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Takami Mariko  高見 真理子

ORCIDConnect your ORCID iD *help
Researcher Number 60770906
Other IDs
Affiliation (Current) 2025: 千葉大学, 大学院医学研究院, 助教
Affiliation (based on the past Project Information) *help 2016 – 2023: 千葉大学, 大学院医学研究院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55040:Respiratory surgery-related / Respiratory surgery
Keywords
Principal Investigator
免疫療法 / NKT細胞 / 肺癌 / AhRシグナル / 二重特異性抗体 / アジュバント効果 / NK細胞 / 免疫治療 / 免疫学
  • Research Projects

    (4 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (5 People)
  •  HER2/CD3二重特異性抗体を用いたNKT細胞療法による肺癌免疫治療の検討Principal Investigator

    • Principal Investigator
      高見 真理子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Chiba University
  •  Adjuvant effect of NK cells for NKT cell-based immunotherapy targeting lung cancerPrincipal Investigator

    • Principal Investigator
      Takami Mariko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Chiba University
  •  A role of AhR signaling in NKT cell based immunotherapy for lung cancerPrincipal Investigator

    • Principal Investigator
      Takami Mariko
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Chiba University
  •  Effect of AhR signaling in iNKT cell based immunotherapy for lung cancerPrincipal Investigator

    • Principal Investigator
      Takami Mariko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Chiba University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner2024

    • Author(s)
      Takami Mariko、Aoki Takahiro、Nishimura Katsuhiro、Tanaka Hidekazu、Onodera Atsushi、Motohashi Shinichiro
    • Journal Title

      Cancer Research Communications

      Volume: 4 Issue: 2 Pages: 446-459

    • DOI

      10.1158/2767-9764.crc-23-0203

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06690, KAKENHI-PROJECT-23K24147, KAKENHI-PROJECT-23K24441
  • [Journal Article] Administration of α-galactosylceramide-pulsed Antigen Presenting Cells in Combination with First-line Chemotherapy for Advanced Lung Cancer2021

    • Author(s)
      Hagiya, M., Tanaka, T., Aita, K., Shiragami, R., Ihara, F., Ishii, A., Takami, M., Homma, T., Wada, Y., Motohashi, S.
    • Journal Title

      Chiba Survey Research Journal

      Volume: 10 Pages: 27-33

    • NAID

      40022745808

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07652
  • [Journal Article] CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy2020

    • Author(s)
      Hara Ayaka、Koyama-Nasu Ryo、Takami Mariko、Toyoda Takahide、Aoki Takahiro、Ihara Fumie、Kobayashi Masayoshi、Hirono Seiichiro、Matsutani Tomoo、Nakayama Toshinori、Iwadate Yasuo、Motohashi Shinichiro
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: - Issue: 5 Pages: 1239-1254

    • DOI

      10.1007/s00262-020-02742-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07652, KAKENHI-PROJECT-20K17952, KAKENHI-PROJECT-18H02892, KAKENHI-PROJECT-18K07257, KAKENHI-PROJECT-19K18379, KAKENHI-PROJECT-19K09451, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19H05650
  • [Journal Article] Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer2020

    • Author(s)
      Toyoda, T., Kamata, T., Tanaka, K., Ihara, F., Takami, M., Suzuki, H., Nakajima, T., Ikeuchi, T., Kawasaki, Y., Hanaoka, H., Nakayama, T., Yoshino, I., and Motohashi, S.
    • Journal Title

      J. Immunother. Cancer

      Volume: 8 Issue: 1 Pages: e000316-e000316

    • DOI

      10.1136/jitc-2019-000316

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
  • [Journal Article] Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d‐independent manner2020

    • Author(s)
      Aoki Takahiro、Takami Mariko、Takatani Tomozumi、Motoyoshi Kiwamu、Ishii Ayana、Hara Ayaka、Toyoda Takahide、Okada Reona、Hino Moeko、Koyama‐Nasu Ryo、Kiuchi Masahiro、Hirahara Kiyoshi、Kimura Motoko Y.、Nakayama Toshinori、Shimojo Naoki、Motohashi Shinichiro
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 7 Pages: 2223-2233

    • DOI

      10.1111/cas.14428

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07652, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21537, KAKENHI-PUBLICLY-19H04800, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-18H02892, KAKENHI-PROJECT-20H03464, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-18K07257, KAKENHI-PROJECT-19K18379
  • [Journal Article] Immunological Features of a Lung Cancer Patient Achieving an Objective Response with Anti-PD-1 Blockade Therapy2019

    • Author(s)
      Kamata, T., Yoshida, S., Takami, M., Ihara, F., Yoshizawa, H., Toyoda, T., Takeshita, Y., Nobuyama, S., Kanetsuna, Y., Sato, T., Yoshino, I., and Motohashi, S.
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 1 Pages: 288-296

