Dauch、Claudia Figueroa-Romero、Lucy Hinder、Junguk Hur、Phillipe O’Brien、Eva L Feldman、近藤正樹、恒川新、加藤義郎、神谷英紀、中村二郎
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09768
[Presentation] ヒト乳歯歯髄幹細胞培養上清が糖尿病性多発神経障害にもたらす効果の検討2019
- Author(s)
  三浦絵美梨、恒川新、成瀬桂子、茂木幹雄、浅野紗恵子、加藤誠、下田博美、山田祐一郎、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09851
[Presentation] シュワン細胞における高グルコースおよび低グルコースによるミトコンドリア酸化ストレス亢進のメカニズム2019
- Author(s)
  加藤文子　巽康彰　八子英司　三五一憲　姫野龍仁　近藤正樹　加藤義郎　神谷英紀　中村二郎　加藤宏一
- Organizer
  第34回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] シュワン細胞における高・低グルコースのミトコンドリア由来活性酸素に対する影響：脂肪酸酸化およびポリオール代謝の関与2019
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] Recurrent short-term hypoglycemia and hyperglycemia enhance apoptosis and oxidative stress through polyol pathway and endoplasmic reticulum stress pathway in Schwann cells2019
- Author(s)
  Ayako Kato, Yasuaki Tatsumi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Hideki Kamiya, Kazunori Sango, Jiro Nakamura and Koichi Kato
- Organizer
  The American Diabetes Association's 79th Scientific Sessions（ADA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] 神経芽細胞種Neuro2a細胞の高グルコース培養条件におけるオートファジー機構の解明2018
- Author(s)
  巽康彰、加藤文子、杉本舜、櫻井健裕、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] Secreted Factors from Dental Pulp Stem Cells Ameliorated Diabetic Polyneuropathy in Streptozotocin-Induced Diabetic Mice2018
- Author(s)
  Emiri Miura-Yura, Shin Tsunekawa, Tatsuhito Himeno, Keiko Naruse, Mikio Motegi, Hiromi Shimoda, Makoto Kato, Yuichiro Yamada, Masaki Kondo, Yoshiro Kato, Hideki Kamiya and Jiro Nakamura
- Organizer
  78th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09851
[Presentation] ヒト乳歯歯髄幹細胞培養上清が糖尿病多発神経障害にもたらす効果の検討2018
- Author(s)
  三浦絵美梨、恒川新、成瀬桂子、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎
- Organizer
  第61回日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-17K09851
[Presentation] Epalrestatはシュワン細胞において抗酸化酵素Ho-1を誘導し高・低グルコースによるアポトーシスおよび酸化ストレス亢進を改善する2018
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] Secreted Factors from Dental Pulp Stem Cells Ameliorated Diabetic Polyneuropathy in Streptozotocin-Induced Diabetic Mice2018
- Author(s)
  EMIRI MIURA-YURA, SHIN TSUNEKAWA, TATSUHITO HIMENO, KEIKO NARUSE, MIKIO MOTEGI, HIROMI SHIMODA, MAKOTO KATO, YUICHIRO YAMADA, MASAKI KONDO, YOSHIRO KATO, HIDEKI KAMIYA, JIRO NAKAMURA
- Organizer
  The American Diabetes Association's 78th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09851
[Presentation] ヒト乳歯歯髄幹細胞培養上清が糖尿病多発神経障害にもたらす効果の検討2018
- Author(s)
  三浦絵美梨、恒川新、成瀬桂子、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09851
[Presentation] RECURRENT HYPOGLYCEMIA AND GLUCOSE FLUCTUATION INDECE APOPTOSIS AND ENHANCE OXIDATIVE STRESS THROUGH ENDOPLASMIC RETICULUM STRESS IN SCHWANN CELLS.2018
- Author(s)
  Koichi Kato, Ayako Kato, Yasuaki Tatsumi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Hideki Kamiya, Kazunori Sango and Jiro Nakamura
- Organizer
  28th annual meeting of the diabetic neuropathy study group of the European Association for the Study of Diabetes(EASD)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] シュワン細胞における血糖変動の酸化ストレスに対する影響とアルドース還元酵素阻害薬の抗酸化酵素機構についての検討2018
- Author(s)
  加藤文子、巽康彰、八子英司、三五一憲、姫野龍仁、近藤正樹、加藤義郎、神谷英紀、中村二郎、加藤宏一
- Organizer
  第32回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K06763
[Presentation] 末梢神経系におけるglucose応答性KATP channelの生理的機能に関する検討2017
- Author(s)
  下田博美、姫野龍仁、茂木幹雄、浅野紗恵子、速水智英、浅野栄水、山田祐一郎、三浦絵美梨、近藤正樹、恒川新、加藤義郎、神谷英紀、中村二郎
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-15H06720
[Presentation] 皮膚幹細胞球状凝集体由来神経前駆細胞の糖尿病多発神経障害治療効果と移植後ミトコンドリア機能回復の検討2017
- Author(s)
  近藤正樹、姫野龍仁、神谷英紀、中村二郎
- Organizer
  第60回日本糖尿病学会年次学術集会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-16K09768
[Presentation] The Functions of Glucose-Responsive ATP-sensitive Potassium Channels in The Peripheral Nervous System of Mice2016
- Author(s)
  Tatsuhito Himeno, Hideki Kamiya, Yusuke Seino, Keiko Naruse, Tomohide Hayami, Mikio Motegi, Saeko Noda, Tetsuji Okawa, Masaki Kondo, Shin Tsunekawa, Susumu Seino, Jiro Nakamura
- Organizer
  the American Diabetes Association's 76th Scientific Sessions
- Place of Presentation
  New Orleans
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06720
[Presentation] The Functions of Glucose-Responsive ATP-sensitive Potassium Channels in The Peripheral Nervous System of Mice2016
- Author(s)
  TATSUHITO HIMENO, HIDEKI KAMIYA, YUSUKE SEINO, KEIKO NARUSE, TOMOHIDE HAYAMI, MIKIO MOTEGI, SAEKO NODA, TETSUJI OKAWA, MASAKI KONDO, SHIN TSUNEKAWA, SUSUMU SEINO, JIRO NAKAMURA,
- Organizer
  the American Diabetes Association’s　76th Scientific Sessions
- Place of Presentation
  New Orleans
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06720

