Hayakawa Yoku 早河翼

Researcher Number	60777655
Other IDs	https://orcid.org/0000-0002-3988-2499
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 東京大学, 医学部附属病院, 講師 2016 – 2021: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Gastroenterology / Basic Section 50010:Tumor biology-related / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 胃癌 / 胃上皮幹細胞 / 幹細胞ニッチ / 内科 / 胃炎 / ゴルジ体 / 糖鎖 / R-spondin / ガストリン / 系譜追跡 … More / マウスモデル / 幹細胞 / 胃 / 消化管癌 / 消化管幹細胞 / 腫瘍微小環境 / 発生・分化 / マイクロアレイ / ゲノム / 細胞・組織 / 遺伝子発現解析 / アセチルコリン / 分化 / 腸上皮化生 / 粘膜再生 / 萎縮性胃炎 / トランスレーショナルリサーチ / 癌 / 腫瘍 / 消化器内科学 … More Except Principal Investigator 胃癌 / 炎症性腸疾患 / Wnt / 幹細胞 / 消化管幹細胞 / Lgr4 / 胃幹細胞 / 胃内細菌叢 / 大腸癌 / Dysbiosis / 分化 / Tuft細胞 / エピゲノム / 代謝 / 胆管癌 / 胃癌起源細胞 / 腫瘍免疫 / Driver bacteria / Bclxl / パネート細胞 / 杯細胞 / 粘膜恒常性 / Lgr / Rspondin / 前駆細胞 / 粘膜再生 / 消化管上皮恒常性 / 消化管 / オルガノイド / 腸管 / 発生 / DLK1 / 胎児 / 小腸 / ガストリン / Fusobactrium / Neisseria subflava / Fusobacterium nucleatum / 胃癌幹細胞niche / H.pylori / 免疫 / 好中球 / B細胞 / 胃炎 / 小腸細菌叢 / 胃細菌叢 / 小腸粘膜障害 / マウスモデル / Fusobacterium / 腸内細菌 / 薬剤性小腸粘膜障害 / 免疫学 / トランスレーショナルリサーチ / 細胞・組織 / 細菌 / 内科 / 腸炎 / Notch経路 / 樹状細胞 / E-cadherin / Notch / 遺伝子変異 / 遺伝子 / 印環細胞癌 / びまん性胃癌 Less

代謝とエピゲノムを基軸とした肝内胆管発癌機構の解明と新規治療標的の探索
- Principal Investigator
  
  藤原弘明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The Institute for Adult Diseases Asahi Life Foundation
Elucidation of the Mechanism by which Dedifferentiation of Gastrointestinal Tuft Cells Leads to Cancer Initiation
- Principal Investigator
  
  阿部創平
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
ヒト胃粘膜内免疫応答の網羅解析を利用した個別化発癌予測モデルの確立
- Principal Investigator
  
  坪井真代
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Intestinal epithelial homeostasis regulated by Paneth cell metaplasia during mucosal injury
- Principal Investigator
  
  黒川憲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Next-generation molecular profiling of gastric atrophy and regeneration utilizing spatial transcriptomics and whole-mount imagingPrincipal Investigator
- Principal Investigator
  
  早河翼
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
異常糖鎖とゴルジ体ストレス反応を標的とした新規胃癌抗腫瘍療法の開発Principal Investigator
- Principal Investigator
  
  早河翼
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
線維芽細胞系譜追跡によるクローン病線維化の起源解明
- Principal Investigator
  
  山田篤生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
胃癌細胞におけるBclxl依存的Wnt活性化機序解明と治療応用
- Principal Investigator
  
  大矢由紀子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Research for gut microbiota-related pathology of human gastric cancer stem cells
- Principal Investigator
  
  新倉量太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical University
Stromal epithelial crosstalk during small intestinal development by Dlk1.
- Principal Investigator
  
  Minami Yuka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Homeostasis and regeneration of intestinal epithelium regulated by goblet cell lineage
- Principal Investigator
  
  Kurokawa Ken
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Simultaneous lineage tracing of multiple gastric stem cells and their paracrine regulation by stem cell nichePrincipal Investigator
- Principal Investigator
  
  Hayakawa Yoku
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Acquired immunity and regulatory mechanism in non-H.pylori gastritis
- Principal Investigator
  
  成田明子
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Mechanism of gastrin-dependent conversion of human stomach stem cells to intestinal metaplasia / gastric cancer origin cells
- Principal Investigator
  
  Niikura Ryota
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical University
  The University of Tokyo
Single cell profiling of GI cancer-initiating cells and their nichePrincipal Investigator
- Principal Investigator
  
