Takami Mariko 高見真理子

Researcher Number	60770906
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 助教
Affiliation (based on the past Project Information) *help	2016 – 2023: 千葉大学, 大学院医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55040:Respiratory surgery-related / Respiratory surgery
Keywords	Principal Investigator 免疫療法 / NKT細胞 / 肺癌 / AhRシグナル / 二重特異性抗体 / アジュバント効果 / NK細胞 / 免疫治療 / 免疫学

HER2/CD3二重特異性抗体を用いたNKT細胞療法による肺癌免疫治療の検討Principal Investigator
- Principal Investigator
  
  高見真理子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba University
Adjuvant effect of NK cells for NKT cell-based immunotherapy targeting lung cancerPrincipal Investigator
- Principal Investigator
  
  Takami Mariko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba University
A role of AhR signaling in NKT cell based immunotherapy for lung cancerPrincipal Investigator
- Principal Investigator
  
  Takami Mariko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Chiba University
Effect of AhR signaling in iNKT cell based immunotherapy for lung cancerPrincipal Investigator
- Principal Investigator
  
  Takami Mariko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Chiba University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner2024
- Author(s)
  Takami Mariko、Aoki Takahiro、Nishimura Katsuhiro、Tanaka Hidekazu、Onodera Atsushi、Motohashi Shinichiro
- Journal Title
  
  Cancer Research Communications
  
  Volume: 4 Issue: 2 Pages: 446-459
- DOI
  10.1158/2767-9764.crc-23-0203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06690, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-23K24441
[Journal Article] Administration of α-galactosylceramide-pulsed Antigen Presenting Cells in Combination with First-line Chemotherapy for Advanced Lung Cancer2021
- Author(s)
  Hagiya, M., Tanaka, T., Aita, K., Shiragami, R., Ihara, F., Ishii, A., Takami, M., Homma, T., Wada, Y., Motohashi, S.
- Journal Title
  
  Chiba Survey Research Journal
  
  Volume: 10 Pages: 27-33
- NAID
  40022745808
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07652
[Journal Article] CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy2020
- Author(s)
  Hara Ayaka、Koyama-Nasu Ryo、Takami Mariko、Toyoda Takahide、Aoki Takahiro、Ihara Fumie、Kobayashi Masayoshi、Hirono Seiichiro、Matsutani Tomoo、Nakayama Toshinori、Iwadate Yasuo、Motohashi Shinichiro
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: - Issue: 5 Pages: 1239-1254
- DOI
  10.1007/s00262-020-02742-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07652, KAKENHI-PROJECT-20K17952, KAKENHI-PROJECT-18H02892, KAKENHI-PROJECT-18K07257, KAKENHI-PROJECT-19K18379, KAKENHI-PROJECT-19K09451, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19H05650
[Journal Article] Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer2020
- Author(s)
  Toyoda, T., Kamata, T., Tanaka, K., Ihara, F., Takami, M., Suzuki, H., Nakajima, T., Ikeuchi, T., Kawasaki, Y., Hanaoka, H., Nakayama, T., Yoshino, I., and Motohashi, S.
- Journal Title
  
  J. Immunother. Cancer
  
  Volume: 8 Issue: 1 Pages: e000316-e000316
- DOI
  10.1136/jitc-2019-000316
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
[Journal Article] Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d‐independent manner2020
- Author(s)
  Aoki Takahiro、Takami Mariko、Takatani Tomozumi、Motoyoshi Kiwamu、Ishii Ayana、Hara Ayaka、Toyoda Takahide、Okada Reona、Hino Moeko、Koyama‐Nasu Ryo、Kiuchi Masahiro、Hirahara Kiyoshi、Kimura Motoko Y.、Nakayama Toshinori、Shimojo Naoki、Motohashi Shinichiro
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 7 Pages: 2223-2233
- DOI
  10.1111/cas.14428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07652, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-18H02892, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07257, KAKENHI-PROJECT-19K18379
[Journal Article] Immunological Features of a Lung Cancer Patient Achieving an Objective Response with Anti-PD-1 Blockade Therapy2019
- Author(s)
  Kamata, T., Yoshida, S., Takami, M., Ihara, F., Yoshizawa, H., Toyoda, T., Takeshita, Y., Nobuyama, S., Kanetsuna, Y., Sato, T., Yoshino, I., and Motohashi, S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 1 Pages: 288-296
- DOI
  10.1111/cas.14222
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
[Journal Article] Regulatory T cells induce CD4－ NKT cell anergy and suppress NKT cell cytotoxic function2019
- Author(s)
  Ihara, F., Sakurai, D., Takami, M., Kamata, T., Kunii, N., Yamasaki, K., Iinuma, T., Nakayama, T., Motohashi, S., and Okamoto, Y.
- Journal Title
  
  Cancer Immunol. Immunother
  
  Volume: 68 Issue: 12 Pages: 1935-1947
- DOI
  10.1007/s00262-019-02417-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
[Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019
- Author(s)
  Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., Motohashi, S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 3 Pages: 888-902
- DOI
  10.1111/cas.13933
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-17H01592, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-18K16274, KAKENHI-PROJECT-16H02778, KAKENHI-PROJECT-18H02892
[Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome.2018
- Author(s)
  Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
- Journal Title
  
  Pediatr. Surg. Int.
  
