Mizuno Mirei 水野美麗

Researcher Number	60766195
Affiliation (based on the past Project Information) *help	2021 – 2024: 昭和大学, 薬学部, 講師 2018 – 2020: 昭和大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 活性酸素 / 抗酸化物質 / 酸化ストレス / サプリメント / スーパーフード / キレート / 鉄イオン / チモキノン / キノン / 抗酸化活性 … More / 銅イオン / プロオキシダント効果 / 抗酸化作用 / 機能性食品 … More Except Principal Investigator アミロイドβ / アルツハイマー病 / α-セクレターゼ / 凝集阻害 / セクレターゼ / ペプチド / 神経細胞毒性 / 凝集阻害活性 / アミロイド / フィセチン / プロシアニジン / カテキン Less

筋力トレーニングに伴う酸化ストレスの制御に有用な抗酸化物質の探索Principal Investigator
- Principal Investigator
  
  水野美麗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Showa University
Development of peptide derivatives with amyloid-beta cleaving activity
- Principal Investigator
  
  福原潔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Showa University
Chemical elucidation of efficacy and safety of health functional foodPrincipal Investigator
- Principal Investigator
  
  Mizuno Mirei
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Showa University
Catechin derivatives useful for the treatment of Alzheimer's disease
- Principal Investigator
  
  Fukuhara Kiyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Showa University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Suppressive effect of resveratrol, catechin and their conformationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils2024
- Author(s)
  Ohinata Hitomi、Phimarn Wiraphol、Mizuno Mirei、Obama Takashi、Fukuhara Kiyoshi、Makiyama Tomohiko、Watanabe Yuichi、Itabe Hiroyuki
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 75 Issue: 1 Pages: 17-23
- DOI
  10.3164/jcbn.23-80
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15486
[Journal Article] Planar catechin increases bone mass by regulating differentiation of osteoclasts in mice2024
- Author(s)
  Daiki Sugawara, Nobuhiro Sakai, Yurie Sato, Yuki Azetsu, Akiko Karakawa, Masahiro Chatani, Mirei Mizuno, Yasubumi Maruoka, Mie Myers, Kiyoshi Fukuhara, Masamichi Takami
- Journal Title
  
  J Oral Biosci.
  
  Volume: - Issue: 1 Pages: 196-204
- DOI
  10.1016/j.job.2024.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-20K18465
[Journal Article] DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination2023
- Author(s)
  Fukuhara Kiyoshi、Nakanishi Ikuo、Imai Kohei、Mizuno Mirei、Matsumoto Ken-ichiro、Ohno Akiko
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 2 Pages: 225-225
- DOI
  10.3390/antiox12020225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06620, KAKENHI-PROJECT-22K06508
[Journal Article] Antioxidant and Prooxidant Effects of Thymoquinone and Its Hydroquinone Metabolite2022
- Author(s)
  M. Mizuno, K. Fukuhara
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 9 Pages: 1389-1393
- DOI
  10.1248/bpb.b22-00199
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06508, KAKENHI-PROJECT-20K15486
[Journal Article] Development of natural antioxidant derivatives in the treatment and prevention of lifestyle-related diseases2021
- Author(s)
  福原潔、水野美麗
- Journal Title
  