  Hayakawa Yoku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Role of gut microbiota for small intestinal ulcer diseases
- Principal Investigator
  
  Nakada Ayako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
The effects of Dysbiosis on intestinal stem cells, inflammation, and cancer
- Principal Investigator
  
  Shimpoh Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Regulatory mechanism of gastric differentiation from gastric stem cellsPrincipal Investigator
- Principal Investigator
  
  Hayakawa Yoku
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
印環細胞型胃癌に対する抗炎症剤による腫瘍抑制効果の検討Principal Investigator
- Principal Investigator
  
  早河翼
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Role of RhoA mutation in diffuse type gastric cancer development
- Principal Investigator
  
  Narita Akiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Association Between Vonoprazan and the Risk of Gastric Cancer After Helicobacter pylori Eradication2024
- Author(s)
  Arai Junya、Miyawaki Atsushi、Aoki Tomonori、Niikura Ryota、Hayakawa Yoku、Fujiwara Hiroaki、Ihara Sozaburo、Fujishiro Mitsuhiro、Kasuga Masato
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: . Issue: 6 Pages: 1217-1225.e6
- DOI
  10.1016/j.cgh.2024.01.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07448
[Journal Article] Upper gastrointestinal involvement of Behcet's disease in Japan: endoscopic findings and clinical features2024
- Author(s)
  Murakami Keita、Arai Junya、Ihara Sozaburo、Tsuchida Yumi、Shoda Hirofumi、Tsuboi Mayo、Kurokawa Ken、Shiomi Chihiro、Suzuki Nobumi、Hayakawa Yoku、Fujio Keishi、Fujishiro Mitsuhiro
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 39 Issue: 4 Pages: 708-715
- DOI
  10.1111/jgh.16479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16007, KAKENHI-PROJECT-22K08028, KAKENHI-PROJECT-21K07976
[Journal Article] Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target.2024
- Author(s)
  Arai Junya、Hayakawa Yoku、Tateno Hiroaki、Murakami Keita、Hayashi Takeru、Hata Masahiro、Matsushita Yuki、Kinoshita Hiroto、Abe Sohei、Kurokawa Ken、Oya Yukiko、Tsuboi Mayo、Ihara Sozaburo、Niikura Ryota、et al.
- Journal Title
  
  Gastroenterology
  
  Volume: . Issue: 3 Pages: 505-521.e19
- DOI
  10.1053/j.gastro.2024.03.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07448, KAKENHI-PROJECT-21H04804
[Journal Article] Association of probiotic use with nivolumab effectiveness against various cancers: A multicenter retrospective cohort study2023
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Suzuki Nobumi、Honda Tetsuro、Okamura Takuma、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Boku Narikazu、Fujishiro Mitsuhiro
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 16 Pages: 16876-16880
- DOI
  10.1002/cam4.6313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08028, KAKENHI-PROJECT-23K07393, KAKENHI-PROJECT-23K07448, KAKENHI-PROJECT-21K07976
[Journal Article] The Association between Diverticular Rebleeding and Early-Morning Blood Pressure and Surge: A Prospective Observational Trial2023
- Author(s)
  Arai Junya、Niikura Ryota、Yamada Atsuo、Aoki Tomonori、Suzuki Nobumi、Tsuji Yosuke、Hayakawa Yoku、Kawai Takashi、Fujishiro Mitsuhiro
- Journal Title
  
  Digestion
  
  Volume: 104 Issue: 5 Pages: 400-408
- DOI
  10.1159/000531099
- Data Source
  KAKENHI-PROJECT-22K08028, KAKENHI-PROJECT-21K07976
[Journal Article] Letter Potassium‐competitive acid blockers may increase the risk of gastric cancer after Helicobacter pylori eradication a retrospective multicentre‐cohort analysis2023
- Author(s)
  Arai Junya、Hayakawa Yoku、Niikura Ryota、Ihara Sozaburo、Aoki Tomonori、Honda Tetsuro、Okamura Takuma、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Fujishiro Mitsuhiro
- Journal Title
  
  Alimentary Pharmacology & Therapeutics
  
  Volume: 57 Issue: 10 Pages: 1196-1198
- DOI
  10.1111/apt.17461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] Non-H. pylori intragastric microbiome modulates procarcinogenic responses and predicts gastric cancer risk2023
- Author(s)
  Niikura Ryota, Hayakawa Yoku, Hatakeyama Masanori, Fujihiro Mitsutoshi, et al.
- Journal Title
  
