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Qin XianYang  Qin XianYang

… Alternative Names

Qin Xian-Yang  Qin XianYang

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Researcher Number 60756815
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0110-6849
Affiliation (Current) 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
Affiliation (based on the past Project Information) *help 2021: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
2019 – 2021: 国立研究開発法人理化学研究所, 開拓研究本部, 研究員
2018 – 2019: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員
2016 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別研究員
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related / Basic Section 49010:Pathological biochemistry-related
Except Principal Investigator
Basic Section 55020:Digestive surgery-related
Keywords
Principal Investigator
がん幹細胞 / MYCN / オミクス解析 / 脂質 / 不飽和脂肪酸 / 肝発がん / 酸化ストレス / 肝癌 / 癌幹細胞 / 化学予防 … More / 癌 / 細胞・組織 / 発生・分化 / シグナル伝達 / 肝がん / バイオマーカー / 代謝 / エクソソーム / 予後予測 / liquid biopsy / 非アルコール性脂肪性肝炎 / 脂肪肝 / トランスグルタミナーゼ / エンドトキシン / 微小環境 / マルチオミクス解析 / ホスファチジルエタノールアミン / LIMK1 / in situイメージング / NASH / 膜脂質 / 膜タンパク質 … More
Except Principal Investigator
術後癒着 / 線維化 / 腹膜中皮細胞 / IL-6 / TNF / TGF / トロンビン / 外科手術後癒着 / 腹膜内皮細胞 / 好中球 / 癒着 / 外科手術術後 / 免疫 / サイトカイン / 中皮細胞 / マイクロアレイ / 抗IL-6受容体抗体 / IL-6受容体 / 線維形成 / 抗体 / 外科手術 / 血液凝固 Less
  • Research Projects

    (4 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (20 People)
  •  Role of membrane lipid-modulated signal transductions in endotoxin hyperresponse of fatty liversPrincipal Investigator

    • Principal Investigator
      Qin XianYang
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Role of circulating MYCN in recurrence and/or metastasis of hepatocellular carcinoma as a biomarker and/or regulatorPrincipal Investigator

    • Principal Investigator
      QIN Xian-Yang
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Molecular mechanisms of regulation of abdominal adhesion formation by anti-IL-6 antibody.

    • Principal Investigator
      Fujimoto Jiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Hyogo Medical University
  •  Systemic analysis of metabolic reprogramming of live cancer stem cellsPrincipal Investigator

    • Principal Investigator
      Qin Xian-Yang
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Institute of Physical and Chemical Research

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Inhibition of Ganglioside Synthesis Suppressed Liver Cancer Cell Proliferation through Targeting Kinetochore Metaphase Signaling2021

    • Author(s)
      Su Ting、Qin Xian-Yang、Dohmae Naoshi、Wei Feifei、Furutani Yutaka、Kojima Soichi、Yu Wenkui
    • Journal Title

      Metabolites

      Volume: 11 Pages: 167-167

    • DOI

      10.3390/metabo11030167

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07349
  • [Journal Article] Latency-associated peptide degradation fragments produced in stellate cells and phagocytosed by macrophages in bile duct-ligated mice liver2021

    • Author(s)
      Inoue Ikuyo、Qin Xian-Yang、Masaki Takahiro、Mezaki Yoshihiro、Matsuura Tomokazu、Kojima Soichi、Furutani Yutaka
    • Journal Title

      J Histochem Cytochem

      Volume: 69 Pages: 723-730

    • DOI

      10.1369/00221554211053665

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07349, KAKENHI-PROJECT-20K08342
  • [Journal Article] Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs2021

    • Author(s)
      Fujii Shinya、Miura Takahiro、Oikawa Tsuyoshi、Qin Xian-Yang、Kojima Soichi、Kagechika Hiroyuki
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 43 Pages: 128065-128065

    • DOI

      10.1016/j.bmcl.2021.128065

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-20K07349
  • [Journal Article] Transglutaminase 2 as a Marker for Inflammation and Therapeutic Target in Sepsis2021

    • Author(s)
      Su Ting、Qin Xian-Yang、Furutani Yutaka
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Pages: 1897-1897

    • DOI

      10.3390/ijms22041897

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07349
  • [Journal Article] Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer2021

    • Author(s)
      Qin Xian-Yang、Gailhouste Luc
    • Journal Title

      Frontiers in Oncology

      Volume: 10 Pages: 618515-618515

    • DOI

      10.3389/fonc.2020.618515

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07349, KAKENHI-PROJECT-20K07604
  • [Journal Article] Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells2021

