NISHIMURA Ryu 西村龍

Researcher Number	60778132
Other IDs
Affiliation (based on the past Project Information) *help	2018: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2016 – 2017: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト助教
Review Section/Research Field	Principal Investigator Gastroenterology
Keywords	Principal Investigator 幹細胞機能評価 / 炎症性腸疾患 / 初代培養 / 幹細胞

Elucidation of stem cell pathogenesis in inflammatory bowel disease using primary intestinal epithelial stem cells culture and development of new therapeutic agentPrincipal Investigator
- Principal Investigator
  
  NISHIMURA Ryu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
ヒト腸管初代培養の幹細胞可視化による幹細胞を標的とした新規治療薬の開発Principal Investigator
- Principal Investigator
  
  西村龍
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2019 2018 2017

All Journal Article Presentation

[Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.2019
- Author(s)
  Nishimura R, Shirasaki T, Tsuchiya K, Miyake Y, Watanabe Y, Hibiya S, Watanabe S, Nakamura T, Watanabe M
- Journal Title
  
  J Gastroenterol.
  
  Volume: in press Issue: 7 Pages: 608-620
- DOI
  10.1007/s00535-018-01540-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-19K17425
[Journal Article] Long-term inflammation transforms intestinal epithelial cells of colonic organoids.2017
- Author(s)
  Hibiya S, Tsuchiya K, Hayashi R, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  J Crohns Colitis.
  
  Volume: 61 Pages: 621-630
- DOI
  10.1093/ecco-jcc/jjw186
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H06770, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-17K15930, KAKENHI-PROJECT-17H06654, KAKENHI-PROJECT-16K09302
[Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019
- Author(s)
  Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ECCO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Ryu Nishimura, Kiichiro Tsuchiya, Tomonori Shirasaki, Syo Watanabe, Syuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, and Mamoru Watanabe.
- Organizer
  13th Congress of ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018
- Author(s)
  Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  DDW2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient2018
- Author(s)
  Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture.2018
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  13th Congress of ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.2018
- Author(s)
  Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.
- Organizer
  DDW2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation2018
- Author(s)
  Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M
- Organizer
  UEGW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells.2017
- Author(s)
  Sho Watanabe, Kiichiro Tsuchiya, Tomoaki Shirasaki, Shuji Hibiya, Shigeru Oshima, Ryu Nishimura, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe.
- Organizer
  UEGW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15930
[Presentation] ヒト大腸オルガノイドを用いた炎症性腸疾患擬似モデルの構築による薬効評価システムへの応用2017
- Author(s)
  西村　龍、土屋　輝一郎、白﨑　友彬、渡辺　翔、日比谷　秀爾、岡本　隆一、中村　哲也、渡辺　守
- Organizer
  第54回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K15930

1. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

NISHIMURA Ryu 西村 龍

Research Projects

Research Products

Co-Researchers

Elucidation of stem cell pathogenesis in inflammatory bowel disease using primary intestinal epithelial stem cells culture and development of new therapeutic agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト腸管初代培養の幹細胞可視化による幹細胞を標的とした新規治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term inflammation transforms intestinal epithelial cells of colonic organoids.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.2019

Author(s)

Organizer

Data Source

[Presentation] The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018

Author(s)

Organizer

Data Source

[Presentation] Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.2018

Author(s)

Organizer

Data Source

[Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient2018

Author(s)

Organizer

Data Source

[Presentation] Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture.2018

Author(s)

Organizer

Data Source

[Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.2018

Author(s)

Organizer

Data Source

[Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation2018

Author(s)

Organizer

Data Source

[Presentation] TP53 mutation acquires higher malignant potential in human colon cancer cells.2017

Author(s)

Organizer

Data Source

[Presentation] ヒト大腸オルガノイドを用いた炎症性腸疾患擬似モデルの構築による薬効評価システムへの応用2017

Author(s)

Organizer

Data Source

NISHIMURA Ryu 西村龍