    • DOI

      10.1111/cas.14222

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
  • [Journal Article] Regulatory T cells induce CD4- NKT cell anergy and suppress NKT cell cytotoxic function2019

    • Author(s)
      Ihara, F., Sakurai, D., Takami, M., Kamata, T., Kunii, N., Yamasaki, K., Iinuma, T., Nakayama, T., Motohashi, S., and Okamoto, Y.
    • Journal Title

      Cancer Immunol. Immunother

      Volume: 68 Issue: 12 Pages: 1935-1947

    • DOI

      10.1007/s00262-019-02417-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
  • [Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019

    • Author(s)
      Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., Motohashi, S.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 3 Pages: 888-902

    • DOI

      10.1111/cas.13933

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-17H01592, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-18K16274, KAKENHI-PROJECT-16H02778, KAKENHI-PROJECT-18H02892
  • [Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome.2018

    • Author(s)
      Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
    • Journal Title

      Pediatr. Surg. Int.

      Volume: 34 Issue: 2 Pages: 195-201

    • DOI

      10.1007/s00383-017-4189-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26462705, KAKENHI-PROJECT-16K19974, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-17H01592
  • [Journal Article] Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer2018

    • Author(s)
      Tanaka K, Kanesaka Y, Takami M, Suzuki A, Hosokawa H, Onodera A, Kamata T, Nagato K, Nakayama T, Yoshino I, Motohashi S
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 506(1) Issue: 1 Pages: 27-32

    • DOI

      10.1016/j.bbrc.2018.10.048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07164, KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
  • [Journal Article] TGF-β suppresses RasGRP1 expression and supports regulatory T cells resistance against p53-induced CD28-dependent T cell apoptosis2018

    • Author(s)
      Takami, M., Cunha, C., Motohashi , S., Nakayama, T., Iwashima, M.
    • Journal Title

      Eur. J. Immunol.

      Volume: 48 Issue: 12 Pages: 1938-1943

    • DOI

      10.1002/eji.201847587

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
  • [Journal Article] Clinical Application of iNKT Cell-mediated Anti-tumor Activity Against Lung Cancer and Head and Neck Cancer2018

    • Author(s)
      Takami, M., Ihara, F., Motohashi, S.
    • Journal Title

      Front. Immunol.

      Volume: 7 Pages: 2021-2021

    • DOI

      10.3389/fimmu.2018.02021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16409, KAKENHI-PROJECT-18H02892
  • [Journal Article] Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors.2018

    • Author(s)
      Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
    • Journal Title

      Pediatr. Surg. Int.

      Volume: 34 Issue: 2 Pages: 169-176

    • DOI

      10.1007/s00383-017-4185-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26462705, KAKENHI-PROJECT-16K19974, KAKENHI-PROJECT-18K08535, KAKENHI-PROJECT-17H01592
  • [Journal Article] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells.2016

    • Author(s)
      Kamata T, Suzuki A, Mise N, Ihara F, Takami T, Makita Y, Horinaka A, Harada K, Kunii K, Yoshida S, Yoshino I, Nakayama T, and Motohashi S.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 65 Issue: 12 Pages: 1477-1489

    • DOI

      10.1007/s00262-016-1901-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181, KAKENHI-PROJECT-26861119, KAKENHI-PROJECT-16K19974
  • [Presentation] HER2/CD3 bispecific antibody enhances antitumor immunity of NKT cells in lung cancer2024

    • Author(s)
      Takami, M., Motohashi, S.
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06690
  • [Presentation] HER2/CD3 bispecific antibody induces antitumor immunity of NKT cells in lung cancer.2024

    • Author(s)
      Takami, M., Motohashi, S.
    • Organizer
      CD1-MR1 2024
    • Data Source
      KAKENHI-PROJECT-23K06690
  • [Presentation] Clinical application of iPS cell-derived NKT cells to cancer immunotherapy2024

    • Author(s)
      Motohashi, S. Aoki, T., Takami, M.
    • Organizer
      CD1-MR1 2024
    • Data Source
      KAKENHI-PROJECT-23K06690
  • [Presentation] Anti-Va24Ja18 TCR antibody enhances NKT cell responses to target and kill CD1d (-) tumors in a CD32 dependent manner2023

    • Author(s)
      Takami, M., Motohashi, S.
    • Organizer
      第27回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-23K06690
  • [Presentation] Anti-NKT cell antibody treatment enhances anti-tumor activity of NKT cells toward CD1d (-) tumors in a CD32 dependent manner2022

    • Author(s)
      Takami, M., Motohashi, S.
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07652
  • [Presentation] Blockade of aryl hydrocarbon receptor (AhR) signaling enhances anti-tumor efficacy of iNKT cell-based immunotherapy2022

