TAKAHASHI NOZOMU 高橋望

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Takahashi Nozomu 高橋望

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Researcher Number	60779172
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 特定研究員
Affiliation (based on the past Project Information) *help	2023: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2022: 熊本大学, 病院, 助教 2021: 熊本大学, 病院, 医員 2019 – 2020: 熊本大学, 病院, 非常勤診療医師 2018: 熊本大学, 医学部付属病院, 非常勤診療医師 2017 – 2018: 熊本大学, 医学部附属病院, 非常勤診療医師
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 口腔扁平上皮癌 / SAS / tRNA修飾 / ミトコンドリア / 抗癌剤耐性 / 抗がん剤耐性 / 質量分析 / チオメチル化修飾 / 癌 / 網羅的解析 … More / 5-FU / 抗がん剤 / 臨床検体 / 口腔癌 Less

New therapeutic strategies targeting mt-tRNA modification for treatment-resistant oral cancerPrincipal Investigator
- Principal Investigator
  
  Takahashi Nozomu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Functional analysis and therapeutic development targeting tRNA methylthiolation in oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Takahashi Nozomu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Exhaustive and functional analysis of tRNA modification in oral squamous cell carcinoma, and development a new treatment strategyPrincipal Investigator
- Principal Investigator
  
  Takahashi Nozomu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University

All 2023 2022 2021 2019 2017

All Journal Article Presentation

[Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023
- Author(s)
  Takeshita Hisashi、Yoshida Ryoji、Inoue Junki、Ishikawa Kohei、Shinohara K、Hirayama M、Oyama T、Kubo R、Yamana K、Nagao Y、Gohara S、Sakata J、Nakashima H、Matsuoka Y、Nakamoto M、Hirayama M、Kawahara K、Takahashi N、Hirosue A、Kuwahara Y、Fukumoto M、Toya R、Murakami R、Nakayama H
- Journal Title
  
  Laboratory Investigation
  
  Volume: 103 Issue: 5 Pages: 100060-100060
- DOI
  10.1016/j.labinv.2022.100060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-22K12379, KAKENHI-PROJECT-21K17145, KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10099
[Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023
- Author(s)
  Seki Yuki、Yamana Keisuke、Yoshida Ryoji、Inoue Junki、Shinohara Kosuke、Oyama Toru、Kubo Ryuta、Nagata Masashi、Kawahara Kenta、Hirayama Masatoshi、Takahashi Nozomu、Nakamoto Masafumi、Hirosue Akiyuki、Kariya Ryusho、Okada Seiji、Nakayama Hideki
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: in press Issue: 4 Pages: 518-525
- DOI
  10.1016/j.ajoms.2023.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K10142
[Journal Article] The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation2022
- Author(s)
  Matsuoka Yuichiro、Yoshida Ryoji、Kawahara Kenta、Sakata Junki、Arita Hidetaka、Nkashima Hikaru、Takahashi Nozomu、Hirayama Masatoshi、Nagata Masashi、Hirosue Akiyuki、Kuwahara Yoshikazu、Fukumoto Manabu、Toya Ryo、Murakami Ryuji、Nakayama Hideki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 102 Issue: 8 Pages: 896-907
- DOI
  10.1038/s41374-022-00776-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K17145
[Journal Article] Extracellular N6-isopentenyladenosine (i6A) addition induces co-transcriptional i6A incorporation into ribosomal RNAs.2022
- Author(s)
  Yakita M, Chujo T, Wei FY, Hirayama M, Kato K, Takahashi N, Naganuma K, Nagata M, Kawahara K, Nakayama H, Tomizawa K.
- Journal Title
  
  RNA
  
  Volume: 28 Issue: 7 Pages: 1013-1027
- DOI
  10.1261/rna.079176.122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02731, KAKENHI-PROJECT-21K10099, KAKENHI-PLANNED-21H05265, KAKENHI-PROJECT-23K21370
[Journal Article] Metastatic renal cell carcinoma in the maxilla: A case report2022
- Author(s)
  Asami Tsuji,Ryo Miyazaki,Natsuko Kimoto,Nozomu Takahashi,Tomoya Miyahara,Yusuke Nishiguchi,Satsuki Okamoto,Nobuo Morita,Tetsuji Omata
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: 34 Issue: 4 Pages: 542-546
- DOI
  10.1016/j.ajoms.2022.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10099
[Journal Article] Breast carcinoma metastasis to the cheek: a case report.2022
- Author(s)
  Ryo Miyazaki,Natsuko Kimoto,Satsuki Okamoto,Asami Tsuji,Yusuke Nishigushi,Tomoya Miyahara,Nozomu Takahashi,Tetsuji Omata
- Journal Title
  