  Volume: 34 Issue: 2 Pages: 195-201
- DOI
  10.1007/s00383-017-4189-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26462705, KAKENHI-PROJECT-16K19974, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-17H01592
[Journal Article] Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer2018
- Author(s)
  Tanaka K, Kanesaka Y, Takami M, Suzuki A, Hosokawa H, Onodera A, Kamata T, Nagato K, Nakayama T, Yoshino I, Motohashi S
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 506(1) Issue: 1 Pages: 27-32
- DOI
  10.1016/j.bbrc.2018.10.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
[Journal Article] TGF-β suppresses RasGRP1 expression and supports regulatory T cells resistance against p53-induced CD28-dependent T cell apoptosis2018
- Author(s)
  Takami, M., Cunha, C., Motohashi , S., Nakayama, T., Iwashima, M.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 48 Issue: 12 Pages: 1938-1943
- DOI
  10.1002/eji.201847587
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
[Journal Article] Clinical Application of iNKT Cell-mediated Anti-tumor Activity Against Lung Cancer and Head and Neck Cancer2018
- Author(s)
  Takami, M., Ihara, F., Motohashi, S.
- Journal Title
  
  Front. Immunol.
  
  Volume: 7 Pages: 2021-2021
- DOI
  10.3389/fimmu.2018.02021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
[Journal Article] Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors.2018
- Author(s)
  Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
- Journal Title
  
  Pediatr. Surg. Int.
  