  Gastro Hep Advances
  
  Volume: － Issue: 5 Pages: 684-700
- DOI
  10.1016/j.gastha.2023.03.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04804, KAKENHI-PROJECT-20K08375
[Journal Article] F4/80+Ly6Chigh Macrophages Lead to Cell Plasticity and Cancer Initiation in Colitis2023
- Author(s)
  Shin Alice E.、Tesfagiorgis Yodit、Larsen Frederikke、Derouet Mathieu、Zeng Peter Y.F.、Good Hayley J.、Zhang Liyue、Rubinstein Mara R.、Han Yiping W.、Kerfoot Steven M.、Nichols Anthony C.、Hayakawa Yoku、Howlett Christopher J.、Wang Timothy C.、Asfaha Samuel
- Journal Title
  
  Gastroenterology
  
  Volume: 164 Issue: 4 Pages: 593-609.e13
- DOI
  10.1053/j.gastro.2023.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] Severe obstructive colitis treated with repeated colonoscopic decompression2023
- Author(s)
  Arai Junya、Suzuki Nobumi、Hayakawa Yoku、Matzuzaki Hiroyuki、Yokoyama Yuichiro、Aoki Tomonori、Ishibashi Rei、Odawara Nariaki、Ihara Sozaburo、Tsuji Yosuke、Ishihara Soichiro、Fujishiro Mitsuhiro
- Journal Title
  
  DEN Open
  
  Volume: 4 Issue: 1
- DOI
  10.1002/deo2.233
- Data Source
  KAKENHI-PROJECT-21K07976
[Journal Article] Risk and preventive factors of early‐onset colorectal neoplasms: endoscopic and histological database analysis2022
- Author(s)
  Arai Junya、Aoki Tomonori、Hayakawa Yoku、Niikura Ryota、Ishibashi Rei、Suzuki Nobumi、Tsuji Yosuke、Yamada Atsuo、Ushiku Tetsuo、Fujishiro Mitsuhiro
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 38 Issue: 2 Pages: 259-268
- DOI
  10.1111/jgh.16045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07976, KAKENHI-PROJECT-22K08028
[Journal Article] The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis2022
- Author(s)
  Kobayashi Hiroki、Gieniec Krystyna A.、(省略）、Hayakawa Yoku、(省略）、Leedham Simon J.、Rustgi Anil K.、Mukherjee Siddhartha、Takahashi Masahide、Wang Timothy C.、Enomoto Atsushi、Woods Susan L.、Worthley Daniel L.
- Journal Title
  
  Gastroenterology
  
  Volume: 162 Issue: 3 Pages: 890-906
- DOI
  10.1053/j.gastro.2021.11.037
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-21K07976, KAKENHI-PROJECT-22K08028
[Journal Article] Chemoprevention for Colorectal Cancers: Are Chemopreventive Effects Different Between Left and Right Sided Colorectal Cancers?2022
- Author(s)
  Arai Junya、Suzuki Nobumi、Niikura Ryota、Ooki Daisuke、Kawahara Takuya、Honda Tetsuro、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Ishibashi Rei、Aoki Tomonori、Tsuji Yosuke、Yamamichi Nobutake、Hayakawa Yoku、Fujishiro Mitsuhiro
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 67 Issue: 11 Pages: 5227-5238
- DOI
  10.1007/s10620-022-07431-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07976, KAKENHI-PROJECT-22K08028
[Journal Article] R-spondin 3 governs secretory differentiation in the gastric oxyntic glands2022
- Author(s)
  Kurokawa Ken、Wang Timothy C.、Hayakawa Yoku
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 21
- DOI
  10.1172/jci163380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-21K19474
[Journal Article] Clinicopathological Features of Gastric Cancer with Autoimmune Gastritis2022
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Suzuki Nobumi、Hirata Yoshihiro、Ushiku Tetsuo、Fujishiro Mitsuhiro
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 4 Pages: 884-884
- DOI
  10.3390/biomedicines10040884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07976
[Journal Article] R‐spondin signaling in the stomach: isthmal Lgr4 rules2022
- Author(s)
  Malagola Ermanno、Hayakawa Yoku、Wang Timothy C
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 13
- DOI
  10.15252/embj.2022111696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-21K19474
[Journal Article] Machine learning?based personalized prediction of gastric cancer incidence using the endoscopic and histologic findings at the initial endoscopy2022
- Author(s)
  Arai Junya、Aoki Tomonori、Sato Masaya、Niikura Ryota、Suzuki Nobumi、Ishibashi Rei、Tsuji Yosuke、Yamada Atsuo、Hirata Yoshihiro、Ushiku Tetsuo、Hayakawa Yoku、Fujishiro Mitsuhiro
- Journal Title
  
