Hayakawa Yoku 早河翼

Researcher Number	60777655
Other IDs	https://orcid.org/0000-0002-3988-2499
Affiliation (Current)	2022: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2016 – 2022: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 胃癌 / 胃上皮幹細胞 / 内科 / 幹細胞ニッチ / 消化器内科学 / 腫瘍 / 癌 / トランスレーショナルリサーチ / 萎縮性胃炎 / 粘膜再生 … More Except Principal Investigator 胃癌 / 炎症性腸疾患 / Dysbiosis / 消化管幹細胞 / 幹細胞 / びまん性胃癌 / 印環細胞癌 / 遺伝子 / 分化 / 遺伝子変異 / Notch / E-cadherin / 樹状細胞 / Notch経路 / 腸炎 / 大腸癌 / 内科 / 細菌 / 細胞・組織 / トランスレーショナルリサーチ / 免疫学 / 薬剤性小腸粘膜障害 / 腸内細菌 / Fusobacterium / マウスモデル / 小腸粘膜障害 / 胃細菌叢 / 小腸細菌叢 / 消化管 / 胎児 / 発生 / 杯細胞 / Wnt / Lgr4 / 胃炎 / B細胞 / 好中球 / 免疫 / H.pylori / 胃癌幹細胞niche / 胃内細菌叢 / Fusobactrium / 胃幹細胞 / ガストリン Less

Dlk1による小腸発生段階における間質上皮crosstalkの解明
- Principal Investigator
  
  小林由佳
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Homeostasis and regeneration of intestinal epithelium regulated by goblet cell lineage
- Principal Investigator
  
  黒川憲
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Simultaneous lineage tracing of multiple gastric stem cells and their paracrine regulation by stem cell nichePrincipal Investigator
- Principal Investigator
  
  早河翼
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Single cell profiling of GI cancer-initiating cells and their nichePrincipal Investigator
- Principal Investigator
  
  早河翼
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Acquired immunity and regulatory mechanism in non-H.pylori gastritis
- Principal Investigator
  
  成田明子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Mechanism of gastrin-dependent conversion of human stomach stem cells to intestinal metaplasia / gastric cancer origin cells
- Principal Investigator
  
  新倉量太
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Role of gut microbiota for small intestinal ulcer diseases
- Principal Investigator
  
  Nakada Ayako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
The effects of Dysbiosis on intestinal stem cells, inflammation, and cancer
- Principal Investigator
  
  Shimpoh Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Regulatory mechanism of gastric differentiation from gastric stem cellsPrincipal Investigator
- Principal Investigator
  
  Hayakawa Yoku
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
印環細胞型胃癌に対する抗炎症剤による腫瘍抑制効果の検討Principal Investigator
- Principal Investigator
  
  早河翼
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Role of RhoA mutation in diffuse type gastric cancer development
- Principal Investigator
  
  Narita Akiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice2021
- Author(s)
  Kim Woosook、Chu Timothy H.、Nienh?ser Henrik、Jiang Zhengyu、Del Portillo Armando、Remotti Helen E.、White Ruth A.、Hayakawa Yoku、Tomita Hiroyuki、Fox James G.、Drake Charles G.、Wang Timothy C.
- Journal Title
  
  Gastroenterology
  
  Volume: 160 Pages: 781-796
- DOI
  10.1053/j.gastro.2020.10.036
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis2020
- Author(s)
  Chang Wenju、Wang Hongshan、Kim Woosook、Liu Yang、Deng Huan、Liu Haibo、Jiang Zhengyu、Niu Zhengchuan、Sheng Weiwei、Napoles Osmel Companioni、Sun Yihong、Xu Jianmin、Sepulveda Antonia、Hayakawa Yoku、Bass Adam J.、Wang Timothy C.
- Journal Title
  
  Cell Stem Cell
  
  Volume: in press
- DOI
  10.1016/j.stem.2020.01.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-20H03656
[Journal Article] Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice2020
- Author(s)
  Nienh?ser Henrik、Kim Woosook、Malagola Ermanno、Ruan Tuo、Valenti Giovanni、Middelhoff Moritz、Bass Adam、Der Channing J、Hayakawa Yoku、Wang Timothy C
- Journal Title
  