  Journal of medical case reports
  
  Volume: 16 Issue: 1 Pages: 108-108
- DOI
  10.1186/s13256-022-03326-6
- Data Source
  KAKENHI-PROJECT-21K10099
[Journal Article] Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars2022
- Author(s)
  Masatoshi Hirayama,Kazushige Inoue,Hidetaka Arita,Nozomu Takahashi,Hikaru Nakashima,Junki Sakata,Manabu Maeshiro,Yuka Nagao,Shunsuke Gohara,Keisuke Yamana,Yuichiro Matsuoka,Akira Yuno,Masafumi Nakamoto,Kenta Kawahara,Masashi Nagata,Akiyuki Hirosue,Daiki Fukuma,Ryoji Yoshida,Hideki Nakayama
- Journal Title
  
  JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
  
  Volume: 34 Issue: 6 Pages: 690-697
- DOI
  10.1016/j.ajoms.2022.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118
[Journal Article] Postoperative delirium in patients undergoing tumor resection with reconstructive surgery for oral cancer2021
- Author(s)
  Takahashi Nozomu、Hiraki Akimitsu、Kawahara Kenta、Nagata Masashi、Yoshida Ryoji、Matsuoka Yuichiro、Tanaka Takuya、Obayashi Yuko、Sakata Junki、Nakashima Hikaru、Arita Hidetaka、Shinohara Masanori、Nakayama Hideki
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 14 Issue: 3 Pages: 60-60
- DOI
  10.3892/mco.2021.2222
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K17145
[Journal Article] miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.2021
- Author(s)
  Kenta Kawahara, Masashi Nagata, Ryoji Yoshida, Akiyuki Hirosue, Takuya Tanaka, Yuichiro Matsuoka, Hidetaka Arita, Hikaru Nakashima, Junki Sakata, Keisuke Yamana, Sho Kawaguchi, Shunsuke Gohara, Yuka Nagao, Masatoshi Hirayama, Nozomu Takahashi, Mayumi Hirayama, Hideki Nakayama
- Journal Title
  
  Biochemistry Biophysics Reports
  
  Volume: 21 Pages: 28-28
- DOI
  10.1016/j.bbrep.2021.101114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699, KAKENHI-PROJECT-21K17145
[Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019
- Author(s)
  Sakata J,Hirosue A,Yoshida R,Kawahara K,Matsuoka Y,Yamamoto T,Nakamoto M,Hirayama M,Takahashi N,Nakamura T,Arita H,Nakashima H,Nagata M,Hiraki A,Shinohara M,Nakayama H
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 20 Issue: 10 Pages: 2473-2473
- DOI
  10.3390/ijms20102473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19204, KAKENHI-PROJECT-19K19237, KAKENHI-PROJECT-18K17202, KAKENHI-PROJECT-19K21413
[Presentation] ミトコンドリアtRNAのms2修飾は口腔扁平上皮癌の抗がん剤耐性獲得に寄与する2019
- Author(s)
  高橋望、八木田麻耶、平山真弓、中山秀樹
- Organizer
  第64回　日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K19204
[Presentation] 口腔扁平上皮癌におけるtRNA修飾の網羅的解析（tRNA modomics）及び機能解析2017
- Author(s)
  高橋　望、魏　范研、平山　真弓、八木田　麻耶、廣末　晃之、吉田　遼司、富澤　一仁、中山　秀樹
- Organizer
  第71回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17273

1. NAKAYAMA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. HIROSUE Akiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 福本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 大野剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 富澤一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 川原健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI NOZOMU 高橋 望

Takahashi Nozomu 高橋 望

Research Projects

Research Products

Co-Researchers

New therapeutic strategies targeting mt-tRNA modification for treatment-resistant oral cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis and therapeutic development targeting tRNA methylthiolation in oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exhaustive and functional analysis of tRNA modification in oral squamous cell carcinoma, and development a new treatment strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular N6-isopentenyladenosine (i6A) addition induces co-transcriptional i6A incorporation into ribosomal RNAs.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metastatic renal cell carcinoma in the maxilla: A case report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Breast carcinoma metastasis to the cheek: a case report.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postoperative delirium in patients undergoing tumor resection with reconstructive surgery for oral cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] ミトコンドリアtRNAのms2修飾は口腔扁平上皮癌の抗がん剤耐性獲得に寄与する2019

Author(s)

Organizer

Data Source

[Presentation] 口腔扁平上皮癌におけるtRNA修飾の網羅的解析（tRNA modomics）及び機能解析2017

Author(s)

Organizer

TAKAHASHI NOZOMU 高橋望

Takahashi Nozomu 高橋望