  Gastrointestinal Endoscopy
  
  Volume: - Issue: 5 Pages: 864-872
- DOI
  10.1016/j.gie.2021.12.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08323, KAKENHI-PROJECT-20H03656
[Journal Article] PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice2021
- Author(s)
  Kim Woosook、Chu Timothy H.、Nienh?ser Henrik、Jiang Zhengyu、Del Portillo Armando、Remotti Helen E.、White Ruth A.、Hayakawa Yoku、Tomita Hiroyuki、Fox James G.、Drake Charles G.、Wang Timothy C.
- Journal Title
  
  Gastroenterology
  
  Volume: 160 Issue: 3 Pages: 781-796
- DOI
  10.1053/j.gastro.2020.10.036
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] Nonsteroidal anti‐inflammatory drugs prevent gastric cancer associated with the use of proton pump inhibitors after Helicobacter pylori eradication2021
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Sato Hiroki、Kawahara Takuya、Honda Tetsuro、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Suzuki Nobumi、Tsuji Yosuke、Yamada Atsuo、Koike Kazuhiko
- Journal Title
  
  JGH Open
  
  Volume: 5 Issue: 7 Pages: 770-777
- DOI
  10.1002/jgh3.12583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08323, KAKENHI-PROJECT-20K08375
[Journal Article] Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis2021
- Author(s)
  Kurosaki Shigeyuki、Nakagawa Hayato、Hayata Yuki、Kawamura Satoshi、Matsushita Yuki、Yamada Tomoharu、Uchino Koji、Hayakawa Yoku、Suzuki Nobumi、Hata Masahiro、Tsuboi Mayo、Kinoshita Hiroto、Tanaka Yasuo、Nakatsuka Takuma、Hirata Yoshihiro、Tateishi Keisuke、Koike Kazuhiko
- Journal Title
  
  JHEP Reports
  
  Volume: 3 Issue: 4 Pages: 100315-100315
- DOI
  10.1016/j.jhepr.2021.100315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07906, KAKENHI-PROJECT-21K19474
[Journal Article] Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis2021
- Author(s)
  S Imai, T Ooki, N Murata-Kamiya, D Komura, K Tahmina, W Wu, Atsushi Takahashi-Kanemitsu, C T Knight, A Kunita, N Suzuki, A Del Valle, M Tsuboi, M Hata, Y Hayakawa, N Ohnishi, K Ueda, M Fukayama, T Ushiku, S Ishikawa, M Hatakeyama
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 29 Issue: 6 Pages: 1-18
- DOI
  10.1016/j.chom.2021.04.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-19K07535, KAKENHI-PROJECT-21H04804, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-20K07422, KAKENHI-PROJECT-21K19474, KAKENHI-PROJECT-21K15526, KAKENHI-PROJECT-20K09712
[Journal Article] OLGIM staging and proton pump inhibitor use predict the risk of gastric cancer2021
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Aoki Tomonori、Yamada Atsuo、Kawai Takashi、Fujishiro Mitsuhiro
- Journal Title
  
  Gut
  
  Volume: - Issue: 5 Pages: 1043-1044
- DOI
  10.1136/gutjnl-2021-325551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08323
[Journal Article] Chemoprevention of Oesophageal Squamous-Cell Carcinoma and Adenocarcinoma: A Multicentre Retrospective Cohort Study2021
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Kawahara Takuya、Honda Tetsuro、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Suzuki Nobumi、Tsuji Yosuke、Yamada Atsuo、Kawai Takashi、Koike Kazuhiko
- Journal Title
  
  Digestion
  
  Volume: 103 Issue: 3 Pages: 192-204
- DOI
  10.1159/000520924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08375
[Journal Article] Stem cells and origins of cancer in the upper gastrointestinal tract2021
- Author(s)
  Hayakawa Yoku、Nakagawa Hiroshi、Rustgi Anil K.、Que Jianwen、Wang Timothy C.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 28 Issue: 8 Pages: 1343-1361
- DOI
  10.1016/j.stem.2021.05.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-21K19474
[Journal Article] Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis2021
- Author(s)
  Del Poggetto Edoardo、Ho I-Lin、省略、Hayakawa Yoku、省略、Viale Andrea
- Journal Title
  
