HORIGANE Shinichiro 堀金慎一郎

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Shin-ichiro Horigane 堀金慎一郎

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Researcher Number	60775906
Other IDs
Affiliation (Current)	2025: 名古屋大学, 環境医学研究所, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 名古屋大学, 環境医学研究所, 講師
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator 神経発達障害 / 神経回路病態 / カルシウムシグナリング / 病態モデルマウス / Timothy症候群 / カルシウムシグナリング破綻 / 自閉スペクトラム症 / L型カルシウムチャネル / 神経回路形成 / 自閉スペクトラム症（ASD）

カルシウムチャネル異常に起因する自閉スペクトラム症の病態解明と治療開発Principal Investigator
- Principal Investigator
  
  堀金慎一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
抑制性神経回路に着目した自閉スペクトラム症病態の解明と新たな治療戦略の探索Principal Investigator
- Principal Investigator
  
  堀金慎一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
Deciphering neural circuit abnormality underlying autism spectrum disorder caused by calcium signaling dysfunctionPrincipal Investigator
- Principal Investigator
  
  Shin-ichiro Horigane
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University

All 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder2022
- Author(s)
  Wang C, Horigane SI, Wakamori M, Ueda S, Kawabata T, Fujii H, Kushima I, Kimura H, Ishizuka K, Nakamura Y, Iwayama Y, Ikeda M, Iwata N, Okada T, Aleksic B, Mori D, Yoshida T, Bito H, Yoshikawa T, Takemoto-Kimura S, Ozaki N
- Journal Title
  
  Translational Psychiatry
  
  Volume: 12 Issue: 1 Pages: 84-84
- DOI
  10.1038/s41398-022-01851-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15929, KAKENHI-PROJECT-20K16490, KAKENHI-PROJECT-19K08044, KAKENHI-PROJECT-20K07256, KAKENHI-PROJECT-20K07917, KAKENHI-PROJECT-18K19633, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-19K07384, KAKENHI-PROJECT-20K09876, KAKENHI-PROJECT-19H01007
[Journal Article] A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development.2020
- Author(s)
  Horigane SI, Ozawa Y, Zhang J, Todoroki H, Miao P, Haijima A, Yanagawa Y, Ueda S, Nakamura S, Kakeyama M, Takemoto-Kimura S.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 8 Pages: 1436-1446
- DOI
  10.1002/2211-5463.12924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20477, KAKENHI-PROJECT-20K15929, KAKENHI-PROJECT-20K16490, KAKENHI-PROJECT-18K03169
[Journal Article] Development of an L-type Ca 2+ channel-dependent Ca 2+ transient during the radial migration of cortical excitatory neurons2020
- Author(s)
  Horigane S, Hamada S, Kamijo S, Yamada H, Yamasaki M, Watanabe M, Bito H, Ohtsuka T, Takemoto-Kimura S
- Journal Title
  