  Journal of The Showa University Society
  
  Volume: 81 Issue: 5 Pages: 402-413
- DOI
  10.14930/jshowaunivsoc.81.402
- NAID
  130008142377
- ISSN
  2187-719X, 2188-529X
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15486
[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Mirei Mizuno, Kiyoshi Fukuhara, Sanju Iwamoto, Toshihiro Aiuchi, Tomohiko Makiyama and Hiroyuki Itabe
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 11 Pages: 1045-1045
- DOI
  10.3390/antiox9111045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin2020
- Author(s)
  Mizuno Mirei、Mori Kazunori、Tsuchiya Keisuke、Takaki Takashi、Misawa Takashi、Demizu Yosuke、Shibanuma Motoko、Fukuhara Kiyoshi
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 36 Pages: 23164-23174
- DOI
  10.1021/acsomega.0c02936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Synthesis and radical-scavenging activity of C-methylated fisetin analogues2019
- Author(s)
  1.K. Imai, I. Nakanishi, K. Ohkubo, A. Ohno, M. Mizuno, S. Fukuzumi, K. Matsumoto, K. Fukuhara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 27 Issue: 8 Pages: 1720-1727
- DOI
  10.1016/j.bmc.2019.02.033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-18K06620, KAKENHI-PUBLICLY-18H04650, KAKENHI-PROJECT-17H03010
[Journal Article] Inhibition of beta-amyloid-induced neurotoxicity by planar analogues of procyanidin B32019
- Author(s)
  M. Mizuno, K. Mori, T. Misawa, Y. Demizu, M. Shibanuma, K. Fukuhara*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 18 Pages: 2659-2663
- DOI
  10.1016/j.bmcl.2019.07.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-19K07423
[Presentation] α-グルコシダーゼを創薬標的とした新規フラボノイド誘導体の開発2024
- Author(s)
  水野美麗、福原潔
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] Aβを創薬標的とした新規カテキン-カプサイシン誘導体の開発2023
- Author(s)
  水野美麗、福原潔
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] アミロイドβの神経毒製を抑制する新規ペプチドの開発2023
- Author(s)
  福原潔、沖山佳生、森一憲、三澤隆史、水野美麗、出水庸介、柴沼質子、大野彰子
- Organizer
  酸化ストレス学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06508
[Presentation] アミロイドβの神経毒性を抑制する新規ペプチドの開発2023
- Author(s)
  福原潔、沖山佳生、三澤隆史、水野美麗、出水庸介、柴沼質子、大野彰子
- Organizer
  第36回日本酸化ストレス学会関東支部会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] 平面型カテキン［planar catechin：PCat］の骨量増加作用2023
- Author(s)
  菅原大貴、高見正道、畔津祐季、唐川亜希子、茶谷昌宏、水野美麗、福原潔、坂井信裕
- Organizer
  第8回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] アミロイドβの神経毒性を抑制する新規ペプチドの開発2022
- Author(s)
  福原潔、森一憲、沖山佳生、三澤隆史、水野美麗、出水庸介、柴沼質子、大野彰子
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] アミロイドβの神経毒性を抑制する新規ペプチドの開発2022
- Author(s)
  福原潔、森一憲、沖山佳生、三澤隆史、水野美麗、出水庸介、柴沼質子、大野彰子
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] キノン構造を有する機能性化合物の抗酸化作用とプロオキシダント効果2022
- Author(s)
  水野美麗、福原潔
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] シリビニンの高機能化を目指した創薬研究2021
- Author(s)
  水野美麗，森一憲，土屋圭輔，髙木孝士，三澤隆史，出水庸介，柴沼質子，福原潔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] シリビニンの高機能化を目指した創薬研究2021
- Author(s)
  水野　美麗
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] C-メチルフィセチンのラジカル消去作用2021
- Author(s)
  福原潔, 中西郁夫, 大久保敬, 今井耕平, 水野美麗, 松本健一郎, 大野彰子
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Functional improvement of silibinin analogues with constrained 3D structures2021
- Author(s)
  M. Mizuno, K. Mori, K. Tsuchiya, M. Shibanuma, K. Fukuhara
- Organizer
  13th AMFC International Medicinal Chemistry symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] Rationally designed peptide modulators of amyloid-β toxicity in Alzheimer’s disease2021
- Author(s)
  Kiyoshi Fukuhara, Kazunori Mori, Yoshio Okiyama, Takashi Misawa, Mirei Mizuno, Yosuke Demizu, Motoko Shibanuma, Akiko Ohno
- Organizer
  13th AMFC International Medicinal Chemistry symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15486
[Presentation] C-メチルフラボノイドのラジカル消去作用2020
- Author(s)
  福原潔, 中西郁夫, 大久保敬, 今井耕平, 水野美麗, 松本健一郎, 大野彰子
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] 分子内環固定によるシリビニンの高機能化2020
- Author(s)
  水野美麗，森一憲，柴沼質子，福原潔
- Organizer
  本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] C-メチルフィセチンのラジカル消去活性2019
- Author(s)
  福原　潔，今井耕平，中西郁夫，大久保敬，大野彰子，水野美麗，福住俊一，松本謙一郎
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Synthesis of silibinin analogues targeting amyloid β2019
- Author(s)
  M. Mizuno, K. Mori, M. Shibanuma, K. Fukuhara
- Organizer
  258th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβを創薬標的としたシリビニン誘導体の開発2019
- Author(s)
  水野美麗,森一憲,三澤隆史,髙木孝士,出水庸介,柴沼質子,福原潔
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβを創薬標的としたプロアントシアニジン誘導体の開発2018
- Author(s)
  水野美麗，森　一憲，柴沼質子，福原　潔
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] Design and synthesis of proanthocyanidin derivatives as an inhibitor of amyloid β aggregation2018
- Author(s)
  M. Mizuno, K. Mori, I. Nakanishi, K. Matsumoto, M. Shibanuma, K. Fukuahra
- Organizer
  256th ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06588
[Presentation] アミロイドβ凝集と神経細胞毒性を抑制するプロアントシアニジン誘導体の開発2018
- Author(s)
  水野美麗，森　一憲，柴沼質子，福原　潔
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06588

1. Fukuhara Kiyoshi (70189968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. 大野彰子 (70356236)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. OBAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 板部洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 牧山智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 畔津佑季

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高見正道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 茶谷昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizuno Mirei 水野 美麗

Research Projects

Research Products

Co-Researchers

筋力トレーニングに伴う酸化ストレスの制御に有用な抗酸化物質の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of peptide derivatives with amyloid-beta cleaving activity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chemical elucidation of efficacy and safety of health functional foodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Catechin derivatives useful for the treatment of Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Suppressive effect of resveratrol, catechin and their conformationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Planar catechin increases bone mass by regulating differentiation of osteoclasts in mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antioxidant and Prooxidant Effects of Thymoquinone and Its Hydroquinone Metabolite2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Development of natural antioxidant derivatives in the treatment and prevention of lifestyle-related diseases2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and radical-scavenging activity of C-methylated fisetin analogues2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of beta-amyloid-induced neurotoxicity by planar analogues of procyanidin B32019

Author(s)

Journal Title

DOI

Mizuno Mirei 水野美麗