  Science
  
  Volume: 373 Issue: 6561 Pages: 6561-6561
- DOI
  10.1126/science.abj0486
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19474
[Journal Article] Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development2021
- Author(s)
  Ichinose Mari、Suzuki Nobumi、et al.
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  Volume: 320 Issue: 4 Pages: 506-520
- DOI
  10.1152/ajpgi.00445.2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17478, KAKENHI-PROJECT-21K07976
[Journal Article] Use of Antibiotics and Probiotics Reduces the Risk of Metachronous Gastric Cancer after Endoscopic Resection2021
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Kawahara Takuya、Honda Tetsuro、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Suzuki Nobumi、Tsuji Yosuke、Yamada Atsuo、Kawai Takashi、Koike Kazuhiko
- Journal Title
  
  Biology
  
  Volume: 10 Issue: 6 Pages: 455-455
- DOI
  10.3390/biology10060455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08323, KAKENHI-PROJECT-20K08375
[Journal Article] Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis2020
- Author(s)
  Chang Wenju、Wang Hongshan、Kim Woosook、Liu Yang、Deng Huan、Liu Haibo、Jiang Zhengyu、Niu Zhengchuan、Sheng Weiwei、Napoles Osmel Companioni、Sun Yihong、Xu Jianmin、Sepulveda Antonia、Hayakawa Yoku、Bass Adam J.、Wang Timothy C.
- Journal Title
  
  Cell Stem Cell
  
  Volume: in press Issue: 5 Pages: 739-754.e8
- DOI
  10.1016/j.stem.2020.01.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-20H03656
[Journal Article] Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice2020
- Author(s)
  Nienh?ser Henrik、Kim Woosook、Malagola Ermanno、Ruan Tuo、Valenti Giovanni、Middelhoff Moritz、Bass Adam、Der Channing J、Hayakawa Yoku、Wang Timothy C
- Journal Title
  
  Gut
  
  Volume: 70 Issue: 4 Pages: 654-665
- DOI
  10.1136/gutjnl-2020-320742
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche2020
- Author(s)
  Middelhoff Moritz、Nienheiser Henrik、Valenti Giovanni、Maurer H. Carlo、Hayakawa Yoku、Takahashi Ryota、Kim Woosook、Jiang Zhengyu、Malagola Ermanno、Cuti Krystle、Tailor Yagnesh、Zamechek Leah B.、Renz Bernhard W.、Quante Michael、Yan Kelley S.、Wang Timothy C.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 111-111
- DOI
  10.1038/s41467-019-13850-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09347
[Journal Article] Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan2020
- Author(s)
  Tsuboi Mayo、Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Ushiku Tetsuo、Koike Kazuhiko
- Journal Title
  
  Biomedicines
  
  Volume: 8 Issue: 10 Pages: 419-419
- DOI
  10.3390/biomedicines8100419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08375, KAKENHI-PROJECT-20K08377, KAKENHI-PROJECT-20H03656
[Journal Article] Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK Activation2020
- Author(s)
  Sheng Weiwei、Malagola Ermanno、Nienh?ser Henrik、Zhang Zhengyu、Kim Woosook、Zamechek Leah、Sepulveda Antonia、Hata Masahiro、Hayakawa Yoku、Zhao Chun-Mei、Chen Duan、Wang Timothy C.
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 10 Issue: 2 Pages: 434-449.e1
- DOI
  10.1016/j.jcmgh.2020.04.008
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] GRP30-expressing gastric chief cells do not differentiate but are eliminated via PDK-dependent cell competition during development of metaplasia.2020
- Author(s)
  1.Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K.
- Journal Title
  
  Gastroenterology
  
  Volume: 158 Issue: 6 Pages: 1650-1666
- DOI
  10.1053/j.gastro.2020.01.046
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05432, KAKENHI-PROJECT-18H02593, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-16H06276
[Journal Article] Dysregulated Immune Responses by ASK1 Deficiency Alter Epithelial Progenitor Cell Fate and Accelerate Metaplasia Development during H. pylori Infection.2020
- Author(s)
  Hayakawa, Y.; Hirata, Y.; Hata, M.; Tsuboi, M.; Oya, Y.; Kurokawa, K.; Abe, S.; Arai, J.; Suzuki, N.; Nakagawa, H.; Fujiwara, H.; Tateishi, K.; Maeda, S.; Koike, K
- Journal Title
  