    • Author(s)
      Gailhouste Luc、Sudoh Masayuki、Qin Xian-Yang、Watashi Koichi、Wakita Takaji、Ochiya Takahiro、Matsuura Tomokazu、Kojima Soichi、Furutani Yutaka
    • Journal Title

      Cell Death Discovery

      Volume: 7 Pages: 130-130

    • DOI

      10.1038/s41420-021-00515-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07349, KAKENHI-PROJECT-20K07604
  • [Journal Article] Establishment of a rapid detection system for ISG20-dependent SARS-CoV-2 subreplicon RNA degradation induced by interferon-α2021

    • Author(s)
      Furutani Yutaka、Toguchi Mariko、Higuchi Shoko、Yanaka Kaori、Gailhouste Luc、Qin Xian-Yang、Masaki Takahiro、Ochi Sae、Matsuura Tomokazu
    • Journal Title

      Int J Mol Sci

      Volume: 22 Pages: 11641-11641

    • DOI

      10.3390/ijms222111641

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07349, KAKENHI-PROJECT-20K07604, KAKENHI-PROJECT-20K08342
  • [Journal Article] MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion2020

    • Author(s)
      Yasukawa Ken、Liew Lee Chuen、Hagiwara Keitaro、Hironaka‐Mitsuhashi Ai、Qin Xian‐Yang、Furutani Yutaka、Tanaka Yasuhito、Nakagama Hitoshi、Kojima Soichi、Kato Takashi、Ochiya Takahiro、Gailhouste Luc
    • Journal Title

      Cancer Science

      Volume: 111 Pages: 869-880

    • DOI

      10.1111/cas.14292

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15833
  • [Journal Article] Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells2020

    • Author(s)
      Qin Xian-Yang、Su Ting、Yu Wenkui、Kojima Soichi
    • Journal Title

      Cell Death & Disease

      Volume: 11(1) Pages: 66-66

    • DOI

      10.1038/s41419-020-2257-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15833
  • [Journal Article] Imaging of the ex vivo transglutaminase activity in liver macrophages of sepsis mice2020

    • Author(s)
      Su Ting、Qin Xian-Yang、Furutani Yutaka、Yu Wenkui、Kojima Soichi
    • Journal Title

      Analytical Biochemistry

      Volume: 597 Pages: 113654-113654

    • DOI

      10.1016/j.ab.2020.113654

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15833
  • [Journal Article] Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres2020

    • Author(s)
      Kikegawa Mami、Qin Xian-Yang、Ito Tomohiro、Nishikawa Hiromi、Nansai Hiroko、Sone Hideko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 5564-5564

    • DOI

      10.3390/ijms21155564

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07349
  • [Journal Article] Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation2019

    • Author(s)
      Naoki Uyama, Hiroko Tsutsui, Songtao Wu, Koubun Yasuda, Etsuro Hatano, Xian-Yang Qin, Soichi Kojima, Jiro Fujimoto
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 17558-17558

    • DOI

      10.1038/s41598-019-54175-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02885, KAKENHI-PROJECT-18K15833
  • [Journal Article] Inhibition of Stearoyl-CoA Desaturase-1 Activity Suppressed SREBP Signaling in Colon Cancer Cells and Their Spheroid Growth2019

    • Author(s)
      Qin, X-Y., and Kojima, S.
    • Journal Title

      Gastrointestinal Disorders

      Volume: 1 Pages: 191-200

    • DOI

      10.3390/gidisord1010014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833
  • [Journal Article] An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes2019

    • Author(s)
      Furutani Yutaka、Toguchi Mariko、Shiozaki-Sato Yumi、Qin Xian-Yang、Ebisui Etsuko、Higuchi Shoko、Sudoh Masayuki、Suzuki Harukazu、Takahashi Nobuaki、Watashi Koichi、Wakita Takaji、Kakeya Hideaki、Kojima Soichi
    • Journal Title

      PLoS One

      Volume: 14

    • DOI

      10.1371/journal.pone.0216139

    • NAID

      120006644069

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15833, KAKENHI-PROJECT-17H04085
  • [Journal Article] Prevention of arachidonic acid?induced liver injury by controlling oxidative stress?mediated transglutaminase activation with garlic extracts2019

    • Author(s)
      Qin Xian-Yang、Su Ting、Kojima Soichi
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 19(2) Pages: 1522-1527

    • DOI

      10.3892/etm.2019.8384

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15833
  • [Journal Article] Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β2018