1. Hideki Kamiya (70542679)

# of Collaborated Projects: 10 results

# of Collaborated Products: 41 results
2. KATO Koichi (40319322)

# of Collaborated Projects: 8 results

# of Collaborated Products: 34 results
3. Nakamura Jiro (40283444)

# of Collaborated Projects: 5 results

# of Collaborated Products: 33 results
4. Yoshiro Kato (40513429)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
5. 近藤正樹 (00717910)

# of Collaborated Projects: 4 results

# of Collaborated Products: 40 results
6. 成瀬桂子 (30387576)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
7. 加藤文子 (60513934)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
8. 下田博美 (40740931)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 巽康彰 (40335055)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
10. 速水智英 (60740933)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 茂木幹雄 (80740935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 三浦絵美梨 (00787575)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. 恒川新 (40612768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. 中村信久 (50619773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 二瓶渉 (70911428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 笹島沙知子 (50840336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 清野祐介 (80534833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 三五一憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Himeno Tatsuhito 姫野 龍仁

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糖尿病性多発神経障害におけるinsulin-Notch連関の異常と再生機構の破綻Principal Investigator

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糖尿病性多発神経障害におけるinsulin-Notch連関の異常と再生機構の破綻Principal Investigator

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The neuroregenerative crosstalk of Insulin-Notch signaling in diabetic polyneuropathyPrincipal Investigator

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The Functions of Glucose-Responsive ATP-sensitive K (KATP) Channels in Peripheral Nervous SystemsPrincipal Investigator

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[Journal Article] Hyperglycaemia Aggravates Oxidised Low-Density Lipoprotein-Induced Schwann Cell Death via Hyperactivation of Toll-like Receptor 42024

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[Journal Article] Docosahexaenoic acid suppresses oxidative stress-induced autophagy and cell death via the AMPK-dependent signaling pathway in the immortalized Fischer rat Schwann cells 12022

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Himeno Tatsuhito 姫野龍仁