  Microorganisms
  
  Volume: 8 Issue: 12 Pages: 1-20
- DOI
  10.3390/microorganisms8121995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08377, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-19K17478, KAKENHI-PROJECT-20K08323, KAKENHI-PROJECT-18KT0067
[Journal Article] The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion2019
- Author(s)
  Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Ogura Keiji、Fujishiro Mitsuhiro、Yamada Atsuo、Ushiku Tetsuo、Konishi Mitsuru、Fukayama Masashi、Koike Kazuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 8 Pages: 1913-1913
- DOI
  10.3390/ijms20081913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case?Control Study, Human Cell Cultures, and In Vivo Preclinical Testing2019
- Author(s)
  Suzuki Nobumi、Niikura Ryota、Ihara Sozaburo、Hikiba Yohko、Kinoshita Hiroto、Higashishima Naoko、Hayakawa Yoku、Yamada Atsuo、Hirata Yoshihiro、Nakata Ryo、Okamoto Makoto、Sano Munetaka、Kushiyama Akifumi、Ichinose Mari、Woods Susan L.、Worthley Daniel、Iwamoto Yasuhiko、Koike Kazuhiko
- Journal Title
  
  Cancer Prevention Research
  
  Volume: 12 Issue: 3 Pages: 185-194
- DOI
  10.1158/1940-6207.capr-18-0288
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K15928, KAKENHI-PROJECT-19K17478
[Journal Article] BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice2019
- Author(s)
  Hayakawa Yoku、Tsuboi Mayo、Asfaha Samuel、Kinoshita Hiroto、Niikura Ryota、Konishi Mitsuru、Hata Masahiro、Oya Yukiko、,,,Koike Kazuhiko、Wang Timothy C.
- Journal Title
  
  Gastroenterology
  
  Volume: 156 Issue: 4 Pages: 1066-1081.e16
- DOI
  10.1053/j.gastro.2018.11.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K15928
[Journal Article] Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.2019
- Author(s)
  Kinoshita H, Hayakawa Y, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Ikenoue T, Ushiku T, Fukayama M, Hirata Y, Koike K.
- Journal Title
  
  Journal of Pathology
  
  Volume: 247 Issue: 1 Pages: 35-47
- DOI
  10.1002/path.5163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-16K09279, KAKENHI-PROJECT-17K15927, KAKENHI-PROJECT-17K09346
[Journal Article] Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers2019
- Author(s)
  Konishi Mitsuru、Hayakawa Yoku、Koike Kazuhiko
- Journal Title
  
  Biomedicines
  
  Volume: 7 Issue: 3 Pages: 58-58
- DOI
  10.3390/biomedicines7030058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09347
[Journal Article] Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease2018
- Author(s)
  Ihara Sozaburo、Hirata Yoshihiro、Hikiba Yohko、Yamashita Aya、Tsuboi Mayo、Hata Masahiro、Konishi Mitsuru、Suzuki Nobumi、Sakitani Kosuke、Kinoshita Hiroto、Hayakawa Yoku、Nakagawa Hayato、Ijichi Hideaki、Tateishi Keisuke、Koike Kazuhiko
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 12 Pages: 1219-1231
- DOI
  10.1093/ecco-jcc/jjy088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-17K15717
[Journal Article] Distinct chemopreventive effects of aspirin in diffuse and intestinal-type gastric cancer.2018
- Author(s)
  Niikura R, Hayakawa Y, Hirata Y, Konishi M, Suzuki N, Ihara S, Yamada A, Ushiku T, Fujishiro M, Fukayama M, Koike K.
- Journal Title
  
  Cancer Prev Res (Phila)
  
  Volume: - Issue: 5 Pages: 279-286
- DOI
  10.1158/1940-6207.capr-17-0276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15928
[Journal Article] Mature gastric chief cells are not required for the development of metaplasia.2018
- Author(s)
  Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: - Issue: 5 Pages: G583-G596
- DOI
  10.1152/ajpgi.00351.2017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09346
[Journal Article] Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis2018
- Author(s)
  Lannagan Tamsin R M、,,,、Hayakawa Yoku,,, Worthley Daniel L、Woods Susan L
- Journal Title
  
  Gut
  
  Volume: 68 Issue: 4 Pages: 684-692
- DOI
  10.1136/gutjnl-2017-315920
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-19K17478
[Journal Article] The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis2018
- Author(s)
  Hayakawa Yoku、Wang Timothy C.
- Journal Title
  
  Cell
  
  Volume: 174 Issue: 2 Pages: 251-253
- DOI
  10.1016/j.cell.2018.06.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-17H05081
[Journal Article] Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy2018
- Author(s)
  Niikura Ryota、Yamada Atsuo、Hirata Yoshihiro、Hayakawa Yoku、Suzuki Hirobumi、Yamamoto Shinzo、Fujishiro Mitsuhiro、Koike Kazuhiko
- Journal Title
  
