Watanabe Naoki 渡邊直希

… Alternative Names

渡邊直希ワタナベナオキ

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Researcher Number	60769339
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 神経難病研究センター, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 滋賀医科大学, 神経難病研究センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator Amyloid-β / ILEI / 遺伝子発現制御 / アルツハイマー病 / 老年期認知症 / γ-Secretase / 神経科学 / 老化 / 脳神経疾患 Except Principal Investigator 先制医療 … More / 予防的介入 / 遺伝子発現制御 / APP / FAM3C / アミロイドβ / ゲノム編集 / リスク遺伝子 / アルツハイマー病 Less

新規amyloid-β抑制因子ILEIの減少に伴うアルツハイマー病リスクと分子制御機構の解析Principal Investigator
- Principal Investigator
  
  渡邊直希
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Examining the risk of developing Alzheimer's disease induced by decreased expression of ILEIPrincipal Investigator
- Principal Investigator
  
  WATANABE Naoki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genes
- Principal Investigator
  
  Nishimura Masaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Can the age-related decrease in the expression of the novel secretory molecule ILEI be the primary factor in Alzheimer's disease?Principal Investigator
- Principal Investigator
  
  Watanabe Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain.2022
- Author(s)
  Watanabe N, Nakano M, Mitsuishi Y, Hara N, Mano T, Iwata A, Murayama S, Suzuki T, Ikeuchi T, Nishimura M
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 31 Issue: 1 Pages: 122-132
- DOI
  10.1093/hmg/ddab226
- NAID
  120007186913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19K17027, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-20H03587, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-16H06277
[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido C T, Murayama S, Kasuga K, Ikeuchi K, Suzuki T, Nishimura M
- Journal Title
  