    • Author(s)
      Li, M., Qin, X-Y., Furutani, Y., Inoue, I., Sekihara, S., Kagechika, H., and Kojima, S.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 504 Pages: 857-864

    • DOI

      10.1016/j.bbrc.2018.09.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833, KAKENHI-PROJECT-16K09386
  • [Journal Article] Arachidonic acid suppresses hepatic cell growth through ROS-mediated activation of transglutaminase2018

    • Author(s)
      Qin, X-Y., Lu, J., Cai, M., and Kojima, S.
    • Journal Title

      FEBS Open Bio

      Volume: 8 Pages: 1703-1710

    • DOI

      10.1002/2211-5463.12511

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833
  • [Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.2018

    • Author(s)
      Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 115 Pages: 4969-4974

    • DOI

      10.1073/pnas.1802279115

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-16K19378, KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K09353, KAKENHI-PROJECT-17K15933
  • [Journal Article] Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming2018

    • Author(s)
      Qin, X-Y., Dohmae, N., and Kojima, S.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115

    • DOI

      10.1073/pnas.1808740115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833
  • [Journal Article] Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes2017

    • Author(s)
      Qin Xian-Yang et al.
    • Journal Title

      EBioMedicine

      Volume: 24 Pages: 257-266

    • DOI

      10.1016/j.ebiom.2017.09.008

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09386, KAKENHI-PROJECT-16K19378
  • [Presentation] Serum MYCN as a predictive biomarker of prognosis and therapeutic response in the prevention of hepatocellular carcinoma2021

    • Author(s)
      Xian-Yang Qin
    • Organizer
      JDDW 2021 KOBE
    • Data Source
      KAKENHI-PROJECT-20K07349
  • [Presentation] Identification of MYCN as a prognostic biomarker of liver cancer stem cells and therapeutic target for recurrence of hepatocellular carcinoma2019

    • Author(s)
      Xian-Yang Qin and Soichi Kojima
    • Organizer
      JDDW2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15833
  • [Presentation] Selective depletion of liver cancer stem cells by retinoids2018

    • Author(s)
      Xian-Yang Qin, Soichi Kojima
    • Organizer
      JSPS Core-to-core Program Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19378
  • [Presentation] Multi-omics analyses on the effect of acyclic retinoid in selective depletion of liver cancer stem cells2018

    • Author(s)
      Xian-Yang Qin, Soichi Kojima
    • Organizer
      THE FOURTH INTERNATIONAL FASEB CONFERENCE ON RETINOIDS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15833
  • [Presentation] Role of transglutaminase 2 in selective deletion of MYCN+CD133+ liver cancer stem cells by acyclic retinoid2017

    • Author(s)
      Xian-Yang Qin, Rajan Shrestha, Sanae Sekihara, Akimori Wada, Soichi Kojima
    • Organizer
      Debrecen University Symposium TGase
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19378
  • [Presentation] Hepatic orosomucoid is an additional essential regulator promoting hepatocyte proliferation during liver regeneration2016

    • Author(s)
      Xian-Yang Qin, Mitsuko Hara, Erik Arner, Yoshikuni Kawaguchi, Norihiro Kokudo, Harukazu Suzuki, Piero Carninci, Alistair Forrest, Soichi Kojima
    • Organizer
      AASLD2016 第67回米国肝臓学会議
    • Place of Presentation
      John B. Hynes Veterans Memorial Convention Center (Boston, MA, USA)
    • Year and Date
      2016-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19378
  • [Presentation] Acyclic retinoid inhibits aberrant lipogenesis to prevent diethylnitrosamine-induced hepatic tumorigenesis2016

    • Author(s)
      Xian-Yang Qin, Yohei Shirakami, Naoto Ishibashi, Masahito Shimizu, Hisataka Moriwaki, Soichi Kojima
    • Organizer
      FASEB's 3rd International Conference on Retinoids
    • Place of Presentation
      Marriott West Palm Beach (West Palm Beach, FL, USA)
    • Year and Date
      2016-06-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19378
  • 1.  Fujimoto Jiro (90199373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  石戸 聡 (10273781)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  筒井 ひろ子 (40236914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  宇山 直樹 (70402873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  波多野 悦朗 (80359801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  小嶋 聡一 (10202061)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  宮下 正寛 (30423883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MASAKI Takahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  OTA Tsuguhito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  SHIMIZU Masahito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  TATSUKAWA Hideki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  古谷 裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  本多 政夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  金子 周一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  井上 啓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  白上 洋平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  岡田 光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  渡士 幸一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  藤井 晋也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  Gailhouste Luc
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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