  Gastrointestinal Endoscopy
  
  Volume: 88 Issue: 3 Pages: 574-574
- DOI
  10.1016/j.gie.2018.04.2344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-17K19673
[Journal Article] Gastric Stem Cell and Cellular Origin of Cancer2018
- Author(s)
  Hata Masahiro、Hayakawa Yoku、Koike Kazuhiko
- Journal Title
  
  Biomedicines
  
  Volume: 6 Issue: 4 Pages: 100-100
- DOI
  10.3390/biomedicines6040100
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models2017
- Author(s)
  Yoku Hayakawa, James G. Fox, Timothy C. Wang
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 印刷中 Issue: 3 Pages: 331-338
- DOI
  10.1016/j.jcmgh.2017.01.013
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06749
[Journal Article] CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development.2017
- Author(s)
  Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, Ono S, Suzuki N, Ihara S, Niu Z, Kim W, Tanaka T, Liu H, Chen X, Tailor Y, Fox JG, Konieczny SF, Onodera H, Sepulveda AR, Asfaha S, Hirata Y, Worthley DL, Koike K, Wang TC.
- Journal Title
  
  Oncotarget.
  
  Volume: Nov 10;8(67) Issue: 67 Pages: 111012-111012
- DOI
  10.18632/oncotarget.22451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-15J00069
[Journal Article] A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.2017
- Author(s)
  Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr., Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.
- Journal Title
  
  Gastroenterology.
  
  Volume: Jul;153(1) Issue: 1 Pages: e6-e13
- DOI
  10.1053/j.gastro.2017.05.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Dclk1-expressing tuft cells: critical modulators of the intestinal niche?2017
- Author(s)
  Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC, Quante M.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: Oct 1;313(4) Issue: 4 Pages: G285-G299
- DOI
  10.1152/ajpgi.00073.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Metaplasia in the Stomach-Precursor of Gastric Cancer?2017
- Author(s)
  Kinoshita H, Hayakawa Y, Koike K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: Sep 27;18(10) Issue: 10 Pages: 2063-2063
- DOI
  10.3390/ijms18102063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Nerves switch on angiogenic metabolism.2017
- Author(s)
  Hayakawa Y, Wang TC
- Journal Title
  
  Science
  
  Volume: Oct 20;358(6361) Issue: 6361 Pages: 305-305
- DOI
  10.1126/science.aaq0365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric Corpus2017
- Author(s)
  Yoku Hayakawa, James G. Fox, Timothy C. Wang
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 印刷中 Issue: 1 Pages: 89-94
- DOI
  10.1016/j.jcmgh.2017.02.009
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06749, KAKENHI-PROJECT-17H05081
[Journal Article] Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment forHelicobacter pylori: a retrospective cohort analysis2017
- Author(s)
  Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Yamada Atsuo、Fujishiro Mitsuhiro、Koike Kazuhiko
- Journal Title
  
  Gut
  
  Volume: epub Issue: 10 Pages: 1908-1910
- DOI
  10.1136/gutjnl-2017-315710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15928, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K19673
[Journal Article] Isthmus Progenitors, Not Chief Cells, Are the Likely Origin of Metaplasia in eR1-CreERT; LSL-KrasG12D Mice.2017
- Author(s)
  Hayakawa Y, Wang TC.
- Journal Title
  
  Gastroenterology
  
  Volume: Jun;152(8) Issue: 8 Pages: 2078-2078
- DOI
  10.1053/j.gastro.2017.02.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer.2017
- Author(s)
  Shimpoh T, Hirata Y, Ihara S, Suzuki N, Kinoshita H, Hayakawa Y, Ota Y, Narita A, Yoshida S, Yamada A, Koike K.
- Journal Title
  