  Volume: 34 Issue: 2 Pages: 169-176
- DOI
  10.1007/s00383-017-4185-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26462705, KAKENHI-PROJECT-16K19974, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-17H01592
[Journal Article] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells.2016
- Author(s)
  Kamata T, Suzuki A, Mise N, Ihara F, Takami T, Makita Y, Horinaka A, Harada K, Kunii K, Yoshida S, Yoshino I, Nakayama T, and Motohashi S.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 65 Issue: 12 Pages: 1477-1489
- DOI
  10.1007/s00262-016-1901-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181, KAKENHI-PROJECT-26861119, KAKENHI-PROJECT-16K19974
[Presentation] HER2/CD3 bispecific antibody enhances antitumor immunity of NKT cells in lung cancer2024
- Author(s)
  Takami, M., Motohashi, S.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06690
[Presentation] HER2/CD3 bispecific antibody induces antitumor immunity of NKT cells in lung cancer.2024
- Author(s)
  Takami, M., Motohashi, S.
- Organizer
  CD1-MR1 2024
- Data Source
  KAKENHI-PROJECT-23K06690
[Presentation] Clinical application of iPS cell-derived NKT cells to cancer immunotherapy2024
- Author(s)
  Motohashi, S. Aoki, T., Takami, M.
- Organizer
  CD1-MR1 2024
- Data Source
  KAKENHI-PROJECT-23K06690
[Presentation] Anti-Va24Ja18 TCR antibody enhances NKT cell responses to target and kill CD1d (-) tumors in a CD32 dependent manner2023
- Author(s)
  Takami, M., Motohashi, S.
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K06690
[Presentation] Anti-NKT cell antibody treatment enhances anti-tumor activity of NKT cells toward CD1d (-) tumors in a CD32 dependent manner2022
- Author(s)
  Takami, M., Motohashi, S.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07652
[Presentation] Blockade of aryl hydrocarbon receptor (AhR) signaling enhances anti-tumor efficacy of iNKT cell-based immunotherapy2022
- Author(s)
  Ishii, A., Takami, M., Motohashi, S.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07652
[Presentation] Anti-NKT cell antibody treatment enhances anti-tumor activity of NKT cells toward CD1d (-) tumors in a CD32 dependent manner2022
- Author(s)
  Takami, M., Motohashi, S.
- Organizer
  EMBO workshop CD1/MR1-restricted T lymphocytes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07652
[Presentation] Blockade of AhR signaling enhances anti-tumor activity of NKT cells in vivo2021
- Author(s)
  Takami, M., Ishii, A., Motohashi, S.
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07652
[Presentation] Adjuvant effect of NK cells on the anti-tumor activity of NKT cells2020
- Author(s)
  Takami, M., Ishii, A., Motohashi, S.
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07652
[Presentation] 膠芽腫に発現するCD1d分子はNKT細胞を用いた免疫療法における有望な標的となる2019
- Author(s)
  原彩佳, 那須亮, 高見真理子, 廣野誠一郎, 松谷智郎, 中山俊憲, 岩立康男, 本橋新一郎
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] CD1d expression in glioblastoma is a promising target for NKT cell- based cancer immunotherapy2019
- Author(s)
  Hara, A., Nasu, R., Takami, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.
- Organizer
  EMBO workshop CD1-MR1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] Invariant NKT cells recognize leukemia cells in a CD1d independent manner2019
- Author(s)
  青木孝浩, 高見真理子, 高谷具純, 本吉究, 石井絢菜, 岡田玲緒奈, 日野もえ子, 下条直樹, 本橋新一郎
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019
- Author(s)
  Yoshizawa, H., Harada, K., Ishii, A., Mise, N., Hishiki, T., Saito, K., Nakata, M., Komatsu, S., Nakayama, T., Yoshida, H., Takami,M., Motohashi, S.
- Organizer
  EMBO workshop CD1-MR1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] Invariant NKT cells target CD1d-negative leukemia cells with TCR and NK receptors2019
- Author(s)
  Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Hino, M., Shimojo, N., Motohashi, S.
- Organizer
  EMBO workshop CD1-MR1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] CD1d expression in glioblastoma is a promising target for NKT cell- based cancer immunotherapy2019
- Author(s)
  Hara, A., Nasu, R., Takami, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] 膠芽腫に発現するCD1d分子はNKT細胞を用いた免疫療法における有望な標的となる2019
- Author(s)
  原彩佳, 那須亮, 高見真理子, 小林正芳, 廣野誠一郎, 松谷智郎, 中山俊憲, 本橋新一郎, 岩立康男
- Organizer
  日本脳神経外科学会第78回学術総会
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] NK cells enhance the anti-tumor activity of NKT cells2019
- Author(s)
  Takami, M., Ihara, F., Ishii, A., Motohashi, S.
- Organizer
  EMBO workshop CD1-MR1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] Phase II study of α-Galactosylceramide-pulsed antigen presenting cells for advanced or recurrent non-small cell lung cancer2018
- Author(s)
  Motohashi, S., Kamata, T., Toyoda, T., Tanaka, T., Ihara, F., Takami, M., Yosino, I., Nakayama, T.
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] Reduced RasGRP1 expression supports survival of regulatory T cells under continuous TCR stimulation2018
- Author(s)
  Takami, M., Cunha, C., Iwashima, M.
- Organizer
  Cold Spring Harbor meeting on Gene Expression & Signaling in the Immune System
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16409
[Presentation] Regulatory T cells increased in advanced head and neck cancer patients suppress NKT cell function and correlate with disease progression.2017
- Author(s)
  Ihara, F., Sakura, D., Takami, M., Okamoto, Y., Motohashi, S.
- Organizer
  CD1-MR1 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19974
[Presentation] AhR signaling enhances moDC function to activate NKT cells.2017
- Author(s)
  Takami, M., Ihara, F., Kamata, T., Motohashi, S.
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19974
[Presentation] NKT細胞のがん免疫療法における役割と今後の展望2017
- Author(s)
  本橋新一郎、高見真理子
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K19974
[Presentation] A role of AhR signaling in NKT cell immunotherapy.2017
- Author(s)
  Takami, M., Ihara, F., Kamata, T., Motohashi, S.
- Organizer
  CD1-MR1 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19974

1. 本橋新一郎 (60345022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. 木村元子 (00345018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 鈴木秀海 (60422226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 伊原史英

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 小野寺淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takami Mariko 高見 真理子

Research Projects

Research Products

Co-Researchers

HER2/CD3二重特異性抗体を用いたNKT細胞療法による肺癌免疫治療の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Adjuvant effect of NK cells for NKT cell-based immunotherapy targeting lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of AhR signaling in NKT cell based immunotherapy for lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of AhR signaling in iNKT cell based immunotherapy for lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Administration of α-galactosylceramide-pulsed Antigen Presenting Cells in Combination with First-line Chemotherapy for Advanced Lung Cancer2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d‐independent manner2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunological Features of a Lung Cancer Patient Achieving an Objective Response with Anti-PD-1 Blockade Therapy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory T cells induce CD4－ NKT cell anergy and suppress NKT cell cytotoxic function2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TGF-β suppresses RasGRP1 expression and supports regulatory T cells resistance against p53-induced CD28-dependent T cell apoptosis2018

Author(s)

Takami Mariko 高見真理子