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Makino Yuki  牧野 祐紀

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Yuki Makino  牧野 祐紀

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Researcher Number 60771334
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 特任助教(常勤)
Affiliation (based on the past Project Information) *help 2020 – 2021: 大阪大学, 医学系研究科, 特任助教(常勤)
2017 – 2019: 大阪大学, 医学部附属病院, 医員
2015: 大阪大学, 大学院医学系研究科, 医員
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
CTGF / 肝細胞癌 / 癌微小環境 / STAT3 / LIF / 肝前駆細胞 / 肝発癌 / p53 / 抗体療法 / 腫瘍間質反応 / 肝星細胞 … More
Except Principal Investigator
… More 肝発癌 / 発癌 / CTGF / Kras Less
  • Research Projects

    (4 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (4 People)
  •  肝発癌および肝癌微小環境におけるLIFの生物学的意義の解析Principal Investigator

    • Principal Investigator
      牧野 祐紀
    • Project Period (FY)
      2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Investigation of the mechanisms of accelerated liver carcinogenesis caused by p53 over-activation.Principal Investigator

    • Principal Investigator
      Makino Yuki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Elucidation of the significance of CTGF in liver cancer for the development of novel therapyPrincipal Investigator

    • Principal Investigator
      Yuki Makino
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University

All 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] CTGF Mediates Tumor?Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression2018

    • Author(s)
      Makino Yuki、Hikita Hayato、Kodama Takahiro、Shigekawa Minoru、Yamada Ryoko、Sakamori Ryotaro、Eguchi Hidetoshi、Morii Eiichi、Yokoi Hideki、Mukoyama Masashi、Hiroshi Suemizu、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 17 Pages: 4902-4914

    • DOI

      10.1158/0008-5472.can-17-3844

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K15943
  • [Presentation] CTGFとIL-6ファミリー分子を介した腫瘍-間質クロストークによるSTAT3活性化と肝癌の増大進展2021

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第28回肝細胞研究会
    • Data Source
      KAKENHI-PROJECT-21K08005
  • [Presentation] STAT3 and CTGF mutually activate each other in hepatoma cells via IL-6 family cytokine-mediated tumor-stroma crosstalk to promote HCC progression.2021

    • Author(s)
      Yuki Makino, Hayato Hikita, Masaya Sugiyama, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Digital International Liver Congress 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08005
  • [Presentation] Over-activation of tumor suppressor p53 in hepatocytes paradoxically promotes hepatocarcinogenesis derived from hepatic progenitor cells.2020

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      American Association for the Study of Liver Diseases (AASLD)
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] Over-activation of hepatocyte p53 promotes progenitor cell-derived liver cancer, which is prevented by acyclic retinoid.2020

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] 慢性肝疾患による肝細胞のp53活性化が肝発癌に及ぼす影響2020

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第56回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] 癌抑制遺伝子p53の活性化による肝発癌促進2019

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] 癌抑制遺伝子p53の過剰な活性化による肝前駆細胞の誘導と肝発癌2019

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第26回肝細胞研究会
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] p53の活性化による肝前駆細胞の誘導と肝発癌2019

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] Overactivation of hepatocyte p53 activates hepatic progenitor cells and promotes hepatocarcinogenesis.2019

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K17432
  • [Presentation] Connective tissue growth factor (CTGF) induces IL-6 production from hepatic stellate cells and promotes the progression of hepatocellular carcinoma2018

    • Author(s)
      Makino Yuki, Hikita Hayato, Kodama Takahiro, Shigekawa Minoru, Kai Yugo, Nozaki Yasutoshi, Nakabori Tasuku, Saito Yoshinobu, Sakamori Ryotaro, Tatsumi Tomohide, Takehara Tetsuo.
    • Organizer
      American Association for the Study of Liver Diseases (AASLD) Liver Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15943
  • [Presentation] 肝線維化および肝癌進展におけるCTGFの意義とバイオマーカー・治療標的としての可能性2018

    • Author(s)
      牧野祐紀、疋田隼人、竹原徹郎
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K15943
  • [Presentation] CTGFによる肝癌細胞と肝星細胞の腫瘍間質反応と肝癌の増大進展2018

    • Author(s)
      牧野祐紀、疋田隼人、竹原徹郎
    • Organizer
      第54回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-17K15943
  • [Presentation] 肝線維化および肝癌進展抑制を目指したCTGFを標的とする新規治療の可能性2017

    • Author(s)
      牧野祐紀 小玉尚宏 竹原徹郎
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K15943
  • [Presentation] Promoting effect of connective tissue growth factor (CTGF) in hepatocellular carcinoma via the interaction with hepatic stellate cells and potential of anti-CTGF neutralizing antibody therapy.2017

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15943
  • [Presentation] 肝癌に対するCTGFを標的とした抗体療法の可能性2017

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第21回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K15943
  • [Presentation] Significance of the up-regulation of connective tissue growth factor in hepatocellular carcinoma2016

    • Author(s)
      Yuki Makino, Hayato Hikita, Takahiro Kodama, Minoru Shigekawa, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, and Tetsuo Takehara
    • Organizer
      The 25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-02-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Significance of connective tissue growth factor in hepatocellular carcinoma2015

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 3rd JSGE International Topic Conference
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-04-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Significance of connective tissue growth factor with the malignant grade of hepatocellular carcinoma and its potential for therapeutic target2015

    • Author(s)
      Yuki Makino, Hayato Hikita, and Tetsuo Takehara
    • Organizer
      第19回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] 肝細胞癌におけるRas経路とCTGFの意義・新規治療標的としての可能性2015

    • Author(s)
      牧野祐紀 疋田隼人 川口司 甲斐優吾 野崎泰俊 中堀輔 齋藤義修 田中聡司 重川稔 小玉尚宏 阪森亮太郎 宮城琢也 巽智秀 竹原徹郎
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Significance of connective tissue growth factor in hepatocellular carcinoma and its potential for therapeutic target2015

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The 66th Annual Meeting of the American Association for the study of Liver Disease
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Role of connective tissue growth factor in hepatocellular carcinoma2015

    • Author(s)
      Yuki Makino, Hayato Hikita, Yasutoshi Nozaki, Kenji Ikezawa, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      日本癌学会第74回総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] 肝発癌・進展におけるRas経路の活性化とCTGF2014

    • Author(s)
      牧野祐紀 疋田隼人 竹原徹郎
    • Organizer
      第18回日本肝臓学会大会(JDDW2014)
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Significance of connective tissue growth factor (CTGF) for the oncogenesis and progression of hepatocellular carcinoma2014

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      日本癌学会第73回総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Data Source
      KAKENHI-PROJECT-26670381
  • [Presentation] Significance of Ras pathway and connective tissue growth factor in the development of hepatocellular carcinoma2014

    • Author(s)
      Yuki Makino, Hayato Hikita, Tsukasa Kawaguchi, Takahiro Kodama, Minoru Shigekawa, Yugo Kai, Yasutoshi Nozaki, Tasuku Nakabori, Yoshinobu Saito, Satoshi Tanaka, Ryotaro Sakamori, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      Significance of Ras pathway and connective tissue growth factor in the development of hepatocellular carcinoma
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-11-09
    • Data Source
      KAKENHI-PROJECT-26670381
  • 1.  Hikita Hayato (20623044)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 2.  Takehara Tetsuo (70335355)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 3.  巽 智秀 (20397699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 4.  小玉 尚宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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