  Gut
  
  Volume: 70 Pages: 654-665
- DOI
  10.1136/gutjnl-2020-320742
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche2020
- Author(s)
  Middelhoff Moritz、Nienheiser Henrik、Valenti Giovanni、Maurer H. Carlo、Hayakawa Yoku、Takahashi Ryota、Kim Woosook、Jiang Zhengyu、Malagola Ermanno、Cuti Krystle、Tailor Yagnesh、Zamechek Leah B.、Renz Bernhard W.、Quante Michael、Yan Kelley S.、Wang Timothy C.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Pages: 111-111
- DOI
  10.1038/s41467-019-13850-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09347
[Journal Article] Dysregulated Immune Responses by ASK1 Deficiency Alter Epithelial Progenitor Cell Fate and Accelerate Metaplasia Development during H. pylori Infection.2020
- Author(s)
  Hayakawa Yoku、Hirata Yoshihiro、Hata Masahiro、Tsuboi Mayo、Oya Yukiko、Kurokawa Ken、Abe Sohei、Arai Junya、Suzuki Nobumi、Nakagawa Hayato、Fujiwara Hiroaki、Tateishi Keisuke、Maeda Shin、Koike Kazuhiko
- Journal Title
  
  Microorganisms
  
  Volume: 8 Pages: 1995-1995
- DOI
  10.3390/microorganisms8121995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08323, KAKENHI-PROJECT-20K08377, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-19K17478
[Journal Article] Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan.2020
- Author(s)
  Tsuboi Mayo、Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Ushiku Tetsuo、Koike Kazuhiko
- Journal Title
  
  Biomedicines.
  
  Volume: 8 Pages: 1-11
- DOI
  10.3390/biomedicines8100419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08375, KAKENHI-PROJECT-20K08377, KAKENHI-PROJECT-20H03656
[Journal Article] Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK Activation2020
- Author(s)
  Sheng Weiwei、Malagola Ermanno、Nienh?ser Henrik、Zhang Zhengyu、Kim Woosook、Zamechek Leah、Sepulveda Antonia、Hata Masahiro、Hayakawa Yoku、Zhao Chun-Mei、Chen Duan、Wang Timothy C.
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 10
- DOI
  10.1016/j.jcmgh.2020.04.008
- Data Source
  KAKENHI-PROJECT-20H03656
[Journal Article] GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia2020
- Author(s)
  1.Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K.
- Journal Title
  
  Gastroenterology
  
  Volume: 158 Pages: 1650-1666
- DOI
  10.1053/j.gastro.2020.01.046
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05432, KAKENHI-PROJECT-18H02593, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-16H06276
[Journal Article] Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.2019
- Author(s)
  Lannagan Tamsin R M、,,,、Hayakawa Yoku,,, Worthley Daniel L、Woods Susan L
- Journal Title
  
  GUT
  
  Volume: 68 Pages: 684-692
- DOI
  10.1136/gutjnl-2017-315920
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-19K17478
[Journal Article] The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion2019
- Author(s)
  Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Ogura Keiji、Fujishiro Mitsuhiro、Yamada Atsuo、Ushiku Tetsuo、Konishi Mitsuru、Fukayama Masashi、Koike Kazuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Pages: 1913-1913
- DOI
  10.3390/ijms20081913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.8 Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.2019
- Author(s)
  Suzuki Nobumi、Niikura Ryota、Ihara Sozaburo、Hikiba Yohko、Kinoshita Hiroto、Higashishima Naoko、Hayakawa Yoku、Yamada Atsuo、Hirata Yoshihiro、Nakata Ryo、Okamoto Makoto、Sano Munetaka、Kushiyama Akifumi、Ichinose Mari、Woods Susan L.、Worthley Daniel、Iwamoto Yasuhiko、Koike Kazuhiko
- Journal Title
  
  Cancer Prev Res (Phila)
  
  Volume: 12 Pages: 185-194
- DOI
  10.1158/1940-6207.capr-18-0288
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K15928, KAKENHI-PROJECT-19K17478
[Journal Article] BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice2019
- Author(s)
  Hayakawa Yoku、Tsuboi Mayo、Asfaha Samuel、Kinoshita Hiroto、Niikura Ryota、Konishi Mitsuru、Hata Masahiro、Oya Yukiko、,,,Koike Kazuhiko、Wang Timothy C.
- Journal Title
  
  Gastroenterology
  
  Volume: 156
- DOI
  10.1053/j.gastro.2018.11.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K15928
[Journal Article] Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium2019
- Author(s)
  Kinoshita H, Hayakawa Y, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Ikenoue T, Ushiku T, Fukayama M, Hirata Y, Koike K.
- Journal Title
  
  J Pathol.
  