  Journal of Alzheimer’s disease
  
  Volume: 80 Issue: 1 Pages: 159-174
- DOI
  10.3233/jad-201174
- NAID
  120007019774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-20K16491, KAKENHI-PROJECT-18H02566, KAKENHI-PROJECT-18K07384, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546
[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
- Author(s)
  Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: - Issue: 1 Pages: 45-60
- DOI
  10.3233/jad-191081
- NAID
  120006859791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20K16491, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-18H02566
[Journal Article] Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease2019
- Author(s)
  Kawatsuki A, Morita S-Y, Watanabe N, Hibino E, Mitsuishi Y, Sugi T, Murayama S, Nishimura M.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 20 Pages: 100704-100704
- DOI
  10.1016/j.bbrep.2019.100704
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-16H06277
[Presentation] PresenilinによるAβ産生のデュアル制御メカニズム2022
- Author(s)
  西村正樹,渡邊直希,中野将希
- Organizer
  第41回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022
- Author(s)
  渡邊直希, 中野将希, 西村正樹
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16491
[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022
- Author(s)
  渡邊直希,中野将希.西村正樹
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生抑制分子ILEI/FAM3Cの発現制御機構2021
- Author(s)
  渡邊直希、村山繁雄、西村正樹
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2021
- Author(s)
  Nakano M, Mitsuishi Y, Liu L, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Aβ産生抑制分子ILEI/FAM3Cの発現制御機構2021
- Author(s)
  渡邊直希, 村山繁雄, 西村正樹
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16491
[Presentation] Aβ産生を抑制するILEI/FAM3Cの転写制御メカニズム解析2020
- Author(s)
  渡邊直希, 中野将希, 西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16491
[Presentation] Aβ産生を抑制するILEI/FAM3Cの転写制御メカニズム解析2020
- Author(s)
  渡邊直希、中野将希、西村正樹
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2020
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Saito T, Saido TC, Suzuki T, Nishimura M
- Organizer
  AAIC 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Presynaptic ILEI/FAM3C is released in an activity-dependent manner like Aβ exocytosis.2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Presynaptic ILEI/FAM3C is released in an activity-dependent manner like Aβ exocytosis2019
- Author(s)
  中野将希、三ツ石弥千代、渡邊直希、日比野絵美、杉拓磨、斉藤貴志、西道隆臣、鈴木利治、西村正樹
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Synaptic activity-dependent release of presynaptic ILEI/FAM3C2019
- Author(s)
  Nakano M, Mitsuishi Y, Watanabe N, Hibino E, Saito T, Saido TC, Suzuki T, Nishimura M.
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] 大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03546
[Presentation] Synaptic activity-dependent release of presynaptic ilei/FAM3C.2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  AAIC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] 大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討2019
- Author(s)
  中野将希, 三ツ石弥千代, 渡邊直希, 日比野絵美, 斉藤貴志, 西道隆臣, 鈴木利治, 西村正樹
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Aβ産生抑制タンパク質ILEIの構造および機能の解析2018
- Author(s)
  日比野絵美, 杉田昌岳, 三ツ石弥千代, 渡邊直希, 中野将希, 杉拓磨, 西村正樹
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Structure-based analysis of ILEI/FAM3C activity to inhibit Aβ generation2018
- Author(s)
  Emi Hibino, Masatake Sugita, Yachiyo Mitsuishi, Naoki Watanabe, Masaki Nakano, Takuma Sugi, Masaki Nishimura
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] 特異な機序でアミロイドβ産生を抑制するILEI / FAM3Cとアルツハイマー病リスク2018
- Author(s)
  日比野絵美、渡邊直希、西村正樹
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Aβ産生抑制タンパク質ILEI/FAM3Cの転写制御機構の解析2018
- Author(s)
  渡邊直希, 日比野絵美, 中野将希, 庄司航, 杉拓磨, 西村正樹
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Aβ産生抑制タンパク質ILEI/FAM3Cの構造と機能の解析2017
- Author(s)
  日比野絵美, 森田修平, 杉田昌岳, 渡邊直希, 川月章弘, 野村礼, 西村正樹
- Organizer
  2017年度生命科学系学会合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Aβ産生抑制分子ILEI/FAM3Cの遺伝子転写制御メカニズム2017
- Author(s)
  渡邊直希, 川月章弘, 日比野絵美, 野村礼, 西村正樹
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] 神経系及び非神経系細胞におけるILEI/FAM3C遺伝子の転写制御解析2017
- Author(s)
  渡邊直希, 庄司航, 川月章弘, 日比野絵美, 野村礼, 西村正樹
- Organizer
  2017年度生命科学系学会合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] 孤発性アルツハイマー病のリスク遺伝子TM2D3の機能解析2017
- Author(s)
  川月章弘, 渡邊直希, 日比野絵美, 野村礼, 西村正樹
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17812
[Presentation] Aβ産生抑制タンパク質ILEIの構造解析に基づく機能メカニズムの検討2017
- Author(s)
  日比野絵美, 森田修平, 野村礼, 川月章弘, 渡邊直希, 西村正樹
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17812

1. Nishimura Masaki (40322739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 中野将希 (00823890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

Watanabe Naoki 渡邊 直希

渡邊 直希 ワタナベ ナオキ

Research Projects

Research Products

Co-Researchers

新規amyloid-β抑制因子ILEIの減少に伴うアルツハイマー病リスクと分子制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Examining the risk of developing Alzheimer's disease induced by decreased expression of ILEIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Can the age-related decrease in the expression of the novel secretory molecule ILEI be the primary factor in Alzheimer's disease?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain.2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] PresenilinによるAβ産生のデュアル制御メカニズム2022

Author(s)

Organizer

Data Source

[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022

Author(s)

Organizer

Data Source

[Presentation] 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証2022

Author(s)

Organizer

Data Source

[Presentation] Aβ産生抑制分子ILEI/FAM3Cの発現制御機構2021

Author(s)

Organizer

Data Source

[Presentation] Extracellular release of ILEI/FAM3C and Aβ is associated with the activation of distinct synapse subpopulation.2021

Author(s)

Organizer

Data Source

[Presentation] Aβ産生抑制分子ILEI/FAM3Cの発現制御機構2021

Author(s)

Organizer

Data Source

[Presentation] Aβ産生を抑制するILEI/FAM3Cの転写制御メカニズム解析2020

Author(s)

Organizer

Data Source

Watanabe Naoki 渡邊直希

渡邊直希ワタナベナオキ