  Gut Pathog
  
  Volume: Jun 12;9 Issue: 1 Pages: 35-35
- DOI
  10.1186/s13099-017-0185-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347
[Patent] MUC6変異胃癌に特異的に発現する糖鎖と同糖鎖に選択的に結合するレクチンを用いたレクチン薬物複合体2023
- Inventor(s)
  早河翼、新井絢也、舘野浩章
- Industrial Property Rights Holder
  早河翼、新井絢也、舘野浩章
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K27435
[Presentation] 当院での潰瘍性大腸炎におけるステロイド漸減に関する検討2024
- Author(s)
  塩見千尋、黒川憲、井原聡三郎、村上恵太、坪井真代、山下綾、木下裕人、早河翼、藤城光弘
- Organizer
  第110回消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K08001
[Presentation] 臓器移植後免疫抑制状態に生じた新規・増悪IBDと感染性腸炎の病態と治療2022
- Author(s)
  黒川憲、早河翼、藤城光弘
- Organizer
  Japan Digestive Disease Week 2022
- Data Source
  KAKENHI-PROJECT-21K08001
[Presentation] REGULATION OF GASTRIC MUCOSAL HOMEOSTASIS BY R-SPONDIN 3-LGR4 SIGNAL2022
- Author(s)
  Ken Kurokawa, Yoku Hayakawa, Mitsuhiro Fujishiro
- Organizer
  Digestive Disease Week 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08001
[Presentation] R-spondin 3/Lgr4シグナルによる胃上皮幹細胞制御2022
- Author(s)
  黒川憲、早河翼、藤城光弘
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K08001
[Presentation] Stem cell origin of gastric cancer and their niche2019
- Author(s)
  Yoku Hayakawa
- Organizer
  JCA-KCA joint symposium
- Invited
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Adrenaline-dependent immunogenic reprogramming in endothelial cells regulate tumor immunity in gastric cancers, poster presentation2019
- Author(s)
  Yoku Hayakawa
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Stem cell origin of gastric metaplasia and cancer2019
- Author(s)
  Yoku Hayakawa
- Organizer
  NCI ThinkTank
- Invited
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Stem cell origin of gastric cancer2019
- Author(s)
  Yoku Hayakawa
- Organizer
  National Cancer Institute Think Tank
- Invited
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] CXCR4シグナルによる胃上皮幹細胞と発癌の制御機構2018
- Author(s)
  早河翼
- Organizer
  2018年日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] The role of gastric microbiome in gastric carcinogenesis2018
- Author(s)
  Yoku Hayakawa
- Organizer
  2018年日本癌学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] MODELING SIGNET RING CELL CANCER BY USING MOUSE MODELS AND ORGANOIDS2018
- Author(s)
  Masahiro Hata, Yoku Hayakawa, Hiroto Kinoshita, Hayato Nakagawa, Yoshihiro Hirata, Timothy C. Wang, Kazuhiko Koike
- Organizer
  米国消化器病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09279
[Presentation] MIST1+ SECRETORY PROGENITOR CELLS CAN GIVE RISE TO CANCER IN THE INTESTINE AND COLON.2018
- Author(s)
  HAYAKAWA YOKU
- Organizer
  Digestive Disease Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09347
[Presentation] Mist1+ secretory progenitor cells can give rise to cancer in the intestine and colon2018
- Author(s)
  Yoku Hayakawa
- Organizer
  Digestive Disease Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Muscarinic acetylcholine receptor subtype 3 regulates gastric stem cell expansion and gastric cancer progression by controlling YAP activation.2017
- Author(s)
  Yoku Hayakawa
- Organizer
  AACR annual meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Neural regulation of gastric stem cells and cancer.2017
- Author(s)
  Yoku Hayakawa
- Organizer
  GESA AGW 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Gastric stem cell and cancer microenvironment2017
- Author(s)
  Yoku Hayakawa
- Organizer
  Intrastellar Initiative (AMED/NYAS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Muscarinic receptor-3 modulates YAP signaling in gastric stem and cancer cells.2017
- Author(s)
  Konishi M, Hayakawa Y, et al.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081

1. Niikura Ryota (90625609)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. Narita Akiko (30772917)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Kurokawa Ken (40868999)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 山田篤生 (80534932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 坪井真代 (40895421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Shimpoh Takayuki (90791591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Nakada Ayako (70815448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Minami Yuka (80724658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平田喜裕 (10529192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 木下裕人 (50645322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 鈴木伸三 (30723746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. 井原聡三郎 (60770039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 大矢由紀子 (80972786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 藤原弘明 (00814500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 工藤洋太郎 (90608358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 阿部創平 (80980359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KONISHI mitsuru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HATA masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. TANAKA Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. IKENOUE Tsuneo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 建石良介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 高橋昌史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 畠山昌則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 昆俊亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayakawa Yoku 早河 翼

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Next-generation molecular profiling of gastric atrophy and regeneration utilizing spatial transcriptomics and whole-mount imagingPrincipal Investigator

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異常糖鎖とゴルジ体ストレス反応を標的とした新規胃癌抗腫瘍療法の開発Principal Investigator

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Simultaneous lineage tracing of multiple gastric stem cells and their paracrine regulation by stem cell nichePrincipal Investigator

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Single cell profiling of GI cancer-initiating cells and their nichePrincipal Investigator

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Hayakawa Yoku 早河翼