  Neurosci Res
  
  Volume: S0168-0102(20)30391-6 Pages: 30391-6
- DOI
  10.1016/j.neures.2020.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16490, KAKENHI-PLANNED-17H06312, KAKENHI-PUBLICLY-19H05014, KAKENHI-PROJECT-19H01007, KAKENHI-PROJECT-19H03324, KAKENHI-PROJECT-20H03410
[Patent] Timothy症候群のモデル動物2021
- Inventor(s)
  竹本さやか, 堀金慎一郎, 阿部学, 小澤享弘
- Industrial Property Rights Holder
  竹本さやか, 堀金慎一郎, 阿部学, 小澤享弘
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K16490
[Presentation] Development of a novel mouse model of intellectual disability2023
- Author(s)
  Ozawa Y, Miao M, Horigane S, Takemoto-Kimura S
- Organizer
  The 112th annual meeting of the Japanese society of pathology
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] Developing multiplex imaging for deciphering Ca2+-dependent biochemical signaling in physiological and pathological neuronal systems2023
- Author(s)
  Fujii H, Kidokoro H, Kondo Y, Kawaguchi M, Horigane S, Natsume J, Takemoto-Kimura S, Bito H
- Organizer
  The 46th Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] A nervous system-specific mouse model of Timothy syndrome shows autism spectrum disorder-like behavior2023
- Author(s)
  Xinzi L, Horigane S, Ozawa Y, Pan M, Ueda S, Abe M, Sakimura K, Takemoto-Kimura S
- Organizer
  The 7th Annual Meeting of the Global Alliance of Medical Excellence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] Developing multiplex imaging for deciphering Ca2+-dependent biochemical signaling in physiological and pathological neuronal systems2023
- Author(s)
  Fujii H, Kidokoro H, Kondo Y, Kawaguchi M, Horigane S, Natsume J, Takemoto-Kimura S, Bito H
- Organizer
  SfN Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] Development of a nervous system-specific conditional knock-in mouse strain of a gain-of-function mutation in L-type Ca2+ channel associated with Timothy syndrome2022
- Author(s)
  Ozawa Y, Pan M, Abe M, Sakimura K, Horigane S, Takemoto-Kimura S
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] Calcium transients control a morphogenetic cycle underlying neuronal migratory movement2022
- Author(s)
  Horigane S, Takemoto-Kimura S, Kamijo S, Adachi-Morishima A, Fujii H, Bito H
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] Phenotypic characterization of a novel mouse model for Timothy syndrome by a behavioral assessment battery2022
- Author(s)
  Pan M, Ozawa Y, Ueda S, Abe M, Sakimura K, Horigane S, Takemoto-Kimura S
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-22K15638
[Presentation] Development of a novel mouse model of Timothy syndrome associated with autism spectrum disorder2021
- Author(s)
  Hyodo F, Ozawa Y, Pan M, Ueda S, Abe M, Sakimura K, Horigane S, Takemoto-Kimura S
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16490
[Presentation] Calcium transient as an intracellular beacon that orchestrates stepwise nucleus deformation required for neuronal migration2021
- Author(s)
  Horigane S, Takemoto-Kimura S, Kamijo S, Adachi-Morishima A, Fujii H, Bito H
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16490
[Presentation] Calcium transients as an intracellular beacon that orchestrates a morphogenetic cycle underlying neuronal migratory movement2020
- Author(s)
  堀金慎一郎
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16490

1. 掛山正心

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 上田修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HORIGANE Shinichiro 堀金 慎一郎

Shin-ichiro Horigane 堀金 慎一郎

Research Projects

Research Products

Co-Researchers

カルシウムチャネル異常に起因する自閉スペクトラム症の病態解明と治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抑制性神経回路に着目した自閉スペクトラム症病態の解明と新たな治療戦略の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering neural circuit abnormality underlying autism spectrum disorder caused by calcium signaling dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an L-type Ca 2+ channel-dependent Ca 2+ transient during the radial migration of cortical excitatory neurons2020

Author(s)

Journal Title

DOI

Data Source

[Patent] Timothy症候群のモデル動物2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] Development of a novel mouse model of intellectual disability2023

Author(s)

Organizer

Data Source

[Presentation] Developing multiplex imaging for deciphering Ca2+-dependent biochemical signaling in physiological and pathological neuronal systems2023

Author(s)

Organizer

Data Source

[Presentation] A nervous system-specific mouse model of Timothy syndrome shows autism spectrum disorder-like behavior2023

Author(s)

Organizer

Data Source

[Presentation] Developing multiplex imaging for deciphering Ca2+-dependent biochemical signaling in physiological and pathological neuronal systems2023

Author(s)

Organizer

Data Source

[Presentation] Development of a nervous system-specific conditional knock-in mouse strain of a gain-of-function mutation in L-type Ca2+ channel associated with Timothy syndrome2022

Author(s)

Organizer

Data Source

[Presentation] Calcium transients control a morphogenetic cycle underlying neuronal migratory movement2022

Author(s)

Organizer

Data Source

[Presentation] Phenotypic characterization of a novel mouse model for Timothy syndrome by a behavioral assessment battery2022

Author(s)

Organizer

Data Source

[Presentation] Development of a novel mouse model of Timothy syndrome associated with autism spectrum disorder2021

Author(s)

Organizer

Data Source

[Presentation] Calcium transient as an intracellular beacon that orchestrates stepwise nucleus deformation required for neuronal migration2021

Author(s)

Organizer

Data Source

HORIGANE Shinichiro 堀金慎一郎

Shin-ichiro Horigane 堀金慎一郎