  Volume: 247 Pages: 35-35
- DOI
  10.1002/path.5163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-16K09279, KAKENHI-PROJECT-17K15927, KAKENHI-PROJECT-17K09346
[Journal Article] Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers2019
- Author(s)
  Konishi Mitsuru、Hayakawa Yoku、Koike Kazuhiko
- Journal Title
  
  Biomedicines
  
  Volume: 7 Pages: 58-58
- DOI
  10.3390/biomedicines7030058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09347
[Journal Article] Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease2018
- Author(s)
  Ihara Sozaburo、Hirata Yoshihiro、Hikiba Yohko、Yamashita Aya、Tsuboi Mayo、Hata Masahiro、Konishi Mitsuru、Suzuki Nobumi、Sakitani Kosuke、Kinoshita Hiroto、Hayakawa Yoku、Nakagawa Hayato、Ijichi Hideaki、Tateishi Keisuke、Koike Kazuhiko
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 12 Pages: 1219-1231
- DOI
  10.1093/ecco-jcc/jjy088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-17K15717
[Journal Article] Distinct Chemopreventive Effects of Aspirin in Diffuse and Intestinal-Type Gastric Cancer2018
- Author(s)
  Niikura R, Hayakawa Y, Hirata Y, Konishi M, Suzuki N, Ihara S, Yamada A, Ushiku T, Fujishiro M, Fukayama M, Koike K.
- Journal Title
  
  Cancer Prevention Research
  
  Volume: - Pages: 279-286
- DOI
  10.1158/1940-6207.capr-17-0276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15928
[Journal Article] Mature gastric chief cells are not required for the development of metaplasia2018
- Author(s)
  Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K.
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  Volume: -
- DOI
  10.1152/ajpgi.00351.2017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K09346
[Journal Article] The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis2018
- Author(s)
  Hayakawa Yoku、Wang Timothy C.
- Journal Title
  
  Cell
  
  Volume: 174 Pages: 251-253
- DOI
  10.1016/j.cell.2018.06.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-17H05081
[Journal Article] Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment for Helicobacter pylori: a retrospective cohort analysis2018
- Author(s)
  Niikura R, Hayakawa Y, Hirata Y, Yamada A, Fujishiro M, Koike K
- Journal Title
  
  Gut
  
  Volume: - Pages: 1908-1910
- DOI
  10.1136/gutjnl-2017-315710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15928
[Journal Article] Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy2018
- Author(s)
  Niikura Ryota、Yamada Atsuo、Hirata Yoshihiro、Hayakawa Yoku、Suzuki Hirobumi、Yamamoto Shinzo、Fujishiro Mitsuhiro、Koike Kazuhiko
- Journal Title
  
  Gastrointestinal Endoscopy
  
  Volume: 88 Pages: 574-574
- DOI
  10.1016/j.gie.2018.04.2344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-17K19673
[Journal Article] Gastric Stem Cell and Cellular Origin of Cancer2018
- Author(s)
  Hata Masahiro、Hayakawa Yoku、Koike Kazuhiko
- Journal Title
  
  Biomedicines
  
  Volume: 6 Pages: 100-100
- DOI
  10.3390/biomedicines6040100
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models2017
- Author(s)
  Yoku Hayakawa, James G. Fox, Timothy C. Wang
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 印刷中
- DOI
  10.1016/j.jcmgh.2017.01.013
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06749
[Journal Article] CXCR4-expressing <i>Mist1</i><sup>+</sup> progenitors in the gastric antrum contribute to gastric cancer development2017
- Author(s)
  Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, Ono S, Suzuki N, Ihara S, Niu Z, Kim W, Tanaka T, Liu H, Chen X, Tailor Y, Fox JG, Konieczny SF, Onodera H, Sepulveda AR, Asfaha S, Hirata Y, Worthley DL, Koike K, Wang TC.
- Journal Title
  
  Oncotarget
  
  Volume: Nov 10;8(67) Pages: 111012-111012
- DOI
  10.18632/oncotarget.22451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-15J00069
[Journal Article] A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.2017
- Author(s)
  Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr., Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.
- Journal Title
  
  Gastroenterology.
  
  Volume: Jul;153(1)
- DOI
  10.1053/j.gastro.2017.05.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Dclk1-expressing tuft cells: critical modulators of the intestinal niche?2017
- Author(s)
  Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC, Quante M.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: Oct 1;313(4)
- DOI
  10.1152/ajpgi.00073.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Metaplasia in the Stomach-Precursor of Gastric Cancer?2017
- Author(s)
  Kinoshita H, Hayakawa Y, Koike K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: Sep 27;18(10)
- DOI
  10.3390/ijms18102063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Nerves switch on angiogenic metabolism.2017
- Author(s)
  Hayakawa Y, Wang TC
- Journal Title
  
  Science
  
  Volume: Oct 20;358(6361) Pages: 305-305
- DOI
  10.1126/science.aaq0365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric Corpus.2017
- Author(s)
  Yoku Hayakawa, James G. Fox, Timothy C. Wang
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 印刷中
- DOI
  10.1016/j.jcmgh.2017.02.009
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06749, KAKENHI-PROJECT-17H05081
[Journal Article] Isthmus Progenitors, Not Chief Cells, Are the Likely Origin of Metaplasia in eR1-CreERT; LSL-KrasG12D Mice.2017
- Author(s)
  Hayakawa Y, Wang TC.
- Journal Title
  