    • Author(s)
      Ishii, A., Takami, M., Motohashi, S.
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07652
  • [Presentation] Anti-NKT cell antibody treatment enhances anti-tumor activity of NKT cells toward CD1d (-) tumors in a CD32 dependent manner2022

    • Author(s)
      Takami, M., Motohashi, S.
    • Organizer
      EMBO workshop CD1/MR1-restricted T lymphocytes
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07652
  • [Presentation] Blockade of AhR signaling enhances anti-tumor activity of NKT cells in vivo2021

    • Author(s)
      Takami, M., Ishii, A., Motohashi, S.
    • Organizer
      第25回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-20K07652
  • [Presentation] Adjuvant effect of NK cells on the anti-tumor activity of NKT cells2020

    • Author(s)
      Takami, M., Ishii, A., Motohashi, S.
    • Organizer
      第24回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-20K07652
  • [Presentation] 膠芽腫に発現するCD1d分子はNKT細胞を用いた免疫療法における有望な標的となる2019

    • Author(s)
      原 彩佳, 那須 亮, 高見 真理子, 廣野 誠一郎, 松谷 智郎, 中山 俊憲, 岩立 康男, 本橋 新一郎
    • Organizer
      第23回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] CD1d expression in glioblastoma is a promising target for NKT cell- based cancer immunotherapy2019

    • Author(s)
      Hara, A., Nasu, R., Takami, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.
    • Organizer
      EMBO workshop CD1-MR1
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] Invariant NKT cells recognize leukemia cells in a CD1d independent manner2019

    • Author(s)
      青木 孝浩, 高見 真理子, 高谷 具純, 本吉 究, 石井 絢菜, 岡田 玲緒奈, 日野 もえ子, 下条 直樹, 本橋 新一郎
    • Organizer
      第23回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019

    • Author(s)
      Yoshizawa, H., Harada, K., Ishii, A., Mise, N., Hishiki, T., Saito, K., Nakata, M., Komatsu, S., Nakayama, T., Yoshida, H., Takami,M., Motohashi, S.
    • Organizer
      EMBO workshop CD1-MR1
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] Invariant NKT cells target CD1d-negative leukemia cells with TCR and NK receptors2019

    • Author(s)
      Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Hino, M., Shimojo, N., Motohashi, S.
    • Organizer
      EMBO workshop CD1-MR1
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] CD1d expression in glioblastoma is a promising target for NKT cell- based cancer immunotherapy2019

    • Author(s)
      Hara, A., Nasu, R., Takami, M., Hirono, S., Matsutani, T., Nakayama, T., Iwadate, Y., Motohashi, S.
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] 膠芽腫に発現するCD1d分子はNKT細胞を用いた免疫療法における有望な標的となる2019

    • Author(s)
      原彩佳, 那須亮, 高見真理子, 小林正芳, 廣野誠一郎, 松谷智郎, 中山俊憲, 本橋新一郎, 岩立康男
    • Organizer
      日本脳神経外科学会第78回学術総会
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] NK cells enhance the anti-tumor activity of NKT cells2019

    • Author(s)
      Takami, M., Ihara, F., Ishii, A., Motohashi, S.
    • Organizer
      EMBO workshop CD1-MR1
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] Phase II study of α-Galactosylceramide-pulsed antigen presenting cells for advanced or recurrent non-small cell lung cancer2018

    • Author(s)
      Motohashi, S., Kamata, T., Toyoda, T., Tanaka, T., Ihara, F., Takami, M., Yosino, I., Nakayama, T.
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] Reduced RasGRP1 expression supports survival of regulatory T cells under continuous TCR stimulation2018

    • Author(s)
      Takami, M., Cunha, C., Iwashima, M.
    • Organizer
      Cold Spring Harbor meeting on Gene Expression & Signaling in the Immune System
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16409
  • [Presentation] Regulatory T cells increased in advanced head and neck cancer patients suppress NKT cell function and correlate with disease progression.2017

    • Author(s)
      Ihara, F., Sakura, D., Takami, M., Okamoto, Y., Motohashi, S.
    • Organizer
      CD1-MR1 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19974
  • [Presentation] AhR signaling enhances moDC function to activate NKT cells.2017

    • Author(s)
      Takami, M., Ihara, F., Kamata, T., Motohashi, S.
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K19974
  • [Presentation] NKT細胞のがん免疫療法における役割と今後の展望2017

    • Author(s)
      本橋 新一郎、高見 真理子
    • Organizer
      第21回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-16K19974
  • [Presentation] A role of AhR signaling in NKT cell immunotherapy.2017

    • Author(s)
      Takami, M., Ihara, F., Kamata, T., Motohashi, S.
    • Organizer
      CD1-MR1 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19974
  • 1.  本橋 新一郎 (60345022)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 2.  木村 元子 (00345018)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  鈴木 秀海 (60422226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  伊原 史英
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  小野寺 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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