  Gastroenterology
  
  Volume: Jun;152(8) Pages: 2078-2078
- DOI
  10.1053/j.gastro.2017.02.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05081
[Journal Article] Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer.2017
- Author(s)
  Shimpoh T, Hirata Y, Ihara S, Suzuki N, Kinoshita H, Hayakawa Y, Ota Y, Narita A, Yoshida S, Yamada A, Koike K.
- Journal Title
  
  Gut Pathog
  
  Volume: Jun 12;9 Pages: 35-35
- DOI
  10.1186/s13099-017-0185-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09347
[Presentation] Stem cell origin of gastric cancer and their niche2019
- Author(s)
  Yoku Hayakawa
- Organizer
  JCA-KCA joint symposium
- Invited
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Adrenaline-dependent immunogenic reprogramming in endothelial cells regulate tumor immunity in gastric cancers, poster presentation2019
- Author(s)
  Yoku Hayakawa
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Stem cell origin of gastric metaplasia and cancer2019
- Author(s)
  Yoku Hayakawa
- Organizer
  NCI ThinkTank
- Invited
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Stem cell origin of gastric cancer2019
- Author(s)
  Yoku Hayakawa
- Organizer
  National Cancer Institute Think Tank
- Invited
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] CXCR4シグナルによる胃上皮幹細胞と発癌の制御機構2018
- Author(s)
  早河翼
- Organizer
  2018年日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] The role of gastric microbiome in gastric carcinogenesis2018
- Author(s)
  Yoku Hayakawa
- Organizer
  2018年日本癌学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] MODELING SIGNET RING CELL CANCER BY USING MOUSE MODELS AND ORGANOIDS2018
- Author(s)
  Masahiro Hata, Yoku Hayakawa, Hiroto Kinoshita, Hayato Nakagawa, Yoshihiro Hirata, Timothy C. Wang, Kazuhiko Koike
- Organizer
  米国消化器病学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09279
[Presentation] MIST1+ SECRETORY PROGENITOR CELLS CAN GIVE RISE TO CANCER IN THE INTESTINE AND COLON.2018
- Author(s)
  HAYAKAWA YOKU
- Organizer
  Digestive Disease Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09347
[Presentation] Mist1+ secretory progenitor cells can give rise to cancer in the intestine and colon2018
- Author(s)
  Yoku Hayakawa
- Organizer
  Digestive Disease Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Muscarinic acetylcholine receptor subtype 3 regulates gastric stem cell expansion and gastric cancer progression by controlling YAP activation.2017
- Author(s)
  Yoku Hayakawa
- Organizer
  AACR annual meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Neural regulation of gastric stem cells and cancer.2017
- Author(s)
  Yoku Hayakawa
- Organizer
  GESA AGW 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Gastric stem cell and cancer microenvironment2017
- Author(s)
  Yoku Hayakawa
- Organizer
  Intrastellar Initiative (AMED/NYAS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081
[Presentation] Muscarinic receptor-3 modulates YAP signaling in gastric stem and cancer cells.2017
- Author(s)
  Konishi M, Hayakawa Y, et al.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05081

1. Narita Akiko (30772917)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 新倉量太 (90625609)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Shimpoh Takayuki (90791591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Nakada Ayako (70815448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 平田喜裕 (10529192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 木下裕人 (50645322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 山田篤生 (80534932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 小林由佳 (80724658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 鈴木伸三 (30723746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 黒川憲 (40868999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KONISHI mitsuru

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. HATA masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. TSUBOI mayo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. KUSHIYAMA Akifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. IKENOUE Tsuneo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 井原聡三郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 藤城光弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
18. 古川貴久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayakawa Yoku 早河 翼

Research Projects

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Co-Researchers

Dlk1による小腸発生段階における間質上皮crosstalkの解明

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Homeostasis and regeneration of intestinal epithelium regulated by goblet cell lineage

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Simultaneous lineage tracing of multiple gastric stem cells and their paracrine regulation by stem cell nichePrincipal Investigator

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Single cell profiling of GI cancer-initiating cells and their nichePrincipal Investigator

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Acquired immunity and regulatory mechanism in non-H.pylori gastritis

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Mechanism of gastrin-dependent conversion of human stomach stem cells to intestinal metaplasia / gastric cancer origin cells

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Role of gut microbiota for small intestinal ulcer diseases

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The effects of Dysbiosis on intestinal stem cells, inflammation, and cancer

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Regulatory mechanism of gastric differentiation from gastric stem cellsPrincipal Investigator

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印環細胞型胃癌に対する抗炎症剤による腫瘍抑制効果の検討Principal Investigator

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Role of RhoA mutation in diffuse type gastric cancer development

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[Journal Article] PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice2021

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[Journal Article] Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis2020

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Hayakawa Yoku 早河翼